Cognitive Function Analysis and qEEG Study in Long COVID-19 Syndrome Patients
Study Details
Study Description
Brief Summary
Over than 30% individuals with COVID-19, including the asymptomatic ones, and around 80% of patients hospitalized with COVID-19 may experience post-COVID sequelae, which is commonly referred to as Long COVID Syndrome. This condition has ties to decreased cognitive function and may lead to neuropsychiatric disorders but still need to be studied further. Using a cross-sectional design, this study will analyze the relationship between cognitive function and neuropsychiatric disorders with brain wave activity in Long COVID patients.
The investigators conducted assessments utilizing the quantitative electroencephalogram (qEEG) measurement method and interviews using instruments such as the MMSE MOCA, mini ICD 10, and SF 36. With this qEEG examination, the investigators hoped that there will be an imbalance/abnormality of brain wave activity that arises related to impaired cognitive function.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
This study is aimed to analyze the cognitive function and neuropsychiatry disorders with brain wave activity using qEEG that occurs after COVID/Long Covid Syndrome.
The whole procedure will run for approximately 12 weeks based on the long COVID range.
The determinants of long COVID patients include: never been vaccinated, old age, comorbid, female population, and hospitalized patients.
The total number of subjects with the post-COVID syndrome in the proportion test is 30 subjects.
The measuring instruments used to measure the decline in cognitive function are the MMSE MOCA questionnaire, mini ICD 10, and SF 36.
The target population is post-COVID-19 patients with Long COVID Syndrome.
The accessible population is post-COVID-19 patients who have been treated at RSCM Kiara and have regular checkups at the RSCM polyclinic with Long COVID Syndrome for 12 weeks or more.
The control population is post-COVID-19 patients who managed to recover without symptoms.
The Long COVID Syndrome patients who meet the inclusion criteria and have signed the consent.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Long COVID-19 Patients post-COVID-19 with Long COVID-19 Syndrome |
Device: Quantitative Electroencephalography
Each qEEG examination of one person lasted about 20 minutes and included two stages: the first-recording of brain waves with eyes closed (5 min), the other with eyes open (5 min)
|
| COVID-19 Patients post-COVID-19 without Long COVID-19 Syndrome |
Device: Quantitative Electroencephalography
Each qEEG examination of one person lasted about 20 minutes and included two stages: the first-recording of brain waves with eyes closed (5 min), the other with eyes open (5 min)
|
Outcome Measures
Primary Outcome Measures
- Cognitive Function [Through study completion, an average of 1 year]
Cognitive Function will be assessed using the qEEG, with an abnormality of brain wave activity, it indicates impairment of cognitive function
Secondary Outcome Measures
- Cognitive quality Assessed by MMSE MOCA [Through study completion, an average of 1 year]
Severe score: ≤9 Moderate score: 10-22 Mild score: 23-26 Normal score: 27-30
- Depression level assessed by Mini International Neuropsychiatric Interview Version ICD-10 (MINI ICD-10) [Through study completion, an average of 1 year]
Will be assessed whether the subject has a depressive episode (Yes/No)
- Health-Related Quality of Life Assessed by The 360-Item Short From Health Survey Questionnaire (SF-36) [Through study completion, an average of 1 year]
Lowest score: 0 Highest score: 100 Higher score indicates better health status, and a mean score of 50 has been articulated as a normative value for all scales
Eligibility Criteria
Criteria
Inclusion Criteria:
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Post-COVID-19 patients with Long COVID-19 Syndrome
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Over 18 years old
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Willing to participate in the research
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Completed the MMSE MOCA, MINI ICD-10, and SF-36 assessment
Exclusion Criteria:
- Patients with neuropsychiatric disorders before being infected with COVID-19
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Rumah Sakit Cipto Manunkusumo | Jakarta Pusat | DKI Jakarta | Indonesia | 10430 |
Sponsors and Collaborators
- Indonesia University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 22-05-0578