Chronic Inflammation and Exercise Responsiveness
The purpose of this study is to determine how chronic inflammation influences skeletal muscle protein metabolism and metabolic function in humans. The investigators will evaluate acute responsiveness to a single bout of exercise in men and women who are either lean or overweight/obese. The investigators will explore the relationship between circulating inflammatory markers and anabolic, proteomic, and transcriptional responses to acute exercise. The investigators will measure skeletal muscle protein synthesis in the postabsorptive state and in response to a single bout of exercise.
|Condition or Disease||Intervention/Treatment||Phase|
Arms and Interventions
Body mass index less than 25 kg/m2
Body mass index 25-45 kg/m2
Primary Outcome Measures
- Maximal oxygen consumption rates in mitochondria isolated from skeletal muscles [1 day]
Age 30-55 years
BMI 19-45 kg/m2
Anemia (female subjects hemoglobin of <11 g/dl and male subjects hemoglobin <12 g/dl)
Active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment)
Renal insufficiency/failure (serum creatinine > 1.5mg/dl)
Oral warfarin group medications or history of blood clotting disorders.
Pregnancy or breastfeeding
Alcohol consumption greater than 2 glasses/day or other substance abuse
Untreated or uncontrolled thyroid disorders
Debilitating chronic disease (at the discretion of the investigators)
Contacts and Locations
|1||Mayo Clinic||Rochester||Minnesota||United States||55905|
Sponsors and Collaborators
- Mayo Clinic
- Principal Investigator: Ian R Lanza, PhD, Mayo Clinic
Study Documents (Full-Text)None provided.