DOCK: Diuretics and Volume Overload in Early CKD

Sponsor

VA Office of Research and Development (U.S. Fed)

Overall Status

Not yet recruiting

CT.gov ID

NCT05171686

Collaborator

(none)

Enrollment

Location

Arm

Anticipated Duration (Months)

1.6

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Almost 15% of Americans have chronic kidney disease (CKD), with an even higher rate in Veterans due to common risk factors such as high blood pressure and diabetes. People with CKD have a high risk of cardiovascular (CV) diseases, such as heart attacks, heart failure, and strokes. Extra fluid in the body, called volume overload, may lead to CV disease in people with CKD. It is unknown if volume overload develops in the earliest stages of CKD, when treating it with common, inexpensive medicines called diuretics may improve long-term CV outcomes. This study will lay important groundwork to answer this question in Veterans with early CKD by comparing two ways to measure volume overload and studying the change in common symptoms like fatigue and short-term CV function after treatment with diuretic medicines.

Condition or Disease	Intervention/Treatment	Phase
Chronic Kidney Disease Hypertension	Drug: Diuretic augmentation (hydrochlorothiazide, chlorthalidone, furosemide, torsemide, or bumetanide)	Phase 4

Detailed Description

The investigators previously showed that brain natriuretic peptide (BNP) and N-terminal-pro-BNP (NT-pro-BNP), measures of ventricular stretch, are associated with death and cardiovascular (CV) outcomes in patients with chronic kidney disease (CKD) stages 1-3, and the investigators' preliminary pilot results suggest that these natriuretic peptides may correlate with objective measures of excess extracellular volume (ECV) and with symptoms common in CKD. The overarching objective is to determine if initiation of diuretic treatment or increase in dose is associated with changes in BNP and NT-pro-BNP, patient-reported symptom burden, and short-term hemodynamic parameters in patients with CKD stages 1-3 and elevated blood pressure, and whether these changes correlate with changes in ECV. The central hypothesis is that the change in ECV after starting or increasing diuretics in Veterans with stages 1-3 CKD is associated with changes in 1) natriuretic peptides, 2) patient-level factors, and 3) CV physiology.

The investigators will compare the changes in natriuretic peptides, symptoms, and CV parameters with the change in ECV after diuretic initiation or dose increase. The primary aim is to determine if initiation of diuretic treatment or increase in diuretic dose is associated with changes in natriuretic peptides. Secondary aims are to determine the effect of diuretic change on patient-reported symptom burden, and CV physiology.

This clinical trial will include 46 outpatients with CKD stages 1-3 and blood pressure

140/90 mmHg. At the first visit, the investigators will initiate or increase the dose of a thiazide or loop diuretic. Study measures other than echocardiogram will be repeated 4 weeks after the intervention to determine changes in these parameters. ECV will be measured by whole-body multifrequency bioimpedance spectroscopy (BIS), which is a validated, non-invasive, painless measure of ECV. Plasma BNP and NT-pro-BNP will be measured, and patient-reported fatigue, depression, and quality of life will be quantified using validated questionnaires. Hemodynamic parameters include blood pressure, pulse pressure, and total peripheral resistance index (TPRI) and cardiac index measured by Non-Invasive Hemodynamic Monitoring. A transthoracic echocardiogram will measure left ventricular mass index, valvular disease, and diastolic dysfunction.

Variables will be compared within participants between baseline and Visit 2 using paired Wilcoxon Signed Rank tests or paired Student's t tests, depending on variable distributions. Correlations between change in ECV/total body weight and all continuous outcome measures will be analyzed using Spearman or Pearson correlations, applying appropriate transformations. Linear regression analysis will control for clinically relevant variables. The relationship between ECV/total body weight and natriuretic peptides from both visits will be evaluated using a mixed effects model to account for the change in these measures between baseline and Visit 2.

Study Design

Study Type:

Interventional

Anticipated Enrollment :

46 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Intervention Model Description:

Open label single arm clinical trialOpen label single arm clinical trial

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

Association of Diuretics With Change in Extracellular Volume, Natriuretic Peptides, Symptoms, and Cardiovascular Outcomes in CKD

Anticipated Study Start Date :

Sep 1, 2022

Anticipated Primary Completion Date :

Dec 31, 2024

Anticipated Study Completion Date :

Dec 31, 2024

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Diuretic augmentation The participant's blood pressure medication regimen will be altered to initiate a thiazide-type or loop diuretic in those not already prescribed a diuretic, or to increase the dose if one is already prescribed.	Drug: Diuretic augmentation (hydrochlorothiazide, chlorthalidone, furosemide, torsemide, or bumetanide) The participant's blood pressure medication regimen will then be altered to initiate a thiazide-type (hydrochlorothiazide or chlorthalidone) or loop diuretic (furosemide, bumetanide, or torsemide) in those not already prescribed a diuretic, or to increase the dose if one is already prescribed

Arm

Intervention/Treatment

Experimental: Diuretic augmentation

The participant's blood pressure medication regimen will be altered to initiate a thiazide-type or loop diuretic in those not already prescribed a diuretic, or to increase the dose if one is already prescribed.

Drug: Diuretic augmentation (hydrochlorothiazide, chlorthalidone, furosemide, torsemide, or bumetanide)

The participant's blood pressure medication regimen will then be altered to initiate a thiazide-type (hydrochlorothiazide or chlorthalidone) or loop diuretic (furosemide, bumetanide, or torsemide) in those not already prescribed a diuretic, or to increase the dose if one is already prescribed

Outcome Measures

Primary Outcome Measures

Change in NT-pro-BNP [4 weeks]
Change in NT-pro-BNP from baseline to 4 weeks after intervention

Secondary Outcome Measures

Change in BNP [4 weeks]
Change in BNP from baseline to 4 weeks after intervention
Change in FACIT-F score [4 weeks]
Change in fatigue as measured by FACIT-F score from baseline to 4 weeks after intervention
Change in QIDS-SR16 [4 weeks]
Change in depression as measured by the QIDS-SR16 from baseline to 4 weeks after intervention
Change in KDQOL [4 weeks]
Change in quality of life as measured by the KDQOL from baseline to 4 weeks after intervention
Change in total peripheral resistance index [4 weeks]
Change in total peripheral resistance index from baseline to 4 weeks after intervention
Change in systolic blood pressure [4 weeks]
Change in systolic blood pressure from baseline to 4 weeks after intervention
Change in diastolic blood pressure [4 weeks]
Change in diastolic blood pressure from baseline to 4 weeks after intervention
Change in mean arterial pressure [4 weeks]
Change in mean arterial pressure from baseline to 4 weeks after intervention
Change in pulse pressure [4 weeks]
Change in pulse pressure from baseline to 4 weeks after intervention
Change in cardiac index [4 weeks]
Change in cardiac index from baseline to 4 weeks after intervention
Change in extracellular volume normalized/total body weight [4 weeks]
Change in extracellular volume normalized to total body weight from baseline to 4 weeks after intervention

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Male or female Veterans age 18 years or older. There will be no upper age limit.
The presence of CKD stages 1, 2, or 3, as defined below by Kidney Disease Improving Global Outcomes guidelines, for a period of at least 3 months.
Stage 1: eGFR 90 mL/min/1.73 m2 and spot urine albumin-to-creatinine ratio 30 mg/g.
Stage 2: eGFR 60-89 mL/min/1.73 m2 and spot urine albumin-to-creatinine ratio 30 mg/g.
Stage 3: eGFR 30-59 mL/min/1.73 m2.
Measured blood pressure either >140 mmHg systolic or >90 mmHg diastolic at the two most recent clinic visits.
Able to understand and sign informed consent after the nature of the study has been fully explained.

Exclusion Criteria:

Unable to understand or provide informed consent.
Unwilling or unable to participate in the protocol or comply with any of its components.
CKD stages 4-5, defined as eGFR <30 mL/min/1.73 m2.
Receiving chronic hemodialysis or peritoneal dialysis.
Recipient of a kidney transplant.
Serum potassium <3.5 mEq/L at baseline.
Known left ventricular ejection fraction <40% on visual estimate based on chart review of available echocardiogram data.
Known hepatic cirrhosis.
Major limb amputation.
Known pregnancy.
Presence of a pacemaker or defibrillator.