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Chocolate's Effect on the Cerebral Vasculature

Sponsor
NHS Greater Glasgow and Clyde (Other)
Overall Status
Completed
CT.gov ID
NCT01507259
Collaborator
University of Glasgow (Other)
24
Enrollment
1
Location

Study Details

Study Description

Brief Summary

The popularity of chocolate can largely be attributed to its mood elevating properties, research shows that it contains antioxidants that also provide physical health benefits. Dark chocolate, in particular, contains high levels of an antioxidant called epicatechin, which is known to cause changes in blood vessels by relaxing them and increasing blood flow.

Little is know about the immediate effects of chocolate consumption, or the differences between milk and dark chocolate with regards to these effects. The project will investigate the effect of a single bar of dark or milk chocolate upon blood flow to the brain, using simple ultrasound tests.

Condition or Disease Intervention/Treatment Phase
  • Other: cocoa

Study Design

Study Type:
Observational
Actual Enrollment :
24 participants
Observational Model:
Case-Crossover
Time Perspective:
Prospective
Official Title:
A Randomised Trial of Effect of Chocolate Upon Cerebrovascular Reactivity in Healthy Adult Volunteers
Study Start Date :
Feb 1, 2012
Actual Study Completion Date :
Feb 1, 2012

Arms and Interventions

Arm Intervention/Treatment
100 g containing 70% or 34% cocoa

Healthy controls

Other: cocoa
70% versus 34%

Outcome Measures

Primary Outcome Measures

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 40 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    • No regular medication including vitamins/antioxidants

    • Able to provide informed consent

    Exclusion Criteria:

    • Inability to perform breath-hold test

    • Any known cardiovascular disease, diabetes, throid disease, high blood pressure, hyperlipidaemia or pregnancy

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Western Infirmary Glasgow United Kingdom G11 6NT

    Sponsors and Collaborators

    • NHS Greater Glasgow and Clyde
    • University of Glasgow

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Steven Burke, Sponsor's representative, NHS Greater Glasgow and Clyde
    ClinicalTrials.gov Identifier:
    NCT01507259
    Other Study ID Numbers:
    • GN11MT497
    First Posted:
    Jan 10, 2012
    Last Update Posted:
    Jul 27, 2012
    Last Verified:
    Jul 1, 2012
    Keywords provided by Steven Burke, Sponsor's representative, NHS Greater Glasgow and Clyde
    Determine effect on cerebral vasculature

    Study Results

    No Results Posted as of Jul 27, 2012