Aronia, Cognition, and Eye Health (ACE)
Study Details
Study Description
Brief Summary
There is great interest in improving cognitive performance and eye health as working from home becomes more prominent. Working from home as well as stress in the workplace is an increasing problem. Students and work professional can therefore benefit from improved attention and thus performance in academic and other work environments. A completely natural supplement with aronia melanocarpa extract could be a promising way to naturally improve cognitive performance
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
The shift of on-site education/working to online education/working has had a detrimental impact on motivation to study or work and ultimately on mental health. Moreover, online education has been shown to have a negative effect on concentration, learning, and academic performance. Stress in the workplace is an increasing problem, leading to decreased productivity and overall well-being of working adults. Consequently, there is a great interest in improving cognitive performance, including memory and attention.
Previous studies in young adults have mainly focused on acute or short-term (e.g. 1 week) effects of anthocyanin supplementation on cognitive performance. The research hypothesis of the current study is that long term (6 weeks) AME supplementation affects domains of cognitive performance in a randomized, double-blind, placebo controlled, cross-over study in healthy young adults (18-35 years old).
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Aronia Aronia Melanocarpa supplementation |
Dietary Supplement: Aronia supplementation
As described in experimental arm
|
| Placebo Comparator: Control Cellulose supplementation |
Dietary Supplement: Cellulose supplementation
As described in placebo comparator arm
|
Outcome Measures
Primary Outcome Measures
- Cognitive Function [After 6 weeks of supplementation]
Quantified through the Cambridge Neuropsychological Test Automated Battery (CANTAB). Focus on attention/psychomotor speed, memory, and executive function
Secondary Outcome Measures
- Eye Health [At baseline and after 6 weeks of supplementation]
Tear fluid collection (volume)
- Subjective Eye Fatigue [At baseline and after 6 weeks of supplementation]
Subjective Eye Fatigue Questionnaire
- Vascular Function [At baseline and after 6 weeks of supplementation]
Fundus photography
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Healthy men and women, aged between 18-35 years
-
BMI between 18-30 kg/m2
-
Systolic blood pressure < 160 mmHg and diastolic blood pressure < 100 mmHg
-
Stable body weight (weight gain or loss < 3 kg in the past three months)
-
Willingness to give up being a blood donor from 8 weeks before the start of the study, during the study and for 4 weeks after completion of the study
-
No difficult venipuncture as evidenced during the screening visit
Exclusion Criteria:
-
Smoking or smoking cessation < 12 months
-
Contact lens wearers
-
Past refractive surgery
-
Severe medical conditions, including asthma, chronic obstructive pulmonary disease (COPD), kidney failure, auto-inflammatory diseases, rheumatoid arthritis, diabetes mellitus, cardiovascular disease
-
Use of dietary supplements or medication affecting the main outcomes of the study
-
Use of an investigational product within another biomedical intervention trial within the previous month
-
Familial hypercholesterolemia
-
Abuse of drugs
-
More than 3 alcoholic consumptions per day
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Maastricht University | Maastricht | Netherlands |
Sponsors and Collaborators
- Maastricht University Medical Center
- BioActor B.V.
Investigators
- Principal Investigator: Jogchum Plat, Prof, Maastricht University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- BB-04