Collection of Blood and Bone Marrow From Healthy Volunteers and Patients for Research Purposes

Sponsor

National Heart, Lung, and Blood Institute (NHLBI) (NIH)

Overall Status

Completed

CT.gov ID

NCT00001627

Collaborator

(none)

154

Enrollment

Location

161.5

Actual Duration (Months)

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This study is designed to provide bone marrow and/or blood cells for other research studies. Patients participating in this study will be asked to provide small amounts of medical information and undergo a limited physical examination designed to detect the presence of any obvious blood disease. A blood and bone marrow sample will be obtained to verify that the patient has normal blood cell production.

Researchers plan to obtain bone marrow samples to be used in laboratory studies directed toward understanding the formation of blood cells. Bone marrow samples will be taken from the hip bone of patients and healthy volunteers.

These samples are valuable to many research studies within the Hematology Branch of the National Heart, Lung, and Blood Institute, including studies of normal and abnormal production of blood cells, the viral causes of blood diseases, and the role of the immune system in bone marrow failure and related conditions....

Condition or Disease	Intervention/Treatment	Phase
Bone Marrow Diseases Healthy Volunteers

Detailed Description

This protocol defines in general terms the purposes for which blood and bone marrow specimens will be collected by members of the Hematology Branch and the conditions under which the sampling will be performed. Samples of blood and bone marrow from healthy volunteers and from patients are indispensable for many research projects, including studies of normal and abnormal hematopoiesis, the viral etiology of blood diseases, and the role of the immune system in marrow failure and related conditions.

Study Design

Study Type:

Observational

Actual Enrollment :

154 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

Collection of Blood and Bone Marrow From Healthy Volunteers and Patients for Research Purposes

Actual Study Start Date :

Jul 8, 1997

Actual Primary Completion Date :

Dec 22, 2010

Actual Study Completion Date :

Dec 22, 2010

Arms and Interventions

Arm	Intervention/Treatment
Group 1 Normal Volunteers and patients.

Outcome Measures

Primary Outcome Measures

To provide a readily available supply of samples for blood and bone marrow for in vitro studies in the Hematology Branch laboratories [Ongoing]
The collection of adequate cells for laboratory research.

Eligibility Criteria

Criteria

Ages Eligible for Study:

2 Years to 110 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

INCLUSION CRITERIA:

Healthy volunteers age greater than or equal to 18 years.

Subjects with hematologic disease age greater than or equal to 2 (for subjects less than 18, blood and bone marrow specimens will be obtained concurrently with clinically indicated sampling).