Collection of Bone Marrow Aspirate From Volunteer Donors
Study Details
Study Description
Brief Summary
The purpose of this study is to collect bone marrow cells for research purposes.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
|
Detailed Description
This study is designed to provide bone marrow cells for other research studies. The research is being done because there are ongoing experiments in a number of National Institute on Aging (NIA) laboratories that require access to normal human bone marrow aspirate for their studies of the immune system. These studies are done to understand how blood cells are formed and how they function. Samples will be used to study problems such as the immune system in bone marrow failure and related conditions. Cells will be used in laboratory research and may be banked for future laboratory studies
Study Design
Outcome Measures
Primary Outcome Measures
Eligibility Criteria
Criteria
Inclusion Criteria:
- Healthy volunteers age 18 and over
Exclusion Criteria:
-
Significant abnormalities on health history questionnaire or in the results of blood tests
-
Pregnant or nursing mother
-
Participation in another research study within the past six weeks that is felt by the Principal Investigator to be incompatible with this study
-
Severe infection in the past two months
-
Immune disorder, or use of any medication that can alter immune system function
-
A medical or mental health finding showing inability to go through the procedure
-
Body mass index (BMI) greater than 29%
-
Chronic back pain, sciatica, or a compression fracture of the spine
-
Positive test results for viral infections: Hepatitis B, Hepatitis C, or HIV (AIDS)
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | NIA Clinical Research Unit located at Harbor Hospital | Baltimore | Maryland | United States | 21225 |
Sponsors and Collaborators
- National Institute on Aging (NIA)
Investigators
- Principal Investigator: Dan L. Longo, MD, National Institute on Aging (NIA)
Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
- Cashman J, Clark-Lewis I, Eaves A, Eaves C. Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice. Blood. 2002 Feb 1;99(3):792-9.
- Exley MA, Tahir SM, Cheng O, Shaulov A, Joyce R, Avigan D, Sackstein R, Balk SP. A major fraction of human bone marrow lymphocytes are Th2-like CD1d-reactive T cells that can suppress mixed lymphocyte responses. J Immunol. 2001 Nov 15;167(10):5531-4.
- Johnson BS, Mueller L, Si J, Collins SJ. The cytokines IL-3 and GM-CSF regulate the transcriptional activity of retinoic acid receptors in different in vitro models of myeloid differentiation. Blood. 2002 Feb 1;99(3):746-53.
- AG0046