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A Clinical Model for Dialysis Discontinuation in AKI

Sponsor
University of Sao Paulo General Hospital (Other)
Overall Status
Completed
CT.gov ID
NCT06005896
Collaborator
(none)
124
Enrollment
1
Location
16
Actual Duration (Months)
7.7
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

A retrospective study evaluating AKI patients in whom RRT was interrupted for at least 48 hours. Patients who were still RRT-independent 7 days after initial RRT cessation were included in the "Success" group, as opposed to the "Failure" group. Baseline characteristics and variables at the time of RRT interruption were collected. Multivariable analysis was performed and a model was generated to evaluate the prediction of success.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    124 participants
    Observational Model:
    Cohort
    Time Perspective:
    Retrospective
    Official Title:
    A Clinical Model to Predict Successful Renal Replacement Therapy (RRT) Discontinuation in Patients With Acute Kidney Injury (AKI)
    Actual Study Start Date :
    Oct 1, 2020
    Actual Primary Completion Date :
    Feb 1, 2022
    Actual Study Completion Date :
    Feb 1, 2022

    Arms and Interventions

    Arm Intervention/Treatment
    Success

    Patients who were alive and free from RRT 7 days after interrupting RRT.
    Failure

    Patients who were not alive or who needed to dialyse again after interrupting RRT for at least 48h.

    Outcome Measures

    Primary Outcome Measures

    1. Success in RRT discontinuation [7 days]

      To be alive and free from RRT 7 days after interrupting RRT.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    • All patients receiving kidney replacement therapy due to AKI from October 2020 to February 2022 were considered for inclusion in the study. Patients who managed to remain at least 48 consecutive hours without receiving kidney replacement therapy prescription were included.
    Exclusion Criteria:
    • Patients who had kidney replacement therapy interrupted exclusively due to haemodynamic instability, death or decision for palliative care were excluded.

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 University of São Paulo School of Medicine São Paulo SP Brazil 01246903

    Sponsors and Collaborators

    • University of Sao Paulo General Hospital

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    University of Sao Paulo General Hospital
    ClinicalTrials.gov Identifier:
    NCT06005896
    Other Study ID Numbers:
    • 51678521.0.0000.0068
    First Posted:
    Aug 23, 2023
    Last Update Posted:
    Aug 23, 2023
    Last Verified:
    Aug 1, 2023
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Additional relevant MeSH terms:
    Acute Kidney Injury

    Study Results

    No Results Posted as of Aug 23, 2023