Clinical Study of Functional Magnetic Resonance Imaging and Radiomics of Joint Synovial Disease
Study Details
Study Description
Brief Summary
Through the high-throughput feature extraction of magnetic resonance images, the radiomics prediction model of joint synovial lesions is constructed to explore whether functional magnetic resonance and radiomics can be used for the diagnosis, differential diagnosis and curative effect monitoring of joint synovial lesions.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
The study applies functional magnetic resonance and radiomics to the diagnosis of joint synovial lesions, including diffusion weighted imaging (DWI), Intro-Voxel Incoherent Movement (IVIM) and dynamic contrast enhancement Magnetic resonance imaging (DCE-MRI), from the existing conventional magnetic resonance evaluation to multimodal magnetic resonance evaluation, aims to have a more comprehensive understanding of the pathophysiology of the occurrence and development of joint synovial lesions. As a non-invasive imaging method to assess the condition of the disease, radiomics excavates the deep features contained in the image, quantifies the joint synovial lesions, and then gives more information to the clinician in the diagnosis and differential diagnosis of the joint synovial lesions, provide important information for the planning of individualized treatment plans for patients with joint synovial diseases.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Group of patients with good prognosis Western Ontario and McMaster University Osteoarthritis Index (WOMAC) self-assessment questionnaire scale assesses the frequency of osteoarthritis pain, the severity of pain, body stiffness, and physical dysfunction. The visual analog scale (VAS) is used to evaluate the pain The degree is represented by a total of 11 numbers from 0 to 10 (0 means no pain, 10 means the most painful), and patients are scored according to their own pain levels. |
Diagnostic Test: Patient Comprehensive Rating Scale
Patient subjective rating scale
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Group of patients with poor prognosis Western Ontario and McMaster University Osteoarthritis Index (WOMAC) self-assessment questionnaire scale assesses the frequency of osteoarthritis pain, the severity of pain, body stiffness, and physical dysfunction. The visual analog scale (VAS) is used to evaluate the pain The degree is represented by a total of 11 numbers from 0 to 10 (0 means no pain, 10 means the most painful), and patients are scored according to their own pain levels. |
Diagnostic Test: Patient Comprehensive Rating Scale
Patient subjective rating scale
|
Outcome Measures
Primary Outcome Measures
- Patient quality of life [2019-2023]
Patient quality of life
Eligibility Criteria
Criteria
Inclusion Criteria:
- Inclusion criteria: Patients diagnosed with joint synovial disease through radiological examination, arthroscopy or pathological biopsy of the joint, or whose clinical manifestations meet the diagnostic criteria of the American College of Rheumatology (ACR) for joint synovial disease. The patient agreed to receive pre-treatment DCE-MRI, DWI and IVIM scans and imaging omics analysis, had performed or planned to undergo synovial pathological examination (including needle biopsy and postoperative specimen biopsy), agreed to follow-up after treatment, and was able to understand and Complete the postoperative test and sign the informed consent form.
Exclusion Criteria:
- Exclusion criteria: those who cannot cooperate or refuse to undergo preoperative multimodal magnetic resonance examination; those who have contraindications to MRI scan; those who do not show synovial enhancement changes on MRI scan; the lesion is too small to delineate the area of interest; the pathological diagnosis result is not It belongs to joint synovial disease; patients who have received surgery, medication or other systemic treatment before standardized MRI scan; suffer from kidney disease that requires hemodialysis or peritoneal dialysis; serum creatinine and glomerular filtration rate indicate renal function Insufficiency; a history of tumors in other parts of the joint except for the examination; life-threatening diseases; a history of surgery on the damaged joints in the past 6 months; a history of intramedical injection of hyaluronic acid or steroids in the damaged joints 3 months before the examination, Those who cannot understand and complete the postoperative test correctly.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Peking University third hospital | Beijing | Please Select An Option Below | China | 100089 |
Sponsors and Collaborators
- Peking University Third Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- LM2019168