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Testing the Addition of Radiotherapy to the Usual Treatment (Chemotherapy) for Patients With Esophageal and Gastric Cancer That Has Spread to a Limited Number of Other Places in the Body

Sponsor
ECOG-ACRIN Cancer Research Group (Other)
Overall Status
Recruiting
CT.gov ID
NCT04248452
Collaborator
National Cancer Institute (NCI) (NIH)
314
Enrollment
381
Locations
6
Arms
46.8
Anticipated Duration (Months)
0.8
Patients Per Site
0
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This phase III trial studies how well the addition of radiotherapy to the usual treatment (chemotherapy) works compared to the usual treatment alone in treating patients with esophageal and gastric cancer that has spread to a limited number of other places in the body (oligometastatic disease). Radiotherapy uses high energy x-rays, gamma rays, or protons to kill tumor cells and shrink tumors. Drugs used in usual chemotherapy, such as leucovorin, 5-fluorouracil, oxaliplatin, and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Adding radiotherapy to the usual chemotherapy may work better compared to the usual chemotherapy alone in treating patients with esophageal and gastric cancer.

Condition or Disease Intervention/Treatment Phase
Phase 3

Detailed Description

PRIMARY OBJECTIVE:
  1. To establish superiority of consolidative radiation therapy over continuation of systemic therapy alone in patients with oligometastatic esophageal and gastric adenocarcinoma (EGA) that does not progress on first-line therapy.
OUTLINE:

STEP 1 (INDUCTION PHASE): Patients are assigned to 1 of 2 arms.

ARM A: Patients receive oxaliplatin intravenously (IV) over 1.5 hours, leucovorin IV over 1.5 hours, and 5-fluorouracil IV over 46-48 hours on days 1 and 15. Treatment repeats every 28 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity.

ARM B: Patients receive oxaliplatin IV over 2 hours on day 1 and capecitabine orally (PO) twice daily (BID) on days 1-14. Treatment repeats every 21 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity.

STEP 2: Patients are randomized to 1 of 4 arms.

ARM C: One week post induction of patients in ARM A, patients undergo radiation therapy for up to 15 days. Within 2-4 weeks post radiation therapy, patients receive oxaliplatin, leucovorin, and 5-fluorouracil as in Arm A for 2 years in the absence of disease progression or unacceptable toxicity.

ARM D: Post induction of patients in ARM A, patients continue oxaliplatin, leucovorin, and 5-fluorouracil as in Arm A for 2 years in the absence of disease progression or unacceptable toxicity.

ARM E: One week post induction of patients in ARM B, patients undergo radiation therapy for up to 15 days. Within 2-4 weeks post radiation therapy, patients receive oxaliplatin and capecitabine as in Arm B for 2 years in the absence of disease progression or unacceptable toxicity.

ARM F: Post induction of patients in ARM B, patients continue oxaliplatin and capecitabine as in Arm B for 2 years in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up periodically for up to 5 years from study entry. Patients experiencing disease progression are followed up every 3 months in years 1-2, and then every 6 months for up to 5 years from study entry.

Study Design

Study Type:
Interventional
Anticipated Enrollment :
314 participants
Allocation:
Randomized
Intervention Model:
Sequential Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
A Phase III Study of Consolidative Radiotherapy in Patients With Oligometastatic HER2 Negative Esophageal and Gastric Adenocarcinoma (EGA)
Actual Study Start Date :
Feb 6, 2020
Anticipated Primary Completion Date :
Dec 31, 2023
Anticipated Study Completion Date :
Dec 31, 2023

Arms and Interventions

Arm Intervention/Treatment
Experimental: Arm A (FOLXFOX)

Patients receive oxaliplatin IV over 1.5 hours, leucovorin IV over 1.5 hours, and 5-fluorouracil IV over 46-48 hours on days 1 and 15. Treatment repeats every 28 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity.

Drug: Fluorouracil
Given IV
Other Names:
  • 5 Fluorouracil
  • 5 Fluorouracilum
  • 5 FU
  • 5-Fluoro-2,4(1H, 3H)-pyrimidinedione
  • 5-Fluorouracil
  • 5-Fluracil
  • 5-FU
  • 5FU
  • AccuSite
  • Carac
  • Fluoro Uracil
  • Fluouracil
  • Flurablastin
  • Fluracedyl
  • Fluracil
  • Fluril
  • Fluroblastin
  • Ribofluor
  • Ro 2-9757
  • Ro-2-9757

    • Drug: Leucovorin
    Given IV
    Other Names:
  • folinic acid

    • Drug: Leucovorin Calcium
    Given IV
    Other Names:
  • Adinepar
  • Calcifolin
  • Calcium (6S)-Folinate
  • Calcium Folinate
  • Calcium Leucovorin
  • Calfolex
  • Calinat
  • Cehafolin
  • Citofolin
  • Citrec
  • Citrovorum Factor
  • Cromatonbic Folinico
  • Dalisol
  • Disintox
  • Divical
  • Ecofol
  • Emovis
  • Factor, Citrovorum
  • Flynoken A
  • Folaren
  • Folaxin
  • FOLI-cell
  • Foliben
  • Folidan
  • Folidar
  • Folinac
  • Folinate Calcium
  • folinic acid
  • Folinic Acid Calcium Salt Pentahydrate
  • Folinoral
  • Folinvit
  • Foliplus
  • Folix
  • Imo
  • Lederfolat
  • Lederfolin
  • Leucosar
  • leucovorin
  • Rescufolin
  • Rescuvolin
  • Tonofolin
  • Wellcovorin

    • Drug: Oxaliplatin
    Given IV
    Other Names:
  • 1-OHP
  • Ai Heng
  • Aiheng
  • Dacotin
  • Dacplat
  • Diaminocyclohexane Oxalatoplatinum
  • Eloxatin
  • Eloxatine
  • JM-83
  • Oxalatoplatin
  • Oxalatoplatinum
  • RP 54780
  • RP-54780
  • SR-96669

    		•
    Experimental: Arm B (CAPOX)

    Patients receive oxaliplatin IV over 2 hours on day 1 and capecitabine PO BID on days 1-14. Treatment repeats every 21 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity.

    Drug: Capecitabine
    Given PO
    Other Names:
  • Ro 09-1978/000
  • Xeloda

    • Drug: Oxaliplatin
    Given IV
    Other Names:
  • 1-OHP
  • Ai Heng
  • Aiheng
  • Dacotin
  • Dacplat
  • Diaminocyclohexane Oxalatoplatinum
  • Eloxatin
  • Eloxatine
  • JM-83
  • Oxalatoplatin
  • Oxalatoplatinum
  • RP 54780
  • RP-54780
  • SR-96669

    		•
    Experimental: Arm C (radiation therapy, FOLFOX)

    One week post induction of patients in ARM A, patients undergo radiation therapy for up to 15 days. Within 2-4 weeks post radiation therapy, patients receive oxaliplatin, leucovorin, and 5-fluorouracil as in Arm A for 2 years in the absence of disease progression or unacceptable toxicity.

    Drug: Fluorouracil
    Given IV
    Other Names:
  • 5 Fluorouracil
  • 5 Fluorouracilum
  • 5 FU
  • 5-Fluoro-2,4(1H, 3H)-pyrimidinedione
  • 5-Fluorouracil
  • 5-Fluracil
  • 5-FU
  • 5FU
  • AccuSite
  • Carac
  • Fluoro Uracil
  • Fluouracil
  • Flurablastin
  • Fluracedyl
  • Fluracil
  • Fluril
  • Fluroblastin
  • Ribofluor
  • Ro 2-9757
  • Ro-2-9757

    • Drug: Leucovorin
    Given IV
    Other Names:
  • folinic acid

    • Drug: Leucovorin Calcium
    Given IV
    Other Names:
  • Adinepar
  • Calcifolin
  • Calcium (6S)-Folinate
  • Calcium Folinate
  • Calcium Leucovorin
  • Calfolex
  • Calinat
  • Cehafolin
  • Citofolin
  • Citrec
  • Citrovorum Factor
  • Cromatonbic Folinico
  • Dalisol
  • Disintox
  • Divical
  • Ecofol
  • Emovis
  • Factor, Citrovorum
  • Flynoken A
  • Folaren
  • Folaxin
  • FOLI-cell
  • Foliben
  • Folidan
  • Folidar
  • Folinac
  • Folinate Calcium
  • folinic acid
  • Folinic Acid Calcium Salt Pentahydrate
  • Folinoral
  • Folinvit
  • Foliplus
  • Folix
  • Imo
  • Lederfolat
  • Lederfolin
  • Leucosar
  • leucovorin
  • Rescufolin
  • Rescuvolin
  • Tonofolin
  • Wellcovorin

    • Drug: Oxaliplatin
    Given IV
    Other Names:
  • 1-OHP
  • Ai Heng
  • Aiheng
  • Dacotin
  • Dacplat
  • Diaminocyclohexane Oxalatoplatinum
  • Eloxatin
  • Eloxatine
  • JM-83
  • Oxalatoplatin
  • Oxalatoplatinum
  • RP 54780
  • RP-54780
  • SR-96669

    • Radiation: Radiation Therapy
    Undergo radiation therapy
    Other Names:
  • Cancer Radiotherapy
  • Irradiate
  • irradiated
  • Irradiation
  • RADIATION
  • Radiation Therapy, NOS
  • Radiotherapeutics
  • RADIOTHERAPY
  • RT
  • Therapy, Radiation

    		•
    Active Comparator: Arm D (FOLFOX)

    Post induction of patients in ARM A, patients continue oxaliplatin, leucovorin, and 5-fluorouracil as in Arm A for 2 years in the absence of disease progression or unacceptable toxicity.

    Drug: Fluorouracil
    Given IV
    Other Names:
  • 5 Fluorouracil
  • 5 Fluorouracilum
  • 5 FU
  • 5-Fluoro-2,4(1H, 3H)-pyrimidinedione
  • 5-Fluorouracil
  • 5-Fluracil
  • 5-FU
  • 5FU
  • AccuSite
  • Carac
  • Fluoro Uracil
  • Fluouracil
  • Flurablastin
  • Fluracedyl
  • Fluracil
  • Fluril
  • Fluroblastin
  • Ribofluor
  • Ro 2-9757
  • Ro-2-9757

    • Drug: Leucovorin
    Given IV
    Other Names:
  • folinic acid

    • Drug: Leucovorin Calcium
    Given IV
    Other Names:
  • Adinepar
  • Calcifolin
  • Calcium (6S)-Folinate
  • Calcium Folinate
  • Calcium Leucovorin
  • Calfolex
  • Calinat
  • Cehafolin
  • Citofolin
  • Citrec
  • Citrovorum Factor
  • Cromatonbic Folinico
  • Dalisol
  • Disintox
  • Divical
  • Ecofol
  • Emovis
  • Factor, Citrovorum
  • Flynoken A
  • Folaren
  • Folaxin
  • FOLI-cell
  • Foliben
  • Folidan
  • Folidar
  • Folinac
  • Folinate Calcium
  • folinic acid
  • Folinic Acid Calcium Salt Pentahydrate
  • Folinoral
  • Folinvit
  • Foliplus
  • Folix
  • Imo
  • Lederfolat
  • Lederfolin
  • Leucosar
  • leucovorin
  • Rescufolin
  • Rescuvolin
  • Tonofolin
  • Wellcovorin

    • Drug: Oxaliplatin
    Given IV
    Other Names:
  • 1-OHP
  • Ai Heng
  • Aiheng
  • Dacotin
  • Dacplat
  • Diaminocyclohexane Oxalatoplatinum
  • Eloxatin
  • Eloxatine
  • JM-83
  • Oxalatoplatin
  • Oxalatoplatinum
  • RP 54780
  • RP-54780
  • SR-96669

    		•
    Experimental: Arm E (radiation therapy, CAPOX)

    One week post induction of patients in ARM B, patients undergo radiation therapy for up to 15 days. Within 2-4 weeks post radiation therapy, patients receive oxaliplatin and capecitabine as in Arm B for 2 years in the absence of disease progression or unacceptable toxicity.

    Drug: Capecitabine
    Given PO
    Other Names:
  • Ro 09-1978/000
  • Xeloda

    • Drug: Oxaliplatin
    Given IV
    Other Names:
  • 1-OHP
  • Ai Heng
  • Aiheng
  • Dacotin
  • Dacplat
  • Diaminocyclohexane Oxalatoplatinum
  • Eloxatin
  • Eloxatine
  • JM-83
  • Oxalatoplatin
  • Oxalatoplatinum
  • RP 54780
  • RP-54780
  • SR-96669

    • Radiation: Radiation Therapy
    Undergo radiation therapy
    Other Names:
  • Cancer Radiotherapy
  • Irradiate
  • irradiated
  • Irradiation
  • RADIATION
  • Radiation Therapy, NOS
  • Radiotherapeutics
  • RADIOTHERAPY
  • RT
  • Therapy, Radiation

    		•
    Active Comparator: Arm F (CAPOX)

    Post induction of patients in ARM B, patients continue oxaliplatin and capecitabine as in Arm B for 2 years in the absence of disease progression or unacceptable toxicity.

    Drug: Capecitabine
    Given PO
    Other Names:
  • Ro 09-1978/000
  • Xeloda

    • Drug: Oxaliplatin
    Given IV
    Other Names:
  • 1-OHP
  • Ai Heng
  • Aiheng
  • Dacotin
  • Dacplat
  • Diaminocyclohexane Oxalatoplatinum
  • Eloxatin
  • Eloxatine
  • JM-83
  • Oxalatoplatin
  • Oxalatoplatinum
  • RP 54780
  • RP-54780
  • SR-96669

    		•

    Outcome Measures

    Primary Outcome Measures

    1. Overall survival [From the time of randomization, assessed up to 5 years post treatment]

    Secondary Outcome Measures

    1. Incidence of adverse events [Up to 5 years post treatment]

      Toxicity will be evaluated in all treated subjects. All toxicity grades and all reportable adverse events will be graded using the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 5.0.

    2. Progression-free survival [From the time of randomization, assessed up to 5 years post treatment]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • REGISTRATION TO STEP 1

    • Patient must have histologically confirmed HER2 negative metastatic esophageal or gastric adenocarcinoma (American Joint Committee on Cancer [AJCC] 8th edition)

    • Patient must have oligometastatic disease at the time of registration, which is defined as the following:

    • At most 3 radiologically visible metastatic lesions (not sites), in addition to the primary site. Computed tomography (CT) or magnetic resonance imaging (MRI) scans will be performed for staging purposes. Patients with oligometastatic sites that are only detected with positron emission tomography (PET)/CT will be eligible for participation, as long as radiation planning and administration is feasible after discussion with treating radiation oncologist. Malignant lymph node should be at least 1 cm in size or biopsy proven involved by disease

    • Anatomically defined lymphadenopathy will be considered as 1 site of metastatic disease. For example, 2 enlarged paraaortic lymph nodes will be considered as one site, and 2 additional sites will be allowed to meet protocol definition of oligometastatic disease. However, if supraclavicular or cervical nodes are involved for distal esophageal tumors or gastric tumors, these are counted separately from intrathoracic nodes. For upper thoracic/cervical esophageal tumors, the involvement of celiac nodes are counted separately from intrathoracic nodes. Intrathoracic nodes, defined as hilar and mediastinal nodes, will be collectively counted as one

    • Patients with radiologically evident peritoneal metastasis will be excluded.

    • Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-1

    • Women of childbearing potential and sexually active males must not expect to conceive or father children by using accepted and effective method(s) of contraception (both double barrier contraception and birth control pills or implants) or by abstaining from sexual intercourse for at least one month after the last dose of protocol treatment and continuing for 5 months after the last dose of protocol treatment (for female patients) and for 7 months after the last dose of protocol treatment (for male patients who are sexually active with women of child bearing potential [WOCBP]). Investigators must counsel WOCBP and male patients who are sexually active with WOCBP on the importance of pregnancy prevention and the implications of an unexpected pregnancy

    • Absolute neutrophil count (ANC) >= 1.5 x 10^9/L (obtained within 28 days prior to registration)

    • Hemoglobin >= 8 g/dL (obtained within 28 days prior to registration)

    • Platelets (PLT) >= 100 x 10^9/L (obtained within 28 days prior to registration)

    • Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3.0 x upper limit of normal (ULN) (obtained within 28 days prior to registration)

    • Bilirubin =< 1.5 x institutional ULN (obtained within 28 days prior to registration)

    • Serum creatinine =< 1.5 x institutional ULN (Cockcroft and Gault formula) (obtained within 28 days prior to registration)

    • Albumin > 2.5 g/dL (obtained within 28 days prior to registration)

    • Patient must be able to understand and willing to sign and date the written voluntary informed consent form prior to any protocol-specific procedures

    • Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial. Patients must have CD4 > 200 at the time of registration

    • NOTE: HIV testing is not required for eligibility

    • Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial

    • Patients who had prior definitive treatment for early stage EGA with either surgery or chemoradiation are eligible for participation as long as recurrent disease developed at least 6 months after completion of all prior therapies

    • Any major surgery must have been completed >= 4 weeks prior to registration

    • REGISTRATION TO STEP 2

    • Patient must have histologically confirmed HER2 negative metastatic esophageal or gastric adenocarcinoma (AJCC 8th edition) with stable disease after about 4 months of fluorouracil, leucovorin calcium, and oxaliplatin (FOLFOX) or 6 cycles of capecitabine and oxaliplatin (CAPOX) (Step 1 treatment)

    • Patient must have no evidence of disease progression based on Response Evaluation Criteria in Solid Tumors (RECIST) criteria since Step 1 registration. Patients with complete radiologic response are eligible for Step 2

    • Patient must have an ECOG performance status 0-1

    Exclusion Criteria:

    • Patient must not have any contraindications to 5-fluorouracil (5-FU) or capecitabine, oxaliplatin

    • Patient must not have any contraindications to radiation therapy based on consultation with a radiation oncologist. Formal radiation oncology evaluation will be required for eligibility purposes. Prior palliative or definitive radiation to the primary site is allowed, as long as it was completed at least 2 weeks before registration

    • Women must not be pregnant or breast-feeding due to the potential harm to unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used

    • All females of child bearing potential must have a serum or urine pregnancy test to rule out pregnancy within 14 days prior to registration

    • A female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: has achieved menarche at some point, has not undergone a hysterectomy or bilateral oophorectomy; or has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)

    • Patient must not have had any prior treatment with 5-FU or capecitabine and/or oxaliplatin containing systemic therapy

    • NOTE: Patients previously treated with radiosensitizing doses of 5-FU will be eligible for participation as long as adequate time has elapsed from past treatments

    • NOTE: Patients who received systemic 5-FU or capecitabine and/or oxaliplatin as part of the treatment for their locoregional disease are eligible for participation, as long as all definitive therapy has been completed at least 6 months prior to trial enrollment

    • Patients with known central nervous system (CNS) metastasis will be excluded from trial participation, regardless of the status of the CNS disease

    • Patient must not have any uncontrolled intercurrent illness including, but not limited to ongoing or active infection requiring treatment, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements

    • Patient must not have had live vaccines within 30 days prior to registration. Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, yellow fever, rabies, Bacillus Calmette Guerin (BCG), and typhoid (oral) vaccine. Seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines and are not allowed

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Anchorage Associates in Radiation Medicine Anchorage Alaska United States 98508
    2 Anchorage Radiation Therapy Center Anchorage Alaska United States 99504
    3 Alaska Breast Care and Surgery LLC Anchorage Alaska United States 99508
    4 Alaska Oncology and Hematology LLC Anchorage Alaska United States 99508
    5 Alaska Women's Cancer Care Anchorage Alaska United States 99508
    6 Anchorage Oncology Centre Anchorage Alaska United States 99508
    7 Katmai Oncology Group Anchorage Alaska United States 99508
    8 Providence Alaska Medical Center Anchorage Alaska United States 99508
    9 Kingman Regional Medical Center Kingman Arizona United States 86401
    10 Mercy Hospital Fort Smith Fort Smith Arkansas United States 72903
    11 PCR Oncology Arroyo Grande California United States 93420
    12 Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank California United States 91505
    13 Salinas Valley Memorial Salinas California United States 93901
    14 Holy Cross Hospital Fort Lauderdale Florida United States 33308
    15 Saint Alphonsus Cancer Care Center-Boise Boise Idaho United States 83706
    16 Saint Luke's Cancer Institute - Boise Boise Idaho United States 83712
    17 Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho United States 83605
    18 Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho United States 83814
    19 Walter Knox Memorial Hospital Emmett Idaho United States 83617
    20 Saint Luke's Cancer Institute - Fruitland Fruitland Idaho United States 83619
    21 Idaho Urologic Institute-Meridian Meridian Idaho United States 83642
    22 Saint Luke's Cancer Institute - Meridian Meridian Idaho United States 83642
    23 Saint Alphonsus Medical Center-Nampa Nampa Idaho United States 83686
    24 Saint Luke's Cancer Institute - Nampa Nampa Idaho United States 83686
    25 Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho United States 83854
    26 Kootenai Cancer Clinic Sandpoint Idaho United States 83864
    27 Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho United States 83301
    28 Saint Anthony's Health Alton Illinois United States 62002
    29 Rush - Copley Medical Center Aurora Illinois United States 60504
    30 Illinois CancerCare-Bloomington Bloomington Illinois United States 61704
    31 Illinois CancerCare-Canton Canton Illinois United States 61520
    32 Memorial Hospital of Carbondale Carbondale Illinois United States 62902
    33 SIH Cancer Institute Carterville Illinois United States 62918
    34 Illinois CancerCare-Carthage Carthage Illinois United States 62321
    35 Centralia Oncology Clinic Centralia Illinois United States 62801
    36 Northwestern University Chicago Illinois United States 60611
    37 University of Illinois Chicago Illinois United States 60612
    38 Carle on Vermilion Danville Illinois United States 61832
    39 Cancer Care Specialists of Illinois - Decatur Decatur Illinois United States 62526
    40 Decatur Memorial Hospital Decatur Illinois United States 62526
    41 Northwestern Medicine Cancer Center Kishwaukee DeKalb Illinois United States 60115
    42 Illinois CancerCare-Dixon Dixon Illinois United States 61021
    43 Carle Physician Group-Effingham Effingham Illinois United States 62401
    44 Crossroads Cancer Center Effingham Illinois United States 62401
    45 Illinois CancerCare-Eureka Eureka Illinois United States 61530
    46 Illinois CancerCare-Galesburg Galesburg Illinois United States 61401
    47 Western Illinois Cancer Treatment Center Galesburg Illinois United States 61401
    48 Northwestern Medicine Cancer Center Delnor Geneva Illinois United States 60134
    49 Loyola Medicine Homer Glen Homer Glen Illinois United States 60491
    50 Illinois CancerCare-Kewanee Clinic Kewanee Illinois United States 61443
    51 Northwestern Medicine Lake Forest Hospital Lake Forest Illinois United States 60045
    52 Illinois CancerCare-Macomb Macomb Illinois United States 61455
    53 Carle Physician Group-Mattoon/Charleston Mattoon Illinois United States 61938
    54 Loyola University Medical Center Maywood Illinois United States 60153
    55 Marjorie Weinberg Cancer Center at Loyola-Gottlieb Melrose Park Illinois United States 60160
    56 Good Samaritan Regional Health Center Mount Vernon Illinois United States 62864
    57 Cancer Care Center of O'Fallon O'Fallon Illinois United States 62269
    58 Illinois CancerCare-Ottawa Clinic Ottawa Illinois United States 61350
    59 Illinois CancerCare-Pekin Pekin Illinois United States 61554
    60 OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center Pekin Illinois United States 61554
    61 Illinois CancerCare-Peoria Peoria Illinois United States 61615
    62 OSF Saint Francis Radiation Oncology at Peoria Cancer Center Peoria Illinois United States 61615
    63 Methodist Medical Center of Illinois Peoria Illinois United States 61636
    64 OSF Saint Francis Medical Center Peoria Illinois United States 61637
    65 Illinois CancerCare-Peru Peru Illinois United States 61354
    66 Valley Radiation Oncology Peru Illinois United States 61354
    67 Illinois CancerCare-Princeton Princeton Illinois United States 61356
    68 Southern Illinois University School of Medicine Springfield Illinois United States 62702
    69 Springfield Clinic Springfield Illinois United States 62702
    70 Memorial Medical Center Springfield Illinois United States 62781
    71 Southwest Illinois Health Services LLP Swansea Illinois United States 62226
    72 Carle Cancer Center Urbana Illinois United States 61801
    73 The Carle Foundation Hospital Urbana Illinois United States 61801
    74 Northwestern Medicine Cancer Center Warrenville Warrenville Illinois United States 60555
    75 Illinois CancerCare - Washington Washington Illinois United States 61571
    76 Rush-Copley Healthcare Center Yorkville Illinois United States 60560
    77 Reid Health Richmond Indiana United States 47374
    78 Saint Anthony Regional Hospital Carroll Iowa United States 51401
    79 Iowa Methodist Medical Center Des Moines Iowa United States 50309
    80 Medical Oncology and Hematology Associates-Des Moines Des Moines Iowa United States 50309
    81 Broadlawns Medical Center Des Moines Iowa United States 50314
    82 Iowa Lutheran Hospital Des Moines Iowa United States 50316
    83 Trinity Regional Medical Center Fort Dodge Iowa United States 50501
    84 Methodist West Hospital West Des Moines Iowa United States 50266-7700
    85 Central Care Cancer Center - Garden City Garden City Kansas United States 67846
    86 Central Care Cancer Center - Great Bend Great Bend Kansas United States 67530
    87 MaineHealth Coastal Cancer Treatment Center Bath Maine United States 04530
    88 MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford Biddeford Maine United States 04005
    89 Maine Medical Center-Bramhall Campus Portland Maine United States 04102
    90 MaineHealth Cancer Care Center of York County Sanford Maine United States 04073
    91 MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford Sanford Maine United States 04073
    92 Maine Medical Center- Scarborough Campus Scarborough Maine United States 04074
    93 Maine Medical Partners - South Portland South Portland Maine United States 04106
    94 Mercy Medical Center Springfield Massachusetts United States 01104
    95 Saint Joseph Mercy Hospital Ann Arbor Michigan United States 48106
    96 Bronson Battle Creek Battle Creek Michigan United States 49017
    97 McLaren Cancer Institute-Bay City Bay City Michigan United States 48706
    98 Saint Joseph Mercy Brighton Brighton Michigan United States 48114
    99 Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan United States 48114
    100 Saint Joseph Mercy Canton Canton Michigan United States 48188
    101 Trinity Health IHA Medical Group Hematology Oncology - Canton Canton Michigan United States 48188
    102 Caro Cancer Center Caro Michigan United States 48723
    103 Saint Joseph Mercy Chelsea Chelsea Michigan United States 48118
    104 Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea Michigan United States 48118
    105 Hematology Oncology Consultants-Clarkston Clarkston Michigan United States 48346
    106 McLaren Cancer Institute-Clarkston Clarkston Michigan United States 48346
    107 Newland Medical Associates-Clarkston Clarkston Michigan United States 48346
    108 Wayne State University/Karmanos Cancer Institute Detroit Michigan United States 48201
    109 Ascension Saint John Hospital Detroit Michigan United States 48236
    110 Great Lakes Cancer Management Specialists-Doctors Park East China Township Michigan United States 48054
    111 Weisberg Cancer Treatment Center Farmington Hills Michigan United States 48334
    112 Genesee Cancer and Blood Disease Treatment Center Flint Michigan United States 48503
    113 Genesee Hematology Oncology PC Flint Michigan United States 48503
    114 Genesys Hurley Cancer Institute Flint Michigan United States 48503
    115 Hurley Medical Center Flint Michigan United States 48503
    116 McLaren Cancer Institute-Flint Flint Michigan United States 48532
    117 Singh and Arora Hematology Oncology PC Flint Michigan United States 48532
    118 Helen DeVos Children's Hospital at Spectrum Health Grand Rapids Michigan United States 49503
    119 Mercy Health Saint Mary's Grand Rapids Michigan United States 49503
    120 Spectrum Health at Butterworth Campus Grand Rapids Michigan United States 49503
    121 Academic Hematology Oncology Specialists Grosse Pointe Woods Michigan United States 48236
    122 Great Lakes Cancer Management Specialists-Van Elslander Cancer Center Grosse Pointe Woods Michigan United States 48236
    123 Michigan Breast Specialists-Grosse Pointe Woods Grosse Pointe Woods Michigan United States 48236
    124 Bronson Methodist Hospital Kalamazoo Michigan United States 49007
    125 West Michigan Cancer Center Kalamazoo Michigan United States 49007
    126 Ascension Borgess Cancer Center Kalamazoo Michigan United States 49009
    127 Borgess Medical Center Kalamazoo Michigan United States 49048
    128 Karmanos Cancer Institute at McLaren Greater Lansing Lansing Michigan United States 48910
    129 Mid-Michigan Physicians-Lansing Lansing Michigan United States 48912
    130 Sparrow Hospital Lansing Michigan United States 48912
    131 McLaren Cancer Institute-Lapeer Region Lapeer Michigan United States 48446
    132 Hope Cancer Clinic Livonia Michigan United States 48154
    133 Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan United States 48154
    134 Great Lakes Cancer Management Specialists-Macomb Medical Campus Macomb Michigan United States 48044
    135 Michigan Breast Specialists-Macomb Township Macomb Michigan United States 48044
    136 Saint Mary's Oncology/Hematology Associates of Marlette Marlette Michigan United States 48453
    137 McLaren Cancer Institute-Macomb Mount Clemens Michigan United States 48043
    138 McLaren Cancer Institute-Central Michigan Mount Pleasant Michigan United States 48858
    139 Mercy Health Mercy Campus Muskegon Michigan United States 49444
    140 Lakeland Hospital Niles Niles Michigan United States 49120
    141 Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores Michigan United States 49444
    142 Ascension Providence Hospitals - Novi Novi Michigan United States 48374
    143 McLaren Cancer Institute-Northern Michigan Petoskey Michigan United States 49770
    144 21st Century Oncology-Pontiac Pontiac Michigan United States 48341
    145 Hope Cancer Center Pontiac Michigan United States 48341
    146 Newland Medical Associates-Pontiac Pontiac Michigan United States 48341
    147 Saint Joseph Mercy Oakland Pontiac Michigan United States 48341
    148 McLaren-Port Huron Port Huron Michigan United States 48060
    149 Spectrum Health Reed City Hospital Reed City Michigan United States 49677
    150 Great Lakes Cancer Management Specialists-Rochester Hills Rochester Hills Michigan United States 48309
    151 Ascension Saint Mary's Hospital Saginaw Michigan United States 48601
    152 Oncology Hematology Associates of Saginaw Valley PC Saginaw Michigan United States 48604
    153 Lakeland Medical Center Saint Joseph Saint Joseph Michigan United States 49085
    154 Marie Yeager Cancer Center Saint Joseph Michigan United States 49085
    155 Ascension Providence Hospitals - Southfield Southfield Michigan United States 48075
    156 Bhadresh Nayak MD PC-Sterling Heights Sterling Heights Michigan United States 48312
    157 Ascension Saint Joseph Hospital Tawas City Michigan United States 48764
    158 Munson Medical Center Traverse City Michigan United States 49684
    159 Advanced Breast Care Center PLLC Warren Michigan United States 48088
    160 Great Lakes Cancer Management Specialists-Macomb Professional Building Warren Michigan United States 48093
    161 Macomb Hematology Oncology PC Warren Michigan United States 48093
    162 Michigan Breast Specialists-Warren Warren Michigan United States 48093
    163 Saint John Macomb-Oakland Hospital Warren Michigan United States 48093
    164 Saint Mary's Oncology/Hematology Associates of West Branch West Branch Michigan United States 48661
    165 Metro Health Hospital Wyoming Michigan United States 49519
    166 Huron Gastroenterology PC Ypsilanti Michigan United States 48106
    167 Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan United States 48197
    168 Sanford Joe Lueken Cancer Center Bemidji Minnesota United States 56601
    169 Fairview Ridges Hospital Burnsville Minnesota United States 55337
    170 Minnesota Oncology - Burnsville Burnsville Minnesota United States 55337
    171 Cambridge Medical Center Cambridge Minnesota United States 55008
    172 Mercy Hospital Coon Rapids Minnesota United States 55433
    173 Fairview Southdale Hospital Edina Minnesota United States 55435
    174 Unity Hospital Fridley Minnesota United States 55432
    175 Fairview Clinics and Surgery Center Maple Grove Maple Grove Minnesota United States 55369
    176 Minnesota Oncology Hematology PA-Maplewood Maplewood Minnesota United States 55109
    177 Saint John's Hospital - Healtheast Maplewood Minnesota United States 55109
    178 Abbott-Northwestern Hospital Minneapolis Minnesota United States 55407
    179 Hennepin County Medical Center Minneapolis Minnesota United States 55415
    180 Health Partners Inc Minneapolis Minnesota United States 55454
    181 Monticello Cancer Center Monticello Minnesota United States 55362
    182 New Ulm Medical Center New Ulm Minnesota United States 56073
    183 Fairview Northland Medical Center Princeton Minnesota United States 55371
    184 North Memorial Medical Health Center Robbinsdale Minnesota United States 55422
    185 Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota United States 55416
    186 Regions Hospital Saint Paul Minnesota United States 55101
    187 United Hospital Saint Paul Minnesota United States 55102
    188 Saint Francis Regional Medical Center Shakopee Minnesota United States 55379
    189 Lakeview Hospital Stillwater Minnesota United States 55082
    190 Sanford Thief River Falls Medical Center Thief River Falls Minnesota United States 56701
    191 Ridgeview Medical Center Waconia Minnesota United States 55387
    192 Rice Memorial Hospital Willmar Minnesota United States 56201
    193 Minnesota Oncology Hematology PA-Woodbury Woodbury Minnesota United States 55125
    194 Sanford Cancer Center Worthington Worthington Minnesota United States 56187
    195 Fairview Lakes Medical Center Wyoming Minnesota United States 55092
    196 Saint Louis Cancer and Breast Institute-Ballwin Ballwin Missouri United States 63011
    197 Central Care Cancer Center - Bolivar Bolivar Missouri United States 65613
    198 Cox Cancer Center Branson Branson Missouri United States 65616
    199 Saint Francis Medical Center Cape Girardeau Missouri United States 63703
    200 Southeast Cancer Center Cape Girardeau Missouri United States 63703
    201 Siteman Cancer Center at West County Hospital Creve Coeur Missouri United States 63141
    202 Parkland Health Center - Farmington Farmington Missouri United States 63640
    203 Capital Region Southwest Campus Jefferson City Missouri United States 65109
    204 Freeman Health System Joplin Missouri United States 64804
    205 Mercy Hospital Joplin Joplin Missouri United States 64804
    206 Delbert Day Cancer Institute at PCRMC Rolla Missouri United States 65401
    207 Mercy Clinic-Rolla-Cancer and Hematology Rolla Missouri United States 65401
    208 Heartland Regional Medical Center Saint Joseph Missouri United States 64506
    209 Saint Louis Cancer and Breast Institute-South City Saint Louis Missouri United States 63109
    210 Washington University School of Medicine Saint Louis Missouri United States 63110
    211 Mercy Hospital South Saint Louis Missouri United States 63128
    212 Siteman Cancer Center-South County Saint Louis Missouri United States 63129
    213 Missouri Baptist Medical Center Saint Louis Missouri United States 63131
    214 Siteman Cancer Center at Christian Hospital Saint Louis Missouri United States 63136
    215 Mercy Hospital Saint Louis Saint Louis Missouri United States 63141
    216 Siteman Cancer Center at Saint Peters Hospital Saint Peters Missouri United States 63376
    217 Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri United States 63670
    218 Mercy Hospital Springfield Springfield Missouri United States 65804
    219 CoxHealth South Hospital Springfield Missouri United States 65807
    220 Missouri Baptist Sullivan Hospital Sullivan Missouri United States 63080
    221 Missouri Baptist Outpatient Center-Sunset Hills Sunset Hills Missouri United States 63127
    222 Mercy Hospital Washington Washington Missouri United States 63090
    223 Community Hospital of Anaconda Anaconda Montana United States 59711
    224 Billings Clinic Cancer Center Billings Montana United States 59101
    225 Bozeman Deaconess Hospital Bozeman Montana United States 59715
    226 Benefis Healthcare- Sletten Cancer Institute Great Falls Montana United States 59405
    227 Great Falls Clinic Great Falls Montana United States 59405
    228 Kalispell Regional Medical Center Kalispell Montana United States 59901
    229 Saint Patrick Hospital - Community Hospital Missoula Montana United States 59802
    230 Community Medical Hospital Missoula Montana United States 59804
    231 Carson Tahoe Regional Medical Center Carson City Nevada United States 89703
    232 Cancer and Blood Specialists-Henderson Henderson Nevada United States 89052
    233 Comprehensive Cancer Centers of Nevada - Henderson Henderson Nevada United States 89052
    234 Comprehensive Cancer Centers of Nevada-Horizon Ridge Henderson Nevada United States 89052
    235 Las Vegas Cancer Center-Henderson Henderson Nevada United States 89052
    236 OptumCare Cancer Care at Seven Hills Henderson Nevada United States 89052
    237 Comprehensive Cancer Centers of Nevada-Southeast Henderson Henderson Nevada United States 89074
    238 GenesisCare USA - Henderson Henderson Nevada United States 89074
    239 Las Vegas Urology - Green Valley Henderson Nevada United States 89074
    240 Las Vegas Urology - Pebble Henderson Nevada United States 89074
    241 Urology Specialists of Nevada - Green Valley Henderson Nevada United States 89074
    242 Las Vegas Urology - Pecos Las Vegas Nevada United States 89074
    243 Desert West Surgery Las Vegas Nevada United States 89102
    244 OptumCare Cancer Care at Charleston Las Vegas Nevada United States 89102
    245 University Medical Center of Southern Nevada Las Vegas Nevada United States 89102
    246 Hope Cancer Care of Nevada Las Vegas Nevada United States 89103
    247 Cancer and Blood Specialists-Shadow Las Vegas Nevada United States 89106
    248 Radiation Oncology Centers of Nevada Central Las Vegas Nevada United States 89106
    249 Urology Specialists of Nevada - Central Las Vegas Nevada United States 89106
    250 GenesisCare USA - Las Vegas Las Vegas Nevada United States 89109
    251 HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway Las Vegas Nevada United States 89109
    252 Sunrise Hospital and Medical Center Las Vegas Nevada United States 89109
    253 HealthCare Partners Medical Group Oncology/Hematology-San Martin Las Vegas Nevada United States 89113
    254 Las Vegas Prostate Cancer Center Las Vegas Nevada United States 89113
    255 Las Vegas Urology - Sunset Las Vegas Nevada United States 89113
    256 Urology Specialists of Nevada - Southwest Las Vegas Nevada United States 89113
    257 Radiation Oncology Centers of Nevada Southeast Las Vegas Nevada United States 89119
    258 Ann M Wierman MD LTD Las Vegas Nevada United States 89128
    259 Cancer and Blood Specialists-Tenaya Las Vegas Nevada United States 89128
    260 Comprehensive Cancer Centers of Nevada - Northwest Las Vegas Nevada United States 89128
    261 GenesisCare USA - Vegas Tenaya Las Vegas Nevada United States 89128
    262 HealthCare Partners Medical Group Oncology/Hematology-Tenaya Las Vegas Nevada United States 89128
    263 Las Vegas Urology - Cathedral Rock Las Vegas Nevada United States 89128
    264 Las Vegas Urology - Smoke Ranch Las Vegas Nevada United States 89128
    265 OptumCare Cancer Care at MountainView Las Vegas Nevada United States 89128
    266 Urology Specialists of Nevada - Northwest Las Vegas Nevada United States 89128
    267 Alliance for Childhood Diseases/Cure 4 the Kids Foundation Las Vegas Nevada United States 89135
    268 Comprehensive Cancer Centers of Nevada - Town Center Las Vegas Nevada United States 89144
    269 Comprehensive Cancer Centers of Nevada-Summerlin Las Vegas Nevada United States 89144
    270 Summerlin Hospital Medical Center Las Vegas Nevada United States 89144
    271 Las Vegas Cancer Center-Medical Center Las Vegas Nevada United States 89148-2405
    272 Comprehensive Cancer Centers of Nevada Las Vegas Nevada United States 89148
    273 GenesisCare USA - Fort Apache Las Vegas Nevada United States 89148
    274 OptumCare Cancer Care at Fort Apache Las Vegas Nevada United States 89148
    275 HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills Las Vegas Nevada United States 89149
    276 Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas Nevada United States 89169
    277 University Cancer Center Las Vegas Nevada United States 89169
    278 Hope Cancer Care of Nevada-Pahrump Pahrump Nevada United States 89048
    279 Renown Regional Medical Center Reno Nevada United States 89502
    280 Saint Mary's Regional Medical Center Reno Nevada United States 89503
    281 Radiation Oncology Associates Reno Nevada United States 89509
    282 Sanford Bismarck Medical Center Bismarck North Dakota United States 58501
    283 Sanford South University Medical Center Fargo North Dakota United States 58103
    284 Southpointe-Sanford Medical Center Fargo Fargo North Dakota United States 58103
    285 Sanford Medical Center Fargo Fargo North Dakota United States 58104
    286 Sanford Broadway Medical Center Fargo North Dakota United States 58122
    287 Sanford Roger Maris Cancer Center Fargo North Dakota United States 58122
    288 Indu and Raj Soin Medical Center Beavercreek Ohio United States 45431
    289 Saint Elizabeth Boardman Hospital Boardman Ohio United States 44512
    290 Dayton Physicians LLC-Miami Valley South Centerville Ohio United States 45459
    291 Miami Valley Hospital South Centerville Ohio United States 45459
    292 Oncology Hematology Care Inc-Kenwood Cincinnati Ohio United States 45236
    293 Miami Valley Hospital Dayton Ohio United States 45409
    294 Dayton Physician LLC-Miami Valley Hospital North Dayton Ohio United States 45415
    295 Miami Valley Hospital North Dayton Ohio United States 45415
    296 Armes Family Cancer Center Findlay Ohio United States 45840
    297 Blanchard Valley Hospital Findlay Ohio United States 45840
    298 Orion Cancer Care Findlay Ohio United States 45840
    299 Atrium Medical Center-Middletown Regional Hospital Franklin Ohio United States 45005-1066
    300 Dayton Physicians LLC-Atrium Franklin Ohio United States 45005
    301 Dayton Physicians LLC-Wayne Greenville Ohio United States 45331
    302 Wayne Hospital Greenville Ohio United States 45331
    303 Greater Dayton Cancer Center Kettering Ohio United States 45409
    304 First Dayton Cancer Care Kettering Ohio United States 45420
    305 Kettering Medical Center Kettering Ohio United States 45429
    306 Springfield Regional Cancer Center Springfield Ohio United States 45504
    307 Springfield Regional Medical Center Springfield Ohio United States 45505
    308 Dayton Physicians LLC-Upper Valley Troy Ohio United States 45373
    309 Upper Valley Medical Center Troy Ohio United States 45373
    310 Saint Joseph Warren Hospital Warren Ohio United States 44484
    311 Saint Elizabeth Youngstown Hospital Youngstown Ohio United States 44501
    312 University of Oklahoma Health Sciences Center Oklahoma City Oklahoma United States 73104
    313 Mercy Hospital Oklahoma City Oklahoma City Oklahoma United States 73120
    314 Saint Alphonsus Medical Center-Baker City Baker City Oregon United States 97814
    315 Saint Charles Health System Bend Oregon United States 97701
    316 Clackamas Radiation Oncology Center Clackamas Oregon United States 97015
    317 Providence Cancer Institute Clackamas Clinic Clackamas Oregon United States 97015
    318 Bay Area Hospital Coos Bay Oregon United States 97420
    319 Providence Newberg Medical Center Newberg Oregon United States 97132
    320 Saint Alphonsus Medical Center-Ontario Ontario Oregon United States 97914
    321 Providence Portland Medical Center Portland Oregon United States 97213
    322 Providence Saint Vincent Medical Center Portland Oregon United States 97225
    323 Saint Charles Health System-Redmond Redmond Oregon United States 97756
    324 Lehigh Valley Hospital-Cedar Crest Allentown Pennsylvania United States 18103
    325 Lehigh Valley Hospital - Muhlenberg Bethlehem Pennsylvania United States 18017
    326 Bryn Mawr Hospital Bryn Mawr Pennsylvania United States 19010
    327 Main Line Health Center-Collegeville Collegeville Pennsylvania United States 19426
    328 Pocono Medical Center East Stroudsburg Pennsylvania United States 18301
    329 Main Line Health Center-Exton Exton Pennsylvania United States 19341
    330 Lehigh Valley Hospital-Hazleton Hazleton Pennsylvania United States 18201
    331 Riddle Memorial Hospital Media Pennsylvania United States 19063
    332 Paoli Memorial Hospital Paoli Pennsylvania United States 19301
    333 Reading Hospital West Reading Pennsylvania United States 19611
    334 Lankenau Medical Center Wynnewood Pennsylvania United States 19096
    335 Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota United States 57104
    336 Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota United States 57117-5134
    337 Vanderbilt University/Ingram Cancer Center Nashville Tennessee United States 37232
    338 Parkland Memorial Hospital Dallas Texas United States 75235
    339 UT Southwestern/Simmons Cancer Center-Dallas Dallas Texas United States 75390
    340 Farmington Health Center Farmington Utah United States 84025
    341 University of Utah Sugarhouse Health Center Salt Lake City Utah United States 84106
    342 Huntsman Cancer Institute/University of Utah Salt Lake City Utah United States 84112
    343 Providence Regional Cancer System-Aberdeen Aberdeen Washington United States 98520
    344 Overlake Medical Center Bellevue Washington United States 98004
    345 PeaceHealth Saint Joseph Medical Center Bellingham Washington United States 98225
    346 Providence Regional Cancer System-Centralia Centralia Washington United States 98531
    347 Swedish Cancer Institute-Edmonds Edmonds Washington United States 98026
    348 Providence Regional Cancer Partnership Everett Washington United States 98201
    349 Swedish Cancer Institute-Issaquah Issaquah Washington United States 98029
    350 Kadlec Clinic Hematology and Oncology Kennewick Washington United States 99336
    351 Providence Regional Cancer System-Lacey Lacey Washington United States 98503
    352 PeaceHealth Saint John Medical Center Longview Washington United States 98632
    353 Valley Medical Center Renton Washington United States 98055
    354 Pacific Gynecology Specialists Seattle Washington United States 98104
    355 Swedish Medical Center-Ballard Campus Seattle Washington United States 98107
    356 Swedish Medical Center-First Hill Seattle Washington United States 98122-4307
    357 Swedish Medical Center-Cherry Hill Seattle Washington United States 98122-5711
    358 PeaceHealth United General Medical Center Sedro-Woolley Washington United States 98284
    359 Providence Regional Cancer System-Shelton Shelton Washington United States 98584
    360 PeaceHealth Southwest Medical Center Vancouver Washington United States 98664
    361 Providence Saint Mary Regional Cancer Center Walla Walla Washington United States 99362
    362 North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima Washington United States 98902
    363 Providence Regional Cancer System-Yelm Yelm Washington United States 98597
    364 Langlade Hospital and Cancer Center Antigo Wisconsin United States 54409
    365 HSHS Sacred Heart Hospital Eau Claire Wisconsin United States 54701
    366 Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin United States 54701
    367 Saint Vincent Hospital Cancer Center Green Bay Green Bay Wisconsin United States 54301
    368 Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay Wisconsin United States 54303
    369 UW Cancer Center Johnson Creek Johnson Creek Wisconsin United States 53038
    370 Gundersen Lutheran Medical Center La Crosse Wisconsin United States 54601
    371 University of Wisconsin Carbone Cancer Center Madison Wisconsin United States 53792
    372 Marshfield Medical Center-Marshfield Marshfield Wisconsin United States 54449
    373 Marshfield Clinic-Minocqua Center Minocqua Wisconsin United States 54548
    374 Cancer Center of Western Wisconsin New Richmond Wisconsin United States 54017
    375 Marshfield Medical Center-Rice Lake Rice Lake Wisconsin United States 54868
    376 Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin United States 54482
    377 Aspirus Regional Cancer Center Wausau Wisconsin United States 54401
    378 Marshfield Medical Center - Weston Weston Wisconsin United States 54476
    379 Aspirus Cancer Care - Wisconsin Rapids Wisconsin Rapids Wisconsin United States 54494
    380 Billings Clinic-Cody Cody Wyoming United States 82414
    381 Welch Cancer Center Sheridan Wyoming United States 82801

    Sponsors and Collaborators

    • ECOG-ACRIN Cancer Research Group
    • National Cancer Institute (NCI)

    Investigators

    • Principal Investigator: Nataliya V Uboha, ECOG-ACRIN Cancer Research Group

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    ECOG-ACRIN Cancer Research Group
    ClinicalTrials.gov Identifier:
    NCT04248452
    Other Study ID Numbers:
    • EA2183
    • NCI-2019-06460
    • EA2183
    • EA2183
    • U10CA180820
    First Posted:
    Jan 30, 2020
    Last Update Posted:
    Jul 28, 2022
    Last Verified:
    Jun 1, 2022
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Additional relevant MeSH terms:
    Adenocarcinoma
    Stomach Neoplasms
    Esophageal Neoplasms
    Calcium, Dietary
    Leucovorin
    Folic Acid
    Fluorouracil
    Capecitabine
    Oxaliplatin
    Calcium
    Levoleucovorin

    Study Results

    No Results Posted as of Jul 28, 2022