Clinical-pathological Characterization and Outcomes of Renal Cell Carcinoma in Latin American
Study Details
Study Description
Brief Summary
Observational, retrospective and prospective, analytical study. Data will be collected from medical records and/or contact with physicians and institutions (secondary collection and data). Patients who are included retrospectively or prospectively will be followed up during the data collection period to assess treatments and survival. No intervention is provided for in this protocol
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Patients with pathological diagnosis of renal cell carcinoma
|
Other: Renal cell carcinoma
Clinical-pathological characterization and outcomes of renal cell carcinoma in Latin America
|
Outcome Measures
Primary Outcome Measures
- Build a real-life renal cell cancer database in Brazil and Latin America [2022]
Secondary Outcome Measures
- Sociodemographic characteristics checklist [2022]
Describe sociodemographic characteristics: age at diagnosis, race, education, family income, occupation, personal habits, family history, comorbidities, treatment funding (public or private), treatment institution (public, private or philanthropic).
- Clinicopathological characteristics of patients with renal cell cancer checklist [2022]
date of onset of symptoms, pre-treatment symptoms, histology, clinical and pathological stage, performance status, tests used in staging, date of diagnosis, site of metastases, complications clinics.
- Characteristics of systemic treatment checklist [2022]
date of biopsy; dates, type and lines of drug treatment.
- Time between diagnosis and start of treatment. [2022]
Characteristics of systemic treatment checklist
- Causes of delay or discontinuation of each treatment checklist [2022]
Characteristics of systemic treatment
- Progression-free survival in each therapeutic line [2022]
- Overall survival [2022]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Patients ≥ 18 years of age;
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Proven histology of renal cell carcinoma (any subtype);
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Pathological diagnosis of renal cell carcinoma in January 2015 or later and new cases diagnosed during the period of recruitment of each center;
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Have the medical record available and suitable for collecting data on patient characteristics, treatment and outcome;
Exclusion Criteria:
- Synchronous or other primary tumor within the last 3 years (except thyroid cancer or non-melanoma skin).
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Centro de Pesquisa em Oncologia | Porto Alegre | Rio Grande Do Sul | Brazil | 90619900 |
Sponsors and Collaborators
- Latin American Cooperative Oncology Group
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- Goss PE, Lee BL, Badovinac-Crnjevic T, Strasser-Weippl K, Chavarri-Guerra Y, St Louis J, Villarreal-Garza C, Unger-Saldaña K, Ferreyra M, Debiasi M, Liedke PE, Touya D, Werutsky G, Higgins M, Fan L, Vasconcelos C, Cazap E, Vallejos C, Mohar A, Knaul F, Arreola H, Batura R, Luciani S, Sullivan R, Finkelstein D, Simon S, Barrios C, Kightlinger R, Gelrud A, Bychkovsky V, Lopes G, Stefani S, Blaya M, Souza FH, Santos FS, Kaemmerer A, de Azambuja E, Zorilla AF, Murillo R, Jeronimo J, Tsu V, Carvalho A, Gil CF, Sternberg C, Dueñas-Gonzalez A, Sgroi D, Cuello M, Fresco R, Reis RM, Masera G, Gabús R, Ribeiro R, Knust R, Ismael G, Rosenblatt E, Roth B, Villa L, Solares AL, Leon MX, Torres-Vigil I, Covarrubias-Gomez A, Hernández A, Bertolino M, Schwartsmann G, Santillana S, Esteva F, Fein L, Mano M, Gomez H, Hurlbert M, Durstine A, Azenha G. Planning cancer control in Latin America and the Caribbean. Lancet Oncol. 2013 Apr;14(5):391-436. doi: 10.1016/S1470-2045(13)70048-2.
- Khozin S, Blumenthal GM, Pazdur R. Real-world Data for Clinical Evidence Generation in Oncology. J Natl Cancer Inst. 2017 Nov 1;109(11). doi: 10.1093/jnci/djx187.
- Strasser-Weippl K, Chavarri-Guerra Y, Villarreal-Garza C, Bychkovsky BL, Debiasi M, Liedke PE, Soto-Perez-de-Celis E, Dizon D, Cazap E, de Lima Lopes G Jr, Touya D, Nunes JS, St Louis J, Vail C, Bukowski A, Ramos-Elias P, Unger-Saldaña K, Brandao DF, Ferreyra ME, Luciani S, Nogueira-Rodrigues A, de Carvalho Calabrich AF, Del Carmen MG, Rauh-Hain JA, Schmeler K, Sala R, Goss PE. Progress and remaining challenges for cancer control in Latin America and the Caribbean. Lancet Oncol. 2015 Oct;16(14):1405-38. doi: 10.1016/S1470-2045(15)00218-1. Review.
- Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4.
- LACOG 1120