The Chinese Early-onset Hypertension Study (CHESS)
Study Details
Study Description
Brief Summary
Hypertension (HTN) is the most important cardiovascular risk factor which is responsible for 50% of cardiovascular morbidity and mortality, and also a substantial public health problem affecting approximately 1/4 of the adult population in industrialized societies and over 1 billion people worldwide. Chronically elevated blood pressure without well control puts people at increased risk of target organ damages, including stroke, myocardial infarction, congestive heart failure, end-stage renal disease, blindness, and death. Especially, these damages are dramatically more severe in the early-onset hypertensive population.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
In this study, the hypertensive individuals are consecutively recruited from multiple centers, with an early onset age (less than 40 when diagnosed). A complete clinical history (information on history of hypertension, demographic characteristics, personal and family medical history) are collected by a trained staff using a standardized questionnaire on the first day of baseline observation, and physical examination are also collected in a standard procedure. Blood samples are collected after 12-hour overnight fast and biological variables are determined. Genomic DNA is isolated from leukocytes according to a standard procedure. The individuals will receive follow-up in an ordinal system. The investigators will focus on the clinical and genetic features, genotype-phenotype correlations and influencing factors of prognosis in Chinese early-onset hypertension patients.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| early-onset hypertension early-onset hypertension patients recruited in Chinese multiple centers |
Outcome Measures
Primary Outcome Measures
- primary mortality of early-onset hypertension [through study completion, an average of 5 years]
the primary mortality of early-onset hypertension
Secondary Outcome Measures
- secondary outcomes of heart [through study completion, an average of 5 years]
The incidence rate of left ventricular hypertrophy, myocardial infarction, congestive heart failure, and arrhythmia.
- secondary outcomes of brain [through study completion, an average of 5 years]
The incidence rate of stroke (include cerebral hemorrhage and cerebral ischemia)
- secondary outcomes of kidney [through study completion, an average of 5 years]
The incidence rate of hypertensive renal injure and end-stage renal disease
- secondary outcomes of eyes [through study completion, an average of 5 years]
The incidence rate of hypertensive eye injure
Eligibility Criteria
Criteria
Inclusion Criteria:
- In accordance with the diagnosis of hypertension (BP≥140/90mmHg), and less than 40 years when diagnosed
Exclusion Criteria:
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Fuwai hospital | Beijing | Beijing | China | 100037 |
Sponsors and Collaborators
- China National Center for Cardiovascular Diseases
Investigators
- Principal Investigator: Lei Song, MD.& PhD., Fuwai Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- CEHS-2016