Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients
Study Details
Study Description
Brief Summary
In patients with chronic heart failure (CHF)due to dilated cardiomyopathy diastolic dysfunction occurs frequently and is related to a poor outcome. We have previously shown that parameters of diastolic function significantly correlate with uric acid levels, a marker of impaired oxidative metabolism. We aimed to determine whether inhibition of xanthine oxidase with allopurinol might affect diastolic function in patients with CHF.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
| Phase 4 |
Study Design
Outcome Measures
Primary Outcome Measures
- diastolic function uric acid levels BNP [three months]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
chronic heart failure;
-
left ventricular systolic dysfunction (ejection fraction <45%)
-
stable clinical conditions in the previous three months
-
optimal medical therapy for CHF
-
normal sinus rhythm
-
written informed consent
-
age >18 years
Exclusion Criteria:
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renal failure (s-creatinine >2.5 mg/dl)
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already on allopurinol
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malignancies
-
chronic inflammatory diseases
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Division of Cardiology, University Hospital of Verona | Verona | Italy | 37129 |
Sponsors and Collaborators
- Universita di Verona
Investigators
- Principal Investigator: Mariantonietta Cicoira, MD, PhD, Division of Cardiology, University of Verona, Italy
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 802