VICTOR: A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035)
Sponsor
Merck Sharp & Dohme LLC (Industry)
Overall Status
Recruiting
CT.gov ID
NCT05093933
Collaborator
(none)
6,000
420
2
43.4
14.3
0.3
Study Details
Study Description
Brief Summary
The purpose of this study is to evaluate the efficacy and safety of vericiguat in participants with chronic heart failure with reduced ejection fraction (HFrEF), specifically those with symptomatic chronic HFrEF who have not had a recent hospitalization for heart failure or need for outpatient intravenous (IV) diuretics. The primary hypothesis is that vericiguat is superior to placebo in reducing the risk of cardiovascular death or heart failure hospitalization.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 3 |
Study Design
Study Type:
Interventional
Anticipated Enrollment
:
6000 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose:
Treatment
Official Title:
A Pivotal Phase 3 Randomized, Placebo-controlled Clinical Study to Evaluate the Efficacy and Safety of the sGC Stimulator Vericiguat/MK-1242 in Adults With Chronic Heart Failure With Reduced Ejection Fraction
Actual Study Start Date
:
Nov 2, 2021
Anticipated Primary Completion Date
:
Mar 31, 2025
Anticipated Study Completion Date
:
Jun 15, 2025
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Vericiguat Participants receive a starting dose of 2.5 mg of vericiguat taken orally once daily. The vericiguat dose will be titrated to 5 mg and to 10 mg. |
Drug: Vericiguat
2.5, 5.0, or 10.0 mg orally once daily
Other Names:
|
| Placebo Comparator: Placebo Participants receive a starting matching placebo to vericiguat dose of 2.5 mg taken orally once daily. The matching placebo dose will be sham titrated to 5 mg and to 10 mg. |
Drug: Placebo
0 mg matching placebo for 2.5 mg, 5 mg, and 10 mg of vericiguat
|
Outcome Measures
Primary Outcome Measures
- Time to First Occurrence of Composite Endpoint of Cardiovascular (CV) Death or Heart Failure (HF) Hospitalization [From date of randomization until the date of first occurrence of a CV death or HF hospitalization, assessed up to approximately 40 months]
The first event of CV death or HF hospitalization as confirmed by a clinical events committee (CEC).
Secondary Outcome Measures
- Time to First Occurrence of CV Death [From date of randomization until the date of first occurrence of a CV death, assessed up to approximately 40 months]
The first event of CV death as confirmed by a CEC.
- Time to First Occurrence of HF Hospitalization [From date of randomization until the date of first occurrence of a HF hospitalization, assessed up to approximately 40 months]
The first event of HF hospitalization as confirmed by a CEC.
- Time to Total HF Hospitalizations (Including First and Recurrent Events) [Up to approximately 40 months]
All events of HF hospitalization as confirmed by a CEC.
- Time to First Occurrence of Composite Endpoint of All-Cause Mortality or HF Hospitalization [From date of randomization until the date of first occurrence of death or HF hospitalization, assessed up to approximately 40 months]
The first event of death due to any cause or HF hospitalization as confirmed by a CEC.
- Time to All-Cause Mortality [From date of randomization until the date of death, assessed up to approximately 40 months]
The first event of death due to any cause as confirmed by a CEC.
- Percentage of Participants who Experienced One or More Selected Nonserious Adverse Events (NSAEs) [Up to approximately 40 months]
An adverse event (AE) is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention. An AE can therefore be any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease (new or exacerbated) temporally associated with the use of a study intervention. Selected NSAEs are nonserious AEs that meet any of the following criteria: AEs that lead to study intervention dose modification or discontinuation, AEs that lead to withdrawal from the study, or coronavirus disease (COVID-19) disease-related AEs.
- Percentage of Participants Who Experienced One or More Serious Adverse Events (SAEs) [Up to approximately 40 months]
An SAE is defined as any untoward medical occurrence that, at any dose: Results in death, is life threatening, requires inpatient hospitalization or prolongation of existing hospitalization, results in persistent or significant disability/incapacity, is a congenital anomaly/birth defect, or is another important medical event, as judged medically or scientifically, that may not be immediately life-threatening or result in death or hospitalization but may jeopardize the participant or may require medical or surgical intervention to prevent one of the other outcomes listed above.
- Percentage of Participants Who Experienced One or More Events of Clinical Interest (ECIs) [Up to approximately 40 months]
Events of clinical interest will include: 1) Potential drug-induced liver injury (DILI) events defined as: elevated aspartate aminotransferase (AST) or alanine aminotransferase (ALT) laboratory value that is greater than or equal to 3X the upper limit of normal (ULN) and an elevated total bilirubin laboratory value that is greater than or equal to 2X the ULN and, at the same time, an alkaline phosphatase laboratory value that is less than 2X the ULN, as determined by way of protocol specified laboratory testing or unscheduled laboratory testing, 2) Symptomatic hypotension 3) Anemia.
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
-
History of chronic HF [New York Heart Association (NYHA) Class II to IV] on guideline-directed medical therapy for heart failure (GDMT) with no HF hospitalization within 6 months or outpatient IV diuretic use within 3 months before randomization.
-
Left ventricular ejection fraction (LVEF) of ≤40%, assessed within 12 months before randomization by any imaging method.
-
Elevated N-terminal pro-brain natriuretic peptide (NT-proBNP) levels.
-
A female participant is eligible to participate if she is not pregnant or breastfeeding, is not a woman of childbearing potential (WOCBP), or is a WOCBP and agrees to follow contraceptive guidance during the study intervention period and for at least 1 month after the last dose of study intervention.
Exclusion Criteria:
-
Awaiting heart transplantation, is receiving continuous IV infusion of an inotrope, or has or anticipates receiving an implanted ventricular assist device.
-
Amyloidosis or sarcoidosis.
-
Primary valvular heart disease requiring surgical procedure or intervention or has undergone a valvular surgical procedure or intervention within 3 months before randomization.
-
Hypertrophic cardiomyopathy.
-
Acute myocarditis or Takotsubo cardiomyopathy.
-
History of heart transplant.
-
Tachycardia-induced cardiomyopathy and/or uncontrolled tachyarrhythmia
-
Acute coronary syndrome, or undergone coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) within 3 months before randomization.
-
History of symptomatic carotid stenosis, transient ischemic attack (TIA), or stroke within 3 months before randomization.
-
Malignancy or other noncardiac condition limiting life expectancy to <3 years.
-
Requires continuous home oxygen for severe pulmonary disease.
-
Interstitial lung disease.
-
Discontinuation or dose modification of GDMT or vericiguat within 4 weeks before randomization.
-
Recent history (within the last year) of drug or alcohol abuse or dependence
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Advanced Cardiovascular - Alexander City ( Site 0038) | Alexander City | Alabama | United States | 35010 |
| 2 | Heart Center Research, LLC ( Site 0156) | Huntsville | Alabama | United States | 35801 |
| 3 | Mercy Gilbert Medical Center-Dignity Health Cardiology ( Site 0075) | Gilbert | Arizona | United States | 85297 |
| 4 | Valley Clinical Trials, Inc. ( Site 0085) | Covina | California | United States | 91723 |
| 5 | VA West Los Angeles Medical Center-Cardiology ( Site 0149) | Los Angeles | California | United States | 90073 |
| 6 | Valley Clinical Trials Inc ( Site 0006) | Northridge | California | United States | 91325 |
| 7 | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center ( Site 0010) | Torrance | California | United States | 90502 |
| 8 | Blue Coast Research Center ( Site 0053) | Vista | California | United States | 92083 |
| 9 | Excel Medical Clinical Trials ( Site 0008) | Boca Raton | Florida | United States | 33434 |
| 10 | Holy Cross Hospital ( Site 0100) | Fort Lauderdale | Florida | United States | 33308 |
| 11 | Indago Research and Health Center Inc ( Site 0011) | Hialeah | Florida | United States | 33012 |
| 12 | South Florida Research Solutions ( Site 0058) | Hollywood | Florida | United States | 33021 |
| 13 | East Coast Institute for Research, LLC ( Site 0047) | Jacksonville | Florida | United States | 32216 |
| 14 | Cardiovascular Research Center of South Florida ( Site 0074) | Miami | Florida | United States | 33173 |
| 15 | ProLive Medical Research ( Site 0032) | Miami | Florida | United States | 33175 |
| 16 | BAYCARE MEDICAL GROUP ( Site 0099) | Safety Harbor | Florida | United States | 34695 |
| 17 | East Coast Institute for Research - St. Augustine ( Site 0016) | Saint Augustine | Florida | United States | 32086 |
| 18 | Cardiovascular Center of Sarasota ( Site 0154) | Sarasota | Florida | United States | 34239 |
| 19 | Emory University School of Medicine ( Site 0123) | Atlanta | Georgia | United States | 30322 |
| 20 | IACT Health ( Site 0106) | Columbus | Georgia | United States | 31904 |
| 21 | NSC Research ( Site 0068) | Johns Creek | Georgia | United States | 30024 |
| 22 | Georgia Arrhythmia Consultants and Research Institute ( Site 0042) | Macon | Georgia | United States | 31201 |
| 23 | Cardiovascular Consultants of South Georgia, LLC ( Site 0137) | Thomasville | Georgia | United States | 31792 |
| 24 | Mount Sinai Hospital ( Site 0050) | Chicago | Illinois | United States | 60608 |
| 25 | Chicago Medical Research ( Site 0086) | Hazel Crest | Illinois | United States | 60429 |
| 26 | OSF Healthcare Cardiovascular Institute ( Site 0122) | Peoria | Illinois | United States | 61614 |
| 27 | Methodist Medical Center of Illinois ( Site 0098) | Peoria | Illinois | United States | 61636 |
| 28 | The Heart Center of Lake County Research Institute-Research ( Site 0147) | Merrillville | Indiana | United States | 46410 |
| 29 | Cardiovascular Research of Northwest Indiana ( Site 0036) | Munster | Indiana | United States | 46321 |
| 30 | Reid Physician Associates ( Site 0054) | Richmond | Indiana | United States | 47374 |
| 31 | University of Iowa ( Site 0005) | Iowa City | Iowa | United States | 52242 |
| 32 | Alliance for Multispecialty Research, LLC ( Site 0143) | Wichita | Kansas | United States | 67207 |
| 33 | Norton Healthcare-Norton Heart Specialist ( Site 0062) | Louisville | Kentucky | United States | 40205 |
| 34 | Cambridge Medical Trials ( Site 0041) | Alexandria | Louisiana | United States | 71301 |
| 35 | Louisiana Heart Center - Hammond ( Site 0004) | Hammond | Louisiana | United States | 70403 |
| 36 | The Heart Clinic - Hammond ( Site 0155) | Hammond | Louisiana | United States | 70403 |
| 37 | Cardiovascular Institute of the South ( Site 0072) | Houma | Louisiana | United States | 70360 |
| 38 | Cardiovascular Institute of the South, 3 ( Site 0096) | Lafayette | Louisiana | United States | 70503 |
| 39 | Clinical Trials of America - 1100 North 18th Street ( Site 0112) | Monroe | Louisiana | United States | 71201 |
| 40 | Cardiovascular Institute of the South ( Site 0081) | Opelousas | Louisiana | United States | 70570 |
| 41 | Maryland Cardiovascular Specialists ( Site 0056) | Baltimore | Maryland | United States | 21229 |
| 42 | Ascension Providence Hospital ( Site 0094) | Southfield | Michigan | United States | 48075 |
| 43 | Phillips Medical Services ( Site 0070) | Jackson | Mississippi | United States | 39209 |
| 44 | The University of Mississippi Medical Center-Cardiovascular ( Site 0073) | Jackson | Mississippi | United States | 39216 |
| 45 | Washington University-Department of Medicine ( Site 0044) | Saint Louis | Missouri | United States | 63110 |
| 46 | St. Louis Heart and Vascular, P.C.-Clinical Trials Unit ( Site 0029) | Saint Louis | Missouri | United States | 63136 |
| 47 | Logan Health Research ( Site 0017) | Kalispell | Montana | United States | 59901 |
| 48 | Amici Clinical Research LLC-Research ( Site 0037) | Raritan | New Jersey | United States | 08869 |
| 49 | The Valley Hospital ( Site 0035) | Ridgewood | New Jersey | United States | 07450 |
| 50 | Cardiovascular Associates of the Delaware Valley ( Site 0097) | Washington Township | New Jersey | United States | 08080 |
| 51 | CHEAR Center LLC ( Site 0009) | Bronx | New York | United States | 10455 |
| 52 | Erie County Medical Center ( Site 0160) | Buffalo | New York | United States | 14215 |
| 53 | New York Presbyterian Medical Group Hudson Valley Cardiology ( Site 0127) | Cortlandt Manor | New York | United States | 10567 |
| 54 | Icahn School of Medicine at Mount Sinai ( Site 0161) | New York | New York | United States | 10029 |
| 55 | Southeastern Cardiology and Cardiovascular-Duke HC CRU - Lumberton ( Site 0134) | Lumberton | North Carolina | United States | 28358 |
| 56 | Accellacare - Wilmington ( Site 0090) | Wilmington | North Carolina | United States | 28401 |
| 57 | Aultman Hospital-Cardiology Clinical Trials ( Site 0064) | Canton | Ohio | United States | 44710 |
| 58 | University of Cincinnati Medical Center-Cardiology ( Site 0071) | Cincinnati | Ohio | United States | 45219 |
| 59 | ProMedica Toledo Hospital-ProMedica Heart Failure Clinic ( Site 0061) | Toledo | Ohio | United States | 43606 |
| 60 | Doylestown Hospital-Cardiology ( Site 0030) | Doylestown | Pennsylvania | United States | 18901 |
| 61 | Accellacare - Charleston ( Site 0141) | Charleston | South Carolina | United States | 29407 |
| 62 | Apex Research Foundation ( Site 0001) | Jackson | Tennessee | United States | 38301 |
| 63 | Vanderbilt University Medical Center-Vanderbilt Heart and Vascular Institue ( Site 0060) | Nashville | Tennessee | United States | 37232 |
| 64 | Dallas VA Medical Center ( Site 0084) | Dallas | Texas | United States | 75216 |
| 65 | Southwest Family Medicine Associates ( Site 0131) | Dallas | Texas | United States | 75235 |
| 66 | West Houston Area Clinical Trial Consultants ( Site 0014) | Houston | Texas | United States | 77094 |
| 67 | South Texas Cardiovascular Consultants, PLLC-Research ( Site 0024) | Kerrville | Texas | United States | 78028 |
| 68 | South Texas Cardiovascular Consultants, PLLC-Research ( Site 0020) | San Antonio | Texas | United States | 78201 |
| 69 | Tyler Cardiovascular Consultants ( Site 0039) | Tyler | Texas | United States | 75701 |
| 70 | INOVA Fairfax Medical Campus ( Site 0136) | Falls Church | Virginia | United States | 22042 |
| 71 | Carient Heart & Vascular - Manassas ( Site 0059) | Manassas | Virginia | United States | 20109 |
| 72 | Sentara Norfolk General Hospital ( Site 0114) | Norfolk | Virginia | United States | 23507 |
| 73 | Dominion Medical Associates, Inc. ( Site 0089) | Richmond | Virginia | United States | 23219 |
| 74 | Pulse Heart Institute - Puyallup ( Site 0119) | Puyallup | Washington | United States | 98372 |
| 75 | MultiCare Health System-MultiCare Cardiology - Inland Northwest ( Site 0102) | Spokane | Washington | United States | 99204 |
| 76 | Royal Brisbane and Women's Hospital-Cardiology Research ( Site 0453) | Brisbane | Queensland | Australia | 4029 |
| 77 | The Prince Charles Hospital-Cardiology Research Centre ( Site 0451) | Brisbane | Queensland | Australia | 4032 |
| 78 | Core Research Group ( Site 0452) | Brisbane | Queensland | Australia | 4064 |
| 79 | Royal Adelaide Hospital-Cardiology ( Site 0456) | Adelaide | South Australia | Australia | 5000 |
| 80 | Flinders Medical Centre-Cardiology Research ( Site 0455) | Bedford Park | South Australia | Australia | 5042 |
| 81 | St. John of God Subiaco Hospital ( Site 0457) | Subiaco | Western Australia | Australia | 6008 |
| 82 | Krankenhaus St. Josef Braunau ( Site 0354) | Braunau | Oberosterreich | Austria | 5280 |
| 83 | Medizinische Universität Graz-Department of Cardiology ( Site 0351) | Graz | Steiermark | Austria | 8036 |
| 84 | Imed19-privat ( Site 0353) | Vienna | Wien | Austria | 1190 |
| 85 | Uniklinikum Salzburg-Universitätsklinik für Innere Medizin II, Kardiologie, Internistische Intensiv | Salzburg | Austria | 5020 | |
| 86 | Klinik Floridsdorf-Karl Landsteiner Institute for Cardiovascular and Critical Care Research c/o Dep | Wien | Austria | 1210 | |
| 87 | PUC Trials- Nucleo de Pesquisa clinica da Escola de Medicina da PUCPR ( Site 0555) | Curitiba | Parana | Brazil | |
| 88 | Instituto de Pesquisa clinica de Campinas ( Site 0551) | Campinas | Sao Paulo | Brazil | 13060-080 |
| 89 | University Of Alberta Hospital ( Site 0669) | Edmonton | Alberta | Canada | T6G 1W9 |
| 90 | Victoria Heart Institute Foundation ( Site 0680) | Victoria | British Columbia | Canada | V8R 1B2 |
| 91 | St. Boniface General Hospital ( Site 0667) | Winnipeg | Manitoba | Canada | R2H 2A6 |
| 92 | G A Research Associates ( Site 0652) | Moncton | New Brunswick | Canada | E1G 1A7 |
| 93 | NSHA-QEII Health Sciences Centre-Dickson Bldg-Cardiology ( Site 0664) | Halifax | Nova Scotia | Canada | B3H 3A7 |
| 94 | Cambridge Cardiac Care Centre ( Site 0658) | Cambridge | Ontario | Canada | N1R 6V6 |
| 95 | PACE Cardiology ( Site 0675) | Newmarket | Ontario | Canada | L3Y 2P6 |
| 96 | Oakville Cardiovascular Research LP ( Site 0657) | Oakville | Ontario | Canada | L6K 3W7 |
| 97 | Private Practice - Dr. James Cha ( Site 0655) | Oshawa | Ontario | Canada | L1J 2K1 |
| 98 | Kawartha Cardiology Clinical Trials ( Site 0654) | Peterborough | Ontario | Canada | K9J 0B2 |
| 99 | Corcare-Corcare Cardiovascular Research ( Site 0660) | Toronto | Ontario | Canada | M1B 5N1 |
| 100 | Medicus MFC Research Clinic ( Site 0676) | Toronto | Ontario | Canada | M4P 1E4 |
| 101 | Hôpital de la Cité-de-la-Santé ( Site 0673) | Laval | Quebec | Canada | H7M 3L9 |
| 102 | Montreal General Hospital ( Site 0653) | Montreal | Quebec | Canada | H3G 1A4 |
| 103 | Centro De Estudios Cardiologicos Y De Medicina Interna ( Site 0752) | Temuco | Araucania | Chile | 4780000 |
| 104 | IC La Serena Research ( Site 0769) | La Serena | Coquimbo | Chile | 1720430 |
| 105 | Clinica Alemana Osorno ( Site 0768) | Osorno | Los Lagos | Chile | 5311089 |
| 106 | Clinical Research Chile SpA ( Site 0761) | Valdivia | Los Rios | Chile | 5110683 |
| 107 | Enroll SpA ( Site 0755) | Santiago | Region M. De Santiago | Chile | 7500587 |
| 108 | Clinica Dermacross ( Site 0760) | Santiago | Region M. De Santiago | Chile | 7640881 |
| 109 | Espacio Eme ( Site 0762) | Santiago | Region M. De Santiago | Chile | 7770086 |
| 110 | Hospital y CRS El Pino ( Site 0763) | Santiago | Region M. De Santiago | Chile | 8053095 |
| 111 | Universidad de Chile - Hospital Clínico Universidad de Chile ( Site 0754) | Santiago | Region M. De Santiago | Chile | 8330111 |
| 112 | Clínica Ensenada ( Site 0753) | Santiago | Region M. De Santiago | Chile | 8380465 |
| 113 | Cardio Sur ( Site 0756) | Santiago | Region M. De Santiago | Chile | 8910259 |
| 114 | Aero Space Center Hospital ( Site 0918) | Beijing | Beijing | China | 100049 |
| 115 | Beijing Tsinghua Changgung Hospital ( Site 0911) | Beijing | Beijing | China | 102202 |
| 116 | The Second Affiliated Hospital Chongqing Medical University-Department of Cardiology ( Site 0908) | Chongqing | Chongqing | China | 400010 |
| 117 | Chongqing Three Gorges Central Hospital ( Site 0913) | Wanzhou | Chongqing | China | 404199 |
| 118 | Lanzhou university second hospital-Lanzhou university second hospital ( Site 0863) | Lanzhou | Gansu | China | 730030 |
| 119 | The First People's Hospital of Foshan ( Site 0898) | Foshan | Guangdong | China | 528041 |
| 120 | Guangdong Provincial People's Hospital-Cardiology ( Site 0852) | Guangzhou | Guangdong | China | 510080 |
| 121 | Sun Yat-sen Memorial Hospital, Sun Yat-sen University-Cardiology ( Site 0868) | Guangzhou | Guangdong | China | 510120 |
| 122 | The First Affiliated Hospital of Jinan University ( Site 0897) | Guangzhou | Guangdong | China | 510630 |
| 123 | Hainan General Hospital ( Site 0894) | Haikou | Hainan | China | 570311 |
| 124 | Wuhan Union Hospital ( Site 0919) | Wuhan | Hubei | China | 430022 |
| 125 | Changsha Central Hospital ( Site 0854) | Changsha | Hunan | China | 410004 |
| 126 | Hunan Provincial People's Hospital ( Site 0857) | ChangSha | Hunan | China | 410005 |
| 127 | Xiangya Hospital Central South University-Cardiological Department ( Site 0899) | Changsha | Hunan | China | 410008 |
| 128 | The Third Xiangya Hospital of Central South University-Cardiology ( Site 0860) | Changsha | Hunan | China | 410013 |
| 129 | BAO TOU CENTRAL HOSPITAL ( Site 0866) | Bao Tou | Inner Mongolia | China | 014040 |
| 130 | Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Cardiolggy | Nanjing | Jiangsu | China | 210000 |
| 131 | The Second Affiliated Hospital of Nanjing Medical University-Cardiology ( Site 0900) | Nanjing | Jiangsu | China | 210011 |
| 132 | Wuxi No.2 People's Hospital-Cardiology Department ( Site 0877) | Wuxi | Jiangsu | China | 214002 |
| 133 | Wuxi People's Hospital-Cardiovascular Department ( Site 0870) | Wuxi | Jiangsu | China | 214023 |
| 134 | The Affiliated Hospital of Xuzhou Medical College ( Site 0910) | Xuzhou | Jiangsu | China | 221006 |
| 135 | Northern Jiangsu People's Hospital ( Site 0861) | Yangzhou | Jiangsu | China | 225001 |
| 136 | Affiliated Hospital of Jiangsu University-Cardiology Department ( Site 0917) | Zhenjiang | Jiangsu | China | 212001 |
| 137 | The Second Affiliated Hospital of Nanchang University-Cardiology ( Site 0912) | Nanchang | Jiangxi | China | 330006 |
| 138 | China-Japan Union Hospital-department of cardiology ( Site 0916) | Changchun | Jilin | China | 130033 |
| 139 | Siping Central People's Hospital-Cardiovascular Department ( Site 0915) | Siping | Jilin | China | 136000 |
| 140 | The People's Hospital of Liaoning Province ( Site 0859) | Shenyang | Liaoning | China | 110000 |
| 141 | The First Affiliated Hospital of Xian Jiaotong University ward1 depattment of medical oncology ( Sit | Xi'an | Shaanxi | China | 710061 |
| 142 | Shaanxi provincial people's hospital ( Site 0853) | Xian | Shaanxi | China | 710068 |
| 143 | Zhongshan Hospital,Fudan University-Cardiology ( Site 0851) | Shanghai | Shanghai | China | 200032 |
| 144 | Shanghai Tongji Hospital-Cardiovascular Department ( Site 0905) | Shanghai | Shanghai | China | 200065 |
| 145 | Shanghai Yangpu District Central Hospital-Cardiology ( Site 0876) | Shanghai | Shanghai | China | 200090 |
| 146 | West China Hospital Sichuan University ( Site 0904) | Cheng Du | Sichuan | China | 610041 |
| 147 | The Second Hospital of Tianjin Medical University-Endocrinology ( Site 0902) | Tianjin | Tianjin | China | 300211 |
| 148 | Tianjin Chest Hospital-Cardiology ( Site 0901) | Tianjin | Tianjin | China | 300222 |
| 149 | Tianjin People' s Hospital ( Site 0867) | Tianjin | Tianjin | China | |
| 150 | The First Affiliated Hospital, Zhejiang University ( Site 0907) | Hangzhou | Zhejiang | China | 310003 |
| 151 | Zhejiang Provincial People's Hospital ( Site 0914) | Hangzhou | Zhejiang | China | 311599 |
| 152 | People's Hospital of Lishui City-department of cardiovascular ( Site 0862) | Lishui | Zhejiang | China | 323000 |
| 153 | The First Affiliated Hospital of Wenzhou Medical University-Vasculocardiology Department ( Site 0874 | Wenzhou | Zhejiang | China | 325000 |
| 154 | Fundación Centro de Investigación Clínica CIC ( Site 0955) | Medellín | Antioquia | Colombia | 050021 |
| 155 | Centro Cardiovascular Colombiano Clínica Santa María ( Site 0951) | Medellín | Antioquia | Colombia | 050034 |
| 156 | Rodrigo Botero S.A.S ( Site 0953) | Medellín | Antioquia | Colombia | 50030 |
| 157 | IPS Centro Científico Asistencial S.A.S ( Site 0952) | Barranquilla | Atlantico | Colombia | 0800020 |
| 158 | Clinica de la Costa LTDA ( Site 0954) | Barranquilla | Atlantico | Colombia | 080020 |
| 159 | IPS Médicos Internistas de Caldas ( Site 0959) | Manizales | Caldas | Colombia | 170004 |
| 160 | Instituto Del Corazón De Bucaramanga ( Site 0960) | Bucaramanga | Santander | Colombia | 680002 |
| 161 | Fundación Cardiovascular de Colombia ( Site 0961) | Piedecuesta | Santander | Colombia | 681017 |
| 162 | Fundacion Valle del Lili- CIC-Internal Medicine ( Site 0962) | Cali | Valle Del Cauca | Colombia | 760032 |
| 163 | Centro de Investigaciones Clinicas SAS ( Site 0957) | Cali | Valle Del Cauca | Colombia | 760036 |
| 164 | Instituto de investigaciones Centro Medico Imbanaco ( Site 0963) | Cali | Valle Del Cauca | Colombia | |
| 165 | Fakultní nemocnice Brno Bohunice-Interni kardiologicka klinika ( Site 1058) | Brno | Brno-mesto | Czechia | 62500 |
| 166 | Vojenská Nemocnice Brno-Internal department ( Site 1055) | Brno | Brno-mesto | Czechia | 636 00 |
| 167 | MUDr. Libor Nechvatal s.r.o. , Kardiologie ( Site 1057) | Brno | Jihomoravsky Kraj | Czechia | 602 00 |
| 168 | KIGE ( Site 1060) | Znojmo | Jihomoravsky Kraj | Czechia | 669 02 |
| 169 | Klinika Dr. Pirka ( Site 1065) | Mladá Boleslav | Mlada Boleslav | Czechia | 293 01 |
| 170 | Institut Klinicke a Experimentalni Mediciny-Klinika kardiologie ( Site 1052) | Prague | Praha 4 | Czechia | 140 21 |
| 171 | Ustredni vojenska nemocnice-Oddeleni kardiologie ( Site 1054) | Praha | Praha 6 | Czechia | 169 02 |
| 172 | Nemocnice Slany-Interna - kardiologicka ambulance ( Site 1063) | Slany | Stredocesky Kraj | Czechia | 274 01 |
| 173 | KardioBusak s.r.o. ( Site 1051) | Louny | Czechia | 44001 | |
| 174 | Vseobecna fakultni nemocnice v Praze-Centrum srdečního selhání ( Site 1059) | Praha 2 | Czechia | 12808 | |
| 175 | Rigshospitalet-Cardiology ( Site 1161) | Copenhagen | Hovedstaden | Denmark | 2100 |
| 176 | Amager Hospital ( Site 1163) | CPH | Hovedstaden | Denmark | 2300 |
| 177 | Herlev and Gentofte Hospital-Department of Cardiology ( Site 1158) | Hellerup | Hovedstaden | Denmark | 2900 |
| 178 | Nordsjællands Hospital - Hillerød ( Site 1159) | Hillerod | Hovedstaden | Denmark | 3400 |
| 179 | Hvidovre Hospital-259 ( Site 1151) | Hvidovre | Hovedstaden | Denmark | 2650 |
| 180 | Aarhus Universitetshospital, Skejby ( Site 1160) | Aarhus | Midtjylland | Denmark | 8200 |
| 181 | Sygehus Vendsyssel Hjoerring ( Site 1164) | Hjorring | Nordjylland | Denmark | 9800 |
| 182 | Holbæk Sygehus-Cardiology ( Site 1152) | Holbaek | Sjaelland | Denmark | 4300 |
| 183 | Roskilde Sygehus ( Site 1162) | Roskilde | Sjaelland | Denmark | 4000 |
| 184 | Slagelse Sygehus-Ambulatorium for Hjertesygdomme ( Site 1153) | Slagelse | Sjaelland | Denmark | 4200 |
| 185 | Sydvestjysk Sygehus Esbjerg-Hjertemedicinsk Projekt ( Site 1154) | Esbjerg | Syddanmark | Denmark | 6700 |
| 186 | Svendborg Hospital Odense Universitets hospital-Kardiologisk Forskningsenhed ( Site 1156) | Svendborg | Syddanmark | Denmark | 5700 |
| 187 | Centre Hospitalier Louis Pasteur ( Site 1360) | Le Coudray | Eure-et-Loir | France | 28630 |
| 188 | CHU Rangueil-Cardiology ( Site 1351) | Toulouse | Haute-Garonne | France | 31059 |
| 189 | CHU Charles Nicolle ( Site 1354) | Rouen | Haute-Normandie | France | 76000 |
| 190 | Centre Hospitalier Régional Universitaire de Nancy - Hôpitau-Centre Investigation Clinique Plurithé | Vandoeuvre lès Nancy | Lorraine | France | 54511 |
| 191 | Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre ( Site 1356) | Le Kremlin-Bicêtre | Paris | France | 94270 |
| 192 | Centre Hospitalier intercommunal de Toulon La Seyne sur Mer ( Site 1352) | Toulon | Provence-Alpes-Cote-d Azur | France | 83100 |
| 193 | CHD Vendee ( Site 1361) | La Roche-sur-Yon | Vendee | France | 85000 |
| 194 | Universitaetsklinikum Heidelberg-Klinik für Kardiologie, Angiologie und Pneumologie ( Site 1475) | Heidelberg | Baden-Wurttemberg | Germany | 69120 |
| 195 | Klinikum Coburg ( Site 1464) | Coburg | Bayern | Germany | |
| 196 | Kardiologische Gemeinschaftspraxis ( Site 1460) | Nuremberg | Bayern | Germany | 90402 |
| 197 | ClinPhenomics GmbH & Co KG ( Site 1457) | Frankfurt | Hessen | Germany | 60596 |
| 198 | Klinikum Frankfurt Höchst ( Site 1463) | Frankfurt | Hessen | Germany | 65929 |
| 199 | Asklepios Klinik Langen ( Site 1473) | Langen | Hessen | Germany | 63225 |
| 200 | Universitätsmedizin Greifswald ( Site 1470) | Greifswald | Mecklenburg-Vorpommern | Germany | 17475 |
| 201 | St. Vinzenz-Hospital-Cardiology ( Site 1455) | Cologne | Nordrhein-Westfalen | Germany | 50733 |
| 202 | Klinikum Leverkusen ( Site 1453) | Leverkusen | Nordrhein-Westfalen | Germany | 51375 |
| 203 | Kliniken Maria Hilf-Klinik für Kardiologie ( Site 1454) | Mönchengladbach | Nordrhein-Westfalen | Germany | 41063 |
| 204 | Gemeinschaftspraxis Dr. Fabian Krämer, Dr. Ulrich Overhoff ( Site 1459) | Siegen | Nordrhein-Westfalen | Germany | 57072 |
| 205 | Klinikum Ludwigshafen ( Site 1456) | Ludwigshafen | Rheinland-Pfalz | Germany | 67063 |
| 206 | Marienhaus Klinikum St. Elisabeth Neuwied ( Site 1452) | Neuwied | Rheinland-Pfalz | Germany | 56564 |
| 207 | Staedtisches Klinikum Dresden-2. Medizinische Klinik ( Site 1468) | Dresden | Sachsen | Germany | 01067 |
| 208 | Herzzentrum Dresden GmbH Universitätsklinik ( Site 1469) | Dresden | Sachsen | Germany | |
| 209 | Katholisches Krankenhaus St. Johann Nepomuk ( Site 1462) | Erfurt | Thuringen | Germany | 99097 |
| 210 | Praxis Rankestrasse ( Site 1461) | Berlin | Germany | 10789 | |
| 211 | Cardiologicum Hamburg ( Site 1467) | Hamburg | Germany | 22041 | |
| 212 | General Hospital of Athens Hippokratio ( Site 1552) | Athens | Attiki | Greece | 115 27 |
| 213 | Konstantopoulio General Hospital-Cardiology Clinic ( Site 1553) | Athens | Attiki | Greece | 142 33 |
| 214 | Alexandra Hospital-HEART FAILURE AND CARDIO-ONCOLOGY UNIT ( Site 1559) | Athina | Attiki | Greece | 115 28 |
| 215 | ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 1556) | Chaidari | Attiki | Greece | 124 62 |
| 216 | University Hospital of Ioannina-2nd Department of Cardiology ( Site 1554) | Ioannina | Dytiki Ellada | Greece | 455 00 |
| 217 | University Hospital of Alexandroupolis-First Department of Internal Medicine ( Site 1551) | Alexanroupolis | Evros | Greece | 681 00 |
| 218 | University General Hospital of Larissa ( Site 1555) | Larissa | Thessalia | Greece | 411 10 |
| 219 | AHEPA University General Hospital of Thessaloniki-1st Cardiology Clinic ( Site 1558) | Thessaloniki | Greece | 546 36 | |
| 220 | European Interbalkan Medical Center-2nd Department of Cardiology ( Site 1557) | Thessaloniki | Greece | 57001 | |
| 221 | Grantham Hospital ( Site 1753) | Aberdeen | Hong Kong | 999077 | |
| 222 | Queen Mary Hospital-Medicine - Cardiology ( Site 1752) | Hksar | Hong Kong | ||
| 223 | Princess Margaret Hospital ( Site 1755) | Hong Kong | Hong Kong | ||
| 224 | Prince of Wales Hospital ( Site 1751) | Shatin | Hong Kong | NT | |
| 225 | Bacs-Kiskun Megyei Korhaz-I. Belgyógyászat - Kardiológia ( Site 1873) | Kecskemét | Bacs-Kiskun | Hungary | 6000 |
| 226 | CoroMed ( Site 1867) | Pécs | Baranya | Hungary | 7623 |
| 227 | Pécsi Tudományegyetem Klinikai Központ ( Site 1865) | Pécs | Baranya | Hungary | 7624 |
| 228 | Private Practice - Dr. Lakatos Ferenc ( Site 1854) | Békéscsaba | Bekes | Hungary | 5600 |
| 229 | Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ-Belgyógyászati Klinika ( Site 1874) | Szeged | Csongrad | Hungary | 6725 |
| 230 | TaNa Med ( Site 1866) | Mosonmagyaróvár | Gyor-Moson-Sopron | Hungary | 9200 |
| 231 | Flor Ferenc Hospital of Pest County-5th Department of Internal Medicine ( Site 1852) | Kistarcsa | Pest | Hungary | 2143 |
| 232 | CMed Rehabilitacios es Diagnosztikai Kozpont ( Site 1877) | Székesfehérvár | Szekesfehervar | Hungary | 8000 |
| 233 | Tolna Megyei Balassa János Kórház ( Site 1868) | Szekszárd | Szekszard | Hungary | 7100 |
| 234 | DRC Gyógyszervizsgáló Központ ( Site 1869) | Balatonfüred | Veszprem | Hungary | 8230 |
| 235 | Szent Rókus Kórház ( Site 1858) | Budapest | Hungary | 1085 | |
| 236 | Gottsegen György Országos Kardiológiai Intézet ( Site 1851) | Budapest | Hungary | 1096 | |
| 237 | Semmelweis University-Városmajori Szív- és Érgyógyászati Klinika ( Site 1855) | Budapest | Hungary | 1122 | |
| 238 | Óbudai Egészségügyi Centrum ( Site 1861) | Budapest | Hungary | 1932 | |
| 239 | Medifarma 98 Kft-Outpatient Clinic ( Site 1859) | Nyiregyhaza | Hungary | 4400 | |
| 240 | OEC Clinical Research - Zalaegerszeg ( Site 1864) | Zalaegerszeg | Hungary | 8900 | |
| 241 | St. Michael's Hospital ( Site 1955) | Dun Laoghaire | Dublin | Ireland | A96 D628 |
| 242 | St. James's Hospital-Cardiology ( Site 1951) | Dublin | Ireland | D08 E9P6 | |
| 243 | Assuta Ashdod Medical Center-Cardiology ( Site 2063) | Ashdod | Israel | 7747629 | |
| 244 | Hillel Yaffe Medical Center-Heart Institute ( Site 2058) | Hadera | Israel | 3810101 | |
| 245 | Rambam Health Care Campus-Cardiology ( Site 2053) | Haifa | Israel | 3109601 | |
| 246 | Shaare Zedek Medical Center-Cardiology ( Site 2055) | Jerusalem | Israel | 9013102 | |
| 247 | Hadassah Medical Center-Heart Institute ( Site 2062) | Jerusalem | Israel | 9112001 | |
| 248 | Galilee Medical Center-Cardiology ( Site 2051) | Nahariya | Israel | 2210001 | |
| 249 | Rabin Medical Center-Cardiology - CHF ( Site 2052) | Petah-Tikva | Israel | 49100 | |
| 250 | Sheba Medical Center-Leviev Heart Center ( Site 2064) | Ramat Gan | Israel | 5262100 | |
| 251 | Kaplan Medical Center-Heart Institution ( Site 2054) | Rehovot | Israel | 7610001 | |
| 252 | Yitzhak Shamir Medical Center-Cardiology ( Site 2060) | Zerifin | Israel | 609300 | |
| 253 | Azienda Ospedaliero Universitaria S.Anna ( Site 2152) | Cona | Emilia-Romagna | Italy | 44124 |
| 254 | Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico-U.O.C. Cardiologia ( Site 2161) | Milano | Lombardia | Italy | 20122 |
| 255 | Centro Cardiologico Monzino-Heart Failure Unit ( Site 2153) | Milano | Lombardia | Italy | 20138 |
| 256 | ASST Grande Ospedale Metropolitano Niguarda-Unità Ricerche Cliniche della Cardiologia 4 ( Site 2159) | Milan | Milano | Italy | 20162 |
| 257 | IRCCS San Raffaele Pisana-riabilitazione cardiologica ( Site 2156) | Rome | Roma | Italy | 00163 |
| 258 | ospedale le scotte ( Site 2163) | Siena | Toscana | Italy | 53100 |
| 259 | Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII-Cardiologia 1 ( Site 2151) | Bergamo | Italy | 24127 | |
| 260 | IRCCS - AOU di Bologna-Dept. of Medical and Surgical sciences ( Site 2158) | Bologna | Italy | 40138 | |
| 261 | Azienda Ospedaliera Spedali Civili di Brescia-Cardiology- Day Hospital ( Site 2154) | Brescia | Italy | 25123 | |
| 262 | Fondazione IRCCS Policlinico San Matteo-Cardiology ( Site 2157) | Pavia | Italy | 27100 | |
| 263 | University of Perugia ( Site 2164) | Perugia | Italy | 06132 | |
| 264 | Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino ( Site 2165) | Torino | Italy | 10126 | |
| 265 | Chungbuk National University Hospital-Internal medicine ( Site 3551) | Cheongju-si | Chungbuk | Korea, Republic of | 28644 |
| 266 | Yonsei University-Wonju Severance Christian Hospital ( Site 3555) | Wonju | Kang-won-do | Korea, Republic of | 26426 |
| 267 | Chonnam National University Hospital ( Site 3558) | Gwangju-si | Kwangju-Kwangyokshi | Korea, Republic of | 61469 |
| 268 | Hallym University Sacred Heart Hospital-Cardiovascular center ( Site 3556) | Anyang-si | Kyonggi-do | Korea, Republic of | 14068 |
| 269 | Pusan National University Hospital-Internal Medicine ( Site 3553) | Busan | Pusan-Kwangyokshi | Korea, Republic of | 49241 |
| 270 | Chungnam national university hospital ( Site 3554) | Jung-gu | Taejon-Kwangyokshi | Korea, Republic of | 35015 |
| 271 | Seoul National University Hospital ( Site 3557) | Seoul | Korea, Republic of | 03080 | |
| 272 | Severance Hospital, Yonsei University Health System ( Site 3552) | Seoul | Korea, Republic of | 03722 | |
| 273 | Hospital Universiti Sains Malaysia-Medical Department ( Site 2357) | Kubang Kerian | Kelantan | Malaysia | 16150 |
| 274 | University Malaya Medical Centre ( Site 2351) | Lembah Pantai | Kuala Lumpur | Malaysia | 59100 |
| 275 | Hospital Tengku Ampuan Afzan ( Site 2353) | Kuantan | Pahang | Malaysia | 25100 |
| 276 | Hospital Queen Elizabeth II ( Site 2359) | Kota Kinabalu | Sabah | Malaysia | 88300 |
| 277 | Sarawak Heart Centre ( Site 2352) | Kota Samarahan | Sarawak | Malaysia | 94300 |
| 278 | UiTM Sungai Buloh Campus ( Site 2354) | Sungai Buloh | Selangor | Malaysia | 47000 |
| 279 | Centro de Investigacion Cardiovascular y Metabólica ( Site 2465) | Tijuana | Baja California | Mexico | 22500 |
| 280 | Medivest Centro de Investigación Integral ( Site 2460) | Chihuahua City | Chihuahua | Mexico | 31203 |
| 281 | CIMAB SA de CV ( Site 2456) | Torreon | Coahuila | Mexico | 27000 |
| 282 | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran ( Site 2474) | Mexico City | Distrito Federal | Mexico | 14080 |
| 283 | Instituto Nacional de Cardiologia Ignacio Chavez ( Site 2454) | Mexico | Distrito Federal | Mexico | 14080 |
| 284 | Hospital General de Acapulco ( Site 2469) | Acapulco | Guerrero | Mexico | 39901 |
| 285 | Unidad de Investigaci�n Cl�nica Cardiometabolica de Occidente ( Site 2466) | Guadalajara | Jalisco | Mexico | 44150 |
| 286 | Cardiocent de Guadalajara S.C. ( Site 2464) | Guadalajara | Jalisco | Mexico | 44160 |
| 287 | Instituto Jalisciense de Metabolismo SC ( Site 2467) | Guadalajara | Jalisco | Mexico | 44670 |
| 288 | Unidad biomedica avanzada monterrey ( Site 2462) | Monterrey | Nuevo Leon | Mexico | 64460 |
| 289 | Unidad Médica para la Salud Integral ( Site 2472) | San Nicolás de los Garza | Nuevo Leon | Mexico | 66465 |
| 290 | Centro de Atención e Investigación Cardiovascular del Potosí ( Site 2453) | San Luis Potosí | San Luis Potosi | Mexico | 78200 |
| 291 | Centro de Estudios de Alta Especialidad de Sinaloa ( Site 2463) | Mazatlán | Sinaloa | Mexico | 82113 |
| 292 | Centro de Estudios de Investigacion Metabolicos y Cardiovasculares ( Site 2468) | Ciudad Madero | Tamaulipas | Mexico | 89440 |
| 293 | Hospital Angeles Xalapa ( Site 2451) | Xalapa-Enríquez | Veracruz | Mexico | 91193 |
| 294 | Consultorio de Medicina Especilizada del Sector Privado ( Site 2455) | Xalapa | Veracruz | Mexico | 91193 |
| 295 | Medical Care and Research SA de CV ( Site 2461) | Merida | Yucatan | Mexico | 97070 |
| 296 | Fundación Cardiovascular de Aguascalientes A.C. ( Site 2473) | Aguascalientes | Mexico | 20230 | |
| 297 | Oaxaca Site Management Organization ( Site 2459) | Oaxaca | Mexico | 68000 | |
| 298 | Centro de Investigacion Clinica de Oaxaca ( Site 2457) | Oaxaca | Mexico | 68020 | |
| 299 | Christchurch Heart Institute ( Site 2651) | Christchurch | Canterbury | New Zealand | 8011 |
| 300 | Dunedin Hospital-Cardiology Department ( Site 2653) | Dunedin | Otago | New Zealand | 9016 |
| 301 | Waikato Hospital-Cardiology Clinical Trials Unit ( Site 2654) | Hamilton | Waikato | New Zealand | 3204 |
| 302 | Hutt Valley District Health board HVDHB-Cardiology Research Unit ( Site 2652) | Lower hutt | Wellington | New Zealand | 5010 |
| 303 | North Shore Hospital-Cardiology Research ( Site 2656) | Auckland | New Zealand | 0622 | |
| 304 | Clínica Javier Prado ( Site 2853) | Lima | Peru | 15046 | |
| 305 | Clínica El Golf-Cardiologia ( Site 2857) | Lima | Peru | 15076 | |
| 306 | Beata Miklaszewicz & Dariusz Dabrowski CARDIAMED s.j. ( Site 3070) | Legnica | Dolnoslaskie | Poland | 59-220 |
| 307 | Instytut Chorób Serca, Zakład Badań Klinicznych Chorób Układu Krążenia ( Site 3057) | Wrocaw | Dolnoslaskie | Poland | 50-556 |
| 308 | NZOZ Centrum Medyczne KERmed ( Site 3066) | Bydgoszcz | Kujawsko-pomorskie | Poland | 85-231 |
| 309 | Praktyka Lekarska Lidia Pawlowicz ( Site 3053) | Torun | Kujawsko-pomorskie | Poland | 87-100 |
| 310 | Wojewodzki Szpital Zespolony im Ludwika Rydygiera w Toruniu-Oddz.Klin.Kardiologii i Int.T.Kard. ( Si | Toruń | Kujawsko-pomorskie | Poland | 87-100 |
| 311 | NZOZ Twoja Przychodnia ( Site 3051) | Lublin | Lubelskie | Poland | 20-857 |
| 312 | SP ZOZ w Puławach- Oddział Kardiologii ( Site 3071) | Pulawy | Lubelskie | Poland | 24-100 |
| 313 | Polsko-Amerykańskie Kliniki Serca PAKS Małopolskie Centrum Sercowo-Naczyniowe ( Site 3062) | Chrzanow | Malopolskie | Poland | 32-500 |
| 314 | Centrum Medyczne Zdrowa J. Trebacz, W. Zajdel Sp. J. ( Site 3061) | Krakow | Malopolskie | Poland | 31-216 |
| 315 | Centrum Zdrowia Tuchów-Poradnia Chorób Metabolicznych ( Site 3063) | Wierzchosławice | Malopolskie | Poland | 33-122 |
| 316 | ETG Warszawa ( Site 3052) | Warszawa | Mazowieckie | Poland | 02-793 |
| 317 | Polsko-Amerykańskie Kliniki Serca ( Site 3077) | Kedzierzyn-Kozle | Opolskie | Poland | 47-200 |
| 318 | Centrum Medyczne Medyk ( Site 3065) | Rzeszow | Podkarpackie | Poland | 35-055 |
| 319 | Centrum Medyczne Dr Sudnik s.c. Wanda i Jerzy Sudnik ( Site 3073) | Sokolka | Podlaskie | Poland | 16-100 |
| 320 | Indywidualna Specjalistyczna Praktyka Lekarska w Dziedzinie Kardiologii Lek. med. Krzysztof Cymerman | Gdynia | Pomorskie | Poland | 81-157 |
| 321 | Cooperativa De Facultad Medica Sanacoop-Instituto Sanacoop ( Site 3151) | Bayamon | Puerto Rico | 00961 | |
| 322 | Private Practice - Dr. Yolanda Figueroa-Torres ( Site 3156) | Humacao | Puerto Rico | 00791 | |
| 323 | Research and Cardiovascular Corp. ( Site 3152) | Ponce | Puerto Rico | 00717-1322 | |
| 324 | Caparra Internal Medicine ( Site 3155) | Rio Grande | Puerto Rico | 00745 | |
| 325 | Ivanovo Regional Healthcare Institution Cardiology Dispensary ( Site 3265) | Ivanovo | Ivanovskaya Oblast | Russian Federation | 153012 |
| 326 | Krasnodar Regional Clinical Hospital Number 1 S.V. Ochapovskogo ( Site 3281) | Krasnodar | Krasnodarskiy Kray | Russian Federation | 350073 |
| 327 | City Hospital No. 4 ( Site 3269) | Sochi | Krasnodarskiy Kray | Russian Federation | 354057 |
| 328 | First Pavlov State Medical University of Saint Petersburg-Сardiology department ( Site 3257) | Saint Petersburg | Leningradskaya Oblast | Russian Federation | 197022 |
| 329 | State budgetary Healthcare Institution of the city of Moscow "V. V. Vinogradov City Clinical Hospita | Moscow | Moskva | Russian Federation | 117292 |
| 330 | Omsk Regional Clinical Health Service Number 9 ( Site 3296) | Omsk | Omskaya Oblast | Russian Federation | 644018 |
| 331 | Perm Regional Hospital for War Veterans ( Site 3272) | Perm | Permskiy Kray | Russian Federation | 614990 |
| 332 | Rostov State Medical University ( Site 3259) | Rostov-on-Don | Rostovskaya Oblast | Russian Federation | 344022 |
| 333 | Rostov-on-Don City Emergency Hospital ( Site 3271) | Rostov-on-Don | Rostovskaya Oblast | Russian Federation | 344068 |
| 334 | Ryazan State Medical University named after Academician I.P. Pavlova ( Site 3260) | Ryazan | Ryazanskaya Oblast | Russian Federation | 390026 |
| 335 | First Pavlov State Medical University of Saint Petersburg ( Site 3288) | Saint Petersburg | Sankt-Peterburg | Russian Federation | 197022 |
| 336 | Almazov National Medical Research Centre ( Site 3320) | Saint Petersburg | Sankt-Peterburg | Russian Federation | 197341 |
| 337 | Pokrovskaya Municipal Hospital ( Site 3252) | Saint Petersburg | Sankt-Peterburg | Russian Federation | 199106 |
| 338 | Pokrovskaya Municipal Hospital-1-st cardiology department ( Site 3251) | Saint Petersburg | Sankt-Peterburg | Russian Federation | 199106 |
| 339 | Astarta Clinic ( Site 3276) | Saint-Petersburg | Sankt-Peterburg | Russian Federation | 199226 |
| 340 | Clinical Hospital S.R.Mirotvortseva name SSMU ( Site 3254) | Saratov | Saratovskaya Oblast | Russian Federation | 410054 |
| 341 | Interregional Clinical Diagnostic Center-Department of Clinical Trials ( Site 3307) | Kazan | Tatarstan, Respublika | Russian Federation | 420101 |
| 342 | Volgograd State Medical University ( Site 3258) | Volgograd | Volgogradskaya Oblast | Russian Federation | 400131 |
| 343 | Institute for Medical Research ( Site 3316) | Sankt-Peterburg | Russian Federation | 196084 | |
| 344 | Clinical Trial Systems ( Site 3452) | Pretoria | Gauteng | South Africa | 0186 |
| 345 | TREAD Research ( Site 3451) | Cape Town | Western Cape | South Africa | 7500 |
| 346 | Hospital Germans Trias i Pujol ( Site 3664) | Badalona | Barcelona | Spain | 08916 |
| 347 | Hospital Quiron Barcelona ( Site 3655) | Barcelona | Cataluna | Spain | 08023 |
| 348 | Hospital Universitari de Bellvitge-Unitat Multidisciplinar d'Insuficiència Cardíaca Comunitària (UM | L'Hospitalet de Llobregat | Cataluna | Spain | 08907 |
| 349 | CHUAC-Complejo Hospitalario Universitario A Coruña ( Site 3666) | A Coruña | La Coruna | Spain | 15006 |
| 350 | CHUS - Hospital Clinico Universitario-Cardiology - Clinical Research Unit ( Site 3651) | Santiago de Compostela | La Coruna | Spain | 15706 |
| 351 | Hospital Universitario Ramón y Cajal ( Site 3662) | Madrid | Madrid, Comunidad De | Spain | 28034 |
| 352 | Hospital Universitario La Paz ( Site 3665) | Madrid | Madrid, Comunidad De | Spain | 28046 |
| 353 | HOSPITAL CLINICO DE VALENCIA ( Site 3656) | Valencia | Valenciana, Comunitat | Spain | 46010 |
| 354 | Parc de Salut Mar - Hospital del Mar ( Site 3663) | Barcelona | Spain | 08003 | |
| 355 | Hospital Universitari Vall d'Hebron ( Site 3659) | Barcelona | Spain | 08035 | |
| 356 | Hospital Clinico San Carlos-Cardiology ( Site 3661) | Madrid | Spain | 28040 | |
| 357 | Hospital Universitario Virgen de Valme ( Site 3654) | Sevilla | Spain | 41014 | |
| 358 | Falu Lasarett-Dep of Cardiology ( Site 3756) | Falun | Dalarnas Lan | Sweden | 791 31 |
| 359 | Universitetssjukhuset Örebro-Heart-Lung-Physiology Clinic ( Site 3754) | Örebro | Orebro Lan | Sweden | 701 85 |
| 360 | Clemenstorgets Hjartmottagning ( Site 3755) | Lund | Skane Lan | Sweden | 22221 |
| 361 | Karolinska Universitetssjukhuset Solna-Heart and Vascular theme ( Site 3759) | Solna | Stockholms Lan | Sweden | 171 64 |
| 362 | Aleris Specialistvård Sabbatsberg ( Site 3762) | Stockholm | Stockholms Lan | Sweden | 113 61 |
| 363 | Skellefteå Lasarett-Research unit, floor 5 ( Site 3760) | Skellefteå | Vasterbottens Lan | Sweden | 931 86 |
| 364 | Västmanlands Sjukhus Västerås ( Site 3757) | Västerås | Vastmanlands Lan | Sweden | 72189 |
| 365 | Sahlgrenska Universitetssjukhuset-Cardiology Research Unit ( Site 3753) | Gothenburg | Vastra Gotalands Lan | Sweden | 413 45 |
| 366 | Kaohsiung Medical University Hospital ( Site 3856) | Kaohsiung | Taiwan | ||
| 367 | Taichung Veterans General Hospital ( Site 3855) | Taichung | Taiwan | 407 | |
| 368 | Taipei Veterans General Hospital-General Clinical Research Center ( Site 3851) | Taipei | Taiwan | 11217 | |
| 369 | Chang Gung Medical Foundation-Linkou Branch ( Site 3854) | Taoyuan | Taiwan | 333 | |
| 370 | Afyon Kocatepe Üniversitesi Tıp Fakültesi-Cardiology Department ( Site 4058) | Afyonkarahisar | Turkey | 03200 | |
| 371 | Hacettepe Universitesi ( Site 4061) | Ankara | Turkey | 06230 | |
| 372 | Ankara City Hospital-cardiology ( Site 4053) | Ankara | Turkey | 06800 | |
| 373 | Antalya Egitim ve Arastırma Hastanesi-Cardiology ( Site 4064) | Antalya | Turkey | 07100 | |
| 374 | Eskisehir Osmangazi University-Cardiology ( Site 4052) | Eskisehir | Turkey | 26480 | |
| 375 | Istanbul University Cerrahpasa Medical School Internal Diseases Institute-CARDIOLOGY INSTITUTE ( Sit | Istanbul | Turkey | 34098 | |
| 376 | Başkent Üniversitesi Istanbul Hastanesi ( Site 4057) | Istanbul | Turkey | 34662 | |
| 377 | Dr. Siyami Ersek Göğüs Kalp Ve Damar Cerrahisi Eğitim Ve Araştırma Hastanesi ( Site 4063) | Istanbul | Turkey | 34668 | |
| 378 | Dokuz Eylül Üniversitesi-CARDIOLOGY ( Site 4055) | İzmir | Turkey | 35340 | |
| 379 | Medical Park zmir Hastanesi-cardiology ( Site 4059) | Izmir | Turkey | 35510 | |
| 380 | Kocaeli Üniversitesi-Cardiology ( Site 4060) | Kocaeli | Turkey | 41380 | |
| 381 | Mersin University ( Site 4056) | Mersin | Turkey | 33343 | |
| 382 | Communal non-profit enterprise "Cherkasy Regional Hospital of Сherkasy Regional Council" ( Site 4292 | Cherkasy | Cherkaska Oblast | Ukraine | 18000 |
| 383 | Cherkasy Regional Hospital-Cardiorheumatology ( Site 4283) | Cherkasy | Cherkaska Oblast | Ukraine | 18009 |
| 384 | Municipal Non-commercial Enterprise "Ivano-Frankivsk Regional Clinical Cardiology Center of Ivano-Fr | Ivano-Frankivsk | Ivano-Frankivska Oblast | Ukraine | 76018 |
| 385 | Clinical medical and diagnostic center Limited Liability Company "Simedgroup" ( Site 4284) | Івано-Франківськ | Ivano-Frankivska Oblast | Ukraine | 76000 |
| 386 | Central clinical hospital - Ukrzalisnytsia-2nd Cardiology ( Site 4306) | Kharkiv | Kharkivska Oblast | Ukraine | 61000 |
| 387 | Communal non-profit enterprise "City Clinical Hospital # 27" of Kharkiv City Council ( Site 4262) | Kharkiv | Kharkivska Oblast | Ukraine | 61000 |
| 388 | L.T. Mala National Institute of Therapy of NAMS of Ukraine-Clinical Pharmacology and Pharmacogeneti | Kharkiv | Kharkivska Oblast | Ukraine | 61039 |
| 389 | Municipal Non-Profit Enterprise -City clinical hospital No8 of Kharkiv city council ( Site 4278) | Kharkiv | Kharkivska Oblast | Ukraine | 61176 |
| 390 | Khmelnytskyi Regional Cardiovascular Center-department of invasive cardiology and interventional ra | Khmelnytskyi | Khmelnytska Oblast | Ukraine | 29001 |
| 391 | Medbud Clinic ( Site 4265) | Kyiv | Kyivska Oblast | Ukraine | 03037 |
| 392 | State Institution National Scientific Center M.D. Strazhesko-Essential Hypertension ( Site 4259) | Kyiv | Kyivska Oblast | Ukraine | 03680 |
| 393 | Kyiv Railway Clinical Hospital No.2 of Branch Health Center of the Public Joint Stock Company Ukrain | Kiev | Kyiv | Ukraine | 03049 |
| 394 | Medical Center of Limited Liability Company "Medical Center "Consilium Medical" ( Site 4257) | Kiev | Kyiv | Ukraine | 04050 |
| 395 | Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council ( Site 42 | Odesa | Odeska Oblast | Ukraine | 65025 |
| 396 | Ukrayins'kyy Derzhavnyy Naukovo-Doslidnyy Instytut Rebilitatsiyi Invalidiv ( Site 4274) | Vinnytsia | Vinnytska Oblast | Ukraine | 21029 |
| 397 | Lutsk City Clinical Hospital-Center for Cardiovascular Disease ( Site 4255) | Lutsk | Volynska Oblast | Ukraine | 43024 |
| 398 | Zakarpattya Regional Clinical Cardiology Dispensary-Dept. of Hospital Therapy, Uzhhorod National Un | Uzhgorod | Zakarpatska Oblast | Ukraine | 88000 |
| 399 | Communal Non-profit Enterprise "City Hospital #6" Zaporizhzhia City Counci-Therapy department ( Site | Zaporizhia | Zaporizka Oblast | Ukraine | 69035 |
| 400 | Communal nonprofit enterprise "City Hospital #9" of Zaporizhzhia City Council ( Site 4251) | Zaporizhia | Zaporizka Oblast | Ukraine | 69065 |
| 401 | Communal Enterprise "Hospital #1" of Zhytomyr City Council-Advisory and Treatment department of Sci | Zhytomyr | Zhytomyrska Oblast | Ukraine | 10002 |
| 402 | Consultative - Diagnostic Centre of Pechersky District-Therapeutic department ( Site 4307) | Kyiv | Ukraine | 01103 | |
| 403 | MNE " Kyiv City Clinical Emergency Hospital" of Kyiv Regional Council (KCSA) ( Site 4256) | Kyiv | Ukraine | 02166 | |
| 404 | State Institution National Scientific Center M.D. Strazhesko-Department of clinical arrhythmology a | Kyiv | Ukraine | 03151 | |
| 405 | State Institution National Scientific Center M.D. Strazhesko-Resuscitation and Intensive care ( Site | Kyiv | Ukraine | 03680 | |
| 406 | Ninewells Hospital and Medical School-Cardiology ( Site 4164) | Dundee | Angus | United Kingdom | DD1 9SY |
| 407 | Cumberland Infirmary ( Site 4174) | Carlisle | Cumbria | United Kingdom | CA2 7HY |
| 408 | West Cumberland Hospital ( Site 4176) | Whitehaven | Cumbria | United Kingdom | CA28 8JG |
| 409 | Chesterfield Royal Hospital ( Site 4159) | Calow Chesterfield | Derbyshire | United Kingdom | S44 5BL |
| 410 | Carmel Medical Practice ( Site 4152) | Darlington | England | United Kingdom | DL3 7RD |
| 411 | Russells Hall Hospital ( Site 4153) | Dudley | England | United Kingdom | DY1 2HQ |
| 412 | King's College Hospital-Cardiac Research Department ( Site 4154) | London | England | United Kingdom | SE5 9RS |
| 413 | St. George's Hospital-Cardiology Clinical Academic Group ( Site 4156) | London | England | United Kingdom | SW17 0QT |
| 414 | Prince Charles Hospital ( Site 4171) | Merthyr Tydfil | Great Britain | United Kingdom | CF47 9DT |
| 415 | William Harvey Heart Centre ( Site 4169) | London | London, City Of | United Kingdom | EC1M 5PZ |
| 416 | Craigavon Area Hospital ( Site 4162) | Belfast | Northern Ireland | United Kingdom | BT63 5QQ |
| 417 | Princess of Wales Hospital ( Site 4178) | Bridgend | Wales | United Kingdom | CF31 1RQ |
| 418 | Blackpool Victoria Hospital ( Site 4161) | Blackpool | United Kingdom | FY3 8NR | |
| 419 | University Hospital Coventry & Warwickshire-Research & Development ( Site 4170) | Coventry | United Kingdom | CV2 2DX | |
| 420 | University Hospital of North Tees ( Site 4172) | Stockton-On-Tees | United Kingdom | TS19 8PE |
Sponsors and Collaborators
- Merck Sharp & Dohme LLC
Investigators
- Study Director: Medical Director, Merck Sharp & Dohme LLC
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
Merck Sharp & Dohme LLC
ClinicalTrials.gov Identifier:
NCT05093933
Other Study ID Numbers:
- 1242-035
- MK-1242-035
- 2022-500881-80-00
- 2020-005941-18
First Posted:
Oct 26, 2021
Last Update Posted:
Aug 19, 2022
Last Verified:
Aug 1, 2022
Individual Participant Data (IPD) Sharing Statement:
Yes
Plan to Share IPD:
Yes
Studies a U.S. FDA-regulated Drug Product:
Yes
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms: