A Cohort Study on Anti-microbial Stewardship in PICU
Study Details
Study Description
Brief Summary
Appropriate antimicrobial therapy is essential to ensuring positive patient outcomes. Inappropriate or suboptimal utilization of antibiotics can lead to increased length of stay, multidrug-resistant infections, and mortality. Critically ill intensive care patients are at risk of antibiotic failure and secondary infections associated with incorrect antibiotic use. Initiating effective therapy for infections based upon patients' risk factors, collection of appropriate cultures, daily evaluation of clinical status, and laboratory data, including antibiotic time outs, and shortened duration of therapy are ways to improve patients outcomes. Antimicrobial stewardship teams can assist ICU providers in managing and implementing these tactics. ICUs would benefit from employing empiric guidelines for antibiotic use, collecting appropriate specimens and implementing molecular diagnostics, optimizing the dosing of antibiotics, and reducing the duration of total therapy.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Appropriate antimicrobial therapy is essential to ensuring positive patient outcomes. Inappropriate or suboptimal utilization of antibiotics can lead to increased length of stay, multidrug-resistant infections, and mortality. Critically ill intensive care patients are at risk of antibiotic failure and secondary infections associated with incorrect antibiotic use. Initiating effective therapy for infections based upon patients' risk factors, collection of appropriate cultures, daily evaluation of clinical status, and laboratory data, including antibiotic time outs, and shortened duration of therapy are ways to improve patients outcomes. Antimicrobial stewardship teams can assist ICU providers in managing and implementing these tactics. ICUs would benefit from employing empiric guidelines for antibiotic use, collecting appropriate specimens and implementing molecular diagnostics, optimizing the dosing of antibiotics, and reducing the duration of total therapy. This study conducted an antibiotic management cohort study in PICUs to discover the distribution of nosocomial infections in PICUs and to find controllable factors for the occurrence of nosocomial infections.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Infection patients with infection |
Other: antimicrobial therapy
antimicrobial therapy
|
| non-infection patients without infection |
Outcome Measures
Primary Outcome Measures
- survival rate [21 days after ICU admission]
the survival rate of children in 21 days after ICU admission
Secondary Outcome Measures
- the length of ICU stay time [21 days after ICU admission]
the length of ICU stay time
Eligibility Criteria
Criteria
Inclusion Criteria:
- Patients admitted to the ICU for more than 48 hour
Exclusion Criteria:
- Patients admitted to ICU less than 48 hours
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Children's Hospital of Fudan University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- fdpicu-29