Cognitive Impact in Patients With COVID-19 Infection
Study Details
Study Description
Brief Summary
SARS-COV-2 infection reframed medical knowledge in many aspects, yet there is still a lot to be discovered. Coronavirus disease 19 (COVID-19) can cause neuropsychiatric, psychological and psychosocial impairments. Literature regarding cognitive impact of COVID-19 is still limited.
Objective: evaluation of cognitive function, anxiety and depression among patients with Coronavirus disease 19.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
COVID-19 results in a variety of symptoms with multi-organ affection, including fever, cough; grave respiratory symptoms, gastrointestinal manifestations and fatigue. As more is learned, neurological and psychological symptoms appear to manifest in a large subscale of patients. Headache, dizziness and even a cerebrovascular event have been reported. Anosmia and ageusia reported as early indicators of SARS-CoV-2 infection, suggesting that early neurological involvement may be relevant.
Public health emergencies as COVID-19 are likely to cause adverse neuropsychiatric impacts. Cognitive impairments after SARS-COV-2 infection were noticed, COVID-19 patients complain of poor concentration, declined memory, and insomnia, as well as anxiety and depression symptoms.
The battle against COVID-19 is still continuing worldwide. People's adherence to confinement regulations and response to vaccination campaigns is essential, which is largely affected by their knowledge, attitudes, and practices towards COVID-19. Home isolation and social distancing are also associated with fear, frustrations, uncertainty, anxiety and depressive symptoms.
During the acute phase of COVID-19 infection, about 36% of cases develop neurological symptoms of which 25% can be attributed to the direct involvement of the central nervous system. Patients who show neurological symptoms included cases with or without pre-existing neurological disorders. While on intensive care units, patients showed agitation, confusion, and corticospinal tract signs such as enhanced tendon reflexes and clonus. COVID-19 can further lead to changes of coagulation and, in particular, to inflammation-induced disseminated intravascular coagulation (DIC).
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| COVID-19 cases O2 saturation readings, Mini-mental state examination (MMSE), Hamilton's anxiety (HAM-A) Hamilton's depression rating scales (HAM-D) |
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| control O2 saturation readings, Mini-mental state examination (MMSE), Hamilton's anxiety (HAM-A) Hamilton's depression rating scales (HAM-D) |
Outcome Measures
Primary Outcome Measures
- Cognitive impairment [1 month]
degree of affection in cognition due to COVID-19 infection
Secondary Outcome Measures
- Level of Anxiety and depression among COVID-19 cases [1 month]
Level of Anxiety and depression among COVID-19 cases
Eligibility Criteria
Criteria
Inclusion Criteria:
- covid-19 patients diagnosed using Real Time-Polymerase Chain Reaction to confirm the diagnosis
Exclusion Criteria:
- neurological disorders, psychological disorders, dementia, Alzheimer's disease, end-organ failure conditions
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Assiut University | Assiut | Egypt | 711111 |
Sponsors and Collaborators
- Assiut University
Investigators
- Principal Investigator: Waleed Gamal elddin, MD, Assiut university hospitals
Study Documents (Full-Text)
None provided.More Information
Publications
- Alemanno F, Houdayer E, Parma A, Spina A, Del Forno A, Scatolini A, Angelone S, Brugliera L, Tettamanti A, Beretta L, Iannaccone S. COVID-19 cognitive deficits after respiratory assistance in the subacute phase: A COVID-rehabilitation unit experience. PLoS One. 2021 Feb 8;16(2):e0246590. doi: 10.1371/journal.pone.0246590. eCollection 2021.
- Germani A, Buratta L, Delvecchio E, Gizzi G, Mazzeschi C. Anxiety Severity, Perceived Risk of COVID-19 and Individual Functioning in Emerging Adults Facing the Pandemic. Front Psychol. 2020 Dec 7;11:567505. doi: 10.3389/fpsyg.2020.567505. eCollection 2020.
- WGEK-NCG