Clinical Markers of Panic and Generalized Anxiety Disorder
Study Details
Study Description
Brief Summary
The goal of this observational study is to compare socio-demographic and clinical features in patients affected by Generalized Anxiety Disorder (GAD) and by Panic Disorder (PD). The main questions it aims to answer are:
-
which socio-demographic/clinical markers are associated to GAD or PD diagnosis?
-
which factors are associated with a longer duration of untreated illness (DUI) in GAD and in PD? Participants will signed a written informed consent and socio-demographic/clinical variables will be retrospectively collected. Researchers will compare GAD and PD groups in terms of socio-demographic and clinical features, including DUI, to better characterize the two disorders and to investigate factors associated to a longer DUI.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Generalized Anxiety Disorder (GAD) Patients affected by GAD |
Diagnostic Test: Structured Clinical Interview for DSM-5
A structured interview will be administered to confirm the diagnosis reported in clinical charts
|
| Panic Disorder (PD) Patients affected by Panic Disorder |
Diagnostic Test: Structured Clinical Interview for DSM-5
A structured interview will be administered to confirm the diagnosis reported in clinical charts
|
Outcome Measures
Primary Outcome Measures
- Quantitative socio-demographic / clinical variables [Three months]
Age (years), age at onset (years), duration of illness (years), duration of treatment (years)
- Sex [Three months]
Sex (male/female)
- Occupation [Three months]
Occupation (employed/unemployed)
- Pre-/post-onset Comorbidity [Three months]
Psychiatric and medical comorbidity
- Substance misuse [Three months]
Substance misuse
- Treatment [Three months]
Treatment, treatment discontinuation and side effects
- Dichotomous socio-demographic / clinical variables [Three months]
Multiple family history of psychiatric disorders (yes/no), pre- and post-onset psychiatric poly-comorbidities (yes/no), presence of personality disorder (yes/no), pre- and post-onset poly-substance misuse (yes/no), pre- and post-onset medical poly-comorbidities (yes/no), suicide attempts (yes/no), hospitalizations (yes/no), poly-therapy (yes/no), presence of poly-side effects (yes/no), presence of lifetime psychotherapy (yes/no)
Secondary Outcome Measures
- Duration of untreated illness (DUI) in months = time between the onset of PD and the first appropriate pharmacological treatment. [Three months]
Factors associated to DUI among GAD and PD groups. Information about DUI have been registered according to what the patient reported (clinical records and structured interviews)
Eligibility Criteria
Criteria
Inclusion Criteria:
-
age 18-65 years;
-
ability and willing to give informed consent;
-
fluency in Italian language;
-
diagnosis of GAD or PD according to the criteria of the Diagnostic and Statistical Manual of Mental Disorder, 5th edition.
Exclusion Criteria:
-
intellectual disability;
-
lack of clinical and socio-demographic information;
-
patients treated for less than three months in the outpatient clinics for the impossibility of a comprehensive collection of clinical variables.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of Milano Bicocca - Fondazione IRCCS San Gerardo dei Tintori | Monza | MB | Italy | 20900 |
Sponsors and Collaborators
- University of Milano Bicocca
- University of Milan
Investigators
- Principal Investigator: Alice Caldiroli, Doctor, University of Milano Bicocca - Fondazione IRCCS San Gerardo dei Tintori
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- GAD-PD-3955