CADKID: Chronic Arterial Disease, Quality of Life and Mortality in Chronic Kidney Injury
Study Details
Study Description
Brief Summary
CADKID-study is a prospective follow-up study assessing arterial disease, quality of life, mortality and their predictors in patients with severe chronic kidney disease.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
Chronic kidney disease (CKD) is associated with increased risk of cardiovascular disease and mortality as well as impaired quality of life. Participants of this study all have severe CKD, defined as estimated glomerular filtration rate < 30 ml/min per 1.73 m^2. Stress ergometry, echocardiography, ultrasound assessment of arterial intima-media thickness, lateral lumbar radiograph, ECG, laboratory tests and quality of life assessment were performed at the baseline of the study and will be repeated during follow-up. Atrial fibrillation and other cardiac arrhythmias as well as pulse wave velocity measurements will be explored. Diet diaries are gathered and analysed. The aim of the study is to identify factors associated with cardiovascular disease, quality of life and mortality in this cohort.
Study Design
Outcome Measures
Primary Outcome Measures
- Mortality [5 years]
- Cardiovascular morbidity [5 years]
Secondary Outcome Measures
- Changes in quality of life [2 years, 5 years]
Kidney Disease Quality of Life Short Form (KDQOL-SF) instrument, consisting of 20 subscales (0-100), higher score indicating better quality of life
- Number of participants with cardiac arrhythmias [2 years, 5 years]
- Rate of hospitalizations [2 years, 5 years]
- Abdominal aortic calcification (AAC) score [2 years, 5 years]
Scale 0-24, higher values indicate more calcification
- Carotid intima-media thickness [2 years, 5 years]
- Femoral intima-media thickness [2 years, 5 years]
- Flow-mediated dilatation of brachial artery [2 years, 5 years]
Dilatation at 60 seconds after the release of a cuff with pressure of 250 millimeters of mercury for 4.5 minutes, compared to at rest diameter
- Maximal bicycle stress ergometry performance [2 years, 5 years]
Mean work load (watts) of the last 4 minutes of exercise, higher values indicating better performance
- Left ventricular hypertrophy [2 years, 5 years]
Echocardiography (Interventricular septum thickness, Posterior wall thickness, Left ventricular end-diastolic diameter, Left ventricular mass index)
- Cardiac systolic function [2 years, 5 years]
Echocardiography (Left ventricular ejection fraction, Left ventricular global longitudinal strain)
- Cardiac diastolic function [2 years, 5 years]
Echocardiography (ratio of the early to late ventricular filling velocities, ratio of transmitral Doppler early filling velocity to tissue Doppler early diastolic mitral annular velocity)
Eligibility Criteria
Criteria
Inclusion Criteria:
- estimated glomerular filtration rate < 30 ml/min per 1.73 m^2
Exclusion Criteria:
-
age under 18 years
-
inability to give informed consent
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Turku University Hospital | Turku | Finland |
Sponsors and Collaborators
- Turku University Hospital
Investigators
- Principal Investigator: Kaj Metsärinne, MD, PhD, Turku University Hospital Kidney Center
- Principal Investigator: Mikko J Järvisalo, MD, PhD, Turku University Hospital Intensive Care Unit
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- T41/2013