Assessment of Potential Interactions Between Cocaine and Tolcapone - 1

• Sponsor: National Institute on Drug Abuse (NIDA) (NIH)
• Overall Status: Unknown status
• CT.gov ID: NCT00033059
• Collaborator: (none)
• Enrollment: 16
• Location: 1
• Duration (Months): 8
• Patients Per Site Per Month: 2

Study Details

Study Description

Brief Summary

The purpose of this study is to assess the potential interactions between intravenous (IV) cocaine and tolcapone.

Condition or Disease	Intervention/Treatment	Phase
Cocaine-Related Disorders	Drug: Tolcapone	Phase 1

Detailed Description

Double-blind, inpatient study by screening responses to cocaine infusions of 20 and 40 mg i.v. subjects into 1 of 2 treatment groups to assess potential interactions between i.v. cocaine infusion and treatment with tolcapone.

Study Design

• Study Type: Interventional
• Allocation: Randomized
• Masking: Double
• Primary Purpose: Treatment
• Official Title: Assessment of Potential Interactions Between Intravenous Cocaine and Tolcapone
• Study Start Date: Jul 1, 2001
• Study Completion Date: Mar 1, 2002

Outcome Measures

Primary Outcome Measures

1. Safety []

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 45 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

Volunteers dependent on cocaine and are non-treatment seeking; between 18-45 yrs of age; DSM-4 criteria for cocaine abuse or dependence

Exclusion Criteria:

Additional criteria available during screening at the site

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	UCLA Integrated Substance Abuse Program	Los Angeles	California	United States	90024

Sponsors and Collaborators

• National Institute on Drug Abuse (NIDA)

Investigators

• Principal Investigator: Thomas Newton, M.D., National Institute on Drug Abuse (NIDA)

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• ClinicalTrials.gov Identifier: NCT00033059
• Other Study ID Numbers: NIDA-CTO-0003-1; NCT00024765
• First Posted: Apr 8, 2002
• Last Update Posted: Jan 11, 2017
• Last Verified: Aug 1, 2003

• Additional relevant MeSH terms: Cocaine-Related Disorders; Tolcapone

Study Results

No Results Posted as of Jan 11, 2017