Cognitive Impairment in Parkinson's Disease Categorised in Accordance to Motor Symptoms

Sponsor

University of Aarhus (Other)

Overall Status

Completed

CT.gov ID

NCT00476372

Collaborator

(none)

107

Enrollment

Location

Duration (Months)

2.1

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Background: Approximately 40% of patients with Parkinson's disease (PD) have cognitive impairments. There is a lack of consensus as to the extent to which psychiatric symptoms, depression, age at disease onset, disease duration, and medication is related to the type and severity of cognitive impairment. This discrepancy can in part be caused by the lack of distinction between patients with different motor symptoms and disease severity.

Objective: To identify the extent to which psychiatric symptoms, depression, age at disease onset, disease duration, and medication is related to the severity and type of cognitive dysfunction in patients with idiopathic PD categorized according to motor symptoms and disease severity.

Methods: the population of patients with PD in the old county of Aarhus is described on the background of medical records, and stratified in accordance to age, sex and cardinal symptoms. Through proportional allocation a sample of a minimum of 50 patients with PD is drawn from the population. The patients and 30 healthy matched controls will undergo comprehensive neuropsychological assessment including tests of language, memory, executive function, and visuospatial function. Furthermore, all participants will be screened for depression (Geriatric Depression Scale) and psychiatric symptoms (Neuropsychiatric Inventory and Symptom Checklist). The patients will be categorized in accordance with their motor symptoms via cluster analysis for the purpose of analyzing the effect of psychiatric symptoms, depression, and age of disease onset, disease duration, and medication on cognition.

Condition or Disease	Intervention/Treatment	Phase
Parkinson's Disease

Study Design

Study Type:

Observational

Actual Enrollment :

107 participants

Observational Model:

Cohort

Time Perspective:

Cross-Sectional

Official Title:

Cognitive Impairment in Parkinson's Disease Categorised in Accordance to Motor Symptoms -the Relation Between Cognitive Deficits and Comorbid Psychiatric Disorders, Medication, and Age at Disease Onset

Study Start Date :

Aug 1, 2007

Actual Primary Completion Date :

Dec 1, 2011

Actual Study Completion Date :

Dec 1, 2011

Arms and Interventions

Arm	Intervention/Treatment
Parkinson's disease Pt with parkinsons disease

Outcome Measures

Primary Outcome Measures

cognitive measures [1 hour]

Eligibility Criteria

Criteria

Ages Eligible for Study:

50 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Idiopathic Parkinson's in accordance to UK Parkinson's Disease Society Brain Bank Clinical Diagnostic Criteria,
Born and raised in Denmark ,
50 years

Exclusion Criteria:

Cerebrovascular disease,
Dementia not caused by Parkinson's Disease,
Metabolism anomaly,
Abuse of drugs, medication or alcohol,
History of head injuries,
Severe psychiatric disorder, excluding depression,
Resident outside the region of Aarhus h) DBS -

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Aarhus Universitetshospital	Aarhus		Denmark	8000

Sponsors and Collaborators

University of Aarhus

Investigators

Study Chair: Karen Østergaard, neurologist, Aarhus Universitetshospital
Study Chair: Lars Larsen, MSc, PhD, Associate Professor, The Institute of Psychology