Clinical and Biological Sample Database of Chinese Elderly Patients With Multiple Diseases

Sponsor

Beijing Anzhen Hospital (Other)

Overall Status

Recruiting

CT.gov ID

NCT05797402

Collaborator

Chinese PLA General Hospital (Other), Beijing Chao Yang Hospital (Other), Beijing Tiantan Hospital (Other), Beijing Geriatric Hospital (Other), China-Japan Friendship Hospital (Other), Xuanwu Hospital, Beijing (Other), Wuhan TongJi Hospital (Other), Cancer Institute and Hospital, Chinese Academy of Medical Sciences (Other), Beijing Friendship Hospital (Other)

10,000,000

Enrollment

Location

124.9

Anticipated Duration (Months)

80035.5

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The investigators aim to establish a clinical database and biobank for elderly patients with multiple diseases. The collected data will include demographic information, comorbidity characteristic, FRAIL scale, age-adjusted Charlson comorbidity index, relevant blood tests, the results of imaging examination, prescription of drugs, length of hospital stay, number of overall rehospitalizations and death. With this database, the investigators intend to formulate an individualized treatment strategy for these patients.

Condition or Disease	Intervention/Treatment	Phase
Comorbidities and Coexisting Conditions Old Age; Debility

Detailed Description

According to the China Health and Aging Tracking Survey, a significant proportion of elderly individuals aged over 65 suffer from two or more chronic diseases, with prevalence rates ranging from 22.5% to 47.5%. However, due to the decentralized storage of health data, lack of standardization, and collaboration barriers, it is challenging to make use of this information in a meaningful way.Therefore, there is an urgent need to overcome the technical challenges and build an intelligent diagnosis and treatment system for this vulnerable population.

To achieve this goal, it is necessary to establish a clinical database and biobank that includes data on all elderly patients with multimorbidity. This will enable researchers to conduct clinical research on various factors, including clinical and biological predictors of adverse events such as emergency visits, strokes, heart failure, myocardial infarction, tumors, and acute chronic obstructive pulmonary disease. Additionally, the database will facilitate the development of systematic and individualized evaluation tools for elderly patients with multimorbidity, identify prognostic factors that improve short- and long-term outcomes, and enable the participation in multi-center trials at the national or international level. Ultimately, this effort will help establish clinical database and biobank data collection standards for future studies.

Study Design

Study Type:

Observational

Anticipated Enrollment :

10000000 participants

Observational Model:

Cohort

Time Perspective:

Cross-Sectional

Official Title:

Construction of Integrated Management and Sharing Platform for Clinical and Biological Sample Database of Chinese Elderly Patients With Multiple Diseases

Actual Study Start Date :

Jan 1, 2013

Anticipated Primary Completion Date :

May 15, 2023

Anticipated Study Completion Date :

Jun 1, 2023

Arms and Interventions

Arm	Intervention/Treatment
young-aged patients Patients aged 18 to 45 years old.
middle-aged patients Patients aged 46 to 64 years old.
elderly patients Patients aged 65 and older.

Outcome Measures

Primary Outcome Measures

The incidence of geriatric syndromes including falls, cognitive impairment, dizziness and frailty [1 year]
collection of clinical data in the medical record and follow-up update