Clinical Indicators and Brain Image Data: a Study Based on Kailuan Cohort
Study Details
Study Description
Brief Summary
The investigators will analyze the relationship between the medical history, physiological indicators and the cerebral small vessel disease as well as the structural and functional changes of the brain/head and neck organs in a large sample size of subjects (participants), to identify the influencing factors of the occurrence and development of cerebral small vessel disease as well as the structural and functional changes of the brain/head and neck organs, so as to provide objective clues for early intervention of the disease and improve clinical outcomes.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| subjects from Kailuan community 1. Age from 18 to 90 years old; 2. Comes from the Kailuan Cohort, completed ≥1 visits which the medical history, physiological indicators were measured; 3. Without contraindications of CT and MR scan; 4. Can cooperate with the measurement of the medical history, physiological indicators and brain imaging. Subjects with the following conditions should be excluded: 1. Known clinical history with congenital or acquired organic diseases (such as aortic stenosis); 2. Known history of drug abuse; 3. Pregnant and lactating women; 4. With clinical history of psychiatric diseases (such as schizophrenia). |
Other: No intervention will be applied.
This is an observational study.
|
Outcome Measures
Primary Outcome Measures
- Blood pressure (both Systolic and Diastolic Blood Pressure) [every two years up to 30 years]
- BMI (body mass index) [every two years up to 30 years]
Secondary Outcome Measures
- blood glucose level [every two years up to 30 years]
- Cervical vascular ultrasound [every two years up to 30 years]
- Abdominal ultrasound [every two years up to 30 years]
- White matter hyperintensity of the brain measured by MRI (magnetic resonance imaging) [every two years up to 30 years]
- microbleeds of the brain measured by MRI (magnetic resonance imaging) [every two years up to 30 years]
- Lacunes of the brain measured by MRI (magnetic resonance imaging) [every two years up to 30 years]
- Brain volume measured by MRI (magnetic resonance imaging) [every two years up to 30 years]
- White matter microstructural integrity of the brain measured by MRI (magnetic resonance imaging) [every two years up to 30 years]
- Cerebral blood flow measured by MRI (magnetic resonance imaging) [every two years up to 30 years]
- Fundus color photography of the eyes [every two years up to 30 years]
- Fundus optical coherence tomography (OCT) [every two years up to 30 years]
Other Outcome Measures
- Pulse Wave Velocity, PWV [every two years up to 30 years]
- Lipoprotein [every two years up to 30 years]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Age from 18 to 90 years old;
-
Comes from the Kailuan Cohort, completed ≥1 visits which the medical history, physiological indicators were measured;
-
Without contraindications of CT and MR scan;
-
Can cooperate with the measurement of the medical history, physiological indicators and brain imaging.
Exclusion Criteria:
-
Known clinical history with congenital or acquired organic diseases (such as aortic stenosis);
-
Known history of drug abuse;
-
Pregnant and lactating women; 4. With clinical history of psychiatric diseases (such as schizophrenia).
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Beijing Friendship Hospital, Capital Medical University | Beijing | Beijing | China | 100050 |
| 2 | Kailuan General Hospital | Tangshan | Hebei | China | 063000 |
Sponsors and Collaborators
- Beijing Friendship Hospital
- KaiLuan General Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 202201