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Choline Quantification in Breast Cancer by MRS

Sponsor
Norwegian University of Science and Technology (Other)
Overall Status
Withdrawn
CT.gov ID
NCT00201487
Collaborator
The Norwegian Women´s Public Health Association (Other)
0
Enrollment

Study Details

Study Description

Brief Summary

Choline has been found in increased concentration in breast cancer patients. Hypothesis: The choline signal as observed by MRS is sensitive to treatment, and a positive response to treatment will give a reduction in choline concentration.

The purpose of this study is to establish methods for quantification of choline in breast cancer by MRS

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    1. Establishment of new MRS sequence for choline quantification of choline. This sequence is choline-selective, and signals from water and lipids are suppressed simultaneously.

    2. Compare to different methods for choline quantification. The first method is quantification through an external phantom standard, containing a known concentration of choline. The other method is based on the utilisation of internal water signal as a reference.

    Both calculations can be performed from the same MR exam. Ten patients will be included in the study.

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    0 participants
    Observational Model:
    Cohort
    Time Perspective:
    Prospective
    Official Title:
    Choline Quantification in Breast Cancer by MRS
    Study Start Date :
    Nov 1, 2007
    Actual Primary Completion Date :
    Nov 1, 2007
    Actual Study Completion Date :
    Nov 1, 2007

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      20 Years and Older
      Sexes Eligible for Study:
      Female
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:
      • breast cancer
      Exclusion Criteria:

      Contacts and Locations

      Locations

      No locations specified.

      Sponsors and Collaborators

      • Norwegian University of Science and Technology
      • The Norwegian Women´s Public Health Association

      Investigators

      • Principal Investigator: Tone Bathen, PhD, NTNU, Faculty of medicine,

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      Norwegian University of Science and Technology
      ClinicalTrials.gov Identifier:
      NCT00201487
      Other Study ID Numbers:
      • 11870
      First Posted:
      Sep 20, 2005
      Last Update Posted:
      Oct 31, 2013
      Last Verified:
      Oct 1, 2013
      Additional relevant MeSH terms:
      Breast Neoplasms

      Study Results

      No Results Posted as of Oct 31, 2013