Clinical Implication of DAC (Detrusor After-contraction)

Sponsor

Seoul National University Hospital (Other)

Overall Status

Completed

CT.gov ID

NCT01154946

Collaborator

(none)

2,309

Enrollment

Location

Duration (Months)

100.4

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The aims of this study are

to confirm whether detrusor after-contraction (DAC) is a true contraction or not with a new approach
and to understand clinical implication of DAC

Condition or Disease	Intervention/Treatment	Phase
Voiding Dysfunction

Detailed Description

The definition of detrusor after-contraction (DAC) is usually accepted as the increase of detrusor pressure (Pdet), whether it is sudden or not, after cessation of urinary flow. The amount of increase in Pdet is sometimes included in the definition of DAC (14, 15, 20 cmH2O or at least two times the level of the maximal Pdet during the voiding phase). However, it is clear that the lack of a well-established definition may induce much bias in the interpretation of the clinical implication of DAC. The previous studies showed a wide range of prevalence.1-4 DAC seemed to occur more frequently in children and the occurrence rate usually decreased with age in urodynamic studies.

Study Design

Study Type:

Observational

Actual Enrollment :

2309 participants

Observational Model:

Case-Control

Time Perspective:

Retrospective

Official Title:

A New Approach to Clinical Implication of Detrusor After-contraction (DAC)

Study Start Date :

Jan 1, 2007

Actual Primary Completion Date :

Dec 1, 2008

Actual Study Completion Date :

Dec 1, 2008

Arms and Interventions

Arm	Intervention/Treatment
DAC group patients who show detrusor after-contraction during voiding cystometrography (CMG)

Outcome Measures

Primary Outcome Measures

to confirm whether DAC is a true contraction or not [up to 2 years (2007.Jan-2008.Dec)]
no change of Pdet when patients cough could confirm that DAC was a true contraction. Because an artifact occurred when a catheter was pressed against bladder wall or urethra, no change of intravesical pressure and increase of abdominal pressure finally induced a negative deflection of Pdet and this change of Pdet could be regarded as an artifact.

Secondary Outcome Measures

Past medical history including neurological disorders and pelvic irradiation were also included in the database [up to 2 years (2007.Jan-2008.Dec)]
One-way analysis of variance and the chi-square test were performed to determine whether there was a relationship between the presence of DAC and the underlying neurogenic and non-neurogenic conditions

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Indications and selection of patients for conduction of urodynamic studies (UDS) were followed as the recommendation of ICS (international continence society).