Immunotherapy With Nivolumab and Ipilimumab Followed by Nivolumab or Nivolumab With Cabozantinib for Patients With Advanced Kidney Cancer, The PDIGREE Study

• Sponsor: National Cancer Institute (NCI) (NIH)
• Overall Status: Recruiting
• CT.gov ID: NCT03793166
• Collaborator: (none)
• Enrollment: 1,046
• Locations: 822
• Arms: 2
• Anticipated Duration (Months): 40.2
• Patients Per Site: 1.3
• Patients Per Site Per Month: 0

Study Details

Study Description

Brief Summary

This phase III trial compares the usual treatment (treatment with ipilimumab and nivolumab followed by nivolumab alone) to treatment with ipilimumab and nivolumab, followed by nivolumab with cabozantinib in patients with untreated renal cell carcinoma that has spread to other parts of the body. The addition of cabozantinib to the usual treatment may make it work better. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known how well the combination of cabozantinib and nivolumab after initial treatment with ipilimumab and nivolumab works in treating patients with renal cell cancer that has spread to other parts of the body.

Condition or Disease	Intervention/Treatment	Phase
Clear Cell Renal Cell Carcinoma; Metastatic Malignant Neoplasm in the Bone; Metastatic Malignant Neoplasm in the Lymph Nodes; Metastatic Malignant Neoplasm in the Soft Tissues; Metastatic Malignant Neoplasm in the Viscera; Sarcomatoid Renal Cell Carcinoma; Stage IV Renal Cell Cancer AJCC v8	Drug: Cabozantinib; Biological: Ipilimumab; Biological: Nivolumab; Other: Quality-of-Life Assessment; Other: Questionnaire Administration	Phase 3

Detailed Description

PRIMARY OBJECTIVE:

1. To compare the overall survival (OS) in patients with metastatic renal cell cancer (RCC) treated with ipilimumab-nivolumab followed by either nivolumab versus cabozantinib-nivolumab.

SECONDARY OBJECTIVES:

1. To determine progression free survival (PFS) of patients treated with nivolumab versus nivolumab-cabozantinib.

2. To evaluate the 12-month complete response rate in patients treated with ipilimumab-nivolumab followed by cabozantinib-nivolumab versus ipilimumab-nivolumab followed by nivolumab (patients who have complete response [CR] and relapse before 12 months will not be counted as a CR at 12-months).

3. To evaluate the rates of discontinuing therapy at 1 year. IV. To compare objective response rates (ORR, assessed by Response Evaluation Criteria in Solid Tumors [RECIST] 1.1 and Immune Response Evaluation Criteria in Solid Tumors [iRECIST] criteria) for patients treated with ipilimumab-nivolumab followed by cabozantinib-nivolumab versus ipilimumab-nivolumab followed by nivolumab.

4. To document the adverse event profile of ipilimumab-nivolumab followed by cabozantinib-nivolumab.

BIOMARKER OBJECTIVES:

1. To evaluate biomarkers associated with exceptional responses in both arms (exceptional responses defined as CRs with treatment discontinuation at 12 months or 24 months).

2. To evaluate whether baseline IL-6 is predictive of outcome in patients treated with cabozantinib-containing regimen.

QUALITY OF LIFE (QOL) OBJECTIVES:

1. To compare health-related quality of life at 18 months post-registration as assessed by the Functional Assessment of Cancer Therapy (FACT)-Kidney Symptom Index 19 (FKSI-19) between patients randomized to nivolumab (nivo) versus (vs) cabozantinib (cabo)/nivo.

2. To compare health-related quality of life as assessed by the FKSI-19 between patients randomized to nivo vs cabo/nivo at other time points.

3. To compare patient-reported fatigue using Patient-Reported Outcomes Measurement Information System (PROMIS)-Fatigue between patients randomized to nivo vs cabo/nivo.

4. To compare quality-adjusted survival (overall survival x utility score assessed by EuroQol five-dimensional questionnaire [EQ5D-5L]) between patients randomized to nivo vs cabo/nivo.

OUTLINE:

INDUCTION: Patients receive nivolumab intravenously (IV) over 30 minutes and ipilimumab IV over 30 minutes on day 1. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity.

TREATMENT:

Patients with unconfirmed but clinical progression of disease (iuPD) receive cabozantinib orally (PO) daily on days 1-28. Treatment repeats every 28 days until further disease progression or unacceptable toxicity.

Patients with unconfirmed CR (iCR) receive nivolumab IV between 30-60 minutes on day 1. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.

Patients with non-CR/non-PD or iuPD are randomized to 1 of 2 arms.

ARM A: Patients receive nivolumab IV between 30-60 minutes on day 1. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.

ARM B: Patients receive nivolumab IV between 30-60 minutes on day 1 and cabozantinib PO daily on days 1-28. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up for 5 years.

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 1046 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: None (Open Label)
• Primary Purpose: Treatment
• Official Title: PD-Inhibitor (Nivolumab) and Ipilimumab Followed by Nivolumab vs. VEGF TKI Cabozantinib With Nivolumab: A Phase III Trial in Metastatic Untreated REnal Cell CancEr [PDIGREE]
• Actual Study Start Date: May 9, 2019
• Anticipated Primary Completion Date: Sep 15, 2022
• Anticipated Study Completion Date: Sep 15, 2022

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: Arm A (nivolumab) INDUCTION: Patients receive nivolumab IV over 30 minutes and ipilimumab IV over 30 minutes on day 1. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. TREATMENT: Patients with iuPD receive cabozantinib PO daily on days 1-28. Treatment repeats every 28 days until further disease progression or unacceptable toxicity Patients with iCR receive nivolumab IV over 30 minutes on day 1. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity. Patients with non-CR/non-PD receive nivolumab IV over 30 minutes on day 1. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.	Biological: Ipilimumab; Given IV; Other Names: Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody BMS-734016 Ipilimumab Biosimilar CS1002 MDX-010 MDX-CTLA4 Yervoy ; Biological: Nivolumab; Given IV; Other Names: BMS-936558 CMAB819 MDX-1106 NIVO Nivolumab Biosimilar CMAB819 ONO-4538 Opdivo ; Other: Quality-of-Life Assessment; Ancillary studies; Other Names: Quality of Life Assessment ; Other: Questionnaire Administration; Ancillary studies
Experimental: Arm B (nivolumab, cabozantinib) INDUCTION: Patients receive nivolumab IV over 30 minutes and ipilimumab IV over 30 minutes on day 1. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. TREATMENT: Patients with iuPD receive cabozantinib PO daily on days 1-28. Treatment repeats every 28 days until further disease progression or unacceptable toxicity. Patients with iCR receive nivolumab IV over 30 minutes on day 1. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity. Patients with non-CR/non-PD receive nivolumab IV over 30 minutes on day 1 and cabozantinib PO daily on days 1-28. Treatment repeats every 28 days in the absence of	Drug: Cabozantinib; Given PO; Biological: Ipilimumab; Given IV; Other Names: Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody BMS-734016 Ipilimumab Biosimilar CS1002 MDX-010 MDX-CTLA4 Yervoy ; Biological: Nivolumab; Given IV; Other Names: BMS-936558 CMAB819 MDX-1106 NIVO Nivolumab Biosimilar CMAB819 ONO-4538 Opdivo ; Other: Quality-of-Life Assessment; Ancillary studies; Other Names: Quality of Life Assessment ; Other: Questionnaire Administration; Ancillary studies

Outcome Measures

Primary Outcome Measures

1. Overall survival (OS) [From registration to date of death from any cause for non-randomized patients, from time of randomization until death from any cause for randomized patients, assessed up to 5 years]

   OS of patients who achieve complete response (CR) and progressive disease (PD) from ipilimumab-nivolumab induction phase will be summarized. The stratified log-rank statistic will be the primary analysis to compare the hypothesis on OS with the stratification factors (presence of bone metastases and IMDC risk criteria). The Kaplan-Meier product-limit estimator will be used to estimate the OS. A stratified proportional hazards model will be used to generate estimates for the OS hazard ratio. For the randomized patients, OS will be calculated and compared from the time of randomization until the time of an OS event or time of last-follow-up, whatever occurs first. For the patients who were initially CR or PD, OS will be measured from the time of study registration. A comparison of OS will be made across the patient groups (randomized patients, patients initially CR, and patients initially PD).

Secondary Outcome Measures

1. Progression-free survival (PFS) [From date of registration to date of progression or death from any cause, whichever occurs first, assessed up to 5 years]

   Progression will be defined using the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria. PFS of patients who achieve CR and PD from ipilimumab-nivolumab induction phase will be summarized (secondary analysis). The Kaplan-Meier product-limit estimator will be used to estimate the PFS distribution. A stratified proportional hazards model will be used to generate estimates for the PFS hazard ratio. For the randomized patients, PFS will be calculated and compared from the time of randomization until the time of a PFS event or time of last-follow-up, whatever occurs first. For the patients who were initially CR or PD, PFS will be measured from the time of study registration. A comparison of PFS will be made across the patient groups (randomized patients, patients initially CR, and patients initially PD). For this comparison, PFS will be measured from time of study registration all the patients, regardless of whether they were randomized or not.

2. Complete response (CR) (randomized patients) [At 12 months from date of randomization]

   Patients who had a CR prior to 12 months but have experienced a disease recurrence prior to 12 months, will not be considered to be a CR at 12 months. The Cochran-Mantel-Haenszel test will be used to compare the two arms on the proportion of patients who have a 12-month CR adjusting on the stratification factors.

3. Objective response [Up to 5 years]

   Defined as the best response observed that has been confirmed by a scan performed 4 or more weeks after the observation of the initial response. The objective response will be confirmed using RECIST 1.1. In addition, objective responses will also be confirmed using Immune Response Evaluation Criteria in Solid Tumors (iRECIST).

4. Proportion of patients who discontinue protocol-directed treatment prior to 1 year from date of study registration [Up to 5 years]

   Patients who stop their protocol directed treatment for any reason prior to one year from study registration will be considered to have discontinued their treatment. The Cochran-Mantel-Haenszel test will also be used to compare the proportion of patients who discontinue their treatment prior to one-year after study registration.

5. Incidence of adverse events [Up to 5 years]

   Assessed with National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0. A Fisher's exact test will be used to compare the two treatment arms on the proportion of patient with a grade 3 or higher adverse event.

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• STEP I REGISTRATION CRITERIA

• Histologically documented renal cell carcinoma with clear cell component, including patients who have sarcomatoid features.

• Any metastatic disease, including visceral, lymph node, other soft tissue and bone, measurable per RECIST 1.1.

• Measurable disease as defined in the protocol.

• Must be intermediate or poor risk patient per International Metastatic Renal Cell Carcinoma Database (IMDC) criteria (1 or more of the following: Karnofsky performance status [KPS] < 80, < 1 year from diagnosis [including initial nephrectomy] to systemic treatment for metastatic disease, hemoglobin less than lower limit of normal [LLN], corrected calcium concentration greater than upper limit of normal [ULN], absolute neutrophil count greater than ULN, platelet count > ULN).

• Central nervous system (CNS) disease permitted, if stable and not otherwise causing symptoms or needing active treatment.

• Karnofsky performance status >= 70%.

• No prior treatment with PD-1, PD-L1, or CTLA-4 targeting agents (including but not limited to nivolumab, pembrolizumab, pidilizumab, durvalumab, atezolizumab, tremelimumab, and ipilimumab), or any other drug or antibody specifically targeting T-cell co-stimulation or checkpoint pathways. The only exception is for prior treatment with nivolumab or other PD-1/PD-L1/CTLA-4 targeting therapy on pre- or post-operative trials, as long as > 1 year since completion of systemic therapy.

• No prior previous systemic therapy for renal cell carcinoma (prior HD IL-2 [> 28 days] and prior adjuvant sunitinib > 180 days since completion and prior immunotherapy as above are allowed).

• No cancer therapy less than 28 days prior to registration; this includes radiation therapy, except for bone lesions less than 14 days prior to registration. There must be a complete recovery and no ongoing complications from radiotherapy.

• Not pregnant and not nursing, because this study involves an agent that has known genotoxic, mutagenic and teratogenic effects. Therefore, for women of childbearing potential only, a negative serum or urine pregnancy test done =< 14 days prior to registration is required.

• Age >= 18 years

• Absolute neutrophil count (ANC) >= 1,500/mm^3.

• Platelet count >= 100,000/mm^3.

• Hemoglobin >= 8 g/dL.

• Calculated (Calc.) creatinine clearance >= 30 mL/min.

• Urine protein =< 1+ or urine protein to creatinine (UPC) ratio < 1.

• Total bilirubin =< 1.5 x upper limit of normal (ULN).

• Aspartate aminotransferase/alanine aminotransferase (AST/ALT) =< 2.5 x upper limit of normal (ULN) or < 5 x ULN if hepatic metastases present.

• STEP 2 REGISTRATION ELIGIBILITY CRITERIA

• Successful completion of at least 1 cycle of ipilimumab/nivolumab.

• Resolution of any treatment-related adverse events to grade 1 or less per dose modification section (this criteria does not include any adverse events [AEs] not attributable to treatment which are present due to disease). Exceptions for this criteria include patients receiving replacement hormone treatments (such as levothyroxine for treatment-related hypothyroidism or glucocorticoid replacement for adrenal insufficiency). Please contact study chair if further discussion is needed.

• No more than 70 days from last dose of ipilimumab/nivolumab.

Exclusion Criteria:

• Active autoimmune disease requiring ongoing therapy.

• Ongoing acute toxicity > grade 2 from previous treatment.

• History of severe allergic, anaphylactic or other hypersensitivity reactions to chimeric or humanized antibodies.

• History of human immunodeficiency virus (HIV) or active hepatitis B/C, or active tuberculosis (purified protein derivative [PPD] response without active TB is allowed).

• Concurrent use of immunosuppressive medication including prednisone above 10 mg daily.

• Uncontrolled adrenal insufficiency.

• Uncontrolled hypertension (systolic blood pressure [BP] >150 mmHg or diastolic BP > 90 mmHg).

• Major surgery less than 28 days prior to registration.

• Any serious non-healing wound, ulcer, or bone fracture within 28 days prior to registration.

• Any arterial thrombotic events within 180 days prior to registration.

• Clinically significant hematuria, hematemesis, or hemoptysis within 12 weeks prior to registration.

• Cavitating pulmonary lesions or known endotracheal or endobronchial disease manifestations.

• Lesions encasing or invading any major blood vessels (this does not include tumor thrombus extending into/through renal vein/inferior vena cava [IVC]). Patients with tumor thrombus extending into/through renal vein are considered eligible.

• Moderate of severe hepatic impairment (Child-Pugh B or C).

• Any history of untreated pulmonary embolism or deep venous thrombosis (DVT) in the 180 days prior to registration. (Any asymptomatic, treated pulmonary embolism or asymptomatic, treated deep venous thrombosis > 30 days prior to registration allowed).

• Corrected QT interval calculated by the Fridericia formula (QTcF) > 500 ms.

• Unstable cardiac arrhythmia within 6 months prior to registration.

• Any gastrointestinal (GI) bleeding =< 180 days, hemoptysis, or other signs of pulmonary hemorrhage =< 90 days prior to registration.

• History of abdominal fistula, gastrointestinal perforation, intra-abdominal abscess, bowel obstruction, or gastric outlet obstruction within 180 days prior to registration.

• Active peptic ulcer disease, inflammatory bowel disease, or malabsorption syndrome within 28 days prior to registration.

• Untreated hypothyroidism, evidence of pancreatitis, history of organ transplant, or history of congenital QT syndrome.

• Active treatment with coumarin agents (e.g., warfarin), direct thrombin inhibitors (e.g., dabigatran), direct Xa inhibitor betrixaban or platelet inhibitors (e.g., clopidogrel) within 5 days of registration. Allowed anticoagulants include: prophylactic use of low-dose aspirin for cardio-protection (per local applicable guidelines) and low-dose low molecular weight heparins (LMWH), therapeutic doses of LMWH or anticoagulation with direct factor Xa inhibitors rivaroxaban, edoxaban, apixaban. Allowed also in patients with known brain metastases who are on a stable dose of the anticoagulant for at least 1 week prior to registration without clinically significant hemorrhagic complications from the anticoagulation regimen or the tumor.

• Significant cardiac ischemia events (ST elevation myocardial infarction [STEMI] or non-ST elevation myocardial infarction [NSTEMI]) within 6 months or active NY Heart Association class 3-4 heart failure symptoms

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Anchorage Associates in Radiation Medicine	Anchorage	Alaska	United States	98508
2	Anchorage Radiation Therapy Center	Anchorage	Alaska	United States	99504
3	Alaska Breast Care and Surgery LLC	Anchorage	Alaska	United States	99508
4	Alaska Oncology and Hematology LLC	Anchorage	Alaska	United States	99508
5	Alaska Women's Cancer Care	Anchorage	Alaska	United States	99508
6	Anchorage Oncology Centre	Anchorage	Alaska	United States	99508
7	Katmai Oncology Group	Anchorage	Alaska	United States	99508
8	Providence Alaska Medical Center	Anchorage	Alaska	United States	99508
9	Fairbanks Memorial Hospital	Fairbanks	Alaska	United States	99701
10	Kingman Regional Medical Center	Kingman	Arizona	United States	86401
11	Cancer Center at Saint Joseph's	Phoenix	Arizona	United States	85004
12	Mercy Hospital Fort Smith	Fort Smith	Arkansas	United States	72903
13	CHI Saint Vincent Cancer Center Hot Springs	Hot Springs	Arkansas	United States	71913
14	Kaiser Permanente-Anaheim	Anaheim	California	United States	92806
15	Mission Hope Medical Oncology - Arroyo Grande	Arroyo Grande	California	United States	93420
16	PCR Oncology	Arroyo Grande	California	United States	93420
17	Kaiser Permanente-Baldwin Park	Baldwin Park	California	United States	91706
18	Kaiser Permanente-Bellflower	Bellflower	California	United States	90706
19	Providence Saint Joseph Medical Center/Disney Family Cancer Center	Burbank	California	United States	91505
20	Community Cancer Institute	Clovis	California	United States	93611
21	University Oncology Associates	Clovis	California	United States	93611
22	Kaiser Permanente-Fontana	Fontana	California	United States	92335
23	Kaiser Permanente - Harbor City	Harbor City	California	United States	90710
24	Kaiser Permanente-Irvine	Irvine	California	United States	92618
25	UC San Diego Moores Cancer Center	La Jolla	California	United States	92093
26	Kaiser Permanente Los Angeles Medical Center	Los Angeles	California	United States	90027
27	Kaiser Permanente West Los Angeles	Los Angeles	California	United States	90034
28	Kaiser Permanente-Ontario	Ontario	California	United States	91761
29	Kaiser Permanente - Panorama City	Panorama City	California	United States	91402
30	Kaiser Permanente-Riverside	Riverside	California	United States	92505
31	University of California Davis Comprehensive Cancer Center	Sacramento	California	United States	95817
32	Kaiser Permanente-San Diego Mission	San Diego	California	United States	92108
33	Kaiser Permanente-San Diego Zion	San Diego	California	United States	92120
34	Sharp Memorial Hospital	San Diego	California	United States	92123
35	Naval Medical Center -San Diego	San Diego	California	United States	92134
36	UCSF Medical Center-Mission Bay	San Francisco	California	United States	94158
37	Pacific Central Coast Health Center-San Luis Obispo	San Luis Obispo	California	United States	93401
38	Kaiser Permanente-San Marcos	San Marcos	California	United States	92078
39	Mission Hope Medical Oncology - Santa Maria	Santa Maria	California	United States	93444
40	Kaiser Permanente-Woodland Hills	Woodland Hills	California	United States	91367
41	Rocky Mountain Cancer Centers-Aurora	Aurora	Colorado	United States	80012
42	The Medical Center of Aurora	Aurora	Colorado	United States	80012
43	University of Colorado Hospital	Aurora	Colorado	United States	80045
44	Boulder Community Hospital	Boulder	Colorado	United States	80301
45	Boulder Community Foothills Hospital	Boulder	Colorado	United States	80303
46	Rocky Mountain Cancer Centers-Boulder	Boulder	Colorado	United States	80304
47	Rocky Mountain Cancer Centers - Centennial	Centennial	Colorado	United States	80112
48	Penrose-Saint Francis Healthcare	Colorado Springs	Colorado	United States	80907
49	Rocky Mountain Cancer Centers-Penrose	Colorado Springs	Colorado	United States	80907
50	UCHealth Memorial Hospital Central	Colorado Springs	Colorado	United States	80909
51	Memorial Hospital North	Colorado Springs	Colorado	United States	80920
52	Cancer Center of Colorado at Sloan's Lake	Denver	Colorado	United States	80204
53	Kaiser Permanente-Franklin	Denver	Colorado	United States	80205
54	National Jewish Health-Main Campus	Denver	Colorado	United States	80206
55	The Women's Imaging Center	Denver	Colorado	United States	80209
56	Porter Adventist Hospital	Denver	Colorado	United States	80210
57	Colorado Blood Cancer Institute	Denver	Colorado	United States	80218
58	Presbyterian - Saint Lukes Medical Center - Health One	Denver	Colorado	United States	80218
59	Rocky Mountain Cancer Centers-Midtown	Denver	Colorado	United States	80218
60	SCL Health Saint Joseph Hospital	Denver	Colorado	United States	80218
61	Rocky Mountain Cancer Centers-Rose	Denver	Colorado	United States	80220
62	Rose Medical Center	Denver	Colorado	United States	80220
63	Western Surgical Care	Denver	Colorado	United States	80220
64	Mercy Medical Center	Durango	Colorado	United States	81301
65	Southwest Oncology PC	Durango	Colorado	United States	81301
66	Mountain Blue Cancer Care Center - Swedish	Englewood	Colorado	United States	80113
67	Rocky Mountain Cancer Centers - Swedish	Englewood	Colorado	United States	80113
68	Swedish Medical Center	Englewood	Colorado	United States	80113
69	The Melanoma and Skin Cancer Institute	Englewood	Colorado	United States	80113
70	Poudre Valley Hospital	Fort Collins	Colorado	United States	80524
71	Cancer Care and Hematology-Fort Collins	Fort Collins	Colorado	United States	80528
72	National Jewish Health-Western Hematology Oncology	Golden	Colorado	United States	80401
73	Saint Mary's Hospital and Regional Medical Center	Grand Junction	Colorado	United States	81501
74	North Colorado Medical Center	Greeley	Colorado	United States	80631
75	UCHealth Greeley Hospital	Greeley	Colorado	United States	80631
76	UCHealth Highlands Ranch Hospital	Highlands Ranch	Colorado	United States	80129
77	Good Samaritan Medical Center	Lafayette	Colorado	United States	80026
78	Kaiser Permanente-Rock Creek	Lafayette	Colorado	United States	80026
79	Rocky Mountain Cancer Centers-Lakewood	Lakewood	Colorado	United States	80228
80	Saint Anthony Hospital	Lakewood	Colorado	United States	80228
81	Rocky Mountain Cancer Centers-Littleton	Littleton	Colorado	United States	80120
82	Littleton Adventist Hospital	Littleton	Colorado	United States	80122
83	Kaiser Permanente-Lone Tree	Lone Tree	Colorado	United States	80124
84	Rocky Mountain Cancer Centers-Sky Ridge	Lone Tree	Colorado	United States	80124
85	Sky Ridge Medical Center	Lone Tree	Colorado	United States	80124
86	UCHealth Lone Tree Health Center	Lone Tree	Colorado	United States	80124
87	Longmont United Hospital	Longmont	Colorado	United States	80501
88	Rocky Mountain Cancer Centers-Longmont	Longmont	Colorado	United States	80501
89	Medical Center of the Rockies	Loveland	Colorado	United States	80538
90	McKee Medical Center	Loveland	Colorado	United States	80539
91	Parker Adventist Hospital	Parker	Colorado	United States	80138
92	Saint Mary Corwin Medical Center	Pueblo	Colorado	United States	81004
93	National Jewish Health-Northern Hematology Oncology	Thornton	Colorado	United States	80260
94	Rocky Mountain Cancer Centers-Thornton	Thornton	Colorado	United States	80260
95	SCL Health Lutheran Medical Center	Wheat Ridge	Colorado	United States	80033
96	Stamford Hospital/Bennett Cancer Center	Stamford	Connecticut	United States	06904
97	Beebe South Coastal Health Campus	Frankford	Delaware	United States	19945
98	Beebe Medical Center	Lewes	Delaware	United States	19958
99	Delaware Clinical and Laboratory Physicians PA	Newark	Delaware	United States	19713
100	Helen F Graham Cancer Center	Newark	Delaware	United States	19713
101	Medical Oncology Hematology Consultants PA	Newark	Delaware	United States	19713
102	Christiana Care Health System-Christiana Hospital	Newark	Delaware	United States	19718
103	Beebe Health Campus	Rehoboth Beach	Delaware	United States	19971
104	TidalHealth Nanticoke / Allen Cancer Center	Seaford	Delaware	United States	19973
105	Christiana Care Health System-Wilmington Hospital	Wilmington	Delaware	United States	19801
106	MedStar Georgetown University Hospital	Washington	District of Columbia	United States	20007
107	MedStar Washington Hospital Center	Washington	District of Columbia	United States	20010
108	George Washington University Medical Center	Washington	District of Columbia	United States	20037
109	UM Sylvester Comprehensive Cancer Center at Coral Gables	Coral Gables	Florida	United States	33146
110	UM Sylvester Comprehensive Cancer Center at Deerfield Beach	Deerfield Beach	Florida	United States	33442
111	Holy Cross Hospital	Fort Lauderdale	Florida	United States	33308
112	University of Florida Health Science Center - Gainesville	Gainesville	Florida	United States	32610
113	University of Miami Miller School of Medicine-Sylvester Cancer Center	Miami	Florida	United States	33136
114	UM Sylvester Comprehensive Cancer Center at Kendall	Miami	Florida	United States	33176
115	Orlando Health Cancer Institute	Orlando	Florida	United States	32806
116	UM Sylvester Comprehensive Cancer Center at Plantation	Plantation	Florida	United States	33324
117	Northside Hospital	Atlanta	Georgia	United States	30342
118	Northside Hospital - Duluth	Duluth	Georgia	United States	30096
119	Northside Hospital - Gwinnett	Lawrenceville	Georgia	United States	30046
120	Lewis Cancer and Research Pavilion at Saint Joseph's/Candler	Savannah	Georgia	United States	31405
121	Suburban Hematology Oncology Associates - Snellville	Snellville	Georgia	United States	30078
122	Hawaii Cancer Care - Savio	'Aiea	Hawaii	United States	96701
123	Pali Momi Medical Center	'Aiea	Hawaii	United States	96701
124	Queen's Cancer Center - Pearlridge	'Aiea	Hawaii	United States	96701
125	The Cancer Center of Hawaii-Pali Momi	'Aiea	Hawaii	United States	96701
126	Hawaii Cancer Care Inc - Waterfront Plaza	Honolulu	Hawaii	United States	96813
127	Island Urology	Honolulu	Hawaii	United States	96813
128	Queen's Cancer Cenrer - POB I	Honolulu	Hawaii	United States	96813
129	Queen's Medical Center	Honolulu	Hawaii	United States	96813
130	Straub Clinic and Hospital	Honolulu	Hawaii	United States	96813
131	University of Hawaii Cancer Center	Honolulu	Hawaii	United States	96813
132	Queen's Cancer Center - Kuakini	Honolulu	Hawaii	United States	96817
133	The Cancer Center of Hawaii-Liliha	Honolulu	Hawaii	United States	96817
134	Kapiolani Medical Center for Women and Children	Honolulu	Hawaii	United States	96826
135	Wilcox Memorial Hospital and Kauai Medical Clinic	Lihue	Hawaii	United States	96766
136	Saint Alphonsus Cancer Care Center-Boise	Boise	Idaho	United States	83706
137	Saint Luke's Cancer Institute - Boise	Boise	Idaho	United States	83712
138	Saint Alphonsus Cancer Care Center-Caldwell	Caldwell	Idaho	United States	83605
139	Kootenai Health - Coeur d'Alene	Coeur d'Alene	Idaho	United States	83814
140	Walter Knox Memorial Hospital	Emmett	Idaho	United States	83617
141	Saint Luke's Cancer Institute - Fruitland	Fruitland	Idaho	United States	83619
142	Idaho Urologic Institute-Meridian	Meridian	Idaho	United States	83642
143	Saint Luke's Cancer Institute - Meridian	Meridian	Idaho	United States	83642
144	Saint Alphonsus Medical Center-Nampa	Nampa	Idaho	United States	83686
145	Saint Luke's Cancer Institute - Nampa	Nampa	Idaho	United States	83686
146	Kootenai Clinic Cancer Services - Post Falls	Post Falls	Idaho	United States	83854
147	Kootenai Cancer Clinic	Sandpoint	Idaho	United States	83864
148	Saint Luke's Cancer Institute - Twin Falls	Twin Falls	Idaho	United States	83301
149	Saint Anthony's Health	Alton	Illinois	United States	62002
150	Rush - Copley Medical Center	Aurora	Illinois	United States	60504
151	Illinois CancerCare-Bloomington	Bloomington	Illinois	United States	61704
152	Loyola Center for Health at Burr Ridge	Burr Ridge	Illinois	United States	60527
153	Illinois CancerCare-Canton	Canton	Illinois	United States	61520
154	Memorial Hospital of Carbondale	Carbondale	Illinois	United States	62902
155	SIH Cancer Institute	Carterville	Illinois	United States	62918
156	Illinois CancerCare-Carthage	Carthage	Illinois	United States	62321
157	Centralia Oncology Clinic	Centralia	Illinois	United States	62801
158	Northwestern University	Chicago	Illinois	United States	60611
159	John H Stroger Jr Hospital of Cook County	Chicago	Illinois	United States	60612
160	Rush University Medical Center	Chicago	Illinois	United States	60612
161	University of Chicago Comprehensive Cancer Center	Chicago	Illinois	United States	60637
162	Carle on Vermilion	Danville	Illinois	United States	61832
163	Cancer Care Specialists of Illinois - Decatur	Decatur	Illinois	United States	62526
164	Decatur Memorial Hospital	Decatur	Illinois	United States	62526
165	Northwestern Medicine Cancer Center Kishwaukee	DeKalb	Illinois	United States	60115
166	Illinois CancerCare-Dixon	Dixon	Illinois	United States	61021
167	Carle Physician Group-Effingham	Effingham	Illinois	United States	62401
168	Crossroads Cancer Center	Effingham	Illinois	United States	62401
169	Elmhurst Memorial Hospital	Elmhurst	Illinois	United States	60126
170	Illinois CancerCare-Eureka	Eureka	Illinois	United States	61530
171	Illinois CancerCare-Galesburg	Galesburg	Illinois	United States	61401
172	Western Illinois Cancer Treatment Center	Galesburg	Illinois	United States	61401
173	Northwestern Medicine Cancer Center Delnor	Geneva	Illinois	United States	60134
174	Ingalls Memorial Hospital	Harvey	Illinois	United States	60426
175	Loyola Medicine Homer Glen	Homer Glen	Illinois	United States	60491
176	Duly Health and Care Joliet	Joliet	Illinois	United States	60435
177	Illinois CancerCare-Kewanee Clinic	Kewanee	Illinois	United States	61443
178	Northwestern Medicine Lake Forest Hospital	Lake Forest	Illinois	United States	60045
179	Illinois CancerCare-Macomb	Macomb	Illinois	United States	61455
180	Carle Physician Group-Mattoon/Charleston	Mattoon	Illinois	United States	61938
181	Loyola University Medical Center	Maywood	Illinois	United States	60153
182	Marjorie Weinberg Cancer Center at Loyola-Gottlieb	Melrose Park	Illinois	United States	60160
183	Good Samaritan Regional Health Center	Mount Vernon	Illinois	United States	62864
184	Edward Hospital/Cancer Center	Naperville	Illinois	United States	60540
185	UC Comprehensive Cancer Center at Silver Cross	New Lenox	Illinois	United States	60451
186	Cancer Care Center of O'Fallon	O'Fallon	Illinois	United States	62269
187	University of Chicago Medicine-Orland Park	Orland Park	Illinois	United States	60462
188	Illinois CancerCare-Ottawa Clinic	Ottawa	Illinois	United States	61350
189	Illinois CancerCare-Pekin	Pekin	Illinois	United States	61554
190	Illinois CancerCare-Peoria	Peoria	Illinois	United States	61615
191	Methodist Medical Center of Illinois	Peoria	Illinois	United States	61636
192	Illinois CancerCare-Peru	Peru	Illinois	United States	61354
193	Valley Radiation Oncology	Peru	Illinois	United States	61354
194	Edward Hospital/Cancer Center?Plainfield	Plainfield	Illinois	United States	60585
195	Illinois CancerCare-Princeton	Princeton	Illinois	United States	61356
196	Southern Illinois University School of Medicine	Springfield	Illinois	United States	62702
197	Springfield Clinic	Springfield	Illinois	United States	62702
198	Memorial Medical Center	Springfield	Illinois	United States	62781
199	Southwest Illinois Health Services LLP	Swansea	Illinois	United States	62226
200	Carle Cancer Center	Urbana	Illinois	United States	61801
201	The Carle Foundation Hospital	Urbana	Illinois	United States	61801
202	Northwestern Medicine Cancer Center Warrenville	Warrenville	Illinois	United States	60555
203	Illinois CancerCare - Washington	Washington	Illinois	United States	61571
204	Rush-Copley Healthcare Center	Yorkville	Illinois	United States	60560
205	Indiana University/Melvin and Bren Simon Cancer Center	Indianapolis	Indiana	United States	46202
206	Sidney and Lois Eskenazi Hospital	Indianapolis	Indiana	United States	46202
207	Franciscan Health Indianapolis	Indianapolis	Indiana	United States	46237
208	Woodland Cancer Care Center	Michigan City	Indiana	United States	46360
209	Franciscan Health Mooresville	Mooresville	Indiana	United States	46158
210	Reid Health	Richmond	Indiana	United States	47374
211	Mary Greeley Medical Center	Ames	Iowa	United States	50010
212	McFarland Clinic PC - Ames	Ames	Iowa	United States	50010
213	McFarland Clinic PC-Boone	Boone	Iowa	United States	50036
214	Saint Anthony Regional Hospital	Carroll	Iowa	United States	51401
215	Medical Oncology and Hematology Associates-West Des Moines	Clive	Iowa	United States	50325
216	Mercy Cancer Center-West Lakes	Clive	Iowa	United States	50325
217	Alegent Health Mercy Hospital	Council Bluffs	Iowa	United States	51503
218	Greater Regional Medical Center	Creston	Iowa	United States	50801
219	Iowa Methodist Medical Center	Des Moines	Iowa	United States	50309
220	Medical Oncology and Hematology Associates-Des Moines	Des Moines	Iowa	United States	50309
221	Broadlawns Medical Center	Des Moines	Iowa	United States	50314
222	Medical Oncology and Hematology Associates-Laurel	Des Moines	Iowa	United States	50314
223	Mercy Medical Center - Des Moines	Des Moines	Iowa	United States	50314
224	Iowa Lutheran Hospital	Des Moines	Iowa	United States	50316
225	McFarland Clinic PC-Trinity Cancer Center	Fort Dodge	Iowa	United States	50501
226	Trinity Regional Medical Center	Fort Dodge	Iowa	United States	50501
227	McFarland Clinic PC-Jefferson	Jefferson	Iowa	United States	50129
228	McFarland Clinic PC-Marshalltown	Marshalltown	Iowa	United States	50158
229	Siouxland Regional Cancer Center	Sioux City	Iowa	United States	51101
230	Methodist West Hospital	West Des Moines	Iowa	United States	50266-7700
231	Mercy Medical Center-West Lakes	West Des Moines	Iowa	United States	50266
232	University of Kansas Clinical Research Center	Fairway	Kansas	United States	66205
233	Central Care Cancer Center - Garden City	Garden City	Kansas	United States	67846
234	Central Care Cancer Center - Great Bend	Great Bend	Kansas	United States	67530
235	HaysMed University of Kansas Health System	Hays	Kansas	United States	67601
236	Lawrence Memorial Hospital	Lawrence	Kansas	United States	66044
237	Kansas Institute of Medicine Cancer and Blood Center	Lenexa	Kansas	United States	66219
238	Minimally Invasive Surgery Hospital	Lenexa	Kansas	United States	66219
239	Olathe Health Cancer Center	Olathe	Kansas	United States	66061
240	Menorah Medical Center	Overland Park	Kansas	United States	66209
241	Ascension Via Christi - Pittsburg	Pittsburg	Kansas	United States	66762
242	Salina Regional Health Center	Salina	Kansas	United States	67401
243	University of Kansas Health System Saint Francis Campus	Topeka	Kansas	United States	66606
244	University of Kansas Hospital-Westwood Cancer Center	Westwood	Kansas	United States	66205
245	Cancer Center of Kansas-Wichita Medical Arts Tower	Wichita	Kansas	United States	67208
246	Ascension Via Christi Hospitals Wichita	Wichita	Kansas	United States	67214
247	Cancer Center of Kansas - Wichita	Wichita	Kansas	United States	67214
248	Flaget Memorial Hospital	Bardstown	Kentucky	United States	40004
249	Commonwealth Cancer Center-Corbin	Corbin	Kentucky	United States	40701
250	Saint Joseph Radiation Oncology Resource Center	Lexington	Kentucky	United States	40504
251	Saint Joseph Hospital East	Lexington	Kentucky	United States	40509
252	University of Kentucky/Markey Cancer Center	Lexington	Kentucky	United States	40536
253	Saint Joseph London	London	Kentucky	United States	40741
254	Jewish Hospital	Louisville	Kentucky	United States	40202
255	Saints Mary and Elizabeth Hospital	Louisville	Kentucky	United States	40215
256	UofL Health Medical Center Northeast	Louisville	Kentucky	United States	40245
257	Jewish Hospital Medical Center South	Shepherdsville	Kentucky	United States	40165
258	LSU Health Baton Rouge-North Clinic	Baton Rouge	Louisiana	United States	70805
259	Our Lady of The Lake	Baton Rouge	Louisiana	United States	70808
260	Hematology/Oncology Clinic PLLC	Baton Rouge	Louisiana	United States	70809
261	Louisiana Hematology Oncology Associates LLC	Baton Rouge	Louisiana	United States	70809
262	Mary Bird Perkins Cancer Center	Baton Rouge	Louisiana	United States	70809
263	Our Lady of the Lake Physicians Group - Medical Oncology	Baton Rouge	Louisiana	United States	70809
264	Ochsner High Grove	Baton Rouge	Louisiana	United States	70836
265	Northshore Oncology Associates-Covington	Covington	Louisiana	United States	70433
266	Ochsner Hematology Oncology North Shore - Covington (West Region)	Covington	Louisiana	United States	70433
267	Oncology Center of The South Incorporated	Houma	Louisiana	United States	70360
268	Terrebonne General Medical Center	Houma	Louisiana	United States	70360
269	East Jefferson General Hospital	Metairie	Louisiana	United States	70006
270	LSU Healthcare Network / Metairie Multi-Specialty Clinic	Metairie	Louisiana	United States	70006
271	Ochsner LSU Health Monroe Medical Center	Monroe	Louisiana	United States	71202
272	Louisiana State University Health Science Center	New Orleans	Louisiana	United States	70112
273	Tulane University Health Sciences Center	New Orleans	Louisiana	United States	70112
274	University Medical Center New Orleans	New Orleans	Louisiana	United States	70112
275	Ochsner Medical Center Jefferson	New Orleans	Louisiana	United States	70121
276	LSU Health Sciences Center at Shreveport	Shreveport	Louisiana	United States	71103
277	Harold Alfond Center for Cancer Care	Augusta	Maine	United States	04330
278	Waldo County General Hospital	Belfast	Maine	United States	04915
279	MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford	Biddeford	Maine	United States	04005
280	Lafayette Family Cancer Center-EMMC	Brewer	Maine	United States	04412
281	Stephens Memorial Hospital	Norway	Maine	United States	04268
282	Penobscot Bay Medical Center	Rockport	Maine	United States	04856
283	MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford	Sanford	Maine	United States	04073
284	Maine Medical Partners - South Portland	South Portland	Maine	United States	04106
285	Greater Baltimore Medical Center	Baltimore	Maryland	United States	21204
286	Dana-Farber Cancer Institute	Boston	Massachusetts	United States	02215
287	Dana-Farber Cancer Institute - Chestnut Hill	Newton	Massachusetts	United States	02467
288	Mercy Medical Center	Springfield	Massachusetts	United States	01104
289	Hickman Cancer Center	Adrian	Michigan	United States	49221
290	Saint Joseph Mercy Hospital	Ann Arbor	Michigan	United States	48106
291	Bronson Battle Creek	Battle Creek	Michigan	United States	49017
292	Saint Joseph Mercy Brighton	Brighton	Michigan	United States	48114
293	Trinity Health IHA Medical Group Hematology Oncology - Brighton	Brighton	Michigan	United States	48114
294	Henry Ford Cancer Institute-Downriver	Brownstown	Michigan	United States	48183
295	Saint Joseph Mercy Canton	Canton	Michigan	United States	48188
296	Trinity Health IHA Medical Group Hematology Oncology - Canton	Canton	Michigan	United States	48188
297	Caro Cancer Center	Caro	Michigan	United States	48723
298	Saint Joseph Mercy Chelsea	Chelsea	Michigan	United States	48118
299	Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital	Chelsea	Michigan	United States	48118
300	Hematology Oncology Consultants-Clarkston	Clarkston	Michigan	United States	48346
301	Newland Medical Associates-Clarkston	Clarkston	Michigan	United States	48346
302	Henry Ford Macomb Hospital-Clinton Township	Clinton Township	Michigan	United States	48038
303	Henry Ford Medical Center-Fairlane	Dearborn	Michigan	United States	48126
304	Henry Ford Hospital	Detroit	Michigan	United States	48202
305	Ascension Saint John Hospital	Detroit	Michigan	United States	48236
306	Great Lakes Cancer Management Specialists-Doctors Park	East China Township	Michigan	United States	48054
307	Green Bay Oncology - Escanaba	Escanaba	Michigan	United States	49829
308	Genesee Cancer and Blood Disease Treatment Center	Flint	Michigan	United States	48503
309	Genesee Hematology Oncology PC	Flint	Michigan	United States	48503
310	Genesys Hurley Cancer Institute	Flint	Michigan	United States	48503
311	Hurley Medical Center	Flint	Michigan	United States	48503
312	Helen DeVos Children's Hospital at Spectrum Health	Grand Rapids	Michigan	United States	49503
313	Mercy Health Saint Mary's	Grand Rapids	Michigan	United States	49503
314	Spectrum Health at Butterworth Campus	Grand Rapids	Michigan	United States	49503
315	Academic Hematology Oncology Specialists	Grosse Pointe Woods	Michigan	United States	48236
316	Great Lakes Cancer Management Specialists-Van Elslander Cancer Center	Grosse Pointe Woods	Michigan	United States	48236
317	Michigan Breast Specialists-Grosse Pointe Woods	Grosse Pointe Woods	Michigan	United States	48236
318	Allegiance Health	Jackson	Michigan	United States	49201
319	Bronson Methodist Hospital	Kalamazoo	Michigan	United States	49007
320	West Michigan Cancer Center	Kalamazoo	Michigan	United States	49007
321	Ascension Borgess Cancer Center	Kalamazoo	Michigan	United States	49009
322	Borgess Medical Center	Kalamazoo	Michigan	United States	49048
323	Sparrow Hospital	Lansing	Michigan	United States	48912
324	Hope Cancer Clinic	Livonia	Michigan	United States	48154
325	Trinity Health Saint Mary Mercy Livonia Hospital	Livonia	Michigan	United States	48154
326	Great Lakes Cancer Management Specialists-Macomb Medical Campus	Macomb	Michigan	United States	48044
327	Michigan Breast Specialists-Macomb Township	Macomb	Michigan	United States	48044
328	Saint Mary's Oncology/Hematology Associates of Marlette	Marlette	Michigan	United States	48453
329	Toledo Clinic Cancer Centers-Monroe	Monroe	Michigan	United States	48162
330	Mercy Health Mercy Campus	Muskegon	Michigan	United States	49444
331	Lakeland Hospital Niles	Niles	Michigan	United States	49120
332	Cancer and Hematology Centers of Western Michigan - Norton Shores	Norton Shores	Michigan	United States	49444
333	Ascension Providence Hospitals - Novi	Novi	Michigan	United States	48374
334	Henry Ford Medical Center-Columbus	Novi	Michigan	United States	48377
335	21st Century Oncology-Pontiac	Pontiac	Michigan	United States	48341
336	Hope Cancer Center	Pontiac	Michigan	United States	48341
337	Newland Medical Associates-Pontiac	Pontiac	Michigan	United States	48341
338	Saint Joseph Mercy Oakland	Pontiac	Michigan	United States	48341
339	Huron Medical Center PC	Port Huron	Michigan	United States	48060
340	Lake Huron Medical Center	Port Huron	Michigan	United States	48060
341	Spectrum Health Reed City Hospital	Reed City	Michigan	United States	49677
342	Great Lakes Cancer Management Specialists-Rochester Hills	Rochester Hills	Michigan	United States	48309
343	Ascension Saint Mary's Hospital	Saginaw	Michigan	United States	48601
344	Oncology Hematology Associates of Saginaw Valley PC	Saginaw	Michigan	United States	48604
345	Lakeland Medical Center Saint Joseph	Saint Joseph	Michigan	United States	49085
346	Marie Yeager Cancer Center	Saint Joseph	Michigan	United States	49085
347	Henry Ford Macomb Health Center - Shelby Township	Shelby	Michigan	United States	48315
348	Ascension Providence Hospitals - Southfield	Southfield	Michigan	United States	48075
349	Bhadresh Nayak MD PC-Sterling Heights	Sterling Heights	Michigan	United States	48312
350	Ascension Saint Joseph Hospital	Tawas City	Michigan	United States	48764
351	Munson Medical Center	Traverse City	Michigan	United States	49684
352	Advanced Breast Care Center PLLC	Warren	Michigan	United States	48088
353	Great Lakes Cancer Management Specialists-Macomb Professional Building	Warren	Michigan	United States	48093
354	Macomb Hematology Oncology PC	Warren	Michigan	United States	48093
355	Michigan Breast Specialists-Warren	Warren	Michigan	United States	48093
356	Saint John Macomb-Oakland Hospital	Warren	Michigan	United States	48093
357	Henry Ford West Bloomfield Hospital	West Bloomfield	Michigan	United States	48322
358	Saint Mary's Oncology/Hematology Associates of West Branch	West Branch	Michigan	United States	48661
359	Metro Health Hospital	Wyoming	Michigan	United States	49519
360	Huron Gastroenterology PC	Ypsilanti	Michigan	United States	48106
361	Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus	Ypsilanti	Michigan	United States	48197
362	Riverwood Healthcare Center	Aitkin	Minnesota	United States	56431
363	Sanford Joe Lueken Cancer Center	Bemidji	Minnesota	United States	56601
364	Essentia Health Saint Joseph's Medical Center	Brainerd	Minnesota	United States	56401
365	Fairview Ridges Hospital	Burnsville	Minnesota	United States	55337
366	Minnesota Oncology - Burnsville	Burnsville	Minnesota	United States	55337
367	Cambridge Medical Center	Cambridge	Minnesota	United States	55008
368	Mercy Hospital	Coon Rapids	Minnesota	United States	55433
369	Essentia Health - Deer River Clinic	Deer River	Minnesota	United States	56636
370	Essentia Health Saint Mary's - Detroit Lakes Clinic	Detroit Lakes	Minnesota	United States	56501
371	Essentia Health Cancer Center	Duluth	Minnesota	United States	55805
372	Essentia Health Saint Mary's Medical Center	Duluth	Minnesota	United States	55805
373	Miller-Dwan Hospital	Duluth	Minnesota	United States	55805
374	Fairview Southdale Hospital	Edina	Minnesota	United States	55435
375	Lake Region Healthcare Corporation-Cancer Care	Fergus Falls	Minnesota	United States	56537
376	Essentia Health - Fosston	Fosston	Minnesota	United States	56542
377	Unity Hospital	Fridley	Minnesota	United States	55432
378	Essentia Health Hibbing Clinic	Hibbing	Minnesota	United States	55746
379	Fairview Clinics and Surgery Center Maple Grove	Maple Grove	Minnesota	United States	55369
380	Minnesota Oncology Hematology PA-Maplewood	Maplewood	Minnesota	United States	55109
381	Saint John's Hospital - Healtheast	Maplewood	Minnesota	United States	55109
382	Abbott-Northwestern Hospital	Minneapolis	Minnesota	United States	55407
383	Hennepin County Medical Center	Minneapolis	Minnesota	United States	55415
384	Minneapolis VA Medical Center	Minneapolis	Minnesota	United States	55417
385	Health Partners Inc	Minneapolis	Minnesota	United States	55454
386	Monticello Cancer Center	Monticello	Minnesota	United States	55362
387	New Ulm Medical Center	New Ulm	Minnesota	United States	56073
388	Essentia Health - Park Rapids	Park Rapids	Minnesota	United States	56470
389	Fairview Northland Medical Center	Princeton	Minnesota	United States	55371
390	North Memorial Medical Health Center	Robbinsdale	Minnesota	United States	55422
391	Coborn Cancer Center at Saint Cloud Hospital	Saint Cloud	Minnesota	United States	56303
392	Park Nicollet Clinic - Saint Louis Park	Saint Louis Park	Minnesota	United States	55416
393	Regions Hospital	Saint Paul	Minnesota	United States	55101
394	United Hospital	Saint Paul	Minnesota	United States	55102
395	Essentia Health Sandstone	Sandstone	Minnesota	United States	55072
396	Saint Francis Regional Medical Center	Shakopee	Minnesota	United States	55379
397	Lakeview Hospital	Stillwater	Minnesota	United States	55082
398	Sanford Thief River Falls Medical Center	Thief River Falls	Minnesota	United States	56701
399	Essentia Health Virginia Clinic	Virginia	Minnesota	United States	55792
400	Ridgeview Medical Center	Waconia	Minnesota	United States	55387
401	Rice Memorial Hospital	Willmar	Minnesota	United States	56201
402	Minnesota Oncology Hematology PA-Woodbury	Woodbury	Minnesota	United States	55125
403	Sanford Cancer Center Worthington	Worthington	Minnesota	United States	56187
404	Fairview Lakes Medical Center	Wyoming	Minnesota	United States	55092
405	Gulfport Memorial Hospital	Gulfport	Mississippi	United States	39502
406	University of Mississippi Medical Center	Jackson	Mississippi	United States	39216
407	Saint Louis Cancer and Breast Institute-Ballwin	Ballwin	Missouri	United States	63011
408	Central Care Cancer Center - Bolivar	Bolivar	Missouri	United States	65613
409	Parkland Health Center-Bonne Terre	Bonne Terre	Missouri	United States	63628
410	Cox Cancer Center Branson	Branson	Missouri	United States	65616
411	Saint Francis Medical Center	Cape Girardeau	Missouri	United States	63703
412	Southeast Cancer Center	Cape Girardeau	Missouri	United States	63703
413	Saint Luke's Hospital	Chesterfield	Missouri	United States	63017
414	University of Missouri - Ellis Fischel	Columbia	Missouri	United States	65212
415	Parkland Health Center - Farmington	Farmington	Missouri	United States	63640
416	Centerpoint Medical Center LLC	Independence	Missouri	United States	64057
417	Capital Region Southwest Campus	Jefferson City	Missouri	United States	65109
418	Freeman Health System	Joplin	Missouri	United States	64804
419	Mercy Hospital Joplin	Joplin	Missouri	United States	64804
420	Truman Medical Centers	Kansas City	Missouri	United States	64108
421	Research Medical Center	Kansas City	Missouri	United States	64132
422	Delbert Day Cancer Institute at PCRMC	Rolla	Missouri	United States	65401
423	Mercy Clinic-Rolla-Cancer and Hematology	Rolla	Missouri	United States	65401
424	Heartland Regional Medical Center	Saint Joseph	Missouri	United States	64506
425	Saint Louis Cancer and Breast Institute-South City	Saint Louis	Missouri	United States	63109
426	Mercy Hospital South	Saint Louis	Missouri	United States	63128
427	Missouri Baptist Medical Center	Saint Louis	Missouri	United States	63131
428	Mercy Hospital Saint Louis	Saint Louis	Missouri	United States	63141
429	Sainte Genevieve County Memorial Hospital	Sainte Genevieve	Missouri	United States	63670
430	Mercy Hospital Springfield	Springfield	Missouri	United States	65804
431	CoxHealth South Hospital	Springfield	Missouri	United States	65807
432	Missouri Baptist Sullivan Hospital	Sullivan	Missouri	United States	63080
433	Missouri Baptist Outpatient Center-Sunset Hills	Sunset Hills	Missouri	United States	63127
434	Mercy Hospital Washington	Washington	Missouri	United States	63090
435	Community Hospital of Anaconda	Anaconda	Montana	United States	59711
436	Billings Clinic Cancer Center	Billings	Montana	United States	59101
437	Saint Vincent Healthcare	Billings	Montana	United States	59101
438	Saint Vincent Frontier Cancer Center	Billings	Montana	United States	59102
439	Bozeman Deaconess Hospital	Bozeman	Montana	United States	59715
440	Saint James Community Hospital and Cancer Treatment Center	Butte	Montana	United States	59701
441	Benefis Healthcare- Sletten Cancer Institute	Great Falls	Montana	United States	59405
442	Great Falls Clinic	Great Falls	Montana	United States	59405
443	Saint Peter's Community Hospital	Helena	Montana	United States	59601
444	Kalispell Regional Medical Center	Kalispell	Montana	United States	59901
445	Saint Patrick Hospital - Community Hospital	Missoula	Montana	United States	59802
446	Community Medical Hospital	Missoula	Montana	United States	59804
447	Nebraska Medicine-Bellevue	Bellevue	Nebraska	United States	68123
448	CHI Health Saint Francis	Grand Island	Nebraska	United States	68803
449	CHI Health Good Samaritan	Kearney	Nebraska	United States	68847
450	Saint Elizabeth Regional Medical Center	Lincoln	Nebraska	United States	68510
451	Cancer Partners of Nebraska - Pine Lake	Lincoln	Nebraska	United States	68516
452	Southeast Nebraska Cancer Center - 68th Street Place	Lincoln	Nebraska	United States	68516
453	Nebraska Cancer Specialists/Oncology Hematology West PC - MECC	Omaha	Nebraska	United States	68114
454	Nebraska Methodist Hospital	Omaha	Nebraska	United States	68114
455	Nebraska Medicine-Village Pointe	Omaha	Nebraska	United States	68118
456	Alegent Health Immanuel Medical Center	Omaha	Nebraska	United States	68122
457	Alegent Health Bergan Mercy Medical Center	Omaha	Nebraska	United States	68124
458	Alegent Health Lakeside Hospital	Omaha	Nebraska	United States	68130
459	Creighton University Medical Center	Omaha	Nebraska	United States	68131
460	University of Nebraska Medical Center	Omaha	Nebraska	United States	68198
461	Midlands Community Hospital	Papillion	Nebraska	United States	68046
462	Carson Tahoe Regional Medical Center	Carson City	Nevada	United States	89703
463	Cancer and Blood Specialists-Henderson	Henderson	Nevada	United States	89052
464	Comprehensive Cancer Centers of Nevada - Henderson	Henderson	Nevada	United States	89052
465	Comprehensive Cancer Centers of Nevada-Horizon Ridge	Henderson	Nevada	United States	89052
466	Las Vegas Cancer Center-Henderson	Henderson	Nevada	United States	89052
467	OptumCare Cancer Care at Seven Hills	Henderson	Nevada	United States	89052
468	Comprehensive Cancer Centers of Nevada-Southeast Henderson	Henderson	Nevada	United States	89074
469	GenesisCare USA - Henderson	Henderson	Nevada	United States	89074
470	Las Vegas Urology - Green Valley	Henderson	Nevada	United States	89074
471	Las Vegas Urology - Pebble	Henderson	Nevada	United States	89074
472	Urology Specialists of Nevada - Green Valley	Henderson	Nevada	United States	89074
473	Las Vegas Urology - Pecos	Las Vegas	Nevada	United States	89074
474	Desert West Surgery	Las Vegas	Nevada	United States	89102
475	OptumCare Cancer Care at Charleston	Las Vegas	Nevada	United States	89102
476	University Medical Center of Southern Nevada	Las Vegas	Nevada	United States	89102
477	Hope Cancer Care of Nevada	Las Vegas	Nevada	United States	89103
478	Cancer and Blood Specialists-Shadow	Las Vegas	Nevada	United States	89106
479	Radiation Oncology Centers of Nevada Central	Las Vegas	Nevada	United States	89106
480	Urology Specialists of Nevada - Central	Las Vegas	Nevada	United States	89106
481	GenesisCare USA - Las Vegas	Las Vegas	Nevada	United States	89109
482	HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway	Las Vegas	Nevada	United States	89109
483	Sunrise Hospital and Medical Center	Las Vegas	Nevada	United States	89109
484	HealthCare Partners Medical Group Oncology/Hematology-San Martin	Las Vegas	Nevada	United States	89113
485	Las Vegas Prostate Cancer Center	Las Vegas	Nevada	United States	89113
486	Las Vegas Urology - Sunset	Las Vegas	Nevada	United States	89113
487	Urology Specialists of Nevada - Southwest	Las Vegas	Nevada	United States	89113
488	Radiation Oncology Centers of Nevada Southeast	Las Vegas	Nevada	United States	89119
489	Ann M Wierman MD LTD	Las Vegas	Nevada	United States	89128
490	Cancer and Blood Specialists-Tenaya	Las Vegas	Nevada	United States	89128
491	Comprehensive Cancer Centers of Nevada - Northwest	Las Vegas	Nevada	United States	89128
492	GenesisCare USA - Vegas Tenaya	Las Vegas	Nevada	United States	89128
493	HealthCare Partners Medical Group Oncology/Hematology-Tenaya	Las Vegas	Nevada	United States	89128
494	Las Vegas Urology - Cathedral Rock	Las Vegas	Nevada	United States	89128
495	Las Vegas Urology - Smoke Ranch	Las Vegas	Nevada	United States	89128
496	OptumCare Cancer Care at MountainView	Las Vegas	Nevada	United States	89128
497	Urology Specialists of Nevada - Northwest	Las Vegas	Nevada	United States	89128
498	Alliance for Childhood Diseases/Cure 4 the Kids Foundation	Las Vegas	Nevada	United States	89135
499	Comprehensive Cancer Centers of Nevada - Town Center	Las Vegas	Nevada	United States	89144
500	Comprehensive Cancer Centers of Nevada-Summerlin	Las Vegas	Nevada	United States	89144
501	Summerlin Hospital Medical Center	Las Vegas	Nevada	United States	89144
502	Las Vegas Cancer Center-Medical Center	Las Vegas	Nevada	United States	89148-2405
503	Comprehensive Cancer Centers of Nevada	Las Vegas	Nevada	United States	89148
504	GenesisCare USA - Fort Apache	Las Vegas	Nevada	United States	89148
505	OptumCare Cancer Care at Fort Apache	Las Vegas	Nevada	United States	89148
506	HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills	Las Vegas	Nevada	United States	89149
507	Comprehensive Cancer Centers of Nevada - Central Valley	Las Vegas	Nevada	United States	89169
508	University Cancer Center	Las Vegas	Nevada	United States	89169
509	Hope Cancer Care of Nevada-Pahrump	Pahrump	Nevada	United States	89048
510	Renown Regional Medical Center	Reno	Nevada	United States	89502
511	Saint Mary's Regional Medical Center	Reno	Nevada	United States	89503
512	Radiation Oncology Associates	Reno	Nevada	United States	89509
513	New Hampshire Oncology Hematology PA-Concord	Concord	New Hampshire	United States	03301
514	Elliot Hospital	Manchester	New Hampshire	United States	03103
515	Solinsky Center for Cancer Care	Manchester	New Hampshire	United States	03103
516	AtlantiCare Health Park-Cape May Court House	Cape May Court House	New Jersey	United States	08210
517	AtlantiCare Surgery Center	Egg Harbor Township	New Jersey	United States	08234
518	Hackensack University Medical Center	Hackensack	New Jersey	United States	07601
519	Saint Barnabas Medical Center	Livingston	New Jersey	United States	07039
520	Inspira Medical Center Mullica Hill	Mullica Hill	New Jersey	United States	08062
521	Rutgers Cancer Institute of New Jersey	New Brunswick	New Jersey	United States	08903
522	University of New Mexico Cancer Center	Albuquerque	New Mexico	United States	87102
523	Hematology Oncology Associates of Central New York-Auburn	Auburn	New York	United States	13021
524	Montefiore Medical Center-Einstein Campus	Bronx	New York	United States	10461
525	Montefiore Medical Center-Weiler Hospital	Bronx	New York	United States	10461
526	Montefiore Medical Center - Moses Campus	Bronx	New York	United States	10467
527	Mary Imogene Bassett Hospital	Cooperstown	New York	United States	13326
528	Hematology Oncology Associates of Central New York-East Syracuse	East Syracuse	New York	United States	13057
529	Glens Falls Hospital	Glens Falls	New York	United States	12801
530	Northwell Health/Center for Advanced Medicine	Lake Success	New York	United States	11042
531	NYP/Weill Cornell Medical Center	New York	New York	United States	10065
532	University of Rochester	Rochester	New York	United States	14642
533	Stony Brook University Medical Center	Stony Brook	New York	United States	11794
534	Hematology Oncology Associates of Central New York-Onondaga Hill	Syracuse	New York	United States	13215
535	AdventHealth Infusion Center Asheville	Asheville	North Carolina	United States	28803
536	UNC Lineberger Comprehensive Cancer Center	Chapel Hill	North Carolina	United States	27599
537	Novant Health Presbyterian Medical Center	Charlotte	North Carolina	United States	28204
538	Wake Forest University at Clemmons	Clemmons	North Carolina	United States	27012
539	Southeastern Medical Oncology Center-Clinton	Clinton	North Carolina	United States	28328
540	AdventHealth Infusion Center Haywood	Clyde	North Carolina	United States	28721
541	Durham VA Medical Center	Durham	North Carolina	United States	27705
542	Duke University Medical Center	Durham	North Carolina	United States	27710
543	Southeastern Medical Oncology Center-Goldsboro	Goldsboro	North Carolina	United States	27534
544	Vidant Medical Center	Greenville	North Carolina	United States	27834
545	Margaret R Pardee Memorial Hospital	Hendersonville	North Carolina	United States	28791
546	AdventHealth Hendersonville	Hendersonville	North Carolina	United States	28792
547	Novant Health Presbyterian Medical Center Huntersville	Huntersville	North Carolina	United States	28078
548	Southeastern Medical Oncology Center-Jacksonville	Jacksonville	North Carolina	United States	28546
549	Vidant Oncology-Kenansville	Kenansville	North Carolina	United States	28349
550	Novant Health Cancer Institute - Kernersville	Kernersville	North Carolina	United States	27284
551	Vidant Oncology-Kinston	Kinston	North Carolina	United States	28501
552	Novant Health Cancer Institute - Mount Airy	Mount Airy	North Carolina	United States	27030
553	Vidant Oncology-Richlands	Richlands	North Carolina	United States	28574
554	Novant Health Cancer Institute - Statesville	Statesville	North Carolina	United States	28625
555	Wake Forest Baptist Health - Hematology Oncology - Statesville	Statesville	North Carolina	United States	28677
556	Novant Health Cancer Institute - Thomasville	Thomasville	North Carolina	United States	27360
557	AdventHealth Infusion Center Weaverville	Weaverville	North Carolina	United States	28787
558	Novant Health Cancer Institute - Wilkesboro	Wilkesboro	North Carolina	United States	28659
559	Wake Forest Baptist Health - Wilkes Medical Center	Wilkesboro	North Carolina	United States	28659
560	Novant Health Forsyth Medical Center	Winston-Salem	North Carolina	United States	27103
561	Wake Forest University Health Sciences	Winston-Salem	North Carolina	United States	27157
562	Sanford Bismarck Medical Center	Bismarck	North Dakota	United States	58501
563	Essentia Health Cancer Center-South University Clinic	Fargo	North Dakota	United States	58103
564	Sanford South University Medical Center	Fargo	North Dakota	United States	58103
565	Southpointe-Sanford Medical Center Fargo	Fargo	North Dakota	United States	58103
566	Sanford Medical Center Fargo	Fargo	North Dakota	United States	58104
567	Sanford Broadway Medical Center	Fargo	North Dakota	United States	58122
568	Sanford Roger Maris Cancer Center	Fargo	North Dakota	United States	58122
569	Altru Cancer Center	Grand Forks	North Dakota	United States	58201
570	Essentia Health - Jamestown Clinic	Jamestown	North Dakota	United States	58401
571	Trinity Cancer Care Center	Minot	North Dakota	United States	58701
572	Indu and Raj Soin Medical Center	Beavercreek	Ohio	United States	45431
573	Strecker Cancer Center-Belpre	Belpre	Ohio	United States	45714
574	Saint Elizabeth Boardman Hospital	Boardman	Ohio	United States	44512
575	Dayton Physicians LLC-Miami Valley South	Centerville	Ohio	United States	45459
576	Miami Valley Hospital South	Centerville	Ohio	United States	45459
577	Adena Regional Medical Center	Chillicothe	Ohio	United States	45601
578	University of Cincinnati Cancer Center-UC Medical Center	Cincinnati	Ohio	United States	45219
579	Good Samaritan Hospital - Cincinnati	Cincinnati	Ohio	United States	45220
580	Oncology Hematology Care Inc-Kenwood	Cincinnati	Ohio	United States	45236
581	Bethesda North Hospital	Cincinnati	Ohio	United States	45242
582	TriHealth Cancer Institute-Westside	Cincinnati	Ohio	United States	45247
583	TriHealth Cancer Institute-Anderson	Cincinnati	Ohio	United States	45255
584	MetroHealth Medical Center	Cleveland	Ohio	United States	44109
585	Ohio State University Comprehensive Cancer Center	Columbus	Ohio	United States	43210
586	Mount Carmel East Hospital	Columbus	Ohio	United States	43213
587	Columbus Oncology and Hematology Associates Inc	Columbus	Ohio	United States	43214
588	Riverside Methodist Hospital	Columbus	Ohio	United States	43214
589	Grant Medical Center	Columbus	Ohio	United States	43215
590	The Mark H Zangmeister Center	Columbus	Ohio	United States	43219
591	Mount Carmel Health Center West	Columbus	Ohio	United States	43222
592	Doctors Hospital	Columbus	Ohio	United States	43228
593	Good Samaritan Hospital - Dayton	Dayton	Ohio	United States	45406
594	Miami Valley Hospital	Dayton	Ohio	United States	45409
595	Dayton Physician LLC-Miami Valley Hospital North	Dayton	Ohio	United States	45415
596	Miami Valley Hospital North	Dayton	Ohio	United States	45415
597	Delaware Health Center-Grady Cancer Center	Delaware	Ohio	United States	43015
598	Grady Memorial Hospital	Delaware	Ohio	United States	43015
599	Columbus Oncology and Hematology Associates	Dublin	Ohio	United States	43016
600	Dublin Methodist Hospital	Dublin	Ohio	United States	43016
601	Armes Family Cancer Center	Findlay	Ohio	United States	45840
602	Blanchard Valley Hospital	Findlay	Ohio	United States	45840
603	Orion Cancer Care	Findlay	Ohio	United States	45840
604	Atrium Medical Center-Middletown Regional Hospital	Franklin	Ohio	United States	45005-1066
605	Dayton Physicians LLC-Atrium	Franklin	Ohio	United States	45005
606	Central Ohio Breast and Endocrine Surgery	Gahanna	Ohio	United States	43230
607	Dayton Physicians LLC-Wayne	Greenville	Ohio	United States	45331
608	Wayne Hospital	Greenville	Ohio	United States	45331
609	Mount Carmel Grove City Hospital	Grove City	Ohio	United States	43123
610	Greater Dayton Cancer Center	Kettering	Ohio	United States	45409
611	First Dayton Cancer Care	Kettering	Ohio	United States	45420
612	Kettering Medical Center	Kettering	Ohio	United States	45429
613	Fairfield Medical Center	Lancaster	Ohio	United States	43130
614	Saint Rita's Medical Center	Lima	Ohio	United States	45801
615	OhioHealth Mansfield Hospital	Mansfield	Ohio	United States	44903
616	Marietta Memorial Hospital	Marietta	Ohio	United States	45750
617	OhioHealth Marion General Hospital	Marion	Ohio	United States	43302
618	Knox Community Hospital	Mount Vernon	Ohio	United States	43050
619	Licking Memorial Hospital	Newark	Ohio	United States	43055
620	Newark Radiation Oncology	Newark	Ohio	United States	43055
621	Mercy Health Perrysburg Cancer Center	Perrysburg	Ohio	United States	43551
622	Southern Ohio Medical Center	Portsmouth	Ohio	United States	45662
623	Springfield Regional Cancer Center	Springfield	Ohio	United States	45504
624	Springfield Regional Medical Center	Springfield	Ohio	United States	45505
625	Saint Vincent Mercy Medical Center	Toledo	Ohio	United States	43608
626	Mercy Health - Saint Anne Hospital	Toledo	Ohio	United States	43623
627	Toledo Clinic Cancer Centers-Toledo	Toledo	Ohio	United States	43623
628	Dayton Physicians LLC-Upper Valley	Troy	Ohio	United States	45373
629	Upper Valley Medical Center	Troy	Ohio	United States	45373
630	Saint Joseph Warren Hospital	Warren	Ohio	United States	44484
631	University of Cincinnati Cancer Center-West Chester	West Chester	Ohio	United States	45069
632	Saint Ann's Hospital	Westerville	Ohio	United States	43081
633	Saint Elizabeth Youngstown Hospital	Youngstown	Ohio	United States	44501
634	Genesis Healthcare System Cancer Care Center	Zanesville	Ohio	United States	43701
635	Cancer Centers of Southwest Oklahoma Research	Lawton	Oklahoma	United States	73505
636	University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	United States	73104
637	Mercy Hospital Oklahoma City	Oklahoma City	Oklahoma	United States	73120
638	Oklahoma Cancer Specialists and Research Institute-Tulsa	Tulsa	Oklahoma	United States	74146
639	Saint Alphonsus Medical Center-Baker City	Baker City	Oregon	United States	97814
640	Saint Charles Health System	Bend	Oregon	United States	97701
641	Clackamas Radiation Oncology Center	Clackamas	Oregon	United States	97015
642	Providence Cancer Institute Clackamas Clinic	Clackamas	Oregon	United States	97015
643	Bay Area Hospital	Coos Bay	Oregon	United States	97420
644	Legacy Mount Hood Medical Center	Gresham	Oregon	United States	97030
645	Providence Newberg Medical Center	Newberg	Oregon	United States	97132
646	Saint Alphonsus Medical Center-Ontario	Ontario	Oregon	United States	97914
647	Legacy Good Samaritan Hospital and Medical Center	Portland	Oregon	United States	97210
648	Providence Portland Medical Center	Portland	Oregon	United States	97213
649	Providence Saint Vincent Medical Center	Portland	Oregon	United States	97225
650	Oregon Health and Science University	Portland	Oregon	United States	97239
651	Saint Charles Health System-Redmond	Redmond	Oregon	United States	97756
652	Legacy Meridian Park Hospital	Tualatin	Oregon	United States	97062
653	Lehigh Valley Hospital-Cedar Crest	Allentown	Pennsylvania	United States	18103
654	Lehigh Valley Hospital - Muhlenberg	Bethlehem	Pennsylvania	United States	18017
655	Bryn Mawr Hospital	Bryn Mawr	Pennsylvania	United States	19010
656	Christiana Care Health System-Concord Health Center	Chadds Ford	Pennsylvania	United States	19317
657	Main Line Health Center-Collegeville	Collegeville	Pennsylvania	United States	19426
658	Geisinger Medical Center	Danville	Pennsylvania	United States	17822
659	Pocono Medical Center	East Stroudsburg	Pennsylvania	United States	18301
660	Main Line Health Center-Exton	Exton	Pennsylvania	United States	19341
661	Geisinger Medical Center-Cancer Center Hazleton	Hazleton	Pennsylvania	United States	18201
662	Lehigh Valley Hospital-Hazleton	Hazleton	Pennsylvania	United States	18201
663	Penn State Milton S Hershey Medical Center	Hershey	Pennsylvania	United States	17033-0850
664	Geisinger Medical Oncology-Lewisburg	Lewisburg	Pennsylvania	United States	17837
665	Lewistown Hospital	Lewistown	Pennsylvania	United States	17044
666	Riddle Memorial Hospital	Media	Pennsylvania	United States	19063
667	Bryn Mawr Health Center	Newtown Square	Pennsylvania	United States	19073
668	Paoli Memorial Hospital	Paoli	Pennsylvania	United States	19301
669	Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	United States	19107
670	Jefferson Methodist Hospital	Philadelphia	Pennsylvania	United States	19148
671	Geisinger Cancer Services-Pottsville	Pottsville	Pennsylvania	United States	17901
672	Guthrie Medical Group PC-Robert Packer Hospital	Sayre	Pennsylvania	United States	18840
673	Community Medical Center	Scranton	Pennsylvania	United States	18510
674	Geisinger Medical Oncology-Selinsgrove	Selinsgrove	Pennsylvania	United States	17870
675	Geisinger Medical Group	State College	Pennsylvania	United States	16801
676	Geisinger Wyoming Valley/Henry Cancer Center	Wilkes-Barre	Pennsylvania	United States	18711
677	Lankenau Medical Center	Wynnewood	Pennsylvania	United States	19096
678	Prisma Health Cancer Institute - Spartanburg	Boiling Springs	South Carolina	United States	29316
679	Medical University of South Carolina	Charleston	South Carolina	United States	29425
680	Prisma Health Cancer Institute - Easley	Easley	South Carolina	United States	29640
681	Gibbs Cancer Center-Gaffney	Gaffney	South Carolina	United States	29341
682	Saint Francis Hospital	Greenville	South Carolina	United States	29601
683	Prisma Health Cancer Institute - Butternut	Greenville	South Carolina	United States	29605
684	Prisma Health Cancer Institute - Faris	Greenville	South Carolina	United States	29605
685	Prisma Health Greenville Memorial Hospital	Greenville	South Carolina	United States	29605
686	Saint Francis Cancer Center	Greenville	South Carolina	United States	29607
687	Prisma Health Cancer Institute - Eastside	Greenville	South Carolina	United States	29615
688	Prisma Health Cancer Institute - Greer	Greer	South Carolina	United States	29650
689	Gibbs Cancer Center-Pelham	Greer	South Carolina	United States	29651
690	Prisma Health Cancer Institute - Seneca	Seneca	South Carolina	United States	29672
691	North Grove Medical Park	Spartanburg	South Carolina	United States	29303
692	Spartanburg Medical Center	Spartanburg	South Carolina	United States	29303
693	Spartanburg Medical Center - Mary Black Campus	Spartanburg	South Carolina	United States	29307
694	MGC Hematology Oncology-Union	Union	South Carolina	United States	29379
695	Avera Cancer Institute-Aberdeen	Aberdeen	South Dakota	United States	57401
696	Rapid City Regional Hospital	Rapid City	South Dakota	United States	57701
697	Sanford Cancer Center Oncology Clinic	Sioux Falls	South Dakota	United States	57104
698	Avera Cancer Institute	Sioux Falls	South Dakota	United States	57105
699	Sanford USD Medical Center - Sioux Falls	Sioux Falls	South Dakota	United States	57117-5134
700	Bristol Regional Medical Center	Bristol	Tennessee	United States	37620
701	Cookeville Regional Medical Center	Cookeville	Tennessee	United States	38501
702	Ballad Health Cancer Care - Kingsport	Kingsport	Tennessee	United States	37660
703	Wellmont Holston Valley Hospital and Medical Center	Kingsport	Tennessee	United States	37660
704	University of Tennessee - Knoxville	Knoxville	Tennessee	United States	37920
705	Dell Seton Medical Center at The University of Texas	Austin	Texas	United States	78701
706	Saint Joseph Regional Cancer Center	Bryan	Texas	United States	77802
707	Parkland Memorial Hospital	Dallas	Texas	United States	75235
708	UT Southwestern/Simmons Cancer Center-Dallas	Dallas	Texas	United States	75390
709	UT Southwestern/Simmons Cancer Center-Fort Worth	Fort Worth	Texas	United States	76104
710	University of Texas Medical Branch	Galveston	Texas	United States	77555-0565
711	Memorial Hermann Texas Medical Center	Houston	Texas	United States	77030
712	UT Southwestern Clinical Center at Richardson/Plano	Richardson	Texas	United States	75080
713	American Fork Hospital / Huntsman Intermountain Cancer Center	American Fork	Utah	United States	84003
714	Sandra L Maxwell Cancer Center	Cedar City	Utah	United States	84720
715	Logan Regional Hospital	Logan	Utah	United States	84321
716	Intermountain Medical Center	Murray	Utah	United States	84107
717	McKay-Dee Hospital Center	Ogden	Utah	United States	84403
718	Utah Valley Regional Medical Center	Provo	Utah	United States	84604
719	Riverton Hospital	Riverton	Utah	United States	84065
720	Saint George Regional Medical Center	Saint George	Utah	United States	84770
721	Utah Cancer Specialists-Salt Lake City	Salt Lake City	Utah	United States	84106
722	LDS Hospital	Salt Lake City	Utah	United States	84143
723	Central Vermont Medical Center/National Life Cancer Treatment	Berlin	Vermont	United States	05602
724	University of Vermont Medical Center	Burlington	Vermont	United States	05401
725	University of Vermont and State Agricultural College	Burlington	Vermont	United States	05405
726	Wellmont Medical Associates-Bristol	Bristol	Virginia	United States	24201
727	Augusta Health Center for Cancer and Blood Disorders	Fishersville	Virginia	United States	22939
728	Centra Lynchburg Hematology-Oncology Clinic Inc	Lynchburg	Virginia	United States	24501
729	Bon Secours Memorial Regional Medical Center	Mechanicsville	Virginia	United States	23116
730	Bon Secours Westchester Emergency Center	Midlothian	Virginia	United States	23113
731	Bon Secours Saint Francis Medical Center	Midlothian	Virginia	United States	23114
732	Bon Secours DePaul Medical Center	Norfolk	Virginia	United States	23505
733	Southwest VA Regional Cancer Center	Norton	Virginia	United States	24273
734	Bon Secours Maryview Medical Center	Portsmouth	Virginia	United States	23707
735	Bon Secours Saint Mary's Hospital	Richmond	Virginia	United States	23226
736	Bon Secours Cancer Institute at Reynolds Crossing	Richmond	Virginia	United States	23230
737	Virginia Commonwealth University/Massey Cancer Center	Richmond	Virginia	United States	23298
738	VCU Community Memorial Health Center	South Hill	Virginia	United States	23970
739	Bon Secours Health Center at Harbour View	Suffolk	Virginia	United States	23435
740	Providence Regional Cancer System-Aberdeen	Aberdeen	Washington	United States	98520
741	MultiCare Auburn Medical Center	Auburn	Washington	United States	98001
742	Overlake Medical Center	Bellevue	Washington	United States	98004
743	PeaceHealth Saint Joseph Medical Center	Bellingham	Washington	United States	98225
744	Harrison HealthPartners Hematology and Oncology-Bremerton	Bremerton	Washington	United States	98310
745	Harrison Medical Center	Bremerton	Washington	United States	98310
746	Highline Medical Center-Main Campus	Burien	Washington	United States	98166
747	Providence Regional Cancer System-Centralia	Centralia	Washington	United States	98531
748	Swedish Cancer Institute-Edmonds	Edmonds	Washington	United States	98026
749	Saint Elizabeth Hospital	Enumclaw	Washington	United States	98022
750	Providence Regional Cancer Partnership	Everett	Washington	United States	98201
751	Saint Francis Hospital	Federal Way	Washington	United States	98003
752	MultiCare Gig Harbor Medical Park	Gig Harbor	Washington	United States	98335
753	Swedish Cancer Institute-Issaquah	Issaquah	Washington	United States	98029
754	Kadlec Clinic Hematology and Oncology	Kennewick	Washington	United States	99336
755	Providence Regional Cancer System-Lacey	Lacey	Washington	United States	98503
756	Saint Clare Hospital	Lakewood	Washington	United States	98499
757	PeaceHealth Saint John Medical Center	Longview	Washington	United States	98632
758	Jefferson Healthcare	Port Townsend	Washington	United States	98368
759	Harrison HealthPartners Hematology and Oncology-Poulsbo	Poulsbo	Washington	United States	98370
760	MultiCare Good Samaritan Hospital	Puyallup	Washington	United States	98372
761	Valley Medical Center	Renton	Washington	United States	98055
762	Pacific Gynecology Specialists	Seattle	Washington	United States	98104
763	Swedish Medical Center-Ballard Campus	Seattle	Washington	United States	98107
764	Swedish Medical Center-First Hill	Seattle	Washington	United States	98122-4307
765	Swedish Medical Center-Cherry Hill	Seattle	Washington	United States	98122-5711
766	PeaceHealth United General Medical Center	Sedro-Woolley	Washington	United States	98284
767	Providence Regional Cancer System-Shelton	Shelton	Washington	United States	98584
768	MultiCare Deaconess Cancer and Blood Specialty Center - Valley	Spokane Valley	Washington	United States	99216
769	MultiCare Deaconess Cancer and Blood Specialty Center - Downtown	Spokane	Washington	United States	99204
770	MultiCare Deaconess Cancer and Blood Specialty Center - North	Spokane	Washington	United States	99218
771	Franciscan Research Center-Northwest Medical Plaza	Tacoma	Washington	United States	98405
772	Mary Bridge Children's Hospital and Health Center	Tacoma	Washington	United States	98405
773	MultiCare Tacoma General Hospital	Tacoma	Washington	United States	98405
774	Northwest Medical Specialties PLLC	Tacoma	Washington	United States	98405
775	PeaceHealth Southwest Medical Center	Vancouver	Washington	United States	98664
776	Legacy Cancer Institute Medical Oncology and Day Treatment	Vancouver	Washington	United States	98684
777	Legacy Salmon Creek Hospital	Vancouver	Washington	United States	98686
778	Providence Saint Mary Regional Cancer Center	Walla Walla	Washington	United States	99362
779	North Star Lodge Cancer Center at Yakima Valley Memorial Hospital	Yakima	Washington	United States	98902
780	Providence Regional Cancer System-Yelm	Yelm	Washington	United States	98597
781	United Hospital Center	Bridgeport	West Virginia	United States	26330
782	West Virginia University Charleston Division	Charleston	West Virginia	United States	25304
783	Edwards Comprehensive Cancer Center	Huntington	West Virginia	United States	25701
784	WVUH-Berkely Medical Center	Martinsburg	West Virginia	United States	25401
785	West Virginia University Healthcare	Morgantown	West Virginia	United States	26506
786	Camden Clark Medical Center	Parkersburg	West Virginia	United States	26101
787	Langlade Hospital and Cancer Center	Antigo	Wisconsin	United States	54409
788	ThedaCare Regional Cancer Center	Appleton	Wisconsin	United States	54911
789	Duluth Clinic Ashland	Ashland	Wisconsin	United States	54806
790	Northwest Wisconsin Cancer Center	Ashland	Wisconsin	United States	54806
791	HSHS Sacred Heart Hospital	Eau Claire	Wisconsin	United States	54701
792	Marshfield Medical Center-EC Cancer Center	Eau Claire	Wisconsin	United States	54701
793	Bellin Memorial Hospital	Green Bay	Wisconsin	United States	54301
794	Saint Vincent Hospital Cancer Center Green Bay	Green Bay	Wisconsin	United States	54301
795	Saint Vincent Hospital Cancer Center at Saint Mary's	Green Bay	Wisconsin	United States	54303
796	Dean Hematology and Oncology Clinic	Madison	Wisconsin	United States	53717
797	University of Wisconsin Carbone Cancer Center	Madison	Wisconsin	United States	53792
798	Holy Family Memorial Hospital	Manitowoc	Wisconsin	United States	54221
799	Saint Vincent Hospital Cancer Center at Marinette	Marinette	Wisconsin	United States	54143
800	Marshfield Medical Center-Marshfield	Marshfield	Wisconsin	United States	54449
801	Aspirus Medford Hospital	Medford	Wisconsin	United States	54451
802	Froedtert Menomonee Falls Hospital	Menomonee Falls	Wisconsin	United States	53051
803	Medical College of Wisconsin	Milwaukee	Wisconsin	United States	53226
804	Marshfield Clinic-Minocqua Center	Minocqua	Wisconsin	United States	54548
805	ProHealth D N Greenwald Center	Mukwonago	Wisconsin	United States	53149
806	Cancer Center of Western Wisconsin	New Richmond	Wisconsin	United States	54017
807	ProHealth Oconomowoc Memorial Hospital	Oconomowoc	Wisconsin	United States	53066
808	Saint Vincent Hospital Cancer Center at Oconto Falls	Oconto Falls	Wisconsin	United States	54154
809	Marshfield Medical Center-Rice Lake	Rice Lake	Wisconsin	United States	54868
810	HSHS Saint Nicholas Hospital	Sheboygan	Wisconsin	United States	53081
811	Marshfield Medical Center-River Region at Stevens Point	Stevens Point	Wisconsin	United States	54482
812	Saint Vincent Hospital Cancer Center at Sturgeon Bay	Sturgeon Bay	Wisconsin	United States	54235-1495
813	ProHealth Waukesha Memorial Hospital	Waukesha	Wisconsin	United States	53188
814	UW Cancer Center at ProHealth Care	Waukesha	Wisconsin	United States	53188
815	Aspirus Regional Cancer Center	Wausau	Wisconsin	United States	54401
816	Froedtert West Bend Hospital/Kraemer Cancer Center	West Bend	Wisconsin	United States	53095
817	Marshfield Medical Center - Weston	Weston	Wisconsin	United States	54476
818	Aspirus Cancer Care - Wisconsin Rapids	Wisconsin Rapids	Wisconsin	United States	54494
819	Cheyenne Regional Medical Center-West	Cheyenne	Wyoming	United States	82001
820	Billings Clinic-Cody	Cody	Wyoming	United States	82414
821	Welch Cancer Center	Sheridan	Wyoming	United States	82801
822	Pan American Center for Oncology Trials LLC	San Juan		Puerto Rico	00902

Sponsors and Collaborators

• National Cancer Institute (NCI)

Investigators

• Principal Investigator: Tian Zhang, Alliance for Clinical Trials in Oncology

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: National Cancer Institute (NCI)
• ClinicalTrials.gov Identifier: NCT03793166
• Other Study ID Numbers: NCI-2018-03694; NCI-2018-03694; A031704; A031704; U10CA180821
• First Posted: Jan 4, 2019
• Last Update Posted: Aug 25, 2022
• Last Verified: Apr 1, 2022

• Individual Participant Data (IPD) Sharing Statement: Yes
• Plan to Share IPD: Yes
• Studies a U.S. FDA-regulated Drug Product: Yes
• Studies a U.S. FDA-regulated Device Product: No
• Additional relevant MeSH terms: Carcinoma; Neoplasms; Carcinoma, Renal Cell; Neoplasms, Second Primary; Nivolumab; Ipilimumab

Study Results

No Results Posted as of Aug 25, 2022