Changes in the Threshold of Electrically Evoked Compound Action Potential in Children Following Cochlear Implantation
Study Details
Study Description
Brief Summary
After cochlear implantation, cochlear nerve is stimulated by giving a current over the electrodes placed in the cochlea and the current is measured by electrically evoked Compound Action Potential (ECAP).This ECAP is measured intra operatively, after 4 weeks( at switch on), after 3months and 6 months following cochlear implantation.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
After cochlear implantation, cochlear nerve is stimulated by giving a current over the electrodes placed in the cochlea and the current is measured by electrically evoked Compound Action Potential (ECAP).This ECAP is measured intra operatively, 4 weeks(at switch on) and after 3months and 6 months following cochlear implantation. Neural Response Telemetry (NRT) is a quick and non-invasive way of recording ECAP of the peripheral auditory nerves in-situ. It gives clinicians valuable information for programming the T- (Threshold) and C-(Comfort) - levels of the recipient's speech processor map. Intraoperative NRT in conjunction with electrode impedance data can help indicate the integrity of the implanted electrodes and the electrode/auditory nerve interface, confirming that the implant is functioning correctly intraoperatively.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Pediatric patients with bilateral sensorineural hearing loss One group will be studied: Patients undergoing cochlear implantation surgery between age 1 and 6 years who meet the above inclusion and exclusion criteria seen in JIPMER during the study period. |
Device: Cochlear implant
After cochlear implantation, cochlear nerve is stimulated by giving a current over the electrodes placed in the cochlea and the current is measured by electrically evoked Compound Action Potential (ECAP).
|
Outcome Measures
Primary Outcome Measures
- Changes in threshold of ECAP after cochlear implantation. [during implantation, at switch on( 4 weeks), after 3months and 6months.]
To evaluate changes in threshold of ECAP during cochlear implantation, at switch on( 4 weeks), after 3 months and 6 months following cochlear implantation.
Secondary Outcome Measures
- Correlate the amplitude of ECAP with T & C levels. [2 years]
Correlating the amplitude of ECAP with threshold and comfortable levels and creating a MAP.
- Correlate amplitude of ECAP with cochlear nerve diameter measured pre-operatively. [2 mins]
By correlating amplitude of ECAP with cochlear nerve diameter we can determine the site to be operated preoperatively.
Eligibility Criteria
Criteria
Inclusion Criteria:
- All children between 1 and 6 years of age undergoing cochlear implantation in JIPMER during the study period.
Exclusion Criteria:
- Incomplete electrode array insertion.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | JIPMER | Puducherry | India | 605006 |
Sponsors and Collaborators
- Jawaharlal Institute of Postgraduate Medical Education & Research
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- Kim JR, Abbas PJ, Brown CJ, Etler CP, O'Brien S, Kim LS. The relationship between electrically evoked compound action potential and speech perception: a study in cochlear implant users with short electrode array. Otol Neurotol. 2010 Sep;31(7):1041-8. doi: 10.1097/MAO.0b013e3181ec1d92.
- van Eijl RH, Buitenhuis PJ, Stegeman I, Klis SF, Grolman W. Systematic review of compound action potentials as predictors for cochlear implant performance. Laryngoscope. 2017 Feb;127(2):476-487. doi: 10.1002/lary.26154. Epub 2016 Nov 2. Review.
- JIP/IEC/2017/0339