Clinical and Molecular Characterization of Familial Microsatellite Stable Colorectal Cancer
Sponsor
Radboud University Medical Center (Other)
Overall Status
Unknown status
CT.gov ID
NCT00220246
Collaborator
(none)
130
1
54
2.4
Study Details
Study Description
Brief Summary
Two major genetic pathways leading to colorectal carcinoma can well be distinguished; the 'suppressor pathway', which is characterized by inactivation of tumor-suppressor genes and the 'mutator pathway', which is characterized by microsatellite instability. The purpose of this study is to explore a third putative pathway; microsatellite and chromosome stable colorectal cancer where an alternative cancer-causative mechanism might play a role.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
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Detailed Description
Patients with familial colorectal cancer will be characterized with respect to family history, medical history and demographic characteristics. The histopathology of the tumors will be reviewed. Tumor specimens will be analysed on molecular defects.
Study Design
Study Type:
Observational
Observational Model:
Defined Population
Time Perspective:
Retrospective
Study Start Date
:
Mar 1, 2004
Study Completion Date
:
Sep 1, 2008
Outcome Measures
Primary Outcome Measures
Eligibility Criteria
Criteria
Ages Eligible for Study:
N/A
to 51 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
- Colorectal cancer before the age of 51 years
Microsatellite stable tumor
Exclusion Criteria:
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Radboud University | Nijmegen | Netherlands |
Sponsors and Collaborators
- Radboud University Medical Center
Investigators
- Principal Investigator: Nicoline Hoogerbrugge, MD, PhD, Department of Human Genetics, Radboud University Nijmegen Medical Center
Study Documents (Full-Text)
None provided.More Information
Publications
- Chan TL, Curtis LC, Leung SY, Farrington SM, Ho JW, Chan AS, Lam PW, Tse CW, Dunlop MG, Wyllie AH, Yuen ST. Early-onset colorectal cancer with stable microsatellite DNA and near-diploid chromosomes. Oncogene. 2001 Aug 9;20(35):4871-6.
- Georgiades IB, Curtis LJ, Morris RM, Bird CC, Wyllie AH. Heterogeneity studies identify a subset of sporadic colorectal cancers without evidence for chromosomal or microsatellite instability. Oncogene. 1999 Dec 23;18(56):7933-40.
- Hawkins NJ, Tomlinson I, Meagher A, Ward RL. Microsatellite-stable diploid carcinoma: a biologically distinct and aggressive subset of sporadic colorectal cancer. Br J Cancer. 2001 Jan;84(2):232-6.
Responsible Party:
,
,
ClinicalTrials.gov Identifier:
NCT00220246
Other Study ID Numbers:
- EOMSD2004
First Posted:
Sep 22, 2005
Last Update Posted:
Mar 1, 2007
Last Verified:
Feb 1, 2007
Keywords provided by ,
,
Additional relevant MeSH terms: