ELSL: The Effect of Laparoscopic Splenectomy on Liver Reserve Function for Cirrhosis Patients
Study Details
Study Description
Brief Summary
In this study, the investigators compared the improvement of liver reserve function related indicators in patients with liver cirrhosis after laparoscopic splenectomy. To determine whether surgical treatment can help enhance postoperative liver reserve function and improve patient prognosis.
Condition or Disease | Intervention/Treatment | Phase |
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N/A |
Detailed Description
The patients were enrolled according to the research criteria, and collected the general basic information of the patients. After the preoperative preparation was perfected, the same surgical team performed laparoscopic splenectomy, and the same nursing team performed the nursing after the operation. Then, patients received a unified treatment plan after surgery, including medication, other treatments and follow-up. During the treatment, the liver reserve function related indicators of the patients were monitored before surgery, 3, 6, 12 and 24 months after surgery, including TBIL, DBIL, ALB, ALT, INR, PT, Child-Pugh, ascites, prealbumin, ICG-K, ICG-R 15 and ICG-T/2.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Other: Experimental Group Laparoscopic splenectomy |
Procedure: Laparoscopic splenectomy
The laparoscopic splenectomy was performed by the same surgical team.
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Outcome Measures
Primary Outcome Measures
- Liver reserve function ICG-K level at 3 months after surgery [3 months]
The level of liver reserve function ICG-K level at 3 months after surgery.
- Liver reserve function ICG-K level at 6 months after surgery. [6 months]
The level of liver reserve function ICG-K level at 6 months after surgery.
- Liver reserve function ICG-K level at 12 months after surgery [12 months]
The level of liver reserve function ICG-K level at 12 months after surgery.
- Liver reserve function ICG-K level at 24 months after surgery. [24 months]
The level of liver reserve function ICG-K level at 24 months after surgery.
- Liver reserve function ICG-R15 level at 3 months after surgery. [3 months]
The level of liver reserve function ICG-R15 level at 3 months after surgery.
- Liver reserve function ICG-R15 level at 6 months after surgery. [6 months]
The level of liver reserve function ICG-R15 level at 6 months after surgery.
- Liver reserve function ICG-R15 level at 12 months after surgery. [12 months]
The level of liver reserve function ICG-R15 level at 12 months after surgery.
- Liver reserve function ICG-R15 level at 24 months after surgery. [24 months]
The level of liver reserve function ICG-R15 level at 24 months after surgery.
- Liver reserve function ICG-T/2 level at 3 months after surgery. [3 months]
The level of liver reserve function ICG-T/2 level at 3 months after surgery.
- Liver reserve function ICG-T/2 level at 6 months after surgery. [6 months]
The level of liver reserve function ICG-T/2 level at 6 months after surgery.
- Liver reserve function ICG-T/2 level at 12 months after surgery. [12 months]
The level of liver reserve function ICG-T/2 level at 12 months after surgery.
- Liver reserve function ICG-T/2 level at 24 months after surgery. [24 months]
The level of liver reserve function ICG-T/2 level at 24 months after surgery.
Eligibility Criteria
Criteria
Inclusion Criteria:
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A clinical, radiological or histologic diagnosis of cirrhosis of any etiology
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Splenomegaly with secondary hypersplenism, Platelet count < 50*10^9/L
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Informed consent to participate in the study
Exclusion Criteria:
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Hepatocellular carcinoma or any other malignancy,
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Child-Pugh grade C
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Recent peptic ulcer disease
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History of Hemorrhagic stroke
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Pregnancy.
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Uncontrolled Hypertension
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Bleeding portal hypertension
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Human immunodeficiency virus (HIV) infection
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Clinical Medical College of Yangzhou University | Yangzhou | Jiangsu | China | 225001 |
Sponsors and Collaborators
- Yangzhou University
Investigators
- Study Chair: Guo-Qing Jiang, MD, Clinical Medical College of Yangzhou University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- YZUC-006