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Chronic Alcohol and Brain Stress Circuit Response

Sponsor
Yale University (Other)
Overall Status
Completed
CT.gov ID
NCT01031264
Collaborator
National Institute on Alcohol Abuse and Alcoholism (NIAAA) (NIH)
120
Enrollment
1
Location
71
Duration (Months)
1.7
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Alcoholism is among the top three causes of preventable death and disease in the US (Mokdad et al., 2004; Room et al., 2005). Stress plays an important role in the development of alcoholism and in high vulnerability to alcohol relapse. This study will provide a greater understanding of the mechanism by which stress and alcohol consumption interacts to influence development of compulsive alcohol seeking and vulnerability to stress-induced drinking, and the results will have significant implications for the development of new prevention and treatment interventions for alcoholism.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    120 participants
    Observational Model:
    Cohort
    Time Perspective:
    Prospective
    Official Title:
    Chronic Alcohol and Brain Stress Circuit Response
    Study Start Date :
    Jan 1, 2009
    Actual Primary Completion Date :
    Dec 1, 2014
    Actual Study Completion Date :
    Dec 1, 2014

    Arms and Interventions

    Arm Intervention/Treatment
    Social drinkers

    Outcome Measures

    Primary Outcome Measures

    1. Assess differences in reactivity to cue imagery [2 years from start of study]

      Physiological measures will be collected (heart rate, blood levels), self-reports of emotional states completed & alcohol taste task performed

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    21 Years to 50 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:
    • ages 21-50

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Yale Stress Center New Haven Connecticut United States 06519

    Sponsors and Collaborators

    • Yale University
    • National Institute on Alcohol Abuse and Alcoholism (NIAAA)

    Investigators

    • Principal Investigator: Rajita Sinha, PhD, Yale University

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Rajita Sinha, Professor, Yale University
    ClinicalTrials.gov Identifier:
    NCT01031264
    Other Study ID Numbers:
    • 0706002821
    • R01AA013892
    First Posted:
    Dec 14, 2009
    Last Update Posted:
    Jul 30, 2015
    Last Verified:
    Jul 1, 2015
    Keywords provided by Rajita Sinha, Professor, Yale University
    social drinkers
    Additional relevant MeSH terms:
    Alcoholism

    Study Results

    No Results Posted as of Jul 30, 2015