Influence of Overground Walking on Biomarkers, Cognitive Function, and Quality of Life in Elderly With Mild Cognitive Impairment
Study Details
Study Description
Brief Summary
The purpose of this research is to investigate the impact of overground walking as a part of a rehabilitation program on the increase in Brain-derived neurotrophic factor (BDNF) levels, decrease in IL-6 levels, decrease in hs-CRP levels, improvement in cognitive function, and enhancement of quality of life (QOL) in older people with mild cognitive impairment. These findings are anticipated to contribute to the efforts to elevate BDNF levels, cognitive function, and QOL while reducing IL-6 and hsCRP levels in the elderly with mild cognitive impairment.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
This research employs a quasi-experimental research design using a Pretest-Posttest Design approach. The Pretest-Posttest method is executed by assessing before and after the intervention within the same group.
All research subjects receive the same treatment, which involves participating in an overground walking program on a flat surface. The selected research subjects are provided with an explanation of the research's objectives and benefits and the exercise and examination procedures, then sign the informed consent.
Research subjects are instructed to walk on a flat surface for a distance of 15 meters, with a duration of 20 minutes, increasing by 5 minutes each week until the target heart rate is achieved during the exercise. After an 8-week post-intervention period, research subjects will undergo a follow-up examination.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Subjects
|
Other: Overground Walking
Walk on a flat surface for a distance of 15 meters, with a duration of 20 minutes, increasing by 5 minutes each week until the target heart rate is achieved during the exercise, for 8 weeks.
|
Outcome Measures
Primary Outcome Measures
- BDNF [8 weeks]
Brain-derived neurotrophic factor level
- IL6 [8 weeks]
Interleukin-6 level
- hsCRP [8 weeks]
hs-CRP level
- MoCAINA [8 weeks]
MONTREAL COGNITIVE ASSESSMENT INDONESIA
- ADQOL [8 weeks]
Alzheimer disease Quality of Life
Eligibility Criteria
Criteria
Inclusion Criteria:
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Mild cognitive impairment (MoCA INA Score 19-25 out of 30
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Barthel Index Score 20
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Geriatric Depression Scale Score ≤ 5
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Timed Up and Go Test < 15 seconds)
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Capable of comprehending verbal and written instructions
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Capable of walking unassisted
Exclusion Criteria:
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The presence of hearing impairment that could hinder the subject from receiving verbal instructions,
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The presence of uncorrected visual impairment
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Having musculoskeletal disorders
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Receiving other rehabilitation programs,
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Presence of diseases causing cognitive impairment
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Severe joint diseases such as osteoarthritis and rheumatoid arthritis that may worsen during exercise or could pose difficulties in carrying out the exercise program,
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Severe cardiovascular diseases as diagnosed by a Cardiologist
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Nursing Home | Bandung | Jawa Barat | Indonesia |
Sponsors and Collaborators
- Universitas Padjadjaran
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
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- Shams A, Nobari H, Afonso J, Abbasi H, Mainer-Pardos E, Perez-Gomez J, Bayati M, Bahrami A, Carneiro L. Effect of Aerobic-Based Exercise on Psychological Well-Being and Quality of Life Among Older People: A Middle East Study. Front Public Health. 2021 Dec 6;9:764044. doi: 10.3389/fpubh.2021.764044. eCollection 2021.
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- IKFR.2023.08.01