Effects of Acetazolamide and CO2 Inhalation on Exercise-induced Periodic Breathing in Heart Failure

• Sponsor: Centro Cardiologico Monzino (Other)
• Overall Status: Completed
• CT.gov ID: NCT00517426
• Collaborator: (none)
• Enrollment: 20
• Location: 1
• Arm: 1
• Duration (Months): 61
• Patients Per Site Per Month: 0.3

Study Details

Study Description

Brief Summary

To evaluate the effects of CO2 inhalation and acetazolamide treatment on exercise-induced periodic breathing in patients with chronic stable heart failure.

Patients will be given CO2 (2%) during a constant workload exercise. Patients will be also evaluated by maximal cardiopulmonary exercise test without and with acetazolamide acute and chronic treatment.

Condition or Disease	Intervention/Treatment	Phase
Chronic Heart Failure	Drug: acetazolamide	Phase 4

Study Design

• Study Type: Interventional
• Actual Enrollment: 20 participants
• Allocation: N/A
• Intervention Model: Single Group Assignment
• Masking: None (Open Label)
• Study Start Date: Jul 1, 2007
• Actual Primary Completion Date: Jul 1, 2011
• Actual Study Completion Date: Aug 1, 2012

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Active Acetazolamide	Drug: acetazolamide; i.v. 500 mg of acetazolamide for the acute study and 500 mg of acetazolamide p.o. t.i.d. for two days; Other Names: Diamox

Outcome Measures

Primary Outcome Measures

1. Suppression of periodic breathing [two days]

Secondary Outcome Measures

1. suppression of sleeping apnea [two days]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 80 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• chronic heart failure in stable clinical condition

• exercise-induced periodic breathing

Exclusion Criteria:

• comorbidities

• NYHA class IV

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Centro Cardiologico Monzino, University of Milan	Milan		Italy	20138

Sponsors and Collaborators

• Centro Cardiologico Monzino

Investigators

• Principal Investigator: Piergiuseppe Agostoni, MD, PhD, Centro Cardiologico Monzino

Study Documents (Full-Text)

None provided.

More Information

Publications

• Agostoni P, Bussotti M, Cattadori G, Margutti E, Contini M, Muratori M, Marenzi G, Fiorentini C. Gas diffusion and alveolar-capillary unit in chronic heart failure. Eur Heart J. 2006 Nov;27(21):2538-43. Epub 2006 Oct 6.

• Responsible Party: Piergiuseppe Agostoni, MD PhD, Centro Cardiologico Monzino
• ClinicalTrials.gov Identifier: NCT00517426
• Other Study ID Numbers: R77-CCM S79/407
• First Posted: Aug 17, 2007
• Last Update Posted: Jan 28, 2016
• Last Verified: Jan 1, 2016

• Keywords provided by Piergiuseppe Agostoni, MD PhD, Centro Cardiologico Monzino: heart failure,; exercise; periodic breathing,; acetazolamide
• Additional relevant MeSH terms: Heart Failure; Acetazolamide

Study Results

No Results Posted as of Jan 28, 2016