Assessing the Ability of Combination Treatment With Venetoclax to Permit Time Limited Therapy in Chronic Lymphocytic Leukemia

• Sponsor: National Cancer Institute (NCI) (NIH)
• Overall Status: Active, not recruiting
• CT.gov ID: NCT03701282
• Collaborator: (none)
• Enrollment: 720
• Locations: 874
• Arms: 2
• Anticipated Duration (Months): 112.1
• Patients Per Site: 0.8
• Patients Per Site Per Month: 0

Study Details

Study Description

Brief Summary

This phase III trial studies how well ibrutinib and obinutuzumab with or without venetoclax work in treating patients with chronic lymphocytic leukemia. Ibrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Obinutuzumab is a monoclonal antibody. It binds to a protein called CD20, which is found on B cells (a type of white blood cell) and some types of cancer cells. This may help the immune system kill cancer cells. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Giving ibrutinib, obinutuzumab, and venetoclax may work better than giving ibrutinib and obinutuzumab in treating patients with chronic lymphocytic leukemia.

Condition or Disease	Intervention/Treatment	Phase
Chronic Lymphocytic Leukemia; Small Lymphocytic Lymphoma	Procedure: Bone Marrow Biopsy; Drug: Ibrutinib; Biological: Obinutuzumab; Other: Quality-of-Life Assessment; Drug: Venetoclax	Phase 3

Detailed Description

PRIMARY OBJECTIVE:

1. To compare the progression free survival (PFS) of the time limited administration of the three-drug combination ibrutinib-obinutuzumab-venetoclax (IOV) to ibrutinib-obinutuzumab (IO) in untreated chronic lymphocytic leukemia (CLL) patients younger than 70 years of age.

SECONDARY OBJECTIVES:

1. Evaluate overall survival (OS) of patients based on treatment arm. II. Monitor and assess toxicity of treatment based on treatment arm. III. Compare minimal residual disease (MRD) status as assessed by flow cytometry at baseline and then sequentially during treatment of the two treatment arms.

2. Collect baseline and response evaluation (after cycle 19) bone marrow and paired blood specimens for evaluation of MRD.

QUALITY OF LIFE (QOL) OBJECTIVES:

1. To compare quality of life (QOL) in CLL patients during the first 19 cycles of treatment among patients on each treatment arm.

2. To compare QOL over the long-term in CLL patients receiving continuous therapy using ibrutinib to that of CLL patients who completed time limited therapy.

3. Evaluate adherence to therapy for the two arms (one of which requires more intense, but shorter duration treatment, and one of which requires less intense, but indefinite duration therapy) and explore how adherence in each arm relates to progression-free survival (PFS).

EXPLORATORY TOBACCO USE OBJECTIVES:

1. To determine the effects of tobacco, operationalized as combustible tobacco (1a), other forms of tobacco (1b), and environmental tobacco exposure (ETS) (1c) on provider-reported cancer-treatment toxicity (adverse events [both clinical and hematologic]) and dose modifications.

2. To determine the effects of tobacco on patient-reported physical symptoms and psychological symptoms.

3. To examine quitting behaviors and behavioral counseling/support and cessation medication utilization.

4. To explore the effect of tobacco use and exposure on treatment duration, relative dose intensity, and therapeutic benefit.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM A: Patients receive ibrutinib orally (PO) daily on days 1-28 and obinutuzumab intravenously (IV) over 4 hours on days 1, 2, 8, and 15 of cycle 1 and on day 1 of cycles 2-6. Patients also receive venetoclax PO once daily (QD) on days 1-28 of cycles 3-14. Treatment repeats every 28 days for up to 19 cycles in the absence of disease progression or unacceptable toxicity.

ARM B: Patients receive ibrutinib PO and obinutuzumab as in arm A. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.

All patients, including those who discontinue therapy early, are followed for response until disease progression, even if non-protocol therapy is initiated. Patients are then followed every 3 months for first 2 years, every 6 months for years 3-5, and then every 12 months for years 6-10. All patients must also be followed through completion of all protocol therapy.

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 720 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: None (Open Label)
• Primary Purpose: Treatment
• Official Title: A Randomized Phase III Study of the Addition of Venetoclax to Ibrutinib and Obinutuzumab Versus Ibrutinib and Obinutuzumab in Untreated Younger Patients With Chronic Lymphocytic Leukemia (CLL)
• Actual Study Start Date: Jan 3, 2019
• Anticipated Primary Completion Date: May 7, 2028
• Anticipated Study Completion Date: May 7, 2028

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Arm A (ibrutinib, obinutuzumab, venetoclax) Patients receive ibrutinib PO daily on days 1-28 and obinutuzumab IV over 4 hours on days 1, 2, 8, and 15 of cycle 1 and on day 1 of cycles 2-6. Patients also receive venetoclax PO QD on days 1-28 of cycles 3-14. Treatment repeats every 28 days for up to 19 cycles in the absence of disease progression or unacceptable toxicity.	Procedure: Bone Marrow Biopsy; Undergo biopsy; Other Names: Biopsy of Bone Marrow Biopsy, Bone Marrow ; Drug: Ibrutinib; Given PO; Other Names: BTK Inhibitor PCI-32765 CRA-032765 Imbruvica PCI-32765 ; Biological: Obinutuzumab; Given IV; Other Names: Anti-CD20 Monoclonal Antibody R7159 GA-101 GA101 Gazyva huMAB(CD20) R7159 RO 5072759 RO-5072759 RO5072759 ; Other: Quality-of-Life Assessment; Ancillary studies; Other Names: Quality of Life Assessment ; Drug: Venetoclax; Given PO; Other Names: ABT-0199 ABT-199 ABT199 GDC-0199 RG7601 Venclexta Venclyxto
Active Comparator: Arm B (ibrutinib, obinutuzumab) Patients receive ibrutinib PO and obinutuzumab as in arm A. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.	Procedure: Bone Marrow Biopsy; Undergo biopsy; Other Names: Biopsy of Bone Marrow Biopsy, Bone Marrow ; Drug: Ibrutinib; Given PO; Other Names: BTK Inhibitor PCI-32765 CRA-032765 Imbruvica PCI-32765 ; Biological: Obinutuzumab; Given IV; Other Names: Anti-CD20 Monoclonal Antibody R7159 GA-101 GA101 Gazyva huMAB(CD20) R7159 RO 5072759 RO-5072759 RO5072759 ; Other: Quality-of-Life Assessment; Ancillary studies; Other Names: Quality of Life Assessment

Outcome Measures

Primary Outcome Measures

1. Progression-free survival [Time from randomization to progression or death without documented progression, assessed up to 10 years]

   The analysis will be performed using the repeated confidence intervals methodology. At each interim or final analysis, two-sided repeated confidence interval will be constructed using the partial likelihood estimate from stratified Cox proportional hazards model and the critical value based on the Lan-DeMets error-spending function that corresponds to the truncated O'brien-Fleming boundaries.

Secondary Outcome Measures

1. Overall survival [Time from randomization to death due to any cause, assessed up to 10 years]

   A hierarchical testing strategy will be used. The analysis will be performed using the repeated confidence intervals methodology. At each interim or final analysis, two-sided repeated confidence interval will be constructed using the partial likelihood estimate from stratified Cox proportional hazards model and the critical value based on the Lan-DeMets error-spending function that corresponds to the truncated O'brien-Fleming boundaries.

2. Incidence of adverse events [Up to 10 years]

   Graded according to Common Terminology Criteria for Adverse Events version 5.0.

Other Outcome Measures

1. Quality of life (QOL) [Baseline up to 10 years]

   Assessed using Functional Assessment of Cancer Therapy-General (FACT-G) and the leukemia sub-scale. FACT-G and the leukemia subscale will be analyzed at randomization, on day 1 of cycles 3, 7, 15, at the end of cycle 19, every 6 months for 2 years post response evaluation, at 48 months after randomization and at the time of disease progression. Linear mixed effects models will be used to perform repeated measures regression analysis. Will compare treatment toxicity-related QOL between the two arms. The entire FACT-Leukemia instrument (FACT-G and the leukemia subscale) at baseline will be analyzed using descriptive statistics to assess the impact of CLL on QOL independent of treatment.

2. FACT-Leu Trial Outcome Index (TOI) score over time [Baseline up to 10 years]

   Will use linear mixed effects models will be used to perform repeated measures regression analysis to examine the treatment effect and time effect on FACT-Leu TOI score.

3. Adherence [Baseline up to 10 years]

   Defined as patients taking 80% or more of their prescribed doses. The ASK-12 Survey will be used to measure the likelihood that a patient will take prescribed medications for patients on both arms at baseline and on day 1 +/- 4 days of the following cycles 3, 7, 15, at the time of response evaluation (end of cycle 19), every 6 months for 2 years post response evaluation, at 48 months after randomization, and at time of disease progression. Descriptive statistics will be used to summarize trend in adherence to prescription.

4. Minimal residual disease (MRD) analysis [Up to 10 years]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 69 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• Diagnosis of CLL according to the National Cancer Institute (NCI)/International Workshop on Chronic Lymphocytic Leukemia (IWCLL) criteria or small lymphocytic lymphoma (SLL) according to the World Health Organization (WHO) criteria. This includes previous documentation of:

• Biopsy-proven small lymphocytic lymphoma OR

• Diagnosis of CLL according to the NCI/IWCLL criteria as evidenced by all of the following:

• Peripheral blood lymphocyte count of greater than 5 x10^9/L

• Immunophenotype consistent with CLL defined as:

• The predominant population of lymphocytes share both B-cell antigens (CD19, CD20 [typically dim expression], or CD23) as well as CD5 in the absence of other pan-T-cell markers (CD3, CD2, etc).

• Clonality as evidenced by kappa or lambda light chain restriction (typically dim immunoglobulin expression)

• Negative fluorescent in situ hybridization (FISH) analysis for t(11;14)(IgH/CCND1) on peripheral blood or tissue biopsy (e.g. marrow aspirate) or negative immunohistochemical stains for cyclin D1 staining on involved tissue biopsy (e.g. marrow aspirate or lymph node biopsy)

• No prior chemotherapy, BTK inhibitor therapy, venetoclax, small molecule signaling inhibitor, or monoclonal anti-body therapy for treatment of CLL or SLL

• Has met at least one of the following indications for treatment:

• Evidence of progressive marrow failure as manifested by the development of worsening anemia (hemoglobin [Hg] < 11 g/dl) and/or thrombocytopenia (platelets < 100 x 10^9/L)

• Symptomatic or progressive lymphadenopathy, splenomegaly, or hepatomegaly

• One or more of the following disease-related symptoms:

• Weight loss >= 10% within the previous 6 months

• Grade 2 or 3 fatigue attributed to CLL

• Fevers > 100.5 degree Fahrenheit (F) for 2 weeks without evidence of infection

• Clinically significant night sweats without evidence of infection

• Progressive lymphocytosis (not due to the effects of corticosteroids) with an increase of > 50% over a two-month period or an anticipated doubling time of less than six months

• Eastern Cooperative Oncology Group (ECOG) performance status between 0-2

• Life expectancy of >= 12 months

• No deletion of 17p13 on cytogenetic analysis by FISH

• Glomerular filtration rate (GFR) > 40 mL/minute as calculated by the Cockcroft-Gault Formula (obtained =< 14 days prior to registration)

• Total bilirubin =< 1.5 x upper limit of normal (ULN) unless due to Gilbert's disease. For those with a total bilirubin > 1.5 x ULN, a direct bilirubin should be performed and must be < 1.5 mg/dL for Gilbert's to be diagnosed (obtained =< 14 days prior to registration)

• Serum glutamic-oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST])/serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) =< 3.0 x the institutional ULN (obtained =< 14 days prior to registration)

• NOTE: If value is higher due to hepatic involvement by CLL, patient is eligible

• Prothrombin time (PT)/international normalized ratio (INR) < 1.5 ULN and partial thromboplastin time (PTT) (activated partial thromboplastin time [aPTT]) < 1.5 x ULN (obtained =< 14 days prior to registration)

• No active hemolytic anemia requiring immunosuppressive therapy or other pharmacologic treatment. Patients who have a positive Coombs test but no evidence of hemolysis are NOT excluded from participation

• No current use of corticosteroids. EXCEPTION: Low doses of steroids (< 10 mg of prednisone or equivalent dose of other steroid; inhaled steroids) used for treatment of non-hematologic medical condition (e.g. chronic adrenal insufficiency) is permitted

• No previous autoimmune complications (e.g. autoimmune hemolytic anemia or immune thrombocytopenia) that have developed since the initial diagnosis of CLL and have required treatment with high dose corticosteroids (e.g. equivalent of > 20 mg/day of prednisone), monoclonal antibody based therapy, or chemotherapy. Prior use of corticosteroids for reasons other than treatment of autoimmune complications is allowed

• No other active primary malignancy (other than non-melanomatous skin cancer or carcinoma in situ of the cervix) requiring treatment or limiting expected survival to =< 2 years

• NOTE: If there is a history of prior malignancy, the patient must not currently be receiving other specific treatment (other than hormonal therapy for their cancer)

• Able to adhere to the study visit schedule and other protocol requirements

• No major surgery within 4 weeks (28 days) of first dose of study drug or minor surgery within 3 days of first dose of study drug

• No radiation therapy =< 4 weeks prior to registration to Step 1

• Patients who are human immunodeficiency virus positive (HIV+) with undetectable HIV viral load are eligible provided they meet all other protocol criteria for participation and are not being treated with protease inhibitors or any non-nucleoside reverse transcriptase inhibitors (NNRTI) that are CYP3A4 inducers; if being treated for HIV, patients should be receiving an alternative antiretroviral therapy (ART) that is not a CYP3A inhibitor

• Women of childbearing potential and sexually active males must be strongly advised to use accepted and highly effective method(s) of contraception or to abstain from sexual intercourse for the duration of their participation in the study and for:

• 18 months after the last dose of obinutuzumab

• 90 days after the last dose of ibrutinib, and

• 30 days after the last dose of venetoclax Male subjects must also agree to refrain from sperm donation until 90 days after the last dose of protocol treatment

• Patient must be able to swallow capsules and not have the following conditions:

• Disease significantly affecting gastrointestinal function

• Resection of the stomach or small bowel

• Symptomatic inflammatory bowel disease

• Ulcerative colitis

• Partial or complete bowel obstruction

• Patient must undergo assessment with Timed Up and Go (TUG) test and comorbidity index

• Patient must be able to receive xanthine oxidase inhibitor or rasburicase for tumor lysis syndrome (TLS) prophylaxis

Exclusion Criteria:

• Patients must not have any of the following conditions:

• Congestive heart failure or New York Heart Association Functional Classification III or IV congestive heart failure

• History of myocardial infarction, unstable angina, or acute coronary syndrome within 6 months prior to registration

• Recent infections requiring systemic treatment; need to have completed anti-biotic therapy > 14 days before the first dose of study drug

• Cerebral vascular accident or intracranial bleed within the last 6 months

• Infection with known chronic, active hepatitis C

• Positive serology for hepatitis B defined as a positive test for hepatitis B surface antigen (HBsAg); in addition, if negative for HBsAg but hepatitis B core antibody (HBcAb) positive (regardless of hepatitis B surface antibody [HBsAb] status), a hepatitis B deoxyribonucleic acid (DNA) test will be performed and, if positive the subject will be ineligible; if the hepatitis (Hep) B DNA test is negative (i.e. viral load undetectable) then the individual is eligible; if a patient who is HBsAg negative, HBsAb negative, HBcAb positive, and Hep B DNA negative is enrolled, they should be considered for either prophylactic anti-viral therapy (J Clin Oncol. 2013 Aug 1;31(22):2765-72) or careful monitoring for Hep B reactivation (J Clin Oncol. 2014 Nov 20;32(33):3736-43)

• Patients are not eligible if they require treatment with a strong cytochrome P450 (CYP) 3A inhibitor

• Patients may not have received the following within 7 days prior to the first dose of study drug:

• Steroid therapy for anti-neoplastic intent

• Strong and moderate CYP3A inhibitors

• Strong and moderate CYP3A inducers

• Patients may not be on any other investigational agents

• Patients may not have received warfarin or another vitamin K antagonist in the preceding 30 days

• Women must not be pregnant or breast-feeding since this study involves investigational agents whose genotoxic, mutagenic, and teratogenic effects on the developing fetus and newborn are unknown; all females of childbearing potential must have a blood test within 2 weeks prior to registration to Step 1 to rule out pregnancy; a female of childbearing potential is defined as any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)

• Patient must not be on any other systemic immunosuppressant therapy other than corticosteroids within 28 days of the first dose of study drug

• Patient must not be vaccinated with live, attenuated vaccines within 4 weeks of first dose of study drug

• Patient must not have any known bleeding disorders (e.g., von Willebrand's disease) or hemophilia

• Patient must not have currently active, clinically significant hepatic impairment (>= moderate hepatic impairment according to the NCI/Child Pugh classification)

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of Alabama at Birmingham Cancer Center	Birmingham	Alabama	United States	35233
2	Anchorage Associates in Radiation Medicine	Anchorage	Alaska	United States	98508
3	Anchorage Radiation Therapy Center	Anchorage	Alaska	United States	99504
4	Alaska Breast Care and Surgery LLC	Anchorage	Alaska	United States	99508
5	Alaska Oncology and Hematology LLC	Anchorage	Alaska	United States	99508
6	Alaska Women's Cancer Care	Anchorage	Alaska	United States	99508
7	Anchorage Oncology Centre	Anchorage	Alaska	United States	99508
8	Katmai Oncology Group	Anchorage	Alaska	United States	99508
9	Providence Alaska Medical Center	Anchorage	Alaska	United States	99508
10	Fairbanks Memorial Hospital	Fairbanks	Alaska	United States	99701
11	Kingman Regional Medical Center	Kingman	Arizona	United States	86401
12	Cancer Center at Saint Joseph's	Phoenix	Arizona	United States	85004
13	Mayo Clinic Hospital in Arizona	Phoenix	Arizona	United States	85054
14	Mayo Clinic in Arizona	Scottsdale	Arizona	United States	85259
15	University of Arizona Cancer Center-Orange Grove Campus	Tucson	Arizona	United States	85704
16	Banner University Medical Center - Tucson	Tucson	Arizona	United States	85719
17	University of Arizona Cancer Center-North Campus	Tucson	Arizona	United States	85719
18	Mercy Hospital Fort Smith	Fort Smith	Arkansas	United States	72903
19	CHI Saint Vincent Cancer Center Hot Springs	Hot Springs	Arkansas	United States	71913
20	Kaiser Permanente-Anaheim	Anaheim	California	United States	92806
21	Kaiser Permanente-Deer Valley Medical Center	Antioch	California	United States	94531
22	Mission Hope Medical Oncology - Arroyo Grande	Arroyo Grande	California	United States	93420
23	PCR Oncology	Arroyo Grande	California	United States	93420
24	Kaiser Permanente-Baldwin Park	Baldwin Park	California	United States	91706
25	Kaiser Permanente-Bellflower	Bellflower	California	United States	90706
26	Providence Saint Joseph Medical Center/Disney Family Cancer Center	Burbank	California	United States	91505
27	UC Irvine Health Cancer Center-Newport	Costa Mesa	California	United States	92627
28	City of Hope Comprehensive Cancer Center	Duarte	California	United States	91010
29	Kaiser Permanente Dublin	Dublin	California	United States	94568
30	Kaiser Permanente-Fontana	Fontana	California	United States	92335
31	Kaiser Permanente-Fremont	Fremont	California	United States	94538
32	Fresno Cancer Center	Fresno	California	United States	93720
33	Kaiser Permanente-Fresno	Fresno	California	United States	93720
34	Kaiser Permanente - Harbor City	Harbor City	California	United States	90710
35	Kaiser Permanente-Irvine	Irvine	California	United States	92618
36	Tibor Rubin VA Medical Center	Long Beach	California	United States	90822
37	Kaiser Permanente Los Angeles Medical Center	Los Angeles	California	United States	90027
38	Kaiser Permanente West Los Angeles	Los Angeles	California	United States	90034
39	Kaiser Permanente-Modesto	Modesto	California	United States	95356
40	Kaiser Permanente Oakland-Broadway	Oakland	California	United States	94611
41	Kaiser Permanente-Oakland	Oakland	California	United States	94611
42	Kaiser Permanente-Ontario	Ontario	California	United States	91761
43	UC Irvine Health/Chao Family Comprehensive Cancer Center	Orange	California	United States	92868
44	Desert Regional Medical Center	Palm Springs	California	United States	92262
45	Stanford Cancer Institute Palo Alto	Palo Alto	California	United States	94304
46	VA Palo Alto Health Care System	Palo Alto	California	United States	94304
47	Kaiser Permanente - Panorama City	Panorama City	California	United States	91402
48	Kaiser Permanente-Rancho Cordova Cancer Center	Rancho Cordova	California	United States	95670
49	Kaiser Permanente-Redwood City	Redwood City	California	United States	94063
50	Kaiser Permanente-Richmond	Richmond	California	United States	94801
51	Kaiser Permanente-Riverside	Riverside	California	United States	92505
52	Rohnert Park Cancer Center	Rohnert Park	California	United States	94928
53	Kaiser Permanente-Roseville	Roseville	California	United States	95661
54	The Permanente Medical Group-Roseville Radiation Oncology	Roseville	California	United States	95678
55	Kaiser Permanente Downtown Commons	Sacramento	California	United States	95814
56	Kaiser Permanente-South Sacramento	Sacramento	California	United States	95823
57	South Sacramento Cancer Center	Sacramento	California	United States	95823
58	Kaiser Permanente - Sacramento	Sacramento	California	United States	95825
59	Kaiser Permanente-San Diego Mission	San Diego	California	United States	92108
60	Kaiser Permanente-San Diego Zion	San Diego	California	United States	92120
61	Kaiser Permanente-San Francisco	San Francisco	California	United States	94115
62	Kaiser Permanente-Santa Teresa-San Jose	San Jose	California	United States	95119
63	Kaiser Permanente San Leandro	San Leandro	California	United States	94577
64	Pacific Central Coast Health Center-San Luis Obispo	San Luis Obispo	California	United States	93401
65	Kaiser Permanente-San Marcos	San Marcos	California	United States	92078
66	Kaiser Permanente-San Rafael	San Rafael	California	United States	94903
67	Kaiser San Rafael-Gallinas	San Rafael	California	United States	94903
68	Kaiser Permanente Medical Center - Santa Clara	Santa Clara	California	United States	95051
69	Mission Hope Medical Oncology - Santa Maria	Santa Maria	California	United States	93444
70	Kaiser Permanente-Santa Rosa	Santa Rosa	California	United States	95403
71	Kaiser Permanente Cancer Treatment Center	South San Francisco	California	United States	94080
72	Kaiser Permanente-South San Francisco	South San Francisco	California	United States	94080
73	Kaiser Permanente-Stockton	Stockton	California	United States	95210
74	Kaiser Permanente Medical Center-Vacaville	Vacaville	California	United States	95688
75	Kaiser Permanente-Vallejo	Vallejo	California	United States	94589
76	Kaiser Permanente-Walnut Creek	Walnut Creek	California	United States	94596
77	Kaiser Permanente-Woodland Hills	Woodland Hills	California	United States	91367
78	Rocky Mountain Cancer Centers-Aurora	Aurora	Colorado	United States	80012
79	The Medical Center of Aurora	Aurora	Colorado	United States	80012
80	Rocky Mountain Regional VA Medical Center	Aurora	Colorado	United States	80045
81	Boulder Community Hospital	Boulder	Colorado	United States	80301
82	Boulder Community Foothills Hospital	Boulder	Colorado	United States	80303
83	Rocky Mountain Cancer Centers-Boulder	Boulder	Colorado	United States	80304
84	Rocky Mountain Cancer Centers - Centennial	Centennial	Colorado	United States	80112
85	Penrose-Saint Francis Healthcare	Colorado Springs	Colorado	United States	80907
86	Rocky Mountain Cancer Centers-Penrose	Colorado Springs	Colorado	United States	80907
87	Cancer Center of Colorado at Sloan's Lake	Denver	Colorado	United States	80204
88	Denver Health Medical Center	Denver	Colorado	United States	80204
89	Kaiser Permanente-Franklin	Denver	Colorado	United States	80205
90	National Jewish Health-Main Campus	Denver	Colorado	United States	80206
91	The Women's Imaging Center	Denver	Colorado	United States	80209
92	Porter Adventist Hospital	Denver	Colorado	United States	80210
93	Colorado Blood Cancer Institute	Denver	Colorado	United States	80218
94	Presbyterian - Saint Lukes Medical Center - Health One	Denver	Colorado	United States	80218
95	Rocky Mountain Cancer Centers-Midtown	Denver	Colorado	United States	80218
96	SCL Health Saint Joseph Hospital	Denver	Colorado	United States	80218
97	Rocky Mountain Cancer Centers-Rose	Denver	Colorado	United States	80220
98	Rose Medical Center	Denver	Colorado	United States	80220
99	Western Surgical Care	Denver	Colorado	United States	80220
100	Mercy Medical Center	Durango	Colorado	United States	81301
101	Southwest Oncology PC	Durango	Colorado	United States	81301
102	Mountain Blue Cancer Care Center - Swedish	Englewood	Colorado	United States	80113
103	Swedish Medical Center	Englewood	Colorado	United States	80113
104	Mountain Blue Cancer Care Center	Golden	Colorado	United States	80401
105	National Jewish Health-Western Hematology Oncology	Golden	Colorado	United States	80401
106	Saint Mary's Hospital and Regional Medical Center	Grand Junction	Colorado	United States	81501
107	Grand Valley Oncology	Grand Junction	Colorado	United States	81505
108	North Colorado Medical Center	Greeley	Colorado	United States	80631
109	Good Samaritan Medical Center	Lafayette	Colorado	United States	80026
110	Kaiser Permanente-Rock Creek	Lafayette	Colorado	United States	80026
111	Rocky Mountain Cancer Centers-Lakewood	Lakewood	Colorado	United States	80228
112	Saint Anthony Hospital	Lakewood	Colorado	United States	80228
113	Rocky Mountain Cancer Centers-Littleton	Littleton	Colorado	United States	80120
114	Littleton Adventist Hospital	Littleton	Colorado	United States	80122
115	Kaiser Permanente-Lone Tree	Lone Tree	Colorado	United States	80124
116	Rocky Mountain Cancer Centers-Sky Ridge	Lone Tree	Colorado	United States	80124
117	Sky Ridge Medical Center	Lone Tree	Colorado	United States	80124
118	Longmont United Hospital	Longmont	Colorado	United States	80501
119	Rocky Mountain Cancer Centers-Longmont	Longmont	Colorado	United States	80501
120	McKee Medical Center	Loveland	Colorado	United States	80539
121	Parker Adventist Hospital	Parker	Colorado	United States	80138
122	Rocky Mountain Cancer Centers-Parker	Parker	Colorado	United States	80138
123	Saint Mary Corwin Medical Center	Pueblo	Colorado	United States	81004
124	Rocky Mountain Cancer Centers - Pueblo	Pueblo	Colorado	United States	81008
125	National Jewish Health-Northern Hematology Oncology	Thornton	Colorado	United States	80260
126	Rocky Mountain Cancer Centers-Thornton	Thornton	Colorado	United States	80260
127	SCL Health Lutheran Medical Center	Wheat Ridge	Colorado	United States	80033
128	Smilow Cancer Hospital-Derby Care Center	Derby	Connecticut	United States	06418
129	Smilow Cancer Hospital Care Center-Fairfield	Fairfield	Connecticut	United States	06824
130	Smilow Cancer Hospital Care Center at Glastonbury	Glastonbury	Connecticut	United States	06033
131	Smilow Cancer Hospital Care Center - Guiford	Guilford	Connecticut	United States	06437
132	Smilow Cancer Hospital Care Center at Saint Francis	Hartford	Connecticut	United States	06105
133	Yale University	New Haven	Connecticut	United States	06520
134	Yale-New Haven Hospital North Haven Medical Center	North Haven	Connecticut	United States	06473
135	Smilow Cancer Hospital-Orange Care Center	Orange	Connecticut	United States	06477
136	Smilow Cancer Hospital Care Center-Trumbull	Trumbull	Connecticut	United States	06611
137	Smilow Cancer Hospital-Waterbury Care Center	Waterbury	Connecticut	United States	06708
138	Smilow Cancer Hospital Care Center - Waterford	Waterford	Connecticut	United States	06385
139	Veterans Affairs Connecticut Healthcare System-West Haven Campus	West Haven	Connecticut	United States	06516
140	Beebe South Coastal Health Campus	Frankford	Delaware	United States	19945
141	Beebe Medical Center	Lewes	Delaware	United States	19958
142	Delaware Clinical and Laboratory Physicians PA	Newark	Delaware	United States	19713
143	Helen F Graham Cancer Center	Newark	Delaware	United States	19713
144	Medical Oncology Hematology Consultants PA	Newark	Delaware	United States	19713
145	Christiana Care Health System-Christiana Hospital	Newark	Delaware	United States	19718
146	Beebe Health Campus	Rehoboth Beach	Delaware	United States	19971
147	TidalHealth Nanticoke / Allen Cancer Center	Seaford	Delaware	United States	19973
148	Christiana Care Health System-Wilmington Hospital	Wilmington	Delaware	United States	19801
149	Holy Cross Hospital	Fort Lauderdale	Florida	United States	33308
150	Broward Health Medical Center	Fort Lauderdale	Florida	United States	33316
151	Mayo Clinic in Florida	Jacksonville	Florida	United States	32224-9980
152	University Cancer and Blood Center LLC	Athens	Georgia	United States	30607
153	Emory University Hospital Midtown	Atlanta	Georgia	United States	30308
154	Emory University Hospital/Winship Cancer Institute	Atlanta	Georgia	United States	30322
155	Emory Saint Joseph's Hospital	Atlanta	Georgia	United States	30342
156	Augusta University Medical Center	Augusta	Georgia	United States	30912
157	Atlanta VA Medical Center	Decatur	Georgia	United States	30033
158	Hawaii Cancer Care - Savio	'Aiea	Hawaii	United States	96701
159	Pali Momi Medical Center	'Aiea	Hawaii	United States	96701
160	Queen's Cancer Center - Pearlridge	'Aiea	Hawaii	United States	96701
161	The Cancer Center of Hawaii-Pali Momi	'Aiea	Hawaii	United States	96701
162	Island Urology-Hilo	Hilo	Hawaii	United States	96720
163	Hawaii Cancer Care Inc - Waterfront Plaza	Honolulu	Hawaii	United States	96813
164	Island Urology	Honolulu	Hawaii	United States	96813
165	Queen's Cancer Cenrer - POB I	Honolulu	Hawaii	United States	96813
166	Queen's Medical Center	Honolulu	Hawaii	United States	96813
167	Straub Clinic and Hospital	Honolulu	Hawaii	United States	96813
168	University of Hawaii Cancer Center	Honolulu	Hawaii	United States	96813
169	Hawaii Cancer Care Inc-Liliha	Honolulu	Hawaii	United States	96817
170	Kuakini Medical Center	Honolulu	Hawaii	United States	96817
171	Queen's Cancer Center - Kuakini	Honolulu	Hawaii	United States	96817
172	The Cancer Center of Hawaii-Liliha	Honolulu	Hawaii	United States	96817
173	Kaiser Permanente Moanalua Medical Center	Honolulu	Hawaii	United States	96819
174	Kapiolani Medical Center for Women and Children	Honolulu	Hawaii	United States	96826
175	Wilcox Memorial Hospital and Kauai Medical Clinic	Lihue	Hawaii	United States	96766
176	Saint Alphonsus Cancer Care Center-Boise	Boise	Idaho	United States	83706
177	Saint Luke's Cancer Institute - Boise	Boise	Idaho	United States	83712
178	Saint Alphonsus Cancer Care Center-Caldwell	Caldwell	Idaho	United States	83605
179	Kootenai Health - Coeur d'Alene	Coeur d'Alene	Idaho	United States	83814
180	Walter Knox Memorial Hospital	Emmett	Idaho	United States	83617
181	Saint Luke's Cancer Institute - Fruitland	Fruitland	Idaho	United States	83619
182	Idaho Urologic Institute-Meridian	Meridian	Idaho	United States	83642
183	Saint Luke's Cancer Institute - Meridian	Meridian	Idaho	United States	83642
184	Saint Alphonsus Medical Center-Nampa	Nampa	Idaho	United States	83686
185	Saint Luke's Cancer Institute - Nampa	Nampa	Idaho	United States	83686
186	Kootenai Clinic Cancer Services - Post Falls	Post Falls	Idaho	United States	83854
187	Kootenai Cancer Clinic	Sandpoint	Idaho	United States	83864
188	Saint Luke's Cancer Institute - Twin Falls	Twin Falls	Idaho	United States	83301
189	Rush - Copley Medical Center	Aurora	Illinois	United States	60504
190	Illinois CancerCare-Bloomington	Bloomington	Illinois	United States	61704
191	Loyola Center for Health at Burr Ridge	Burr Ridge	Illinois	United States	60527
192	Illinois CancerCare-Canton	Canton	Illinois	United States	61520
193	Memorial Hospital of Carbondale	Carbondale	Illinois	United States	62902
194	SIH Cancer Institute	Carterville	Illinois	United States	62918
195	Illinois CancerCare-Carthage	Carthage	Illinois	United States	62321
196	Centralia Oncology Clinic	Centralia	Illinois	United States	62801
197	Northwestern University	Chicago	Illinois	United States	60611
198	Rush University Medical Center	Chicago	Illinois	United States	60612
199	University of Chicago Comprehensive Cancer Center	Chicago	Illinois	United States	60637
200	Carle on Vermilion	Danville	Illinois	United States	61832
201	Cancer Care Specialists of Illinois - Decatur	Decatur	Illinois	United States	62526
202	Decatur Memorial Hospital	Decatur	Illinois	United States	62526
203	Northwestern Medicine Cancer Center Kishwaukee	DeKalb	Illinois	United States	60115
204	Illinois CancerCare-Dixon	Dixon	Illinois	United States	61021
205	Carle Physician Group-Effingham	Effingham	Illinois	United States	62401
206	Crossroads Cancer Center	Effingham	Illinois	United States	62401
207	Illinois CancerCare-Eureka	Eureka	Illinois	United States	61530
208	NorthShore University HealthSystem-Evanston Hospital	Evanston	Illinois	United States	60201
209	Illinois CancerCare-Galesburg	Galesburg	Illinois	United States	61401
210	Western Illinois Cancer Treatment Center	Galesburg	Illinois	United States	61401
211	Northwestern Medicine Cancer Center Delnor	Geneva	Illinois	United States	60134
212	NorthShore University HealthSystem-Glenbrook Hospital	Glenview	Illinois	United States	60026
213	Ingalls Memorial Hospital	Harvey	Illinois	United States	60426
214	NorthShore University HealthSystem-Highland Park Hospital	Highland Park	Illinois	United States	60035
215	Loyola Medicine Homer Glen	Homer Glen	Illinois	United States	60491
216	Illinois CancerCare-Kewanee Clinic	Kewanee	Illinois	United States	61443
217	Northwestern Medicine Lake Forest Hospital	Lake Forest	Illinois	United States	60045
218	Illinois CancerCare-Macomb	Macomb	Illinois	United States	61455
219	Carle Physician Group-Mattoon/Charleston	Mattoon	Illinois	United States	61938
220	Loyola University Medical Center	Maywood	Illinois	United States	60153
221	Marjorie Weinberg Cancer Center at Loyola-Gottlieb	Melrose Park	Illinois	United States	60160
222	Good Samaritan Regional Health Center	Mount Vernon	Illinois	United States	62864
223	UC Comprehensive Cancer Center at Silver Cross	New Lenox	Illinois	United States	60451
224	Cancer Care Center of O'Fallon	O'Fallon	Illinois	United States	62269
225	University of Chicago Medicine-Orland Park	Orland Park	Illinois	United States	60462
226	Illinois CancerCare-Ottawa Clinic	Ottawa	Illinois	United States	61350
227	Illinois CancerCare-Pekin	Pekin	Illinois	United States	61554
228	OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center	Pekin	Illinois	United States	61554
229	Illinois CancerCare-Peoria	Peoria	Illinois	United States	61615
230	OSF Saint Francis Radiation Oncology at Peoria Cancer Center	Peoria	Illinois	United States	61615
231	Methodist Medical Center of Illinois	Peoria	Illinois	United States	61636
232	OSF Saint Francis Medical Center	Peoria	Illinois	United States	61637
233	Illinois CancerCare-Peru	Peru	Illinois	United States	61354
234	Valley Radiation Oncology	Peru	Illinois	United States	61354
235	Illinois CancerCare-Princeton	Princeton	Illinois	United States	61356
236	SwedishAmerican Regional Cancer Center/ACT	Rockford	Illinois	United States	61114
237	North Shore Medical Center	Skokie	Illinois	United States	60076
238	Southern Illinois University School of Medicine	Springfield	Illinois	United States	62702
239	Springfield Clinic	Springfield	Illinois	United States	62702
240	Memorial Medical Center	Springfield	Illinois	United States	62781
241	Southwest Illinois Health Services LLP	Swansea	Illinois	United States	62226
242	Carle Cancer Center	Urbana	Illinois	United States	61801
243	The Carle Foundation Hospital	Urbana	Illinois	United States	61801
244	Northwestern Medicine Cancer Center Warrenville	Warrenville	Illinois	United States	60555
245	Rush-Copley Healthcare Center	Yorkville	Illinois	United States	60560
246	Parkview Regional Medical Center	Fort Wayne	Indiana	United States	46845
247	Community Cancer Center East	Indianapolis	Indiana	United States	46219
248	Community Cancer Center South	Indianapolis	Indiana	United States	46227
249	Franciscan Health Indianapolis	Indianapolis	Indiana	United States	46237
250	Community Cancer Center North	Indianapolis	Indiana	United States	46256
251	Community Howard Regional Health	Kokomo	Indiana	United States	46904
252	Franciscan Health Mooresville	Mooresville	Indiana	United States	46158
253	Reid Health	Richmond	Indiana	United States	47374
254	Union Hospital	Terre Haute	Indiana	United States	47804
255	Mary Greeley Medical Center	Ames	Iowa	United States	50010
256	McFarland Clinic PC - Ames	Ames	Iowa	United States	50010
257	University of Iowa Healthcare Cancer Services Quad Cities	Bettendorf	Iowa	United States	52722
258	McFarland Clinic PC-Boone	Boone	Iowa	United States	50036
259	Physicians' Clinic of Iowa PC	Cedar Rapids	Iowa	United States	52402
260	Mercy Hospital	Cedar Rapids	Iowa	United States	52403
261	Oncology Associates at Mercy Medical Center	Cedar Rapids	Iowa	United States	52403
262	Medical Oncology and Hematology Associates-West Des Moines	Clive	Iowa	United States	50325
263	Mercy Cancer Center-West Lakes	Clive	Iowa	United States	50325
264	Alegent Health Mercy Hospital	Council Bluffs	Iowa	United States	51503
265	Greater Regional Medical Center	Creston	Iowa	United States	50801
266	Blank Children's Hospital	Des Moines	Iowa	United States	50309
267	Iowa Methodist Medical Center	Des Moines	Iowa	United States	50309
268	Medical Oncology and Hematology Associates-Des Moines	Des Moines	Iowa	United States	50309
269	Broadlawns Medical Center	Des Moines	Iowa	United States	50314
270	Medical Oncology and Hematology Associates-Laurel	Des Moines	Iowa	United States	50314
271	Mercy Medical Center - Des Moines	Des Moines	Iowa	United States	50314
272	Iowa Lutheran Hospital	Des Moines	Iowa	United States	50316
273	McFarland Clinic PC-Trinity Cancer Center	Fort Dodge	Iowa	United States	50501
274	Trinity Regional Medical Center	Fort Dodge	Iowa	United States	50501
275	University of Iowa/Holden Comprehensive Cancer Center	Iowa City	Iowa	United States	52242
276	McFarland Clinic PC-Jefferson	Jefferson	Iowa	United States	50129
277	McFarland Clinic PC-Marshalltown	Marshalltown	Iowa	United States	50158
278	Siouxland Regional Cancer Center	Sioux City	Iowa	United States	51101
279	MercyOne Waterloo Medical Center	Waterloo	Iowa	United States	50702
280	Methodist West Hospital	West Des Moines	Iowa	United States	50266-7700
281	Mercy Medical Center-West Lakes	West Des Moines	Iowa	United States	50266
282	Coffeyville Regional Medical Center	Coffeyville	Kansas	United States	67337
283	Central Care Cancer Center - Garden City	Garden City	Kansas	United States	67846
284	Central Care Cancer Center - Great Bend	Great Bend	Kansas	United States	67530
285	HaysMed University of Kansas Health System	Hays	Kansas	United States	67601
286	Cancer Center of Kansas-Independence	Independence	Kansas	United States	67301
287	University of Kansas Cancer Center-West	Kansas City	Kansas	United States	66112
288	University of Kansas Cancer Center	Kansas City	Kansas	United States	66160
289	Lawrence Memorial Hospital	Lawrence	Kansas	United States	66044
290	Olathe Health Cancer Center	Olathe	Kansas	United States	66061
291	University of Kansas Cancer Center-Overland Park	Overland Park	Kansas	United States	66210
292	Ascension Via Christi - Pittsburg	Pittsburg	Kansas	United States	66762
293	Salina Regional Health Center	Salina	Kansas	United States	67401
294	University of Kansas Health System Saint Francis Campus	Topeka	Kansas	United States	66606
295	University of Kansas Hospital-Westwood Cancer Center	Westwood	Kansas	United States	66205
296	Cancer Center of Kansas-Wichita Medical Arts Tower	Wichita	Kansas	United States	67208
297	Ascension Via Christi Hospitals Wichita	Wichita	Kansas	United States	67214
298	Cancer Center of Kansas - Wichita	Wichita	Kansas	United States	67214
299	Wesley Medical Center	Wichita	Kansas	United States	67214
300	Flaget Memorial Hospital	Bardstown	Kentucky	United States	40004
301	Commonwealth Cancer Center-Corbin	Corbin	Kentucky	United States	40701
302	Saint Joseph Radiation Oncology Resource Center	Lexington	Kentucky	United States	40504
303	Saint Joseph Hospital East	Lexington	Kentucky	United States	40509
304	Saint Joseph London	London	Kentucky	United States	40741
305	Jewish Hospital	Louisville	Kentucky	United States	40202
306	Saints Mary and Elizabeth Hospital	Louisville	Kentucky	United States	40215
307	UofL Health Medical Center Northeast	Louisville	Kentucky	United States	40245
308	Jewish Hospital Medical Center South	Shepherdsville	Kentucky	United States	40165
309	Medical Center of Baton Rouge	Baton Rouge	Louisiana	United States	70816
310	Ochsner High Grove	Baton Rouge	Louisiana	United States	70836
311	Ochsner Medical Center Jefferson	New Orleans	Louisiana	United States	70121
312	Harold Alfond Center for Cancer Care	Augusta	Maine	United States	04330
313	Waldo County General Hospital	Belfast	Maine	United States	04915
314	MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford	Biddeford	Maine	United States	04005
315	Stephens Memorial Hospital	Norway	Maine	United States	04268
316	Penobscot Bay Medical Center	Rockport	Maine	United States	04856
317	MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford	Sanford	Maine	United States	04073
318	Maine Medical Partners - South Portland	South Portland	Maine	United States	04106
319	Western Maryland Regional Medical Center	Cumberland	Maryland	United States	21502
320	Tufts Medical Center	Boston	Massachusetts	United States	02111
321	Lahey Hospital and Medical Center	Burlington	Massachusetts	United States	01805
322	Lowell General Hospital	Lowell	Massachusetts	United States	01854
323	Mercy Medical Center	Springfield	Massachusetts	United States	01104
324	Hickman Cancer Center	Adrian	Michigan	United States	49221
325	Saint Joseph Mercy Hospital	Ann Arbor	Michigan	United States	48106
326	Saint Joseph Mercy Brighton	Brighton	Michigan	United States	48114
327	Trinity Health IHA Medical Group Hematology Oncology - Brighton	Brighton	Michigan	United States	48114
328	Henry Ford Cancer Institute-Downriver	Brownstown	Michigan	United States	48183
329	Saint Joseph Mercy Canton	Canton	Michigan	United States	48188
330	Trinity Health IHA Medical Group Hematology Oncology - Canton	Canton	Michigan	United States	48188
331	Caro Cancer Center	Caro	Michigan	United States	48723
332	Saint Joseph Mercy Chelsea	Chelsea	Michigan	United States	48118
333	Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital	Chelsea	Michigan	United States	48118
334	Hematology Oncology Consultants-Clarkston	Clarkston	Michigan	United States	48346
335	Newland Medical Associates-Clarkston	Clarkston	Michigan	United States	48346
336	Henry Ford Macomb Hospital-Clinton Township	Clinton Township	Michigan	United States	48038
337	Beaumont Hospital - Dearborn	Dearborn	Michigan	United States	48124
338	Henry Ford Medical Center-Fairlane	Dearborn	Michigan	United States	48126
339	Wayne State University/Karmanos Cancer Institute	Detroit	Michigan	United States	48201
340	Henry Ford Hospital	Detroit	Michigan	United States	48202
341	Ascension Saint John Hospital	Detroit	Michigan	United States	48236
342	Great Lakes Cancer Management Specialists-Doctors Park	East China Township	Michigan	United States	48054
343	Green Bay Oncology - Escanaba	Escanaba	Michigan	United States	49829
344	Weisberg Cancer Treatment Center	Farmington Hills	Michigan	United States	48334
345	Beaumont Hospital - Farmington Hills	Farmington Hills	Michigan	United States	48336
346	Genesee Cancer and Blood Disease Treatment Center	Flint	Michigan	United States	48503
347	Genesee Hematology Oncology PC	Flint	Michigan	United States	48503
348	Genesys Hurley Cancer Institute	Flint	Michigan	United States	48503
349	Hurley Medical Center	Flint	Michigan	United States	48503
350	Academic Hematology Oncology Specialists	Grosse Pointe Woods	Michigan	United States	48236
351	Great Lakes Cancer Management Specialists-Van Elslander Cancer Center	Grosse Pointe Woods	Michigan	United States	48236
352	Michigan Breast Specialists-Grosse Pointe Woods	Grosse Pointe Woods	Michigan	United States	48236
353	Allegiance Health	Jackson	Michigan	United States	49201
354	Sparrow Hospital	Lansing	Michigan	United States	48912
355	Hope Cancer Clinic	Livonia	Michigan	United States	48154
356	Trinity Health Saint Mary Mercy Livonia Hospital	Livonia	Michigan	United States	48154
357	Great Lakes Cancer Management Specialists-Macomb Medical Campus	Macomb	Michigan	United States	48044
358	Michigan Breast Specialists-Macomb Township	Macomb	Michigan	United States	48044
359	Saint Mary's Oncology/Hematology Associates of Marlette	Marlette	Michigan	United States	48453
360	Toledo Clinic Cancer Centers-Monroe	Monroe	Michigan	United States	48162
361	Henry Ford Medical Center-Columbus	Novi	Michigan	United States	48377
362	21st Century Oncology-Pontiac	Pontiac	Michigan	United States	48341
363	Hope Cancer Center	Pontiac	Michigan	United States	48341
364	Newland Medical Associates-Pontiac	Pontiac	Michigan	United States	48341
365	Saint Joseph Mercy Oakland	Pontiac	Michigan	United States	48341
366	Huron Medical Center PC	Port Huron	Michigan	United States	48060
367	Lake Huron Medical Center	Port Huron	Michigan	United States	48060
368	Great Lakes Cancer Management Specialists-Rochester Hills	Rochester Hills	Michigan	United States	48309
369	Oakland Colon Rectal Associates	Royal Oak	Michigan	United States	48067
370	Cancer Care Associates PC	Royal Oak	Michigan	United States	48073
371	Comprehensive Medical Center PLLC	Royal Oak	Michigan	United States	48073
372	Hematology Oncology Consultants PC	Royal Oak	Michigan	United States	48073
373	Oakland Medical Group	Royal Oak	Michigan	United States	48073
374	William Beaumont Hospital-Royal Oak	Royal Oak	Michigan	United States	48073
375	Ascension Saint Mary's Hospital	Saginaw	Michigan	United States	48601
376	Oncology Hematology Associates of Saginaw Valley PC	Saginaw	Michigan	United States	48604
377	Henry Ford Macomb Health Center - Shelby Township	Shelby	Michigan	United States	48315
378	Bhadresh Nayak MD PC-Sterling Heights	Sterling Heights	Michigan	United States	48312
379	Premier Hematology Oncology Care	Sterling Heights	Michigan	United States	48312
380	Ascension Saint Joseph Hospital	Tawas City	Michigan	United States	48764
381	Michigan Institute of Urology-Town Center	Troy	Michigan	United States	48084
382	William Beaumont Hospital - Troy	Troy	Michigan	United States	48085
383	Hematology Oncology Consultants PC-Troy	Troy	Michigan	United States	48098
384	Advanced Breast Care Center PLLC	Warren	Michigan	United States	48088
385	Great Lakes Cancer Management Specialists-Macomb Professional Building	Warren	Michigan	United States	48093
386	Macomb Hematology Oncology PC	Warren	Michigan	United States	48093
387	Michigan Breast Specialists-Warren	Warren	Michigan	United States	48093
388	Saint John Macomb-Oakland Hospital	Warren	Michigan	United States	48093
389	Henry Ford West Bloomfield Hospital	West Bloomfield	Michigan	United States	48322
390	Saint Mary's Oncology/Hematology Associates of West Branch	West Branch	Michigan	United States	48661
391	Huron Gastroenterology PC	Ypsilanti	Michigan	United States	48106
392	Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus	Ypsilanti	Michigan	United States	48197
393	Riverwood Healthcare Center	Aitkin	Minnesota	United States	56431
394	Sanford Joe Lueken Cancer Center	Bemidji	Minnesota	United States	56601
395	Essentia Health Saint Joseph's Medical Center	Brainerd	Minnesota	United States	56401
396	Fairview Ridges Hospital	Burnsville	Minnesota	United States	55337
397	Minnesota Oncology - Burnsville	Burnsville	Minnesota	United States	55337
398	Cambridge Medical Center	Cambridge	Minnesota	United States	55008
399	Mercy Hospital	Coon Rapids	Minnesota	United States	55433
400	Essentia Health - Deer River Clinic	Deer River	Minnesota	United States	56636
401	Essentia Health Saint Mary's - Detroit Lakes Clinic	Detroit Lakes	Minnesota	United States	56501
402	Essentia Health Cancer Center	Duluth	Minnesota	United States	55805
403	Essentia Health Saint Mary's Medical Center	Duluth	Minnesota	United States	55805
404	Miller-Dwan Hospital	Duluth	Minnesota	United States	55805
405	Fairview Southdale Hospital	Edina	Minnesota	United States	55435
406	Lake Region Healthcare Corporation-Cancer Care	Fergus Falls	Minnesota	United States	56537
407	Essentia Health - Fosston	Fosston	Minnesota	United States	56542
408	Unity Hospital	Fridley	Minnesota	United States	55432
409	Essentia Health Hibbing Clinic	Hibbing	Minnesota	United States	55746
410	Mayo Clinic Health Systems-Mankato	Mankato	Minnesota	United States	56001
411	Fairview Clinics and Surgery Center Maple Grove	Maple Grove	Minnesota	United States	55369
412	Minnesota Oncology Hematology PA-Maplewood	Maplewood	Minnesota	United States	55109
413	Saint John's Hospital - Healtheast	Maplewood	Minnesota	United States	55109
414	Abbott-Northwestern Hospital	Minneapolis	Minnesota	United States	55407
415	Hennepin County Medical Center	Minneapolis	Minnesota	United States	55415
416	Minneapolis VA Medical Center	Minneapolis	Minnesota	United States	55417
417	Health Partners Inc	Minneapolis	Minnesota	United States	55454
418	Monticello Cancer Center	Monticello	Minnesota	United States	55362
419	New Ulm Medical Center	New Ulm	Minnesota	United States	56073
420	Essentia Health - Park Rapids	Park Rapids	Minnesota	United States	56470
421	Fairview Northland Medical Center	Princeton	Minnesota	United States	55371
422	North Memorial Medical Health Center	Robbinsdale	Minnesota	United States	55422
423	Mayo Clinic in Rochester	Rochester	Minnesota	United States	55905
424	Coborn Cancer Center at Saint Cloud Hospital	Saint Cloud	Minnesota	United States	56303
425	Park Nicollet Clinic - Saint Louis Park	Saint Louis Park	Minnesota	United States	55416
426	Regions Hospital	Saint Paul	Minnesota	United States	55101
427	United Hospital	Saint Paul	Minnesota	United States	55102
428	Essentia Health Sandstone	Sandstone	Minnesota	United States	55072
429	Saint Francis Regional Medical Center	Shakopee	Minnesota	United States	55379
430	Lakeview Hospital	Stillwater	Minnesota	United States	55082
431	Sanford Thief River Falls Medical Center	Thief River Falls	Minnesota	United States	56701
432	Essentia Health Virginia Clinic	Virginia	Minnesota	United States	55792
433	Ridgeview Medical Center	Waconia	Minnesota	United States	55387
434	Rice Memorial Hospital	Willmar	Minnesota	United States	56201
435	Minnesota Oncology Hematology PA-Woodbury	Woodbury	Minnesota	United States	55125
436	Sanford Cancer Center Worthington	Worthington	Minnesota	United States	56187
437	Fairview Lakes Medical Center	Wyoming	Minnesota	United States	55092
438	Hattiesburg Clinic - Hematology/Oncology Clinic	Hattiesburg	Mississippi	United States	39401
439	Forrest General Hospital / Cancer Center	Hattiesburg	Mississippi	United States	39404
440	Saint Louis Cancer and Breast Institute-Ballwin	Ballwin	Missouri	United States	63011
441	Central Care Cancer Center - Bolivar	Bolivar	Missouri	United States	65613
442	Parkland Health Center-Bonne Terre	Bonne Terre	Missouri	United States	63628
443	Cox Cancer Center Branson	Branson	Missouri	United States	65616
444	Saint Francis Medical Center	Cape Girardeau	Missouri	United States	63703
445	Southeast Cancer Center	Cape Girardeau	Missouri	United States	63703
446	Saint Luke's Hospital	Chesterfield	Missouri	United States	63017
447	University of Missouri - Ellis Fischel	Columbia	Missouri	United States	65212
448	Siteman Cancer Center at West County Hospital	Creve Coeur	Missouri	United States	63141
449	Parkland Health Center - Farmington	Farmington	Missouri	United States	63640
450	Capital Region Southwest Campus	Jefferson City	Missouri	United States	65109
451	Freeman Health System	Joplin	Missouri	United States	64804
452	Mercy Hospital Joplin	Joplin	Missouri	United States	64804
453	Truman Medical Centers	Kansas City	Missouri	United States	64108
454	The University of Kansas Cancer Center-South	Kansas City	Missouri	United States	64131
455	University of Kansas Cancer Center - North	Kansas City	Missouri	United States	64154
456	University of Kansas Cancer Center - Lee's Summit	Lee's Summit	Missouri	United States	64064
457	University of Kansas Cancer Center at North Kansas City Hospital	North Kansas City	Missouri	United States	64116
458	Delbert Day Cancer Institute at PCRMC	Rolla	Missouri	United States	65401
459	Mercy Clinic-Rolla-Cancer and Hematology	Rolla	Missouri	United States	65401
460	Heartland Regional Medical Center	Saint Joseph	Missouri	United States	64506
461	Saint Louis Cancer and Breast Institute-South City	Saint Louis	Missouri	United States	63109
462	Washington University School of Medicine	Saint Louis	Missouri	United States	63110
463	Mercy Hospital South	Saint Louis	Missouri	United States	63128
464	Siteman Cancer Center-South County	Saint Louis	Missouri	United States	63129
465	Missouri Baptist Medical Center	Saint Louis	Missouri	United States	63131
466	Siteman Cancer Center at Christian Hospital	Saint Louis	Missouri	United States	63136
467	Mercy Hospital Saint Louis	Saint Louis	Missouri	United States	63141
468	Siteman Cancer Center at Saint Peters Hospital	Saint Peters	Missouri	United States	63376
469	Sainte Genevieve County Memorial Hospital	Sainte Genevieve	Missouri	United States	63670
470	Mercy Hospital Springfield	Springfield	Missouri	United States	65804
471	CoxHealth South Hospital	Springfield	Missouri	United States	65807
472	Missouri Baptist Sullivan Hospital	Sullivan	Missouri	United States	63080
473	Missouri Baptist Outpatient Center-Sunset Hills	Sunset Hills	Missouri	United States	63127
474	Mercy Hospital Washington	Washington	Missouri	United States	63090
475	Community Hospital of Anaconda	Anaconda	Montana	United States	59711
476	Billings Clinic Cancer Center	Billings	Montana	United States	59101
477	Saint Vincent Healthcare	Billings	Montana	United States	59101
478	Saint Vincent Frontier Cancer Center	Billings	Montana	United States	59102
479	Bozeman Deaconess Hospital	Bozeman	Montana	United States	59715
480	Saint James Community Hospital and Cancer Treatment Center	Butte	Montana	United States	59701
481	Benefis Healthcare- Sletten Cancer Institute	Great Falls	Montana	United States	59405
482	Great Falls Clinic	Great Falls	Montana	United States	59405
483	Saint Peter's Community Hospital	Helena	Montana	United States	59601
484	Kalispell Regional Medical Center	Kalispell	Montana	United States	59901
485	Saint Patrick Hospital - Community Hospital	Missoula	Montana	United States	59802
486	Community Medical Hospital	Missoula	Montana	United States	59804
487	CHI Health Saint Francis	Grand Island	Nebraska	United States	68803
488	Heartland Hematology and Oncology	Kearney	Nebraska	United States	68845
489	CHI Health Good Samaritan	Kearney	Nebraska	United States	68847
490	Saint Elizabeth Regional Medical Center	Lincoln	Nebraska	United States	68510
491	Alegent Health Immanuel Medical Center	Omaha	Nebraska	United States	68122
492	Hematology and Oncology Consultants PC	Omaha	Nebraska	United States	68122
493	Alegent Health Bergan Mercy Medical Center	Omaha	Nebraska	United States	68124
494	Alegent Health Lakeside Hospital	Omaha	Nebraska	United States	68130
495	Creighton University Medical Center	Omaha	Nebraska	United States	68131
496	Midlands Community Hospital	Papillion	Nebraska	United States	68046
497	Carson Tahoe Regional Medical Center	Carson City	Nevada	United States	89703
498	Cancer and Blood Specialists-Henderson	Henderson	Nevada	United States	89052
499	Comprehensive Cancer Centers of Nevada - Henderson	Henderson	Nevada	United States	89052
500	Comprehensive Cancer Centers of Nevada-Horizon Ridge	Henderson	Nevada	United States	89052
501	Las Vegas Cancer Center-Henderson	Henderson	Nevada	United States	89052
502	OptumCare Cancer Care at Seven Hills	Henderson	Nevada	United States	89052
503	Comprehensive Cancer Centers of Nevada-Southeast Henderson	Henderson	Nevada	United States	89074
504	GenesisCare USA - Henderson	Henderson	Nevada	United States	89074
505	Las Vegas Urology - Green Valley	Henderson	Nevada	United States	89074
506	Las Vegas Urology - Pebble	Henderson	Nevada	United States	89074
507	Urology Specialists of Nevada - Green Valley	Henderson	Nevada	United States	89074
508	Las Vegas Urology - Pecos	Las Vegas	Nevada	United States	89074
509	Desert West Surgery	Las Vegas	Nevada	United States	89102
510	OptumCare Cancer Care at Charleston	Las Vegas	Nevada	United States	89102
511	University Medical Center of Southern Nevada	Las Vegas	Nevada	United States	89102
512	Hope Cancer Care of Nevada	Las Vegas	Nevada	United States	89103
513	Cancer and Blood Specialists-Shadow	Las Vegas	Nevada	United States	89106
514	Radiation Oncology Centers of Nevada Central	Las Vegas	Nevada	United States	89106
515	Urology Specialists of Nevada - Central	Las Vegas	Nevada	United States	89106
516	GenesisCare USA - Las Vegas	Las Vegas	Nevada	United States	89109
517	HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway	Las Vegas	Nevada	United States	89109
518	Sunrise Hospital and Medical Center	Las Vegas	Nevada	United States	89109
519	HealthCare Partners Medical Group Oncology/Hematology-San Martin	Las Vegas	Nevada	United States	89113
520	Las Vegas Prostate Cancer Center	Las Vegas	Nevada	United States	89113
521	Las Vegas Urology - Sunset	Las Vegas	Nevada	United States	89113
522	Urology Specialists of Nevada - Southwest	Las Vegas	Nevada	United States	89113
523	Radiation Oncology Centers of Nevada Southeast	Las Vegas	Nevada	United States	89119
524	Ann M Wierman MD LTD	Las Vegas	Nevada	United States	89128
525	Cancer and Blood Specialists-Tenaya	Las Vegas	Nevada	United States	89128
526	Comprehensive Cancer Centers of Nevada - Northwest	Las Vegas	Nevada	United States	89128
527	GenesisCare USA - Vegas Tenaya	Las Vegas	Nevada	United States	89128
528	HealthCare Partners Medical Group Oncology/Hematology-Tenaya	Las Vegas	Nevada	United States	89128
529	Las Vegas Urology - Cathedral Rock	Las Vegas	Nevada	United States	89128
530	Las Vegas Urology - Smoke Ranch	Las Vegas	Nevada	United States	89128
531	OptumCare Cancer Care at MountainView	Las Vegas	Nevada	United States	89128
532	Urology Specialists of Nevada - Northwest	Las Vegas	Nevada	United States	89128
533	Alliance for Childhood Diseases/Cure 4 the Kids Foundation	Las Vegas	Nevada	United States	89135
534	Comprehensive Cancer Centers of Nevada - Town Center	Las Vegas	Nevada	United States	89144
535	Comprehensive Cancer Centers of Nevada-Summerlin	Las Vegas	Nevada	United States	89144
536	Summerlin Hospital Medical Center	Las Vegas	Nevada	United States	89144
537	Las Vegas Cancer Center-Medical Center	Las Vegas	Nevada	United States	89148-2405
538	Comprehensive Cancer Centers of Nevada	Las Vegas	Nevada	United States	89148
539	GenesisCare USA - Fort Apache	Las Vegas	Nevada	United States	89148
540	OptumCare Cancer Care at Fort Apache	Las Vegas	Nevada	United States	89148
541	HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills	Las Vegas	Nevada	United States	89149
542	Comprehensive Cancer Centers of Nevada - Central Valley	Las Vegas	Nevada	United States	89169
543	University Cancer Center	Las Vegas	Nevada	United States	89169
544	Hope Cancer Care of Nevada-Pahrump	Pahrump	Nevada	United States	89048
545	Renown Regional Medical Center	Reno	Nevada	United States	89502
546	Saint Mary's Regional Medical Center	Reno	Nevada	United States	89503
547	Radiation Oncology Associates	Reno	Nevada	United States	89509
548	New Hampshire Oncology Hematology PA-Concord	Concord	New Hampshire	United States	03301
549	Elliot Hospital	Manchester	New Hampshire	United States	03103
550	Solinsky Center for Cancer Care	Manchester	New Hampshire	United States	03103
551	Ocean Medical Center	Brick	New Jersey	United States	08724
552	Monmouth Medical Center Southern Campus	Lakewood	New Jersey	United States	08701
553	Monmouth Medical Center	Long Branch	New Jersey	United States	07740
554	Southern Ocean County Medical Center	Manahawkin	New Jersey	United States	08050
555	Morristown Medical Center	Morristown	New Jersey	United States	07960
556	Jersey Shore Medical Center	Neptune	New Jersey	United States	07753
557	Rutgers Cancer Institute of New Jersey	New Brunswick	New Jersey	United States	08903
558	Riverview Medical Center/Booker Cancer Center	Red Bank	New Jersey	United States	07701
559	Overlook Hospital	Summit	New Jersey	United States	07902
560	University of New Mexico Cancer Center	Albuquerque	New Mexico	United States	87102
561	Memorial Medical Center - Las Cruces	Las Cruces	New Mexico	United States	88011
562	Hematology Oncology Associates of Central New York-Auburn	Auburn	New York	United States	13021
563	Roswell Park Cancer Institute	Buffalo	New York	United States	14263
564	Cancer Institute at Saint Francis Hospital	East Hills	New York	United States	11548
565	Hematology Oncology Associates of Central New York-East Syracuse	East Syracuse	New York	United States	13057
566	Glens Falls Hospital	Glens Falls	New York	United States	12801
567	NYU Winthrop Hospital	Mineola	New York	United States	11501
568	Laura and Isaac Perlmutter Cancer Center at NYU Langone	New York	New York	United States	10016
569	NYP/Weill Cornell Medical Center	New York	New York	United States	10065
570	University of Rochester	Rochester	New York	United States	14642
571	State University of New York Upstate Medical University	Syracuse	New York	United States	13210
572	Hematology Oncology Associates of Central New York-Onondaga Hill	Syracuse	New York	United States	13215
573	Good Samaritan Hospital Medical Center	West Islip	New York	United States	11795
574	Mission Hospital	Asheville	North Carolina	United States	28801
575	Messino Cancer Centers	Asheville	North Carolina	United States	28806
576	Waverly Hematology Oncology	Cary	North Carolina	United States	27518
577	UNC Lineberger Comprehensive Cancer Center	Chapel Hill	North Carolina	United States	27599
578	Southeastern Medical Oncology Center-Clinton	Clinton	North Carolina	United States	28328
579	Duke University Medical Center	Durham	North Carolina	United States	27710
580	Southeastern Medical Oncology Center-Goldsboro	Goldsboro	North Carolina	United States	27534
581	Wayne Memorial Hospital	Goldsboro	North Carolina	United States	27534
582	Margaret R Pardee Memorial Hospital	Hendersonville	North Carolina	United States	28791
583	Onslow Memorial Hospital	Jacksonville	North Carolina	United States	28546
584	Southeastern Medical Oncology Center-Jacksonville	Jacksonville	North Carolina	United States	28546
585	FirstHealth of the Carolinas-Moore Regional Hospital	Pinehurst	North Carolina	United States	28374
586	Sanford Bismarck Medical Center	Bismarck	North Dakota	United States	58501
587	Essentia Health Cancer Center-South University Clinic	Fargo	North Dakota	United States	58103
588	Sanford South University Medical Center	Fargo	North Dakota	United States	58103
589	Sanford Medical Center Fargo	Fargo	North Dakota	United States	58104
590	Sanford Broadway Medical Center	Fargo	North Dakota	United States	58122
591	Sanford Roger Maris Cancer Center	Fargo	North Dakota	United States	58122
592	Essentia Health - Jamestown Clinic	Jamestown	North Dakota	United States	58401
593	Trinity Cancer Care Center	Minot	North Dakota	United States	58701
594	Indu and Raj Soin Medical Center	Beavercreek	Ohio	United States	45431
595	Strecker Cancer Center-Belpre	Belpre	Ohio	United States	45714
596	Saint Elizabeth Boardman Hospital	Boardman	Ohio	United States	44512
597	Cleveland Clinic Mercy Hospital	Canton	Ohio	United States	44708
598	Mercy Hematology and Oncology Associates Inc	Canton	Ohio	United States	44708
599	Dayton Physicians LLC-Miami Valley South	Centerville	Ohio	United States	45459
600	Miami Valley Hospital South	Centerville	Ohio	United States	45459
601	Adena Regional Medical Center	Chillicothe	Ohio	United States	45601
602	Good Samaritan Hospital - Cincinnati	Cincinnati	Ohio	United States	45220
603	Oncology Hematology Care Inc-Kenwood	Cincinnati	Ohio	United States	45236
604	Bethesda North Hospital	Cincinnati	Ohio	United States	45242
605	TriHealth Cancer Institute-Westside	Cincinnati	Ohio	United States	45247
606	TriHealth Cancer Institute-Anderson	Cincinnati	Ohio	United States	45255
607	MetroHealth Medical Center	Cleveland	Ohio	United States	44109
608	Ohio State University Comprehensive Cancer Center	Columbus	Ohio	United States	43210
609	Mount Carmel East Hospital	Columbus	Ohio	United States	43213
610	Columbus Oncology and Hematology Associates Inc	Columbus	Ohio	United States	43214
611	Riverside Methodist Hospital	Columbus	Ohio	United States	43214
612	Grant Medical Center	Columbus	Ohio	United States	43215
613	The Mark H Zangmeister Center	Columbus	Ohio	United States	43219
614	Mount Carmel Health Center West	Columbus	Ohio	United States	43222
615	Doctors Hospital	Columbus	Ohio	United States	43228
616	Good Samaritan Hospital - Dayton	Dayton	Ohio	United States	45406
617	Miami Valley Hospital	Dayton	Ohio	United States	45409
618	Dayton Physician LLC-Miami Valley Hospital North	Dayton	Ohio	United States	45415
619	Miami Valley Hospital North	Dayton	Ohio	United States	45415
620	Delaware Health Center-Grady Cancer Center	Delaware	Ohio	United States	43015
621	Grady Memorial Hospital	Delaware	Ohio	United States	43015
622	Dublin Methodist Hospital	Dublin	Ohio	United States	43016
623	Armes Family Cancer Center	Findlay	Ohio	United States	45840
624	Blanchard Valley Hospital	Findlay	Ohio	United States	45840
625	Orion Cancer Care	Findlay	Ohio	United States	45840
626	Atrium Medical Center-Middletown Regional Hospital	Franklin	Ohio	United States	45005-1066
627	Dayton Physicians LLC-Atrium	Franklin	Ohio	United States	45005
628	Central Ohio Breast and Endocrine Surgery	Gahanna	Ohio	United States	43230
629	Dayton Physicians LLC-Wayne	Greenville	Ohio	United States	45331
630	Wayne Hospital	Greenville	Ohio	United States	45331
631	Mount Carmel Grove City Hospital	Grove City	Ohio	United States	43123
632	Greater Dayton Cancer Center	Kettering	Ohio	United States	45409
633	First Dayton Cancer Care	Kettering	Ohio	United States	45420
634	Kettering Medical Center	Kettering	Ohio	United States	45429
635	Fairfield Medical Center	Lancaster	Ohio	United States	43130
636	OhioHealth Mansfield Hospital	Mansfield	Ohio	United States	44903
637	Marietta Memorial Hospital	Marietta	Ohio	United States	45750
638	OhioHealth Marion General Hospital	Marion	Ohio	United States	43302
639	Knox Community Hospital	Mount Vernon	Ohio	United States	43050
640	Licking Memorial Hospital	Newark	Ohio	United States	43055
641	Newark Radiation Oncology	Newark	Ohio	United States	43055
642	Mercy Health Perrysburg Cancer Center	Perrysburg	Ohio	United States	43551
643	Southern Ohio Medical Center	Portsmouth	Ohio	United States	45662
644	Springfield Regional Cancer Center	Springfield	Ohio	United States	45504
645	Springfield Regional Medical Center	Springfield	Ohio	United States	45505
646	ProMedica Flower Hospital	Sylvania	Ohio	United States	43560
647	ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital	Toledo	Ohio	United States	43606
648	Mercy Health - Saint Anne Hospital	Toledo	Ohio	United States	43623
649	Toledo Clinic Cancer Centers-Toledo	Toledo	Ohio	United States	43623
650	Dayton Physicians LLC-Upper Valley	Troy	Ohio	United States	45373
651	Upper Valley Medical Center	Troy	Ohio	United States	45373
652	Saint Joseph Warren Hospital	Warren	Ohio	United States	44484
653	Saint Ann's Hospital	Westerville	Ohio	United States	43081
654	Wright-Patterson Medical Center	Wright-Patterson Air Force Base	Ohio	United States	45433
655	Saint Elizabeth Youngstown Hospital	Youngstown	Ohio	United States	44501
656	Genesis Healthcare System Cancer Care Center	Zanesville	Ohio	United States	43701
657	Cancer Centers of Southwest Oklahoma Research	Lawton	Oklahoma	United States	73505
658	University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	United States	73104
659	Mercy Hospital Oklahoma City	Oklahoma City	Oklahoma	United States	73120
660	Oklahoma Cancer Specialists and Research Institute-Tulsa	Tulsa	Oklahoma	United States	74146
661	Saint Alphonsus Medical Center-Baker City	Baker City	Oregon	United States	97814
662	Saint Charles Health System	Bend	Oregon	United States	97701
663	Clackamas Radiation Oncology Center	Clackamas	Oregon	United States	97015
664	Providence Cancer Institute Clackamas Clinic	Clackamas	Oregon	United States	97015
665	Bay Area Hospital	Coos Bay	Oregon	United States	97420
666	Providence Newberg Medical Center	Newberg	Oregon	United States	97132
667	Saint Alphonsus Medical Center-Ontario	Ontario	Oregon	United States	97914
668	Providence Portland Medical Center	Portland	Oregon	United States	97213
669	Providence Saint Vincent Medical Center	Portland	Oregon	United States	97225
670	Kaiser Permanente Northwest	Portland	Oregon	United States	97227
671	Oregon Health and Science University	Portland	Oregon	United States	97239
672	Saint Charles Health System-Redmond	Redmond	Oregon	United States	97756
673	Salem Hospital	Salem	Oregon	United States	97301
674	Lehigh Valley Hospital-Cedar Crest	Allentown	Pennsylvania	United States	18103
675	Lehigh Valley Hospital - Muhlenberg	Bethlehem	Pennsylvania	United States	18017
676	Bryn Mawr Hospital	Bryn Mawr	Pennsylvania	United States	19010
677	Christiana Care Health System-Concord Health Center	Chadds Ford	Pennsylvania	United States	19317
678	Chambersburg Hospital	Chambersburg	Pennsylvania	United States	17201
679	Main Line Health Center-Collegeville	Collegeville	Pennsylvania	United States	19426
680	Geisinger Medical Center	Danville	Pennsylvania	United States	17822
681	Pocono Medical Center	East Stroudsburg	Pennsylvania	United States	18301
682	Ephrata Cancer Center	Ephrata	Pennsylvania	United States	17522
683	Ephrata Community Hospital	Ephrata	Pennsylvania	United States	17522
684	Main Line Health Center-Exton	Exton	Pennsylvania	United States	19341
685	Adams Cancer Center	Gettysburg	Pennsylvania	United States	17325
686	Cherry Tree Cancer Center	Hanover	Pennsylvania	United States	17331
687	Geisinger Medical Center-Cancer Center Hazleton	Hazleton	Pennsylvania	United States	18201
688	Lehigh Valley Hospital-Hazleton	Hazleton	Pennsylvania	United States	18201
689	Penn State Milton S Hershey Medical Center	Hershey	Pennsylvania	United States	17033-0850
690	Sechler Family Cancer Center	Lebanon	Pennsylvania	United States	17042
691	Geisinger Medical Oncology-Lewisburg	Lewisburg	Pennsylvania	United States	17837
692	Lewistown Hospital	Lewistown	Pennsylvania	United States	17044
693	Riddle Memorial Hospital	Media	Pennsylvania	United States	19063
694	Paoli Memorial Hospital	Paoli	Pennsylvania	United States	19301
695	Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	United States	19107
696	Pottstown Hospital	Pottstown	Pennsylvania	United States	19464
697	Geisinger Cancer Services-Pottsville	Pottsville	Pennsylvania	United States	17901
698	Community Medical Center	Scranton	Pennsylvania	United States	18510
699	Geisinger Medical Oncology-Selinsgrove	Selinsgrove	Pennsylvania	United States	17870
700	Geisinger Medical Group	State College	Pennsylvania	United States	16801
701	Geisinger Wyoming Valley/Henry Cancer Center	Wilkes-Barre	Pennsylvania	United States	18711
702	Asplundh Cancer Pavilion	Willow Grove	Pennsylvania	United States	19090
703	Lankenau Medical Center	Wynnewood	Pennsylvania	United States	19096
704	WellSpan Health-York Cancer Center	York	Pennsylvania	United States	17403
705	WellSpan Health-York Hospital	York	Pennsylvania	United States	17403
706	Smilow Cancer Hospital Care Center - Westerly	Westerly	Rhode Island	United States	02891
707	Prisma Health Cancer Institute - Spartanburg	Boiling Springs	South Carolina	United States	29316
708	Medical University of South Carolina	Charleston	South Carolina	United States	29425
709	Prisma Health Cancer Institute - Laurens	Clinton	South Carolina	United States	29325
710	Prisma Health Cancer Institute - Easley	Easley	South Carolina	United States	29640
711	Gibbs Cancer Center-Gaffney	Gaffney	South Carolina	United States	29341
712	Saint Francis Hospital	Greenville	South Carolina	United States	29601
713	BI-LO Charities Children's Cancer Center	Greenville	South Carolina	United States	29605
714	Prisma Health Cancer Institute - Butternut	Greenville	South Carolina	United States	29605
715	Prisma Health Cancer Institute - Faris	Greenville	South Carolina	United States	29605
716	Prisma Health Greenville Memorial Hospital	Greenville	South Carolina	United States	29605
717	Saint Francis Cancer Center	Greenville	South Carolina	United States	29607
718	Prisma Health Cancer Institute - Eastside	Greenville	South Carolina	United States	29615
719	Self Regional Healthcare	Greenwood	South Carolina	United States	29646
720	Prisma Health Cancer Institute - Greer	Greer	South Carolina	United States	29650
721	Gibbs Cancer Center-Pelham	Greer	South Carolina	United States	29651
722	Prisma Health Cancer Institute - Seneca	Seneca	South Carolina	United States	29672
723	Spartanburg Medical Center	Spartanburg	South Carolina	United States	29303
724	MGC Hematology Oncology-Union	Union	South Carolina	United States	29379
725	Avera Cancer Institute-Aberdeen	Aberdeen	South Dakota	United States	57401
726	Avera Cancer Institute at Pierre	Pierre	South Dakota	United States	57501
727	Sanford Cancer Center Oncology Clinic	Sioux Falls	South Dakota	United States	57104
728	Avera Cancer Institute	Sioux Falls	South Dakota	United States	57105
729	Sanford USD Medical Center - Sioux Falls	Sioux Falls	South Dakota	United States	57117-5134
730	Memorial Hospital	Chattanooga	Tennessee	United States	37404
731	Pulmonary Medicine Center of Chattanooga-Hixson	Hixson	Tennessee	United States	37343
732	Memorial GYN Plus	Ooltewah	Tennessee	United States	37363
733	The Don and Sybil Harrington Cancer Center	Amarillo	Texas	United States	79106
734	Saint Joseph Regional Cancer Center	Bryan	Texas	United States	77802
735	Dallas VA Medical Center	Dallas	Texas	United States	75216
736	UT Southwestern/Simmons Cancer Center-Dallas	Dallas	Texas	United States	75390
737	UT Southwestern Clinical Center at Richardson/Plano	Richardson	Texas	United States	75080
738	American Fork Hospital / Huntsman Intermountain Cancer Center	American Fork	Utah	United States	84003
739	Sandra L Maxwell Cancer Center	Cedar City	Utah	United States	84720
740	Logan Regional Hospital	Logan	Utah	United States	84321
741	Intermountain Medical Center	Murray	Utah	United States	84107
742	McKay-Dee Hospital Center	Ogden	Utah	United States	84403
743	Utah Valley Regional Medical Center	Provo	Utah	United States	84604
744	Riverton Hospital	Riverton	Utah	United States	84065
745	Saint George Regional Medical Center	Saint George	Utah	United States	84770
746	Utah Cancer Specialists-Salt Lake City	Salt Lake City	Utah	United States	84106
747	Huntsman Cancer Institute/University of Utah	Salt Lake City	Utah	United States	84112
748	LDS Hospital	Salt Lake City	Utah	United States	84143
749	University of Virginia Cancer Center	Charlottesville	Virginia	United States	22908
750	Inova Schar Cancer Institute	Fairfax	Virginia	United States	22031
751	Inova Fairfax Hospital	Falls Church	Virginia	United States	22042
752	Centra Lynchburg Hematology-Oncology Clinic Inc	Lynchburg	Virginia	United States	24501
753	Virginia Cancer Institute	Richmond	Virginia	United States	23229
754	Virginia Commonwealth University/Massey Cancer Center	Richmond	Virginia	United States	23298
755	VCU Community Memorial Health Center	South Hill	Virginia	United States	23970
756	Providence Regional Cancer System-Aberdeen	Aberdeen	Washington	United States	98520
757	MultiCare Auburn Medical Center	Auburn	Washington	United States	98001
758	Virginia Mason Bainbridge Island Medical Center	Bainbridge Island	Washington	United States	98110
759	Overlake Medical Center	Bellevue	Washington	United States	98004
760	PeaceHealth Saint Joseph Medical Center	Bellingham	Washington	United States	98225
761	Harrison HealthPartners Hematology and Oncology-Bremerton	Bremerton	Washington	United States	98310
762	Harrison Medical Center	Bremerton	Washington	United States	98310
763	Highline Medical Center-Main Campus	Burien	Washington	United States	98166
764	Providence Regional Cancer System-Centralia	Centralia	Washington	United States	98531
765	Swedish Cancer Institute-Edmonds	Edmonds	Washington	United States	98026
766	Saint Elizabeth Hospital	Enumclaw	Washington	United States	98022
767	Providence Regional Cancer Partnership	Everett	Washington	United States	98201
768	Virginia Mason Federal Way Medical Center	Federal Way	Washington	United States	98002
769	Saint Francis Hospital	Federal Way	Washington	United States	98003
770	Tacoma/Valley Radiation Oncology Centers-Gig Harbor	Gig Harbor	Washington	United States	98332
771	MultiCare Gig Harbor Medical Park	Gig Harbor	Washington	United States	98335
772	Swedish Cancer Institute-Issaquah	Issaquah	Washington	United States	98029
773	Kadlec Clinic Hematology and Oncology	Kennewick	Washington	United States	99336
774	Northwest Cancer Clinic	Kennewick	Washington	United States	99336
775	Providence Regional Cancer System-Lacey	Lacey	Washington	United States	98503
776	Saint Clare Hospital	Lakewood	Washington	United States	98499
777	PeaceHealth Saint John Medical Center	Longview	Washington	United States	98632
778	Virginia Mason Lynnwood Medical Center	Lynnwood	Washington	United States	98036
779	Jefferson Healthcare	Port Townsend	Washington	United States	98368
780	Harrison HealthPartners Hematology and Oncology-Poulsbo	Poulsbo	Washington	United States	98370
781	MultiCare Good Samaritan Hospital	Puyallup	Washington	United States	98372
782	Tacoma/Valley Radiation Oncology Centers-Puyallup	Puyallup	Washington	United States	98372
783	Valley Medical Center	Renton	Washington	United States	98055
784	Virginia Mason Medical Center	Seattle	Washington	United States	98101
785	Pacific Gynecology Specialists	Seattle	Washington	United States	98104
786	Swedish Medical Center-Ballard Campus	Seattle	Washington	United States	98107
787	Fred Hutchinson Cancer Research Center	Seattle	Washington	United States	98109
788	Seattle Cancer Care Alliance	Seattle	Washington	United States	98109
789	Kaiser Permanente Washington	Seattle	Washington	United States	98112
790	Swedish Medical Center-First Hill	Seattle	Washington	United States	98122-4307
791	Swedish Medical Center-Cherry Hill	Seattle	Washington	United States	98122-5711
792	Seattle Cancer Care Alliance at Northwest Hospital	Seattle	Washington	United States	98133
793	University of Washington Medical Center - Montlake	Seattle	Washington	United States	98195
794	PeaceHealth United General Medical Center	Sedro-Woolley	Washington	United States	98284
795	Providence Regional Cancer System-Shelton	Shelton	Washington	United States	98584
796	MultiCare Deaconess Cancer and Blood Specialty Center - Valley	Spokane Valley	Washington	United States	99216
797	MultiCare Deaconess Cancer and Blood Specialty Center - Downtown	Spokane	Washington	United States	99204
798	MultiCare Deaconess Cancer and Blood Specialty Center - North	Spokane	Washington	United States	99218
799	Tacoma/Valley Radiation Oncology Centers-Jackson Hall	Tacoma	Washington	United States	97405
800	Franciscan Research Center-Northwest Medical Plaza	Tacoma	Washington	United States	98405
801	Mary Bridge Children's Hospital and Health Center	Tacoma	Washington	United States	98405
802	MultiCare Tacoma General Hospital	Tacoma	Washington	United States	98405
803	Northwest Medical Specialties PLLC	Tacoma	Washington	United States	98405
804	Tacoma/Valley Radiation Oncology Centers-Saint Joe's	Tacoma	Washington	United States	98405
805	PeaceHealth Southwest Medical Center	Vancouver	Washington	United States	98664
806	Providence Saint Mary Regional Cancer Center	Walla Walla	Washington	United States	99362
807	North Star Lodge Cancer Center at Yakima Valley Memorial Hospital	Yakima	Washington	United States	98902
808	Providence Regional Cancer System-Yelm	Yelm	Washington	United States	98597
809	West Virginia University Charleston Division	Charleston	West Virginia	United States	25304
810	Langlade Hospital and Cancer Center	Antigo	Wisconsin	United States	54409
811	ThedaCare Regional Cancer Center	Appleton	Wisconsin	United States	54911
812	Duluth Clinic Ashland	Ashland	Wisconsin	United States	54806
813	Northwest Wisconsin Cancer Center	Ashland	Wisconsin	United States	54806
814	Ascension Southeast Wisconsin Hospital - Elmbrook Campus	Brookfield	Wisconsin	United States	53045
815	Aurora Cancer Care-Southern Lakes VLCC	Burlington	Wisconsin	United States	53105
816	Marshfield Clinic-Chippewa Center	Chippewa Falls	Wisconsin	United States	54729
817	Aurora Saint Luke's South Shore	Cudahy	Wisconsin	United States	53110
818	HSHS Sacred Heart Hospital	Eau Claire	Wisconsin	United States	54701
819	Marshfield Medical Center-EC Cancer Center	Eau Claire	Wisconsin	United States	54701
820	Mayo Clinic Health System-Eau Claire Clinic	Eau Claire	Wisconsin	United States	54701
821	Aurora Health Center-Fond du Lac	Fond Du Lac	Wisconsin	United States	54937
822	Ascension Saint Francis - Reiman Cancer Center	Franklin	Wisconsin	United States	53132
823	Aurora Health Care Germantown Health Center	Germantown	Wisconsin	United States	53022
824	Aurora Cancer Care-Grafton	Grafton	Wisconsin	United States	53024
825	Bellin Memorial Hospital	Green Bay	Wisconsin	United States	54301
826	Saint Vincent Hospital Cancer Center Green Bay	Green Bay	Wisconsin	United States	54301
827	Saint Vincent Hospital Cancer Center at Saint Mary's	Green Bay	Wisconsin	United States	54303
828	Aurora BayCare Medical Center	Green Bay	Wisconsin	United States	54311
829	Aurora Cancer Care-Kenosha South	Kenosha	Wisconsin	United States	53142
830	Gundersen Lutheran Medical Center	La Crosse	Wisconsin	United States	54601
831	Mayo Clinic Health System-Franciscan Healthcare	La Crosse	Wisconsin	United States	54601
832	Marshfield Clinic - Ladysmith Center	Ladysmith	Wisconsin	United States	54848
833	Dean Hematology and Oncology Clinic	Madison	Wisconsin	United States	53717
834	University of Wisconsin Carbone Cancer Center	Madison	Wisconsin	United States	53792
835	Holy Family Memorial Hospital	Manitowoc	Wisconsin	United States	54221
836	Aurora Bay Area Medical Group-Marinette	Marinette	Wisconsin	United States	54143
837	Saint Vincent Hospital Cancer Center at Marinette	Marinette	Wisconsin	United States	54143
838	Marshfield Medical Center-Marshfield	Marshfield	Wisconsin	United States	54449
839	Aspirus Medford Hospital	Medford	Wisconsin	United States	54451
840	Ascension Columbia Saint Mary's Hospital Ozaukee	Mequon	Wisconsin	United States	53097
841	Aurora Cancer Care-Milwaukee	Milwaukee	Wisconsin	United States	53209
842	Ascension Columbia Saint Mary's Hospital - Milwaukee	Milwaukee	Wisconsin	United States	53211
843	Aurora Saint Luke's Medical Center	Milwaukee	Wisconsin	United States	53215
844	Medical College of Wisconsin	Milwaukee	Wisconsin	United States	53226
845	Aurora Sinai Medical Center	Milwaukee	Wisconsin	United States	53233
846	Marshfield Clinic-Minocqua Center	Minocqua	Wisconsin	United States	54548
847	ProHealth D N Greenwald Center	Mukwonago	Wisconsin	United States	53149
848	Cancer Center of Western Wisconsin	New Richmond	Wisconsin	United States	54017
849	ProHealth Oconomowoc Memorial Hospital	Oconomowoc	Wisconsin	United States	53066
850	Saint Vincent Hospital Cancer Center at Oconto Falls	Oconto Falls	Wisconsin	United States	54154
851	Vince Lombardi Cancer Clinic - Oshkosh	Oshkosh	Wisconsin	United States	54904
852	Ascension All Saints Hospital	Racine	Wisconsin	United States	53405
853	Aurora Cancer Care-Racine	Racine	Wisconsin	United States	53406
854	Marshfield Medical Center-Rice Lake	Rice Lake	Wisconsin	United States	54868
855	HSHS Saint Nicholas Hospital	Sheboygan	Wisconsin	United States	53081
856	Vince Lombardi Cancer Clinic-Sheboygan	Sheboygan	Wisconsin	United States	53081
857	Marshfield Medical Center-River Region at Stevens Point	Stevens Point	Wisconsin	United States	54482
858	Saint Vincent Hospital Cancer Center at Sturgeon Bay	Sturgeon Bay	Wisconsin	United States	54235-1495
859	Aurora Medical Center in Summit	Summit	Wisconsin	United States	53066
860	Vince Lombardi Cancer Clinic-Two Rivers	Two Rivers	Wisconsin	United States	54241
861	ProHealth Waukesha Memorial Hospital	Waukesha	Wisconsin	United States	53188
862	UW Cancer Center at ProHealth Care	Waukesha	Wisconsin	United States	53188
863	Aspirus Regional Cancer Center	Wausau	Wisconsin	United States	54401
864	Marshfield Clinic-Wausau Center	Wausau	Wisconsin	United States	54401
865	Ascension Medical Group Southeast Wisconsin - Mayfair Road	Wauwatosa	Wisconsin	United States	53226
866	Aurora Cancer Care-Milwaukee West	Wauwatosa	Wisconsin	United States	53226
867	Aurora West Allis Medical Center	West Allis	Wisconsin	United States	53227
868	Marshfield Medical Center - Weston	Weston	Wisconsin	United States	54476
869	Aspirus Cancer Care - Wisconsin Rapids	Wisconsin Rapids	Wisconsin	United States	54494
870	Marshfield Clinic - Wisconsin Rapids Center	Wisconsin Rapids	Wisconsin	United States	54494
871	Cheyenne Regional Medical Center-West	Cheyenne	Wyoming	United States	82001
872	Billings Clinic-Cody	Cody	Wyoming	United States	82414
873	Welch Cancer Center	Sheridan	Wyoming	United States	82801
874	Shaare Zedek Medical Center	Jerusalem		Israel	91031

Sponsors and Collaborators

• National Cancer Institute (NCI)

Investigators

• Principal Investigator: Tait D Shanafelt, ECOG-ACRIN Cancer Research Group

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: National Cancer Institute (NCI)
• ClinicalTrials.gov Identifier: NCT03701282
• Other Study ID Numbers: NCI-2018-02127; NCI-2018-02127; EA9161; EA9161; U10CA180820
• First Posted: Oct 10, 2018
• Last Update Posted: Jun 30, 2022
• Last Verified: May 1, 2022

• Individual Participant Data (IPD) Sharing Statement: Yes
• Plan to Share IPD: Yes
• Studies a U.S. FDA-regulated Drug Product: Yes
• Studies a U.S. FDA-regulated Device Product: No
• Additional relevant MeSH terms: Leukemia; Leukemia, Lymphoid; Leukemia, Lymphocytic, Chronic, B-Cell; Venetoclax; Obinutuzumab

Study Results

No Results Posted as of Jun 30, 2022