CNS Involvement in Primary Mediastinal Large B-Cell Lymphoma (PMLBCL)
This is a retrospective, multicenter study designed to collect data on the diagnostic, therapeutic management and outcome of patients diagnosed with primary mediastinal lymphoma who have progressed or relapsed with central nervous system (CNS) involvement.
Through this study, an international data set from 6 different countries will be collected on clinical factors, anti-lymphoma therapy administered alone or in conjunction with CNS prophylaxis, re-biopsy site information when available, dose intensity of lymphoma therapy received at recurrence, and patient outcome.
In addition, to better characterize the pathologic features of this rare entity, a central pathologic review of the initial diagnosis and, if available, histologic confirmation of recurrence will be performed.
|Condition or Disease
Primary Outcome Measures
- PT CHARACTERISTICS [2003-2020]
to describe the PMLBCL characteristics at diagnosis and at CNS relapse ( first relapse or second and subsequent recurrences) and the treatment received
- CNS RELAPSE [2003-2020]
to describe the median time to CNS relapse
- PROGNOSTIC FACTORS [2003-2020]
to define prognostic factors of outcome of CNS relapse in PMLBCL patients
- TREATMENT STRATEGY [2003-2020]
to correlate treatment strategy with survival end-points
- PFS [2003-2020]
to evaluate the Progression Free Survical ( PFS) after CNS events
- OS [2003-2020]
to evaluate Overall Survival ( OS) after CNS relapse
- MOLECULAR DIAGNOSTIC [2003-2020]
to central pathological reviewed the initial diagnosis and the relapse and to correlate biological and molecular factors with CNS recurrence
To be eligible for inclusion each patient must fulfil all of the following criteria:
Histologically confirmed diagnosis of Primary Mediastinal Large B Cell Lymphoma (PMLBCL) according WHO Classification
Had a recurrence/progression with Central Nervous System (CNS) involvement
Availability of details on clinical presentation, treatment details and outcome
Availability of details on pathological data for central review
Age ≥18 years
- Patients with CNS lymphoma other than PMLBCL subtype
Contacts and Locations
LocationsNo locations specified.
Sponsors and Collaborators
- Andrés José Maria Ferreri
Study Documents (Full-Text)None provided.
- OSR- PMLBCL SNC+