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Testing the Addition of Ruxolitinib to the Usual Treatment (Tyrosine Kinase Inhibitors) for Chronic Myeloid Leukemia

Sponsor
Southwest Oncology Group (Other)
Overall Status
Recruiting
CT.gov ID
NCT03654768
Collaborator
National Cancer Institute (NCI) (NIH)
84
Enrollment
541
Locations
2
Arms
110.3
Anticipated Duration (Months)
0.2
Patients Per Site
0
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This randomized phase II trial studies how well ruxolitinib phosphate, and bosutnib, dasatinib, imatinib or nilotinib, work in treating patients with chronic myeloid leukemia. Chronic myeloid leukemia cells produce a protein called BCR-ABL. The BCR-ABL protein helps chronic myeloid leukemia cells to grow and divide. Tyrosine kinase inhibitors, such as bosutinib, dasatinib, and nilotinib, stop the BCR-ABL protein from working, which helps to reduce the amount of chronic myeloid leukemia cells in the body. Ruxolitinib is a different type of drug that helps to stop the body from making substances called growth factors. Chronic myeloid leukemia cells need growth factors to grow and divide. The addition of ruxolitinib to the tyrosine kinase inhibitor may or may not help reduce the amount of chronic myeloid leukemia cells in the body.

Condition or Disease Intervention/Treatment Phase
Phase 2

Detailed Description

PRIMARY OBJECTIVE:
  1. To compare the rate of molecular response 4.5 (MR4.5) after 12 months of combination therapy with ruxolitinib phosphate (ruxolitinib) plus a tyrosine-kinase inhibitor (TKI) (bosutinib, dasatinib, imatinib or nilotinib) versus a TKI alone, based on local polymerase chain reaction (PCR) testing to measure BCR-ABL transcripts in chronic phase chronic myelogenous leukemia (CML) patients with molecular evidence of disease.
SECONDARY OBJECTIVES:

  1. To estimate the frequency and severity of toxicities of each regimen in this patient population.

  2. To estimate progression free survival and overall survival of each regimen in this patient population.

ADDITIONAL OBJECTIVES:

  1. To describe patterns of MR4.5 and molecular response 4.0 (MR4.0) attainment and failure over the 3, 6, 9, and 12-month time points of each regimen in this patient population.

  2. To evaluate drug compliance based on patient reported drug intake calendars in this patient population.

  3. To describe the kinetics of response in this patient population (as measured by quantitative BCR-ABL/BCR ratio) in both arms over the 3, 6, 9, and 12-month time points.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM I: Patients receive bosutinib orally (PO) daily or dasatinib PO daily or nilotinib PO twice daily (BID) or imatinib PO daily on days 1-90. Treatment repeats every 90 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity.

ARM II: Patients receive ruxolitinib phosphate PO BID on days 1-90, and bosutinib PO daily or dasatinib PO daily or nilotinib PO BID or imatinib PO daily on days 1-90. Treatment repeats every 90 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 6 months for 2 years, and then annually up to 5 years.

Study Design

Study Type:
Interventional
Anticipated Enrollment :
84 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
A Randomized Phase II Study of Ruxolitinib (NSC-752295) in Combination With BCR-ABL Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia (CML) Patients With Molecular Evidence of Disease
Actual Study Start Date :
Oct 24, 2018
Anticipated Primary Completion Date :
Jan 1, 2024
Anticipated Study Completion Date :
Jan 1, 2028

Arms and Interventions

Arm Intervention/Treatment
Active Comparator: Arm I (bosutinib, dasatinib, nilotinib, imatinib)

Patients receive bosutinib PO daily or dasatinib PO daily or nilotinib PO BID or imatinib PO daily on days 1-90. Treatment repeats every 90 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity.

Drug: Bosutinib
Given PO
Other Names:
  • Bosulif
  • SKI 606
  • SKI-606

    • Drug: Dasatinib
    Given PO
    Other Names:
  • BMS-354825
  • Dasatinib Hydrate
  • Dasatinib Monohydrate
  • Sprycel

    • Other: Laboratory Biomarker Analysis
    Correlative studies

    Drug: Nilotinib
    Given PO
    Other Names:
  • AMN107
  • NILOTINIB HYDROCHLORIDE MONOHYDRATE
  • Nilotinib Monohydrochloride Monohydrate
  • Tasigna

    • Drug: Imatinib
    Given PO
    Other Names:
  • Gleevec®
  • STI-571

    		•
    Experimental: Arm II (ruxolitinib phosphate, dasatinib, nilotinib, imatinib)

    Patients receive ruxolitinib phosphate PO BID on days 1-90, and bosutinib PO daily or dasatinib PO daily or nilotinib PO BID or imatinib PO daily on days 1-90. Treatment repeats every 90 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity.

    Drug: Dasatinib
    Given PO
    Other Names:
  • BMS-354825
  • Dasatinib Hydrate
  • Dasatinib Monohydrate
  • Sprycel

    • Other: Laboratory Biomarker Analysis
    Correlative studies

    Drug: Nilotinib
    Given PO
    Other Names:
  • AMN107
  • NILOTINIB HYDROCHLORIDE MONOHYDRATE
  • Nilotinib Monohydrochloride Monohydrate
  • Tasigna

    • Drug: Ruxolitinib
    Given PO
    Other Names:
  • INCB-18424
  • INCB18424
  • Jakafi
  • Oral JAK Inhibitor INCB18424

    • Drug: Imatinib
    Given PO
    Other Names:
  • Gleevec®
  • STI-571

    		•

    Outcome Measures

    Primary Outcome Measures

    1. Rate of molecular response 4.5 (MR4.5) [At 12 months]

    Secondary Outcome Measures

    1. Overall survival [From the date of randomization until death from any cause with observations censored at the date of last contact for patients last known to be alive, assessed up to 5 years]

      Will be estimated using the Kaplan-Meier method.

    2. Progression-free survival [From the date of randomization on study until the first of treatment failure/loss of response, progression, or death from any cause, assessed up to 5 years]

      Will be estimated using the Kaplan-Meier method.

    3. Incidence of adverse events [Up to 5 years]

      Will be assessed by National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. CTCAE version 5.0 will be utilized for serious adverse events reporting only.

    4. MR4.5 attainment and failure [Up to 12 months]

      Will be summarized descriptively

    5. Molecular rate 4.0 (MR 4.0) attainment and failure [Up to 12 months]

      Will be summarized descriptively

    6. Drug compliance [Up to 5 years]

      Will be summarized descriptively

    7. BCR-ABL/BCR analysis [Up to 5 years]

      Linear regression models will be used to assess associations between treatment arm and the quantitative endpoint.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • Patients must have a diagnosis of chronic phase chronic myeloid leukemia without any history of progression to accelerated or blast phase CML; no new bone marrow aspiration and biopsy is needed to prove diagnosis prior to randomization; however, documentation stating the patient is in chronic phase is required

    • Patients must have detectable BCR-ABL transcripts measured by reverse transcriptase (RT)-PCR at a clinical laboratory improvement act (CLIA)-approved laboratory and reported on the international scale (IS) with a value of > 0.0032% IS and =< 1.0% IS within 21 days prior to randomization; the RT-PCR assay must have the sensitivity to detect a 4.5 log reduction in BCR-ABL transcripts from 100% IS (0.0032% IS or lower)

    • Patients must have been receiving TKI treatment for CML for at least 12 months prior to randomization. Hydroxyurea prior to initiation of TKI is allowed.

    • Patients must be currently receiving treatment with bosutinib (within the allowable dose range of 200-500 mg daily), nilotinib (within the allowable dose range of 150-400 mg BID or a cumulative daily dose of 300-800 mg), dasatinib (within the allowable dose range of 40-140 mg daily), or imatinib (within the allowable dose range of 300-400 mg daily); they must have received their current TKI for a minimum of 6 months prior to randomization and must be expected to remain on the same TKI for the next 12 months

    • Patient must not have a history of resistance to any prior TKI drug; if patient has received more than one TKI, the reason for changing treatment must have been something other than resistance or inadequate response to the prior TKI (for example, intolerance to the prior TKI) and the treatment change must have occurred >= 6 months prior to randomization.

    • Patients must not be receiving any other investigational agents

    • Patients must have complete history and physical examination within 28 days prior to randomization

    • If clinically indicated, patients must have corrected Fridericia's correction formula (QTcF) interval < 500 ms (by Fridericia calculation) on a 12-lead electrocardiography (EKG) within 7 days prior to randomization

    • Platelets >= 100,000/mm3 (100.0 x 109/L) within 7 days prior to randomization

    • Absolute neutrophil count (ANC) > 1,000/mm3 (1.0 x 109/L) within 7 days prior to randomization

    • Hemoglobin >= 8 g/dL within 7 days prior to randomization

    • Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x institutional upper limit of normal (IULN) within 7 days prior to randomization

    • Total bilirubin =< 1.5 x IULN within 7 days prior to randomization (unless the patient has a known diagnosis of Gilbert's syndrome)

    • Serum creatinine =< 1.5 x IULN within 7 days prior to randomization

    • Prior malignancy is allowed providing it does not require concurrent therapy; exception: active hormonal therapy is allowed

    • Patients must not be pregnant or nursing due to the teratogenic potential of the drugs used on this study; women of child-bearing potential must have a negative serum pregnancy test within 7 days prior to randomization; women/men of reproductive potential must have agreed to use an effective contraceptive method during treatment and for 30 days after discontinuation of study drug; a woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months; in addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation; however, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures

    • Patients known to be human immunodeficiency virus positive (HIV+) are eligible provided they meet all other eligibility criteria and have undetectable HIV viral loads on their most recent viral load test which must have been performed in the last 6 months

    • Specimens (peripheral blood) must be collected and submitted to a CLIA-approved laboratory, within 21 days prior to randomization; BCR-ABL transcripts must be measured using RT-PCR and results must be reported using the international scale; the RT-PCR assay must have the sensitivity to detect a 4.5 log reduction in BCR-ABL transcripts from 100% IS (must be able to detect 0.0032% IS or lower)

    • Patients must be offered participation in submission of specimens for central BCR-ABL quantification and banking for future specimens; this submission is highly encouraged as an important protocol endpoint; with patient's consent, specimens must be collected and submitted, within 21 days prior to randomization

    • Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines

    • As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Anchorage Associates in Radiation Medicine Anchorage Alaska United States 98508
    2 Anchorage Radiation Therapy Center Anchorage Alaska United States 99504
    3 Alaska Breast Care and Surgery LLC Anchorage Alaska United States 99508
    4 Alaska Oncology and Hematology LLC Anchorage Alaska United States 99508
    5 Alaska Women's Cancer Care Anchorage Alaska United States 99508
    6 Anchorage Oncology Centre Anchorage Alaska United States 99508
    7 Katmai Oncology Group Anchorage Alaska United States 99508
    8 Providence Alaska Medical Center Anchorage Alaska United States 99508
    9 Fairbanks Memorial Hospital Fairbanks Alaska United States 99701
    10 Kingman Regional Medical Center Kingman Arizona United States 86401
    11 Cancer Center at Saint Joseph's Phoenix Arizona United States 85004
    12 Mercy Hospital Fort Smith Fort Smith Arkansas United States 72903
    13 CHI Saint Vincent Cancer Center Hot Springs Hot Springs Arkansas United States 71913
    14 Mission Hope Medical Oncology - Arroyo Grande Arroyo Grande California United States 93420
    15 PCR Oncology Arroyo Grande California United States 93420
    16 Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank California United States 91505
    17 Providence Queen of The Valley Napa California United States 94558
    18 Pacific Central Coast Health Center-San Luis Obispo San Luis Obispo California United States 93401
    19 Mission Hope Medical Oncology - Santa Maria Santa Maria California United States 93444
    20 Providence Medical Foundation - Santa Rosa Santa Rosa California United States 95403
    21 Providence Santa Rosa Memorial Hospital Santa Rosa California United States 95405
    22 Rocky Mountain Cancer Centers-Aurora Aurora Colorado United States 80012
    23 The Medical Center of Aurora Aurora Colorado United States 80012
    24 Boulder Community Hospital Boulder Colorado United States 80301
    25 Boulder Community Foothills Hospital Boulder Colorado United States 80303
    26 Rocky Mountain Cancer Centers-Boulder Boulder Colorado United States 80304
    27 Rocky Mountain Cancer Centers - Centennial Centennial Colorado United States 80112
    28 Penrose-Saint Francis Healthcare Colorado Springs Colorado United States 80907
    29 Rocky Mountain Cancer Centers-Penrose Colorado Springs Colorado United States 80907
    30 Saint Francis Cancer Center Colorado Springs Colorado United States 80923
    31 Cancer Center of Colorado at Sloan's Lake Denver Colorado United States 80204
    32 Denver Health Medical Center Denver Colorado United States 80204
    33 National Jewish Health-Main Campus Denver Colorado United States 80206
    34 The Women's Imaging Center Denver Colorado United States 80209
    35 Porter Adventist Hospital Denver Colorado United States 80210
    36 Colorado Blood Cancer Institute Denver Colorado United States 80218
    37 Presbyterian - Saint Lukes Medical Center - Health One Denver Colorado United States 80218
    38 Rocky Mountain Cancer Centers-Midtown Denver Colorado United States 80218
    39 SCL Health Saint Joseph Hospital Denver Colorado United States 80218
    40 Rocky Mountain Cancer Centers-Rose Denver Colorado United States 80220
    41 Rose Medical Center Denver Colorado United States 80220
    42 Western Surgical Care Denver Colorado United States 80220
    43 Mercy Medical Center Durango Colorado United States 81301
    44 Southwest Oncology PC Durango Colorado United States 81301
    45 Mountain Blue Cancer Care Center - Swedish Englewood Colorado United States 80113
    46 Rocky Mountain Cancer Centers - Swedish Englewood Colorado United States 80113
    47 Swedish Medical Center Englewood Colorado United States 80113
    48 The Melanoma and Skin Cancer Institute Englewood Colorado United States 80113
    49 Mountain Blue Cancer Care Center Golden Colorado United States 80401
    50 National Jewish Health-Western Hematology Oncology Golden Colorado United States 80401
    51 Saint Mary's Hospital and Regional Medical Center Grand Junction Colorado United States 81501
    52 North Colorado Medical Center Greeley Colorado United States 80631
    53 Good Samaritan Medical Center Lafayette Colorado United States 80026
    54 Rocky Mountain Cancer Centers-Lakewood Lakewood Colorado United States 80228
    55 Saint Anthony Hospital Lakewood Colorado United States 80228
    56 Rocky Mountain Cancer Centers-Littleton Littleton Colorado United States 80120
    57 Littleton Adventist Hospital Littleton Colorado United States 80122
    58 Rocky Mountain Cancer Centers-Sky Ridge Lone Tree Colorado United States 80124
    59 Sky Ridge Medical Center Lone Tree Colorado United States 80124
    60 Longmont United Hospital Longmont Colorado United States 80501
    61 Rocky Mountain Cancer Centers-Longmont Longmont Colorado United States 80501
    62 McKee Medical Center Loveland Colorado United States 80539
    63 Parker Adventist Hospital Parker Colorado United States 80138
    64 Rocky Mountain Cancer Centers-Parker Parker Colorado United States 80138
    65 Saint Mary Corwin Medical Center Pueblo Colorado United States 81004
    66 Rocky Mountain Cancer Centers - Pueblo Pueblo Colorado United States 81008
    67 National Jewish Health-Northern Hematology Oncology Thornton Colorado United States 80260
    68 Rocky Mountain Cancer Centers-Thornton Thornton Colorado United States 80260
    69 SCL Health Lutheran Medical Center Wheat Ridge Colorado United States 80033
    70 Holy Cross Hospital Fort Lauderdale Florida United States 33308
    71 Moffitt Cancer Center-International Plaza Tampa Florida United States 33607
    72 Moffitt Cancer Center - McKinley Campus Tampa Florida United States 33612
    73 Moffitt Cancer Center Tampa Florida United States 33612
    74 Hawaii Cancer Care - Savio 'Aiea Hawaii United States 96701
    75 Pali Momi Medical Center 'Aiea Hawaii United States 96701
    76 Queen's Cancer Center - Pearlridge 'Aiea Hawaii United States 96701
    77 The Cancer Center of Hawaii-Pali Momi 'Aiea Hawaii United States 96701
    78 Island Urology-Hilo Hilo Hawaii United States 96720
    79 Hawaii Cancer Care Inc - Waterfront Plaza Honolulu Hawaii United States 96813
    80 Island Urology Honolulu Hawaii United States 96813
    81 Queen's Cancer Cenrer - POB I Honolulu Hawaii United States 96813
    82 Queen's Medical Center Honolulu Hawaii United States 96813
    83 Straub Clinic and Hospital Honolulu Hawaii United States 96813
    84 University of Hawaii Cancer Center Honolulu Hawaii United States 96813
    85 Hawaii Cancer Care Inc-Liliha Honolulu Hawaii United States 96817
    86 Kuakini Medical Center Honolulu Hawaii United States 96817
    87 Queen's Cancer Center - Kuakini Honolulu Hawaii United States 96817
    88 The Cancer Center of Hawaii-Liliha Honolulu Hawaii United States 96817
    89 Kapiolani Medical Center for Women and Children Honolulu Hawaii United States 96826
    90 Wilcox Memorial Hospital and Kauai Medical Clinic Lihue Hawaii United States 96766
    91 Saint Alphonsus Cancer Care Center-Boise Boise Idaho United States 83706
    92 Saint Luke's Cancer Institute - Boise Boise Idaho United States 83712
    93 Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho United States 83605
    94 Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho United States 83814
    95 Walter Knox Memorial Hospital Emmett Idaho United States 83617
    96 Saint Luke's Cancer Institute - Fruitland Fruitland Idaho United States 83619
    97 Idaho Urologic Institute-Meridian Meridian Idaho United States 83642
    98 Saint Luke's Cancer Institute - Meridian Meridian Idaho United States 83642
    99 Saint Alphonsus Medical Center-Nampa Nampa Idaho United States 83686
    100 Saint Luke's Cancer Institute - Nampa Nampa Idaho United States 83686
    101 Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho United States 83854
    102 Kootenai Cancer Clinic Sandpoint Idaho United States 83864
    103 Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho United States 83301
    104 Saint Anthony's Health Alton Illinois United States 62002
    105 Rush - Copley Medical Center Aurora Illinois United States 60504
    106 Illinois CancerCare-Bloomington Bloomington Illinois United States 61704
    107 Loyola Center for Health at Burr Ridge Burr Ridge Illinois United States 60527
    108 Illinois CancerCare-Canton Canton Illinois United States 61520
    109 Illinois CancerCare-Carthage Carthage Illinois United States 62321
    110 Centralia Oncology Clinic Centralia Illinois United States 62801
    111 Carle on Vermilion Danville Illinois United States 61832
    112 Cancer Care Specialists of Illinois - Decatur Decatur Illinois United States 62526
    113 Decatur Memorial Hospital Decatur Illinois United States 62526
    114 Illinois CancerCare-Dixon Dixon Illinois United States 61021
    115 Carle Physician Group-Effingham Effingham Illinois United States 62401
    116 Crossroads Cancer Center Effingham Illinois United States 62401
    117 Illinois CancerCare-Eureka Eureka Illinois United States 61530
    118 Illinois CancerCare-Galesburg Galesburg Illinois United States 61401
    119 Western Illinois Cancer Treatment Center Galesburg Illinois United States 61401
    120 Loyola Medicine Homer Glen Homer Glen Illinois United States 60491
    121 Illinois CancerCare-Kewanee Clinic Kewanee Illinois United States 61443
    122 Illinois CancerCare-Macomb Macomb Illinois United States 61455
    123 Carle Physician Group-Mattoon/Charleston Mattoon Illinois United States 61938
    124 Loyola University Medical Center Maywood Illinois United States 60153
    125 Marjorie Weinberg Cancer Center at Loyola-Gottlieb Melrose Park Illinois United States 60160
    126 Good Samaritan Regional Health Center Mount Vernon Illinois United States 62864
    127 Illinois CancerCare-Ottawa Clinic Ottawa Illinois United States 61350
    128 Illinois CancerCare-Pekin Pekin Illinois United States 61554
    129 Illinois CancerCare-Peoria Peoria Illinois United States 61615
    130 Methodist Medical Center of Illinois Peoria Illinois United States 61636
    131 Illinois CancerCare-Peru Peru Illinois United States 61354
    132 Valley Radiation Oncology Peru Illinois United States 61354
    133 Illinois CancerCare-Princeton Princeton Illinois United States 61356
    134 Southern Illinois University School of Medicine Springfield Illinois United States 62702
    135 Memorial Medical Center Springfield Illinois United States 62781
    136 Southwest Illinois Health Services LLP Swansea Illinois United States 62226
    137 Carle Cancer Center Urbana Illinois United States 61801
    138 The Carle Foundation Hospital Urbana Illinois United States 61801
    139 Illinois CancerCare - Washington Washington Illinois United States 61571
    140 Rush-Copley Healthcare Center Yorkville Illinois United States 60560
    141 Parkview Regional Medical Center Fort Wayne Indiana United States 46845
    142 Mary Greeley Medical Center Ames Iowa United States 50010
    143 McFarland Clinic PC - Ames Ames Iowa United States 50010
    144 McFarland Clinic PC-Boone Boone Iowa United States 50036
    145 Medical Oncology and Hematology Associates-West Des Moines Clive Iowa United States 50325
    146 Mercy Cancer Center-West Lakes Clive Iowa United States 50325
    147 Alegent Health Mercy Hospital Council Bluffs Iowa United States 51503
    148 Greater Regional Medical Center Creston Iowa United States 50801
    149 Medical Oncology and Hematology Associates-Laurel Des Moines Iowa United States 50314
    150 Mercy Medical Center - Des Moines Des Moines Iowa United States 50314
    151 McFarland Clinic PC-Trinity Cancer Center Fort Dodge Iowa United States 50501
    152 University of Iowa/Holden Comprehensive Cancer Center Iowa City Iowa United States 52242
    153 McFarland Clinic PC-Jefferson Jefferson Iowa United States 50129
    154 McFarland Clinic PC-Marshalltown Marshalltown Iowa United States 50158
    155 Mercy Medical Center-West Lakes West Des Moines Iowa United States 50266
    156 Central Care Cancer Center - Garden City Garden City Kansas United States 67846
    157 Central Care Cancer Center - Great Bend Great Bend Kansas United States 67530
    158 Lawrence Memorial Hospital Lawrence Kansas United States 66044
    159 Kansas Institute of Medicine Cancer and Blood Center Lenexa Kansas United States 66219
    160 Minimally Invasive Surgery Hospital Lenexa Kansas United States 66219
    161 Menorah Medical Center Overland Park Kansas United States 66209
    162 Cancer Center of Kansas-Wichita Medical Arts Tower Wichita Kansas United States 67208
    163 Ascension Via Christi Hospitals Wichita Wichita Kansas United States 67214
    164 Cancer Center of Kansas - Wichita Wichita Kansas United States 67214
    165 Wesley Medical Center Wichita Kansas United States 67214
    166 Flaget Memorial Hospital Bardstown Kentucky United States 40004
    167 Commonwealth Cancer Center-Corbin Corbin Kentucky United States 40701
    168 Saint Joseph Radiation Oncology Resource Center Lexington Kentucky United States 40504
    169 Saint Joseph Hospital East Lexington Kentucky United States 40509
    170 Saint Joseph London London Kentucky United States 40741
    171 Jewish Hospital Louisville Kentucky United States 40202
    172 Saints Mary and Elizabeth Hospital Louisville Kentucky United States 40215
    173 UofL Health Medical Center Northeast Louisville Kentucky United States 40245
    174 Jewish Hospital Medical Center South Shepherdsville Kentucky United States 40165
    175 University of Maryland/Greenebaum Cancer Center Baltimore Maryland United States 21201
    176 Mercy Medical Center Springfield Massachusetts United States 01104
    177 Hickman Cancer Center Adrian Michigan United States 49221
    178 Saint Joseph Mercy Hospital Ann Arbor Michigan United States 48106
    179 Bronson Battle Creek Battle Creek Michigan United States 49017
    180 IHA Hematology Oncology Consultants-Brighton Brighton Michigan United States 48114
    181 Saint Joseph Mercy Brighton Brighton Michigan United States 48114
    182 IHA Hematology Oncology Consultants-Canton Canton Michigan United States 48188
    183 Saint Joseph Mercy Canton Canton Michigan United States 48188
    184 Caro Cancer Center Caro Michigan United States 48723
    185 IHA Hematology Oncology Consultants-Chelsea Chelsea Michigan United States 48118
    186 Saint Joseph Mercy Chelsea Chelsea Michigan United States 48118
    187 Hematology Oncology Consultants-Clarkston Clarkston Michigan United States 48346
    188 Newland Medical Associates-Clarkston Clarkston Michigan United States 48346
    189 Ascension Saint John Hospital Detroit Michigan United States 48236
    190 Great Lakes Cancer Management Specialists-Doctors Park East China Township Michigan United States 48054
    191 Genesee Cancer and Blood Disease Treatment Center Flint Michigan United States 48503
    192 Genesee Hematology Oncology PC Flint Michigan United States 48503
    193 Genesys Hurley Cancer Institute Flint Michigan United States 48503
    194 Hurley Medical Center Flint Michigan United States 48503
    195 Helen DeVos Children's Hospital at Spectrum Health Grand Rapids Michigan United States 49503
    196 Mercy Health Saint Mary's Grand Rapids Michigan United States 49503
    197 Spectrum Health at Butterworth Campus Grand Rapids Michigan United States 49503
    198 Academic Hematology Oncology Specialists Grosse Pointe Woods Michigan United States 48236
    199 Great Lakes Cancer Management Specialists-Van Elslander Cancer Center Grosse Pointe Woods Michigan United States 48236
    200 Michigan Breast Specialists-Grosse Pointe Woods Grosse Pointe Woods Michigan United States 48236
    201 Bronson Methodist Hospital Kalamazoo Michigan United States 49007
    202 West Michigan Cancer Center Kalamazoo Michigan United States 49007
    203 Ascension Borgess Cancer Center Kalamazoo Michigan United States 49009
    204 Borgess Medical Center Kalamazoo Michigan United States 49048
    205 Sparrow Hospital Lansing Michigan United States 48912
    206 Hope Cancer Clinic Livonia Michigan United States 48154
    207 Saint Mary Mercy Hospital Livonia Michigan United States 48154
    208 Great Lakes Cancer Management Specialists-Macomb Medical Campus Macomb Michigan United States 48044
    209 Michigan Breast Specialists-Macomb Township Macomb Michigan United States 48044
    210 Saint Mary's Oncology/Hematology Associates of Marlette Marlette Michigan United States 48453
    211 Toledo Clinic Cancer Centers-Monroe Monroe Michigan United States 48162
    212 Mercy Health Mercy Campus Muskegon Michigan United States 49444
    213 Lakeland Hospital Niles Niles Michigan United States 49120
    214 Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores Michigan United States 49444
    215 21st Century Oncology-Pontiac Pontiac Michigan United States 48341
    216 Hope Cancer Center Pontiac Michigan United States 48341
    217 Newland Medical Associates-Pontiac Pontiac Michigan United States 48341
    218 Saint Joseph Mercy Oakland Pontiac Michigan United States 48341
    219 Huron Medical Center PC Port Huron Michigan United States 48060
    220 Lake Huron Medical Center Port Huron Michigan United States 48060
    221 Spectrum Health Reed City Hospital Reed City Michigan United States 49677
    222 Great Lakes Cancer Management Specialists-Rochester Hills Rochester Hills Michigan United States 48309
    223 Ascension Saint Mary's Hospital Saginaw Michigan United States 48601
    224 Oncology Hematology Associates of Saginaw Valley PC Saginaw Michigan United States 48604
    225 Lakeland Medical Center Saint Joseph Saint Joseph Michigan United States 49085
    226 Marie Yeager Cancer Center Saint Joseph Michigan United States 49085
    227 Bhadresh Nayak MD PC-Sterling Heights Sterling Heights Michigan United States 48312
    228 Ascension Saint Joseph Hospital Tawas City Michigan United States 48764
    229 Munson Medical Center Traverse City Michigan United States 49684
    230 Advanced Breast Care Center PLLC Warren Michigan United States 48088
    231 Great Lakes Cancer Management Specialists-Macomb Professional Building Warren Michigan United States 48093
    232 Macomb Hematology Oncology PC Warren Michigan United States 48093
    233 Michigan Breast Specialists-Warren Warren Michigan United States 48093
    234 Saint John Macomb-Oakland Hospital Warren Michigan United States 48093
    235 Saint Mary's Oncology/Hematology Associates of West Branch West Branch Michigan United States 48661
    236 Metro Health Hospital Wyoming Michigan United States 49519
    237 Huron Gastroenterology PC Ypsilanti Michigan United States 48106
    238 IHA Hematology Oncology Consultants-Ann Arbor Ypsilanti Michigan United States 48197
    239 Sanford Joe Lueken Cancer Center Bemidji Minnesota United States 56601
    240 Fairview Ridges Hospital Burnsville Minnesota United States 55337
    241 Minnesota Oncology - Burnsville Burnsville Minnesota United States 55337
    242 Cambridge Medical Center Cambridge Minnesota United States 55008
    243 Mercy Hospital Coon Rapids Minnesota United States 55433
    244 Fairview Southdale Hospital Edina Minnesota United States 55435
    245 Unity Hospital Fridley Minnesota United States 55432
    246 Fairview Clinics and Surgery Center Maple Grove Maple Grove Minnesota United States 55369
    247 Minnesota Oncology Hematology PA-Maplewood Maplewood Minnesota United States 55109
    248 Saint John's Hospital - Healtheast Maplewood Minnesota United States 55109
    249 Abbott-Northwestern Hospital Minneapolis Minnesota United States 55407
    250 Hennepin County Medical Center Minneapolis Minnesota United States 55415
    251 Health Partners Inc Minneapolis Minnesota United States 55454
    252 Monticello Cancer Center Monticello Minnesota United States 55362
    253 New Ulm Medical Center New Ulm Minnesota United States 56073
    254 Fairview Northland Medical Center Princeton Minnesota United States 55371
    255 North Memorial Medical Health Center Robbinsdale Minnesota United States 55422
    256 Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota United States 55416
    257 Regions Hospital Saint Paul Minnesota United States 55101
    258 United Hospital Saint Paul Minnesota United States 55102
    259 Saint Francis Regional Medical Center Shakopee Minnesota United States 55379
    260 Lakeview Hospital Stillwater Minnesota United States 55082
    261 Sanford Thief River Falls Medical Center Thief River Falls Minnesota United States 56701
    262 Ridgeview Medical Center Waconia Minnesota United States 55387
    263 Rice Memorial Hospital Willmar Minnesota United States 56201
    264 Minnesota Oncology Hematology PA-Woodbury Woodbury Minnesota United States 55125
    265 Sanford Cancer Center Worthington Worthington Minnesota United States 56187
    266 Fairview Lakes Medical Center Wyoming Minnesota United States 55092
    267 Baptist Cancer Center-Grenada Grenada Mississippi United States 38901
    268 Baptist Memorial Hospital and Cancer Center-Union County New Albany Mississippi United States 38652
    269 Baptist Memorial Hospital and Cancer Center-Oxford Oxford Mississippi United States 38655
    270 Baptist Memorial Hospital and Cancer Center-Desoto Southhaven Mississippi United States 38671
    271 Saint Louis Cancer and Breast Institute-Ballwin Ballwin Missouri United States 63011
    272 Central Care Cancer Center - Bolivar Bolivar Missouri United States 65613
    273 Cox Cancer Center Branson Branson Missouri United States 65616
    274 Saint Francis Medical Center Cape Girardeau Missouri United States 63703
    275 Southeast Cancer Center Cape Girardeau Missouri United States 63703
    276 Parkland Health Center - Farmington Farmington Missouri United States 63640
    277 Centerpoint Medical Center LLC Independence Missouri United States 64057
    278 Capital Region Southwest Campus Jefferson City Missouri United States 65109
    279 Freeman Health System Joplin Missouri United States 64804
    280 Mercy Hospital Joplin Joplin Missouri United States 64804
    281 Research Medical Center Kansas City Missouri United States 64132
    282 Delbert Day Cancer Institute at PCRMC Rolla Missouri United States 65401
    283 Mercy Clinic-Rolla-Cancer and Hematology Rolla Missouri United States 65401
    284 Heartland Regional Medical Center Saint Joseph Missouri United States 64506
    285 Saint Louis Cancer and Breast Institute-South City Saint Louis Missouri United States 63109
    286 Mercy Hospital South Saint Louis Missouri United States 63128
    287 Missouri Baptist Medical Center Saint Louis Missouri United States 63131
    288 Mercy Hospital Saint Louis Saint Louis Missouri United States 63141
    289 Mercy Hospital Springfield Springfield Missouri United States 65804
    290 CoxHealth South Hospital Springfield Missouri United States 65807
    291 Mercy Hospital Washington Washington Missouri United States 63090
    292 Community Hospital of Anaconda Anaconda Montana United States 59711
    293 Billings Clinic Cancer Center Billings Montana United States 59101
    294 Saint Vincent Healthcare Billings Montana United States 59101
    295 Saint Vincent Frontier Cancer Center Billings Montana United States 59102
    296 Bozeman Deaconess Hospital Bozeman Montana United States 59715
    297 Saint James Community Hospital and Cancer Treatment Center Butte Montana United States 59701
    298 Benefis Healthcare- Sletten Cancer Institute Great Falls Montana United States 59405
    299 Great Falls Clinic Great Falls Montana United States 59405
    300 Saint Peter's Community Hospital Helena Montana United States 59601
    301 Kalispell Regional Medical Center Kalispell Montana United States 59901
    302 Saint Patrick Hospital - Community Hospital Missoula Montana United States 59802
    303 Community Medical Hospital Missoula Montana United States 59804
    304 CHI Health Saint Francis Grand Island Nebraska United States 68803
    305 Heartland Hematology and Oncology Kearney Nebraska United States 68845
    306 CHI Health Good Samaritan Kearney Nebraska United States 68847
    307 Saint Elizabeth Regional Medical Center Lincoln Nebraska United States 68510
    308 Nebraska Cancer Specialists/Oncology Hematology West PC - MECC Omaha Nebraska United States 68114
    309 Nebraska Methodist Hospital Omaha Nebraska United States 68114
    310 Oncology Associates PC Omaha Nebraska United States 68114
    311 Alegent Health Immanuel Medical Center Omaha Nebraska United States 68122
    312 Hematology and Oncology Consultants PC Omaha Nebraska United States 68122
    313 Alegent Health Bergan Mercy Medical Center Omaha Nebraska United States 68124
    314 Alegent Health Lakeside Hospital Omaha Nebraska United States 68130
    315 Creighton University Medical Center Omaha Nebraska United States 68131
    316 Midlands Community Hospital Papillion Nebraska United States 68046
    317 Carson Tahoe Regional Medical Center Carson City Nevada United States 89703
    318 Cancer and Blood Specialists-Henderson Henderson Nevada United States 89052
    319 Comprehensive Cancer Centers of Nevada - Henderson Henderson Nevada United States 89052
    320 Comprehensive Cancer Centers of Nevada-Horizon Ridge Henderson Nevada United States 89052
    321 Las Vegas Cancer Center-Henderson Henderson Nevada United States 89052
    322 OptumCare Cancer Care at Seven Hills Henderson Nevada United States 89052
    323 Comprehensive Cancer Centers of Nevada-Southeast Henderson Henderson Nevada United States 89074
    324 GenesisCare USA - Henderson Henderson Nevada United States 89074
    325 Las Vegas Urology - Green Valley Henderson Nevada United States 89074
    326 Las Vegas Urology - Pebble Henderson Nevada United States 89074
    327 Urology Specialists of Nevada - Green Valley Henderson Nevada United States 89074
    328 Las Vegas Urology - Pecos Las Vegas Nevada United States 89074
    329 Desert West Surgery Las Vegas Nevada United States 89102
    330 OptumCare Cancer Care at Charleston Las Vegas Nevada United States 89102
    331 University Medical Center of Southern Nevada Las Vegas Nevada United States 89102
    332 Hope Cancer Care of Nevada Las Vegas Nevada United States 89103
    333 Cancer and Blood Specialists-Shadow Las Vegas Nevada United States 89106
    334 Radiation Oncology Centers of Nevada Central Las Vegas Nevada United States 89106
    335 Urology Specialists of Nevada - Central Las Vegas Nevada United States 89106
    336 GenesisCare USA - Las Vegas Las Vegas Nevada United States 89109
    337 HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway Las Vegas Nevada United States 89109
    338 Sunrise Hospital and Medical Center Las Vegas Nevada United States 89109
    339 HealthCare Partners Medical Group Oncology/Hematology-San Martin Las Vegas Nevada United States 89113
    340 Las Vegas Prostate Cancer Center Las Vegas Nevada United States 89113
    341 Las Vegas Urology - Sunset Las Vegas Nevada United States 89113
    342 Urology Specialists of Nevada - Southwest Las Vegas Nevada United States 89113
    343 Radiation Oncology Centers of Nevada Southeast Las Vegas Nevada United States 89119
    344 Cancer Therapy and Integrative Medicine Las Vegas Nevada United States 89121
    345 Ann M Wierman MD LTD Las Vegas Nevada United States 89128
    346 Cancer and Blood Specialists-Tenaya Las Vegas Nevada United States 89128
    347 Comprehensive Cancer Centers of Nevada - Northwest Las Vegas Nevada United States 89128
    348 GenesisCare USA - Vegas Tenaya Las Vegas Nevada United States 89128
    349 HealthCare Partners Medical Group Oncology/Hematology-Tenaya Las Vegas Nevada United States 89128
    350 Las Vegas Urology - Cathedral Rock Las Vegas Nevada United States 89128
    351 Las Vegas Urology - Smoke Ranch Las Vegas Nevada United States 89128
    352 OptumCare Cancer Care at MountainView Las Vegas Nevada United States 89128
    353 Urology Specialists of Nevada - Northwest Las Vegas Nevada United States 89128
    354 Alliance for Childhood Diseases/Cure 4 the Kids Foundation Las Vegas Nevada United States 89135
    355 Comprehensive Cancer Centers of Nevada - Town Center Las Vegas Nevada United States 89144
    356 Comprehensive Cancer Centers of Nevada-Summerlin Las Vegas Nevada United States 89144
    357 Summerlin Hospital Medical Center Las Vegas Nevada United States 89144
    358 Las Vegas Cancer Center-Medical Center Las Vegas Nevada United States 89148-2405
    359 Comprehensive Cancer Centers of Nevada Las Vegas Nevada United States 89148
    360 GenesisCare USA - Fort Apache Las Vegas Nevada United States 89148
    361 OptumCare Cancer Care at Fort Apache Las Vegas Nevada United States 89148
    362 HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills Las Vegas Nevada United States 89149
    363 Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas Nevada United States 89169
    364 University Cancer Center Las Vegas Nevada United States 89169
    365 Hope Cancer Care of Nevada-Pahrump Pahrump Nevada United States 89048
    366 Renown Regional Medical Center Reno Nevada United States 89502
    367 Saint Mary's Regional Medical Center Reno Nevada United States 89503
    368 Radiation Oncology Associates Reno Nevada United States 89509
    369 University of New Mexico Cancer Center Albuquerque New Mexico United States 87102
    370 Roswell Park Cancer Institute Buffalo New York United States 14263
    371 University of Rochester Rochester New York United States 14642
    372 Duke University Medical Center Durham North Carolina United States 27710
    373 Margaret R Pardee Memorial Hospital Hendersonville North Carolina United States 28791
    374 Sanford Bismarck Medical Center Bismarck North Dakota United States 58501
    375 Sanford South University Medical Center Fargo North Dakota United States 58103
    376 Sanford Medical Center Fargo Fargo North Dakota United States 58104
    377 Sanford Broadway Medical Center Fargo North Dakota United States 58122
    378 Sanford Roger Maris Cancer Center Fargo North Dakota United States 58122
    379 Strecker Cancer Center-Belpre Belpre Ohio United States 45714
    380 Adena Regional Medical Center Chillicothe Ohio United States 45601
    381 University of Cincinnati Cancer Center-UC Medical Center Cincinnati Ohio United States 45219
    382 Good Samaritan Hospital - Cincinnati Cincinnati Ohio United States 45220
    383 Bethesda North Hospital Cincinnati Ohio United States 45242
    384 TriHealth Cancer Institute-Westside Cincinnati Ohio United States 45247
    385 TriHealth Cancer Institute-Anderson Cincinnati Ohio United States 45255
    386 Mount Carmel East Hospital Columbus Ohio United States 43213
    387 Columbus Oncology and Hematology Associates Inc Columbus Ohio United States 43214
    388 Riverside Methodist Hospital Columbus Ohio United States 43214
    389 Grant Medical Center Columbus Ohio United States 43215
    390 The Mark H Zangmeister Center Columbus Ohio United States 43219
    391 Mount Carmel Health Center West Columbus Ohio United States 43222
    392 Doctors Hospital Columbus Ohio United States 43228
    393 Delaware Health Center-Grady Cancer Center Delaware Ohio United States 43015
    394 Delaware Radiation Oncology Delaware Ohio United States 43015
    395 Grady Memorial Hospital Delaware Ohio United States 43015
    396 Columbus Oncology and Hematology Associates Dublin Ohio United States 43016
    397 Dublin Methodist Hospital Dublin Ohio United States 43016
    398 Mount Carmel Grove City Hospital Grove City Ohio United States 43123
    399 Fairfield Medical Center Lancaster Ohio United States 43130
    400 Saint Rita's Medical Center Lima Ohio United States 45801
    401 OhioHealth Mansfield Hospital Mansfield Ohio United States 44903
    402 Marietta Memorial Hospital Marietta Ohio United States 45750
    403 OhioHealth Marion General Hospital Marion Ohio United States 43302
    404 Toledo Clinic Cancer Centers-Maumee Maumee Ohio United States 43537
    405 Toledo Radiation Oncology at Northwest Ohio Onocolgy Center Maumee Ohio United States 43537
    406 Knox Community Hospital Mount Vernon Ohio United States 43050
    407 Licking Memorial Hospital Newark Ohio United States 43055
    408 Newark Radiation Oncology Newark Ohio United States 43055
    409 Mercy Health Perrysburg Cancer Center Perrysburg Ohio United States 43551
    410 Southern Ohio Medical Center Portsmouth Ohio United States 45662
    411 Saint Vincent Mercy Medical Center Toledo Ohio United States 43608
    412 Mercy Health - Saint Anne Hospital Toledo Ohio United States 43623
    413 Toledo Clinic Cancer Centers-Toledo Toledo Ohio United States 43623
    414 University of Cincinnati Cancer Center-West Chester West Chester Ohio United States 45069
    415 Saint Ann's Hospital Westerville Ohio United States 43081
    416 Genesis Healthcare System Cancer Care Center Zanesville Ohio United States 43701
    417 University of Oklahoma Health Sciences Center Oklahoma City Oklahoma United States 73104
    418 Mercy Hospital Oklahoma City Oklahoma City Oklahoma United States 73120
    419 Saint Alphonsus Medical Center-Baker City Baker City Oregon United States 97814
    420 Saint Charles Health System Bend Oregon United States 97701
    421 Clackamas Radiation Oncology Center Clackamas Oregon United States 97015
    422 Providence Cancer Institute Clackamas Clinic Clackamas Oregon United States 97015
    423 Bay Area Hospital Coos Bay Oregon United States 97420
    424 Providence Newberg Medical Center Newberg Oregon United States 97132
    425 Saint Alphonsus Medical Center-Ontario Ontario Oregon United States 97914
    426 Providence Portland Medical Center Portland Oregon United States 97213
    427 Providence Saint Vincent Medical Center Portland Oregon United States 97225
    428 Oregon Health and Science University Portland Oregon United States 97239
    429 Saint Charles Health System-Redmond Redmond Oregon United States 97756
    430 Lehigh Valley Hospital-Cedar Crest Allentown Pennsylvania United States 18103
    431 Lehigh Valley Hospital - Muhlenberg Bethlehem Pennsylvania United States 18017
    432 Geisinger Medical Center Danville Pennsylvania United States 17822
    433 Pocono Medical Center East Stroudsburg Pennsylvania United States 18301
    434 Geisinger Medical Center-Cancer Center Hazleton Hazleton Pennsylvania United States 18201
    435 Lehigh Valley Hospital-Hazleton Hazleton Pennsylvania United States 18201
    436 Geisinger Medical Oncology-Lewisburg Lewisburg Pennsylvania United States 17837
    437 Lewistown Hospital Lewistown Pennsylvania United States 17044
    438 Geisinger Cancer Services-Pottsville Pottsville Pennsylvania United States 17901
    439 Community Medical Center Scranton Pennsylvania United States 18510
    440 Geisinger Medical Oncology-Selinsgrove Selinsgrove Pennsylvania United States 17870
    441 Geisinger Medical Group State College Pennsylvania United States 16801
    442 Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre Pennsylvania United States 18711
    443 Prisma Health Cancer Institute - Spartanburg Boiling Springs South Carolina United States 29316
    444 Prisma Health Cancer Institute - Easley Easley South Carolina United States 29640
    445 Gibbs Cancer Center-Gaffney Gaffney South Carolina United States 29341
    446 Prisma Health Cancer Institute - Butternut Greenville South Carolina United States 29605
    447 Prisma Health Cancer Institute - Faris Greenville South Carolina United States 29605
    448 Prisma Health Cancer Institute - Eastside Greenville South Carolina United States 29615
    449 Prisma Health Cancer Institute - Greer Greer South Carolina United States 29650
    450 Gibbs Cancer Center-Pelham Greer South Carolina United States 29651
    451 Prisma Health Cancer Institute - Seneca Seneca South Carolina United States 29672
    452 Spartanburg Medical Center Spartanburg South Carolina United States 29303
    453 MGC Hematology Oncology-Union Union South Carolina United States 29379
    454 Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota United States 57104
    455 Avera Cancer Institute Sioux Falls South Dakota United States 57105
    456 Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota United States 57117-5134
    457 Memorial Hospital Chattanooga Tennessee United States 37404
    458 Baptist Memorial Hospital and Cancer Center-Collierville Collierville Tennessee United States 38017
    459 Pulmonary Medicine Center of Chattanooga-Hixson Hixson Tennessee United States 37343
    460 Baptist Memorial Hospital and Cancer Center-Memphis Memphis Tennessee United States 38120
    461 Memorial GYN Plus Ooltewah Tennessee United States 37363
    462 Saint Joseph Regional Cancer Center Bryan Texas United States 77802
    463 American Fork Hospital / Huntsman Intermountain Cancer Center American Fork Utah United States 84003
    464 Sandra L Maxwell Cancer Center Cedar City Utah United States 84720
    465 Logan Regional Hospital Logan Utah United States 84321
    466 Intermountain Medical Center Murray Utah United States 84107
    467 McKay-Dee Hospital Center Ogden Utah United States 84403
    468 Utah Valley Regional Medical Center Provo Utah United States 84604
    469 Riverton Hospital Riverton Utah United States 84065
    470 Dixie Medical Center Regional Cancer Center Saint George Utah United States 84770
    471 Utah Cancer Specialists-Salt Lake City Salt Lake City Utah United States 84106
    472 Huntsman Cancer Institute/University of Utah Salt Lake City Utah United States 84112
    473 LDS Hospital Salt Lake City Utah United States 84143
    474 George E Wahlen Department of Veterans Affairs Medical Center Salt Lake City Utah United States 84148
    475 Providence Regional Cancer System-Aberdeen Aberdeen Washington United States 98520
    476 MultiCare Auburn Medical Center Auburn Washington United States 98001
    477 Overlake Medical Center Bellevue Washington United States 98004
    478 PeaceHealth Saint Joseph Medical Center Bellingham Washington United States 98225
    479 Harrison HealthPartners Hematology and Oncology-Bremerton Bremerton Washington United States 98310
    480 Harrison Medical Center Bremerton Washington United States 98310
    481 Highline Medical Center-Main Campus Burien Washington United States 98166
    482 Providence Regional Cancer System-Centralia Centralia Washington United States 98531
    483 Swedish Cancer Institute-Edmonds Edmonds Washington United States 98026
    484 Saint Elizabeth Hospital Enumclaw Washington United States 98022
    485 Providence Regional Cancer Partnership Everett Washington United States 98201
    486 Saint Francis Hospital Federal Way Washington United States 98003
    487 MultiCare Gig Harbor Medical Park Gig Harbor Washington United States 98335
    488 Swedish Cancer Institute-Issaquah Issaquah Washington United States 98029
    489 Kadlec Clinic Hematology and Oncology Kennewick Washington United States 99336
    490 Providence Regional Cancer System-Lacey Lacey Washington United States 98503
    491 Saint Clare Hospital Lakewood Washington United States 98499
    492 PeaceHealth Saint John Medical Center Longview Washington United States 98632
    493 Jefferson Healthcare Port Townsend Washington United States 98368
    494 Harrison HealthPartners Hematology and Oncology-Poulsbo Poulsbo Washington United States 98370
    495 MultiCare Good Samaritan Hospital Puyallup Washington United States 98372
    496 Valley Medical Center Renton Washington United States 98055
    497 Pacific Gynecology Specialists Seattle Washington United States 98104
    498 Swedish Medical Center-Ballard Campus Seattle Washington United States 98107
    499 Fred Hutchinson Cancer Research Center Seattle Washington United States 98109
    500 Seattle Cancer Care Alliance Seattle Washington United States 98109
    501 Kaiser Permanente Washington Seattle Washington United States 98112
    502 Swedish Medical Center-First Hill Seattle Washington United States 98122-4307
    503 Swedish Medical Center-Cherry Hill Seattle Washington United States 98122-5711
    504 University of Washington Medical Center - Montlake Seattle Washington United States 98195
    505 PeaceHealth United General Medical Center Sedro-Woolley Washington United States 98284
    506 Providence Regional Cancer System-Shelton Shelton Washington United States 98584
    507 MultiCare Deaconess Cancer and Blood Specialty Center - Valley Spokane Valley Washington United States 99216
    508 MultiCare Deaconess Cancer and Blood Specialty Center - Downtown Spokane Washington United States 99204
    509 MultiCare Deaconess Cancer and Blood Specialty Center - North Spokane Washington United States 99218
    510 Franciscan Research Center-Northwest Medical Plaza Tacoma Washington United States 98405
    511 Mary Bridge Children's Hospital and Health Center Tacoma Washington United States 98405
    512 MultiCare Tacoma General Hospital Tacoma Washington United States 98405
    513 Northwest Medical Specialties PLLC Tacoma Washington United States 98405
    514 PeaceHealth Southwest Medical Center Vancouver Washington United States 98664
    515 Providence Saint Mary Regional Cancer Center Walla Walla Washington United States 99362
    516 North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima Washington United States 98902
    517 Providence Regional Cancer System-Yelm Yelm Washington United States 98597
    518 Aurora Cancer Care-Southern Lakes VLCC Burlington Wisconsin United States 53105
    519 Aurora Saint Luke's South Shore Cudahy Wisconsin United States 53110
    520 Aurora Health Center-Fond du Lac Fond Du Lac Wisconsin United States 54937
    521 Aurora Health Care Germantown Health Center Germantown Wisconsin United States 53022
    522 Aurora Cancer Care-Grafton Grafton Wisconsin United States 53024
    523 Aurora BayCare Medical Center Green Bay Wisconsin United States 54311
    524 Aurora Cancer Care-Kenosha South Kenosha Wisconsin United States 53142
    525 Aurora Bay Area Medical Group-Marinette Marinette Wisconsin United States 54143
    526 Aurora Cancer Care-Milwaukee Milwaukee Wisconsin United States 53209
    527 Aurora Saint Luke's Medical Center Milwaukee Wisconsin United States 53215
    528 Medical College of Wisconsin Milwaukee Wisconsin United States 53226
    529 Aurora Sinai Medical Center Milwaukee Wisconsin United States 53233
    530 Froedtert and MCW Moorland Reserve Health Center New Berlin Wisconsin United States 53151
    531 Cancer Center of Western Wisconsin New Richmond Wisconsin United States 54017
    532 Vince Lombardi Cancer Clinic - Oshkosh Oshkosh Wisconsin United States 54904
    533 Aurora Cancer Care-Racine Racine Wisconsin United States 53406
    534 Vince Lombardi Cancer Clinic-Sheboygan Sheboygan Wisconsin United States 53081
    535 Aurora Medical Center in Summit Summit Wisconsin United States 53066
    536 Vince Lombardi Cancer Clinic-Two Rivers Two Rivers Wisconsin United States 54241
    537 Aurora Cancer Care-Milwaukee West Wauwatosa Wisconsin United States 53226
    538 Aurora West Allis Medical Center West Allis Wisconsin United States 53227
    539 Cheyenne Regional Medical Center-West Cheyenne Wyoming United States 82001
    540 Billings Clinic-Cody Cody Wyoming United States 82414
    541 Welch Cancer Center Sheridan Wyoming United States 82801

    Sponsors and Collaborators

    • Southwest Oncology Group
    • National Cancer Institute (NCI)

    Investigators

    • Principal Investigator: Kendra L Sweet, Southwest Oncology Group

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Southwest Oncology Group
    ClinicalTrials.gov Identifier:
    NCT03654768
    Other Study ID Numbers:
    • S1712
    • NCI-2017-02066
    • S1712
    • S1712
    • U10CA180888
    First Posted:
    Aug 31, 2018
    Last Update Posted:
    May 9, 2022
    Last Verified:
    May 1, 2022
    Studies a U.S. FDA-regulated Drug Product:
    Yes
    Studies a U.S. FDA-regulated Device Product:
    No
    Additional relevant MeSH terms:
    Leukemia
    Leukemia, Myeloid
    Leukemia, Myelogenous, Chronic, BCR-ABL Positive
    Leukemia, Myeloid, Chronic-Phase
    Imatinib Mesylate
    Dasatinib
    Janus Kinase Inhibitors

    Study Results

    No Results Posted as of May 9, 2022