Collecting and Storing Biological Samples From Young Patients With Hodgkin?s Lymphoma
Sponsor
Children's Oncology Group (Other)
Overall Status
Completed
CT.gov ID
NCT00900250
Collaborator
National Cancer Institute (NCI) (NIH)
1,271
183
149.2
6.9
0
Study Details
Study Description
Brief Summary
This laboratory study is collecting and storing samples of tissue and blood from young patients with Hodgkin's lymphoma. Collecting and storing samples of tumor tissue and blood from patients with cancer to study in the laboratory may help the study of cancer in the future.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
OBJECTIVES:
-
Establish a biologic specimen repository (of tumor tissue, tissue arrays, lymphoblastoid cell lines, host DNA, tumor and host RNA, serum, and plasma) and database linked to clinical features and outcomes from well-characterized cohorts of children and young adults with Hodgkin's lymphoma.
-
Provide specimens from diagnosis, early response evaluation, completion of chemotherapy and radiotherapy, long-term follow up, and relapse to study prognostic factors for early response, relapse, long-term outcomes, and identification of new biological targets for therapy.
OUTLINE: This is a multicenter study.
Patients enrolled on Hodgkin's lymphoma (HL) therapeutic clinical trials undergo collection of tumor tissue samples at baseline and at relapse or disease progression. Serum and anticoagulated peripheral blood samples are collected at baseline, at week 1, on day 1 of course 2, after completion of chemotherapy, after completion of radiotherapy, at 1 year after diagnosis, and at relapse or disease progression.
Patients with relapsed or progressive disease who plan to enroll on HL relapse/retrieval clinical trials undergo collection of tumor tissue, serum, and anticoagulated peripheral blood samples at relapse or disease progression.
Patients enrolled more than 1 year after completion of treatment undergo collection of tumor specimens, serum, and anticoagulated peripheral blood samples at time of clinical evaluation.
Study Design
Study Type:
Observational
Actual Enrollment
:
1271 participants
Observational Model:
Case-Only
Time Perspective:
Prospective
Official Title:
Hodgkin Disease (HD) Banking Study
Actual Study Start Date
:
Oct 23, 2006
Actual Primary Completion Date
:
Mar 31, 2019
Actual Study Completion Date
:
Mar 31, 2019
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Ancillary-correlative (specimen collection and baking) Patients enrolled on HL therapeutic clinical trials undergo collection of tumor tissue samples at baseline and at relapse or disease progression. Serum and anticoagulated peripheral blood samples are collected at baseline, at week 1, on day 1 of course 2, after completion of chemotherapy, after completion of radiotherapy, at 1 year after diagnosis, and at relapse or disease progression. Patients with relapsed or progressive disease who plan to enroll on HL relapse/retrieval clinical trials undergo collection of tumor tissue, serum, and anticoagulated peripheral blood samples at relapse or disease progression. Patients enrolled more than 1 year after completion of treatment undergo collection of tumor specimens, serum, and anticoagulated peripheral blood samples at time of clinical evaluation. |
Other: Cytology Specimen Collection Procedure
Correlative studies
Other Names:
|
Outcome Measures
Primary Outcome Measures
- Biologic specimen repository and database [Baseline to up to 5 years]
Eligibility Criteria
Criteria
Ages Eligible for Study:
N/A
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
-
Histologically confirmed Hodgkin's lymphoma (HL) meeting 1 of the following criteria:
-
Newly diagnosed, untreated HL (for patients under 22 years of age)
-
Past or present diagnosis of HL and past or present enrollment on a Children's Oncology Group (COG) or legacy HL clinical trial (for patients of any age)
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Children's Hospital of Alabama | Birmingham | Alabama | United States | 35233 |
| 2 | University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | United States | 35233 |
| 3 | Phoenix Childrens Hospital | Phoenix | Arizona | United States | 85016 |
| 4 | Arkansas Children's Hospital | Little Rock | Arkansas | United States | 72202-3591 |
| 5 | University of Arkansas for Medical Sciences | Little Rock | Arkansas | United States | 72205 |
| 6 | Kaiser Permanente Downey Medical Center | Downey | California | United States | 90242 |
| 7 | Loma Linda University Medical Center | Loma Linda | California | United States | 92354 |
| 8 | Miller Children's and Women's Hospital Long Beach | Long Beach | California | United States | 90806 |
| 9 | Children's Hospital Los Angeles | Los Angeles | California | United States | 90027 |
| 10 | Mattel Children's Hospital UCLA | Los Angeles | California | United States | 90095 |
| 11 | UCLA / Jonsson Comprehensive Cancer Center | Los Angeles | California | United States | 90095 |
| 12 | Valley Children's Hospital | Madera | California | United States | 93636 |
| 13 | Children's Hospital and Research Center at Oakland | Oakland | California | United States | 94609-1809 |
| 14 | Kaiser Permanente-Oakland | Oakland | California | United States | 94611 |
| 15 | Children's Hospital of Orange County | Orange | California | United States | 92868 |
| 16 | Sutter Medical Center Sacramento | Sacramento | California | United States | 95816 |
| 17 | University of California Davis Comprehensive Cancer Center | Sacramento | California | United States | 95817 |
| 18 | Rady Children's Hospital - San Diego | San Diego | California | United States | 92123 |
| 19 | UCSF Medical Center-Parnassus | San Francisco | California | United States | 94143 |
| 20 | UCSF Medical Center-Mission Bay | San Francisco | California | United States | 94158 |
| 21 | Santa Barbara Cottage Hospital | Santa Barbara | California | United States | 93102 |
| 22 | Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center | Torrance | California | United States | 90502 |
| 23 | Children's Hospital Colorado | Aurora | Colorado | United States | 80045 |
| 24 | Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center | Denver | Colorado | United States | 80218 |
| 25 | Connecticut Children's Medical Center | Hartford | Connecticut | United States | 06106 |
| 26 | Alfred I duPont Hospital for Children | Wilmington | Delaware | United States | 19803 |
| 27 | MedStar Georgetown University Hospital | Washington | District of Columbia | United States | 20007 |
| 28 | Broward Health Medical Center | Fort Lauderdale | Florida | United States | 33316 |
| 29 | Lee Memorial Health System | Fort Myers | Florida | United States | 33901 |
| 30 | Golisano Children's Hospital of Southwest Florida | Fort Myers | Florida | United States | 33908 |
| 31 | Memorial Regional Hospital/Joe DiMaggio Children's Hospital | Hollywood | Florida | United States | 33021 |
| 32 | Nemours Children's Clinic-Jacksonville | Jacksonville | Florida | United States | 32207 |
| 33 | University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | United States | 33136 |
| 34 | Nicklaus Children's Hospital | Miami | Florida | United States | 33155 |
| 35 | Miami Cancer Institute | Miami | Florida | United States | 33176 |
| 36 | Florida Hospital Orlando | Orlando | Florida | United States | 32803 |
| 37 | Nemours Children's Clinic - Orlando | Orlando | Florida | United States | 32806 |
| 38 | UF Cancer Center at Orlando Health | Orlando | Florida | United States | 32806 |
| 39 | Nemours Children's Hospital | Orlando | Florida | United States | 32827 |
| 40 | Nemours Children's Clinic - Pensacola | Pensacola | Florida | United States | 32504 |
| 41 | Johns Hopkins All Children's Hospital | Saint Petersburg | Florida | United States | 33701 |
| 42 | Saint Joseph's Hospital/Children's Hospital-Tampa | Tampa | Florida | United States | 33607 |
| 43 | Saint Mary's Hospital | West Palm Beach | Florida | United States | 33407 |
| 44 | Children's Healthcare of Atlanta - Egleston | Atlanta | Georgia | United States | 30322 |
| 45 | University of Hawaii Cancer Center | Honolulu | Hawaii | United States | 96813 |
| 46 | Kapiolani Medical Center for Women and Children | Honolulu | Hawaii | United States | 96826 |
| 47 | Saint Luke's Mountain States Tumor Institute | Boise | Idaho | United States | 83712 |
| 48 | Lurie Children's Hospital-Chicago | Chicago | Illinois | United States | 60611 |
| 49 | University of Illinois | Chicago | Illinois | United States | 60612 |
| 50 | University of Chicago Comprehensive Cancer Center | Chicago | Illinois | United States | 60637 |
| 51 | Advocate Children's Hospital-Oak Lawn | Oak Lawn | Illinois | United States | 60453 |
| 52 | Advocate Children's Hospital-Park Ridge | Park Ridge | Illinois | United States | 60068 |
| 53 | Advocate Lutheran General Hospital | Park Ridge | Illinois | United States | 60068 |
| 54 | Saint Jude Midwest Affiliate | Peoria | Illinois | United States | 61637 |
| 55 | Southern Illinois University School of Medicine | Springfield | Illinois | United States | 62702 |
| 56 | Riley Hospital for Children | Indianapolis | Indiana | United States | 46202 |
| 57 | Saint Vincent Hospital and Health Care Center | Indianapolis | Indiana | United States | 46260 |
| 58 | Blank Children's Hospital | Des Moines | Iowa | United States | 50309 |
| 59 | University of Iowa/Holden Comprehensive Cancer Center | Iowa City | Iowa | United States | 52242 |
| 60 | University of Kansas Cancer Center | Kansas City | Kansas | United States | 66160 |
| 61 | University of Kentucky/Markey Cancer Center | Lexington | Kentucky | United States | 40536 |
| 62 | Norton Children's Hospital | Louisville | Kentucky | United States | 40202 |
| 63 | Tulane University Health Sciences Center | New Orleans | Louisiana | United States | 70112 |
| 64 | Eastern Maine Medical Center | Bangor | Maine | United States | 04401 |
| 65 | University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland | United States | 21201 |
| 66 | Sinai Hospital of Baltimore | Baltimore | Maryland | United States | 21215 |
| 67 | Johns Hopkins University/Sidney Kimmel Cancer Center | Baltimore | Maryland | United States | 21287 |
| 68 | Floating Hospital for Children at Tufts Medical Center | Boston | Massachusetts | United States | 02111 |
| 69 | Baystate Medical Center | Springfield | Massachusetts | United States | 01199 |
| 70 | University of Massachusetts Medical School | Worcester | Massachusetts | United States | 01655 |
| 71 | Wayne State University/Karmanos Cancer Institute | Detroit | Michigan | United States | 48201 |
| 72 | Ascension Saint John Hospital | Detroit | Michigan | United States | 48236 |
| 73 | Michigan State University Clinical Center | East Lansing | Michigan | United States | 48824-7016 |
| 74 | Helen DeVos Children's Hospital at Spectrum Health | Grand Rapids | Michigan | United States | 49503 |
| 75 | Bronson Methodist Hospital | Kalamazoo | Michigan | United States | 49007 |
| 76 | Kalamazoo Center for Medical Studies | Kalamazoo | Michigan | United States | 49008 |
| 77 | Beaumont Children's Hospital-Royal Oak | Royal Oak | Michigan | United States | 48073 |
| 78 | Children's Hospitals and Clinics of Minnesota - Minneapolis | Minneapolis | Minnesota | United States | 55404 |
| 79 | University of Minnesota/Masonic Cancer Center | Minneapolis | Minnesota | United States | 55455 |
| 80 | Mayo Clinic | Rochester | Minnesota | United States | 55905 |
| 81 | University of Mississippi Medical Center | Jackson | Mississippi | United States | 39216 |
| 82 | Columbia Regional | Columbia | Missouri | United States | 65201 |
| 83 | Children's Mercy Hospitals and Clinics | Kansas City | Missouri | United States | 64108 |
| 84 | Cardinal Glennon Children's Medical Center | Saint Louis | Missouri | United States | 63104 |
| 85 | Mercy Hospital Saint Louis | Saint Louis | Missouri | United States | 63141 |
| 86 | Children's Hospital and Medical Center of Omaha | Omaha | Nebraska | United States | 68114 |
| 87 | University of Nebraska Medical Center | Omaha | Nebraska | United States | 68198 |
| 88 | University Medical Center of Southern Nevada | Las Vegas | Nevada | United States | 89102 |
| 89 | Nevada Cancer Research Foundation CCOP | Las Vegas | Nevada | United States | 89106 |
| 90 | Sunrise Hospital and Medical Center | Las Vegas | Nevada | United States | 89109 |
| 91 | Alliance for Childhood Diseases/Cure 4 the Kids Foundation | Las Vegas | Nevada | United States | 89135 |
| 92 | Summerlin Hospital Medical Center | Las Vegas | Nevada | United States | 89144 |
| 93 | Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | United States | 03756 |
| 94 | Hackensack University Medical Center | Hackensack | New Jersey | United States | 07601 |
| 95 | Saint Barnabas Medical Center | Livingston | New Jersey | United States | 07039 |
| 96 | Morristown Medical Center | Morristown | New Jersey | United States | 07960 |
| 97 | Saint Peter's University Hospital | New Brunswick | New Jersey | United States | 08901 |
| 98 | Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital | New Brunswick | New Jersey | United States | 08903 |
| 99 | Newark Beth Israel Medical Center | Newark | New Jersey | United States | 07112 |
| 100 | Saint Joseph's Regional Medical Center | Paterson | New Jersey | United States | 07503 |
| 101 | Overlook Hospital | Summit | New Jersey | United States | 07902 |
| 102 | University of New Mexico Cancer Center | Albuquerque | New Mexico | United States | 87102 |
| 103 | Montefiore Medical Center - Moses Campus | Bronx | New York | United States | 10467 |
| 104 | Brooklyn Hospital Center | Brooklyn | New York | United States | 11201 |
| 105 | Roswell Park Cancer Institute | Buffalo | New York | United States | 14263 |
| 106 | NYU Winthrop Hospital | Mineola | New York | United States | 11501 |
| 107 | The Steven and Alexandra Cohen Children's Medical Center of New York | New Hyde Park | New York | United States | 11040 |
| 108 | Laura and Isaac Perlmutter Cancer Center at NYU Langone | New York | New York | United States | 10016 |
| 109 | NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center | New York | New York | United States | 10032 |
| 110 | University of Rochester | Rochester | New York | United States | 14642 |
| 111 | State University of New York Upstate Medical University | Syracuse | New York | United States | 13210 |
| 112 | New York Medical College | Valhalla | New York | United States | 10595 |
| 113 | Mission Hospital Inc-Memorial Campus | Asheville | North Carolina | United States | 28801 |
| 114 | Carolinas Medical Center/Levine Cancer Institute | Charlotte | North Carolina | United States | 28203 |
| 115 | Novant Health Presbyterian Medical Center | Charlotte | North Carolina | United States | 28204 |
| 116 | Duke University Medical Center | Durham | North Carolina | United States | 27710 |
| 117 | East Carolina University | Greenville | North Carolina | United States | 27834 |
| 118 | Wake Forest University Health Sciences | Winston-Salem | North Carolina | United States | 27157 |
| 119 | Children's Hospital Medical Center of Akron | Akron | Ohio | United States | 44308 |
| 120 | Cincinnati Children's Hospital Medical Center | Cincinnati | Ohio | United States | 45229 |
| 121 | Rainbow Babies and Childrens Hospital | Cleveland | Ohio | United States | 44106 |
| 122 | Cleveland Clinic Foundation | Cleveland | Ohio | United States | 44195 |
| 123 | Nationwide Children's Hospital | Columbus | Ohio | United States | 43205 |
| 124 | Dayton Children's Hospital | Dayton | Ohio | United States | 45404 |
| 125 | The Toledo Hospital/Toledo Children's Hospital | Toledo | Ohio | United States | 43606 |
| 126 | Mercy Children's Hospital | Toledo | Ohio | United States | 43608 |
| 127 | University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | United States | 73104 |
| 128 | Legacy Emanuel Children's Hospital | Portland | Oregon | United States | 97227 |
| 129 | Legacy Emanuel Hospital and Health Center | Portland | Oregon | United States | 97227 |
| 130 | Lehigh Valley Hospital - Muhlenberg | Bethlehem | Pennsylvania | United States | 18017 |
| 131 | Geisinger Medical Center | Danville | Pennsylvania | United States | 17822 |
| 132 | Penn State Children's Hospital | Hershey | Pennsylvania | United States | 17033 |
| 133 | Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | United States | 19104 |
| 134 | Saint Christopher's Hospital for Children | Philadelphia | Pennsylvania | United States | 19134 |
| 135 | Children's Hospital of Pittsburgh of UPMC | Pittsburgh | Pennsylvania | United States | 15224 |
| 136 | Rhode Island Hospital | Providence | Rhode Island | United States | 02903 |
| 137 | Medical University of South Carolina | Charleston | South Carolina | United States | 29425 |
| 138 | Prisma Health Richland Hospital | Columbia | South Carolina | United States | 29203 |
| 139 | BI-LO Charities Children's Cancer Center | Greenville | South Carolina | United States | 29605 |
| 140 | Greenville Cancer Treatment Center | Greenville | South Carolina | United States | 29605 |
| 141 | Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | United States | 57117-5134 |
| 142 | T C Thompson Children's Hospital | Chattanooga | Tennessee | United States | 37403 |
| 143 | East Tennessee Childrens Hospital | Knoxville | Tennessee | United States | 37916 |
| 144 | Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee | United States | 37232 |
| 145 | Texas Tech University Health Sciences Center-Amarillo | Amarillo | Texas | United States | 79106 |
| 146 | Dell Children's Medical Center of Central Texas | Austin | Texas | United States | 78723 |
| 147 | Driscoll Children's Hospital | Corpus Christi | Texas | United States | 78411 |
| 148 | Medical City Dallas Hospital | Dallas | Texas | United States | 75230 |
| 149 | UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas | United States | 75390 |
| 150 | Brooke Army Medical Center | Fort Sam Houston | Texas | United States | 78234 |
| 151 | Cook Children's Medical Center | Fort Worth | Texas | United States | 76104 |
| 152 | Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center | Houston | Texas | United States | 77030 |
| 153 | Covenant Children's Hospital | Lubbock | Texas | United States | 79410 |
| 154 | Methodist Children's Hospital of South Texas | San Antonio | Texas | United States | 78229 |
| 155 | University of Texas Health Science Center at San Antonio | San Antonio | Texas | United States | 78229 |
| 156 | Primary Children's Hospital | Salt Lake City | Utah | United States | 84113 |
| 157 | University of Vermont and State Agricultural College | Burlington | Vermont | United States | 05405 |
| 158 | Children's Hospital of The King's Daughters | Norfolk | Virginia | United States | 23507 |
| 159 | Carilion Clinic Children's Hospital | Roanoke | Virginia | United States | 24014 |
| 160 | Seattle Children's Hospital | Seattle | Washington | United States | 98105 |
| 161 | Providence Sacred Heart Medical Center and Children's Hospital | Spokane | Washington | United States | 99204 |
| 162 | Madigan Army Medical Center | Tacoma | Washington | United States | 98431 |
| 163 | West Virginia University Charleston Division | Charleston | West Virginia | United States | 25304 |
| 164 | Marshfield Medical Center-Marshfield | Marshfield | Wisconsin | United States | 54449 |
| 165 | Children's Hospital of Wisconsin | Milwaukee | Wisconsin | United States | 53226 |
| 166 | Royal Brisbane and Women's Hospital | Herston | Queensland | Australia | 4029 |
| 167 | Royal Children's Hospital-Brisbane | Herston | Queensland | Australia | 4029 |
| 168 | Queensland Children's Hospital | South Brisbane | Queensland | Australia | 4101 |
| 169 | Women's and Children's Hospital-Adelaide | North Adelaide | South Australia | Australia | 5006 |
| 170 | Princess Margaret Hospital for Children | Perth | Western Australia | Australia | 6008 |
| 171 | University of Alberta Hospital | Edmonton | Alberta | Canada | T6G 2B7 |
| 172 | British Columbia Children's Hospital | Vancouver | British Columbia | Canada | V6H 3V4 |
| 173 | CancerCare Manitoba | Winnipeg | Manitoba | Canada | R3E 0V9 |
| 174 | IWK Health Centre | Halifax | Nova Scotia | Canada | B3K 6R8 |
| 175 | McMaster Children's Hospital at Hamilton Health Sciences | Hamilton | Ontario | Canada | L8N 3Z5 |
| 176 | Kingston Health Sciences Centre | Kingston | Ontario | Canada | K7L 2V7 |
| 177 | Children's Hospital of Eastern Ontario | Ottawa | Ontario | Canada | K1H 8L1 |
| 178 | Hospital for Sick Children | Toronto | Ontario | Canada | M5G 1X8 |
| 179 | The Montreal Children's Hospital of the MUHC | Montreal | Quebec | Canada | H3H 1P3 |
| 180 | Centre Hospitalier Universitaire Sainte-Justine | Montreal | Quebec | Canada | H3T 1C5 |
| 181 | Allan Blair Cancer Centre | Regina | Saskatchewan | Canada | S4T 7T1 |
| 182 | Saskatoon Cancer Centre | Saskatoon | Saskatchewan | Canada | S7N 4H4 |
| 183 | Swiss Pediatric Oncology Group - Bern | Bern | Switzerland | 3010 |
Sponsors and Collaborators
- Children's Oncology Group
- National Cancer Institute (NCI)
Investigators
- Principal Investigator: Meghan A Higman, Children's Oncology Group
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
Children's Oncology Group
ClinicalTrials.gov Identifier:
NCT00900250
Other Study ID Numbers:
- AHOD04B1
- NCI-2009-00378
- CDR0000495369
- COG-AHOD04B1
- AHOD04B1
- AHOD04B1
- U10CA180886
- U10CA098543
First Posted:
May 12, 2009
Last Update Posted:
Apr 10, 2019
Last Verified:
Apr 1, 2019