Resistance Training on Growth Factors

Sponsor

Air Force Military Medical University, China (Other)

Overall Status

Not yet recruiting

CT.gov ID

NCT06114550

Collaborator

(none)

Enrollment

Arms

1.2

Anticipated Duration (Months)

Study Details

Study Description

Brief Summary

The goal of this clinial trial study is to explore the effect of high or low intensity resistance training (LIRT) under similar training volume on change in serum levels of BDNF,

IGF-1, VEGF, irisin, and plasma Hcy in young adults.The main questions it aims to answer are:

Whether high and low intensity will increase the serum levels of BDNF, IGF-1, VEGF, irisin, and reduce plasma Hcy.
whether a greater magnitude of change would be suffer in low intensity group when compared to high intensity group, as an effect of greater physiological adaptation produced by more repetitions required to complete.

Participants will performe two different intensity resistance training (HIRT, at 80%1RM with 12 repetitions and 4-5 sets and LIRT, at 40%1RM with 24 repetitions and 4-5 sets).

Researchers will compare the training effects of two different training on these growth factors.

Condition or Disease	Intervention/Treatment	Phase
Cognitive Function	Other: High intensity resistance training Other: Low intensity resistance training	N/A

Study Design

Study Type:

Interventional

Anticipated Enrollment :

12 participants

Allocation:

Randomized

Intervention Model:

Crossover Assignment

Masking:

Triple (Care Provider, Investigator, Outcomes Assessor)

Primary Purpose:

Treatment

Official Title:

Acute Effect of Resistance Training With Different Intensity on Circulating Levels of Neurotrophic Growth Factors and Homocysteine in Young Adults

Anticipated Study Start Date :

Nov 1, 2023

Anticipated Primary Completion Date :

Nov 30, 2023

Anticipated Study Completion Date :

Dec 7, 2023

Arms and Interventions

Arm	Intervention/Treatment
Experimental: High-intensity resistance training group (HIRT) All subjects were instructed to conduct HIRT consisted of 4-5 sets of 12 repetitions at 80%1RM, with 1-2 minutes rests between each set.	Other: High intensity resistance training The HIRT protocol comprised five exercises (bench press, barbell back squat, deadlift, seated leg flexion, and reverse arm curl) at 80% of 1RM, and 4-5 sets of 12 repetitions with 1-2 minutes of rest period between sets for approximately 60 minutes.
Experimental: low-intensity resistance training group (LIRT) All subjects were instructed to conduct LIRT consisted of 4-5 sets of 24 repetitions at 40%1RM, with same period) in random order.	Other: Low intensity resistance training For LIRT protocol, which performed same training exercises as HIRT. The repetitions in the LIRT protocol were assessed using the following equation: 80% of 1RM lifting load (kg) ×repetitions (HIRT)/40% of 1RM to volition fatigue, with 1-2 minutes of rest period between sets. Therefore, the LIRT protocol completed 4-5 sets of 24 repetitions at 40% of 1RM for a total of 60 minutes.

Arm

Intervention/Treatment

Experimental: High-intensity resistance training group (HIRT)

All subjects were instructed to conduct HIRT consisted of 4-5 sets of 12 repetitions at 80%1RM, with 1-2 minutes rests between each set.

Other: High intensity resistance training

The HIRT protocol comprised five exercises (bench press, barbell back squat, deadlift, seated leg flexion, and reverse arm curl) at 80% of 1RM, and 4-5 sets of 12 repetitions with 1-2 minutes of rest period between sets for approximately 60 minutes.

Experimental: low-intensity resistance training group (LIRT)

All subjects were instructed to conduct LIRT consisted of 4-5 sets of 24 repetitions at 40%1RM, with same period) in random order.

Other: Low intensity resistance training

For LIRT protocol, which performed same training exercises as HIRT. The repetitions in the LIRT protocol were assessed using the following equation: 80% of 1RM lifting load (kg) ×repetitions (HIRT)/40% of 1RM to volition fatigue, with 1-2 minutes of rest period between sets. Therefore, the LIRT protocol completed 4-5 sets of 24 repetitions at 40% of 1RM for a total of 60 minutes.

Outcome Measures

Primary Outcome Measures

rata of perceived exertion [pre,post immediately, 30min post]
The rating of perceive exertion (RPE) questionnaire scale was applied to assess participants' subjective fatigue feeling throughout the training period.
blood lactate [pre, post immediately, 30 minutes post intervention]
serum blood lactate
BDNF [pre, post immediately, 30 minutes post intervention]
regulators of neurogenesis
IGF-1 [pre, post immediately, 30 minutes post intervention]
regulators of neurogenesis
VEGF [pre, post immediately, 30 minutes post intervention]
regulators of neurogenesis
Irisin [pre, post immediately, 30 minutes post intervention]
regulators of neurogenesis
Hcy [pre, post immediately, 30 minutes post intervention]
homocysteine (Hcy) increase with age and resulted in cognitive function decline through greater oxidative stress and vascular dysfunction

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 30 Years

Sexes Eligible for Study:

Male

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

age between 18 to 30 years
no experiencing musculoskeletal disorders or sports injuries
had not participated any regular aerobic endurance or resistance training with in the previous half years
no smoking habit or intake alcohol and other medication (e.g., steroid hormone)
good general body condition without any chronic diseases (e.g., osteoarthritis, metabolic syndrome or arthritis)

Exclusion Criteria:

experiencing musculoskeletal disorders or sports injuries in recent 1 month
had regular resistance training exercise
intake any supplementary(drug and hormone)

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

Air Force Military Medical University, China

Investigators

Principal Investigator: chongwen zuo, Doctoral, Air Force Medical Center of Chinese PLA

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Chongwen Zuo, Doctoral, Air Force Military Medical University, China

ClinicalTrials.gov Identifier:

NCT06114550

Other Study ID Numbers:

zuochongwen

First Posted:

Nov 2, 2023

Last Update Posted:

Nov 2, 2023

Last Verified:

Oct 1, 2023

Individual Participant Data (IPD) Sharing Statement:

Yes

Plan to Share IPD:

Yes

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Keywords provided by Chongwen Zuo, Doctoral, Air Force Military Medical University, China

neurotrophic growth factors

Study Results

No Results Posted as of Nov 2, 2023