CogMS: Cognitive Evolution in Tysabri Treated Multiple Sclerosis Patients
Study Details
Study Description
Brief Summary
This study is designed to evaluate the effect of Tysabri on cognition in multiple sclerosis (MS) patients. During a period of 24 months, the study will assess the evolution of cognitive function in Tysabri treated MS patients using the Symbol Digit Modalities Test (SDMT) and the CogState battery of tests.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
Tysabri reduces the relapse frequency, slows progression and preserves cognitive function as compared to placebo as per the AFFIRM trial. The benefit on relapse rate and progression appears to be sustained in longer-term studies such as STRATA. In clinical practice however despite a stable condition on the Expanded Disability Status Scale (EDSS) patients often complain of cognitive deterioration. It has yet to be shown that Tysabri will prevent cognitive deterioration after more than 2 years of treatment.
The Symbol Digit Modalities Test (SDMT) is a sensitive and validated test of cognition in MS. CogState offers a standardized battery of cognitive tests frequently used in clinical research in the fields of dementia and Parkinson's disease. The CogState battery of tests consisting of the Detection test (processing speed), Identification test (attention), One Back test (working memory), International Shopping List test (verbal learning) and the Groton Maze Learning test (reasoning and problem solving) will further confirm and validate the results of the Symbol Digit Modalities Test(SDMT) in MS patients as well as examine other cognitive parameters.
Together the above tests done prospectively can assess the evolution of cognitive function in Tysabri treated MS patients over the longer term.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| cognitive evolution, observational,MS multiple sclerosis tysabri treated patients |
Outcome Measures
Primary Outcome Measures
- SDMT CogState battery [2 years]
Monthly cognitive assessments
Eligibility Criteria
Criteria
Inclusion Criteria:
- Patients with multiple sclerosis who are receiving Tysabri per indication and are willing and able to give an informed consent.
Exclusion Criteria:
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Patients who are depressed as per the Beck depression questionnaire at screening or at any time during the study.
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Patients with cognitive decline from causes other than MS.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Clinique Neuro-Outaouais | Gatineau | Quebec | Canada | J9J 0A5 |
Sponsors and Collaborators
- Clinique Neuro-Outaouais
- CogState Ltd.
Investigators
- Principal Investigator: François H Jacques, MD, Clinique Neuro-Outaouais
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- CNO-001