Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer

• Sponsor: National Cancer Institute (NCI) (NIH)
• Overall Status: Active, not recruiting
• CT.gov ID: NCT00217737
• Collaborator: (none)
• Enrollment: 3,610
• Locations: 936
• Arms: 3
• Anticipated Duration (Months): 201.9
• Patients Per Site: 3.9
• Patients Per Site Per Month: 0

Study Details

Study Description

Brief Summary

This randomized phase III trial studies oxaliplatin, leucovorin calcium, fluorouracil, and bevacizumab to see how well they work compared to oxaliplatin, leucovorin calcium, and fluorouracil in treating patients who have undergone surgery for stage II colon cancer. Drugs used in chemotherapy, such as oxaliplatin, leucovorin calcium, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal antibodies, such as bevacizumab, may interfere with the ability of tumor cells to grow and spread. It is not yet known whether giving combination chemotherapy together with bevacizumab is more effective than combination chemotherapy alone in treating colon cancer.

Condition or Disease	Intervention/Treatment	Phase
Colon Mucinous Adenocarcinoma; Colon Signet Ring Cell Adenocarcinoma; Lynch Syndrome; Stage IIA Colon Cancer AJCC v7; Stage IIB Colon Cancer AJCC v7; Stage IIC Colon Cancer AJCC v7	Biological: Bevacizumab; Drug: Fluorouracil; Other: Laboratory Biomarker Analysis; Drug: Leucovorin Calcium; Drug: Oxaliplatin	Phase 3

Detailed Description

PRIMARY OBJECTIVES:

1. To demonstrate an improvement in 3-year disease-free survival for high-risk stage II colon cancer patients randomly assigned to 5-FU (fluorouracil), leucovorin (leucovorin calcium), oxaliplatin versus 5-FU, leucovorin, oxaliplatin and bevacizumab.

SECONDARY OBJECTIVES:

1. To compare overall survival between the regimens. II. To further define the toxicity profiles of the regimens. III. To prospectively determine the impact of tumor biological characteristics on the survival of patients with stage II colon cancer.

2. To assess the association between oxaliplatin exposure, allelic variants in candidate genes, and neurotoxicity. (Pharmacogenetic ancillary objective)

OUTLINE: Patients with high-risk disease are randomized to 1 of 2 treatment arms (Arms A and B). Patients with low-risk disease are assigned to Arm C.

ARM A: Patients receive oxaliplatin intravenously (IV) over 2 hours and leucovorin calcium IV over 2 hours on day 1. Patients also receive fluorouracil IV continuously over 46 hours beginning on day 1. Treatment repeats every 2 weeks for 12 courses in the absence of disease progression or unacceptable toxicity.

ARM B: Patients receive oxaliplatin, leucovorin calcium, and fluorouracil as in Arm A and bevacizumab IV over 30-90 minutes on day 1. Treatment repeats every 2 weeks for 12 courses in the absence of disease progression or unacceptable toxicity. Patients then receive bevacizumab alone for 12 additional courses in the absence of disease progression or unacceptable toxicity.

ARM C: Patients undergo observation.

After completion of study treatment, patients are followed up every 3 months for 2 years, every 6 months for 3 years, and then every 12 months for 10 years.

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 3610 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: None (Open Label)
• Primary Purpose: Treatment
• Official Title: A Randomized Phase III Study Comparing 5-FU, Leucovorin and Oxaliplatin Versus 5-FU, Leucovorin, Oxaliplatin and Bevacizumab in Patients With Stage II Colon Cancer at High Risk for Recurrence to Determine Prospectively the Prognostic Value of Molecular Markers
• Actual Study Start Date: Aug 4, 2005
• Anticipated Primary Completion Date: Jun 1, 2022
• Anticipated Study Completion Date: Jun 1, 2022

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: Arm A (oxaliplatin, leucovorin calcium, fluorouracil) Patients receive oxaliplatin IV over 2 hours and leucovorin calcium IV over 2 hours on day 1. Patients also receive fluorouracil IV continuously over 46 hours beginning on day 1. Treatment repeats every 2 weeks for 12 courses in the absence of disease progression or unacceptable toxicity.	Drug: Fluorouracil; Given IV; Other Names: 5 Fluorouracil 5 Fluorouracilum 5 FU 5-Fluoro-2,4(1H, 3H)-pyrimidinedione 5-Fluorouracil 5-Fluracil 5-Fu 5FU AccuSite Carac Fluoro Uracil Fluouracil Flurablastin Fluracedyl Fluracil Fluril Fluroblastin Ribofluor Ro 2-9757 Ro-2-9757 ; Other: Laboratory Biomarker Analysis; Correlative studies; Drug: Leucovorin Calcium; Given IV; Other Names: Adinepar Calcifolin Calcium (6S)-Folinate Calcium Folinate Calcium Leucovorin Calfolex Calinat Cehafolin Citofolin Citrec Citrovorum Factor Cromatonbic Folinico Dalisol Disintox Divical Ecofol Emovis Factor, Citrovorum Flynoken A Folaren Folaxin FOLI-cell Foliben Folidan Folidar Folinac Folinate Calcium folinic acid Folinic Acid Calcium Salt Pentahydrate Folinoral Folinvit Foliplus Folix Imo Lederfolat Lederfolin Leucosar leucovorin Rescufolin Rescuvolin Tonofolin Wellcovorin ; Drug: Oxaliplatin; Given IV; Other Names: 1-OHP Ai Heng Aiheng Dacotin Dacplat Diaminocyclohexane Oxalatoplatinum Eloxatin Eloxatine JM-83 Oxalatoplatin Oxalatoplatinum RP 54780 RP-54780 SR-96669
Experimental: Arm B (combination chemotherapy, bevacizumab) Patients receive oxaliplatin, leucovorin calcium, and fluorouracil as in Arm A and bevacizumab IV over 30-90 minutes on day 1. Treatment repeats every 2 weeks for 12 courses in the absence of disease progression or unacceptable toxicity. Patients then receive bevacizumab alone for 12 additional courses in the absence of disease progression or unacceptable toxicity.	Biological: Bevacizumab; Given IV; Other Names: ABP 215 Anti-VEGF Anti-VEGF Humanized Monoclonal Antibody Anti-VEGF rhuMAb Avastin Bevacizumab awwb Bevacizumab Biosimilar ABP 215 Bevacizumab Biosimilar BEVZ92 Bevacizumab Biosimilar BI 695502 Bevacizumab Biosimilar CBT 124 Bevacizumab Biosimilar CT-P16 Bevacizumab Biosimilar FKB238 Bevacizumab Biosimilar GB-222 Bevacizumab Biosimilar HD204 Bevacizumab Biosimilar HLX04 Bevacizumab Biosimilar IBI305 Bevacizumab Biosimilar LY01008 Bevacizumab Biosimilar MIL60 Bevacizumab Biosimilar Mvasi Bevacizumab Biosimilar MYL-1402O Bevacizumab Biosimilar QL 1101 Bevacizumab Biosimilar RPH-001 Bevacizumab Biosimilar SCT501 Bevacizumab Biosimilar Zirabev Bevacizumab-awwb Bevacizumab-bvzr BP102 BP102 Biosimilar HD204 Immunoglobulin G1 (Human-Mouse Monoclonal rhuMab-VEGF Gamma-Chain Anti-Human Vascular Endothelial Growth Factor), Disulfide With Human-Mouse Monoclonal rhuMab-VEGF Light Chain, Dimer Mvasi MYL-1402O Recombinant Humanized Anti-VEGF Monoclonal Antibody rhuMab-VEGF SCT501 Zirabev ; Drug: Fluorouracil; Given IV; Other Names: 5 Fluorouracil 5 Fluorouracilum 5 FU 5-Fluoro-2,4(1H, 3H)-pyrimidinedione 5-Fluorouracil 5-Fluracil 5-Fu 5FU AccuSite Carac Fluoro Uracil Fluouracil Flurablastin Fluracedyl Fluracil Fluril Fluroblastin Ribofluor Ro 2-9757 Ro-2-9757 ; Other: Laboratory Biomarker Analysis; Correlative studies; Drug: Leucovorin Calcium; Given IV; Other Names: Adinepar Calcifolin Calcium (6S)-Folinate Calcium Folinate Calcium Leucovorin Calfolex Calinat Cehafolin Citofolin Citrec Citrovorum Factor Cromatonbic Folinico Dalisol Disintox Divical Ecofol Emovis Factor, Citrovorum Flynoken A Folaren Folaxin FOLI-cell Foliben Folidan Folidar Folinac Folinate Calcium folinic acid Folinic Acid Calcium Salt Pentahydrate Folinoral Folinvit Foliplus Folix Imo Lederfolat Lederfolin Leucosar leucovorin Rescufolin Rescuvolin Tonofolin Wellcovorin ; Drug: Oxaliplatin; Given IV; Other Names: 1-OHP Ai Heng Aiheng Dacotin Dacplat Diaminocyclohexane Oxalatoplatinum Eloxatin Eloxatine JM-83 Oxalatoplatin Oxalatoplatinum RP 54780 RP-54780 SR-96669
No Intervention: Arm C (observation) Patients undergo observation.

Outcome Measures

Primary Outcome Measures

1. Disease-free survival [Up to 10 years]

Secondary Outcome Measures

1. Overall survival [Up to 10 years]

2. Incidence of adverse events graded by NCI CTCAE 4.0 [Up to 10 years]

   We will tabulate and report adverse events by treatment arm and note those events that differ statistically between arms. No formal type I error adjustment will be done for the toxicity analyses.

3. Impact of tumor biologic characteristics and their relationship to overall survival [Up to 10 years]

   Analysis of tumor biological characteristics and their relationship to overall survival will be conducted between high and low risk populations.

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• STEP 1: INITIAL REGISTRATION

• The distal extent of the tumor must be >= 12 cm from the anal verge on endoscopy; if this distance was not confirmed on endoscopy pre-operatively, then the distal extent of the tumor must be >= 12 cm from the anal verge as determined by surgical examination; colonoscopy should be performed postoperatively for those unable to have a preoperative colonoscopy to guarantee there are no synchronous lesions; (if tumor is located beyond sigmoid colon and centimeter distance unavailable, include anatomic region of colon, e.g. right colon, transverse colon, hepatic flexure descending colon, cecum etc.)

• Patients must have paraffin-embedded tumor specimen available for evaluation of microsatellite instability and loss of heterozygosity at 18q, to determine high risk versus low risk

• High-risk patients will be randomized to treatment Arms A or B

• Low-risk patients will be registered to Arm C for observation

• NOTE: Every effort should be made to submit blocks (tumor and normal mucosa) to the Principal Coordinates Analysis (PCO) immediately; blocks CANNOT be accepted after day 50 (post surgery) in order to allow for molecular assessment

• Specific laboratory requirements for Step 2 must be obtained within 2 weeks prior to Step 2 randomization

• Patients must not have synchronous tumors

• Patients must not have appendiceal tumors

• Patients must not have a history of inflammatory bowel disease (IBD)

• Patients with hereditary non-polyposis colorectal cancer (HNPCC) are eligible

• Patients must have no history of isolated, distant, or non-contiguous intra-abdominal metastases, even if restricted

• Patients must have histologically confirmed adenocarcinoma of the colon that meets the criteria below:

• Stage II adenocarcinoma (pT3/pT4a/pT4b pN0 M0 according to the definitions of the American Joint Committee on Cancer, 7th Edition, 2010): the tumor invades through the muscularis propria into pericolic tissues (pT3), penetrates to the surface of the visceral peritoneum (pT4a), or directly invades other organs or structures (pT4b); patients with mesenteric tumor deposits or satellites without identifiable residual lymph node in the absence of lymph node involvement are now designated pN1c, rather than pT3; patients with such tumor deposits are not eligible for E5202; patients must have had a complete resection (R0 resection)

• Patients must have >= 8 lymph nodes evaluated and reported

• Patients must not have presented with clinical complete obstruction or perforation of the bowel

• Patients must not have had any systemic or radiation therapy initiated for this malignancy

• Patients must not have a previous or concurrent malignancy; exceptions are made for patients who meet any of the following conditions:

• Non-melanoma skin cancer, in situ cervical cancer, or breast cancer in situ

• Prior malignancy completely excised or removed and patient has been continuously disease free for > 5 years

• Patients with completely excised or removed breast cancer and disease free > 5 years, regardless of the continuation of hormonal therapy

• Patients with previous radiation therapy (RT) to the pelvic region will be ineligible

• Patients must have Eastern Cooperative Oncology Group (ECOG) performance status of 0-2

• STEP 2: RANDOMIZATION (HIGH RISK PATIENTS - ARMS A AND B ONLY)

• Within 2 weeks prior to randomization, postoperative absolute granulocyte count (AGC) must be >= 1500/mm^{3 (or < 1500/mm}3, if in the opinion of the investigator, this represents an ethnic or racial variation of normal)

• Within 2 weeks prior to randomization, the postoperative platelet count must be >= 100,000/mm^3

• Within 2 weeks prior to randomization, there must be postoperative evidence of adequate hepatic function; bilirubin must be =< upper limit of normal (ULN) unless the patient has a chronic grade 1 bilirubin elevation due to Gilbert's disease or similar syndrome due to slow conjugation of bilirubin

• Within 2 weeks prior to randomization, there must be postoperative evidence of adequate hepatic function; alkaline phosphatase must be < 2.5 x ULN

• Within 2 weeks prior to randomization, there must be postoperative evidence of adequate hepatic function; aspartate transaminase (AST) must be < 1.5 x ULN

• Within 2 weeks prior to randomization, there must be postoperative evidence of adequate renal function; serum creatinine =< 1.5 x ULN

• Within 2 weeks prior to randomization, there must be postoperative evidence of adequate renal function; urine protein/creatinine (UPC) ratio of < 1.0; patients with a UPC ratio >= 1.0 must undergo a 24-hour urine collection, which must be an adequate collection and must demonstrate < 1 gm of protein in order to participate

• Patients with any significant bleeding that is not related to the primary colon tumor within 6 months prior to study entry are not eligible

• Patients with gastroduodenal ulcer(s) determined to be active by endoscopy are not eligible

• Patients with a history of hypertension must measure < 150/90 mmHg and be on a stable regimen of anti-hypertensive therapy

• Patients must not have a serious or non-healing wound, skin ulcers or bone fracture

• Patients experiencing clinically significant peripheral neuropathy at the time of step 2 randomization (defined in the National Cancer Institute [NCI] Common Terminology Criteria for Adverse Events version 4.0 [CTCAE 4.0] as grade 2 or greater neurosensory or neuromotor toxicity) are not eligible

• Patients must not have had invasive procedures, defined as follows:

• Major surgical procedure, open biopsy or significant traumatic injury within 28 days prior to randomization

• Core biopsy or other minor procedure, excluding placement of a vascular access device, within 7 days prior to randomization

• Or anticipate the need for major surgical procedure(s) during the course of the study

• Patients must begin adjuvant treatment no less than 28 days and no more than 60 days from surgery

• Eligible patients of reproductive potential (both sexes) must agree to use an accepted and effective method of contraceptive during study therapy and for at least 3 months after the completion of bevacizumab; women must not be pregnant or breast-feeding; all females of childbearing potential must have a serum pregnancy test to rule out pregnancy within 2 weeks prior to step 2 randomization

• Patients with prothrombin time (PT) (international normalized ratio [INR]) > 1.5 are not eligible, unless the patient is on full-dose anticoagulants; if so, the following criteria must be met for enrollment:

• The subject must have an in-range INR (usually between 2 and 3) on a stable dose of warfarin or on a stable dose of low molecular weight heparin

• The subject must not have active bleeding or a pathological condition that is associated with a high risk of bleeding

• Patients with non-malignant systemic disease (cardiovascular, renal, hepatic, etc.) that would preclude any of the study therapy drugs are not eligible; specifically excluded are the following conditions:

• New York Heart Association (NYHA) class III or IV congestive heart failure

• Current symptomatic arrhythmia

• Any non-malignant systemic disease

• Patients with a history of transient ischemic attack (TIA) or cerebrovascular accident (CVA) are not eligible

• Patients with a history of the following within twelve months of study entry are not eligible:

• Arterial thromboembolic events

• Unstable angina

• Myocardial infarction

• Patients with symptomatic peripheral vascular disease are not eligible

• Patients with psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude them from meeting the study requirements are not eligible

• Patients must not have a known allergy to platinum compounds

• STEP 2: REGISTRATION (LOW-RISK PATIENTS - ARM C)

• Patients determined to be low risk are eligible

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Northeast Alabama Regional Medical Center	Anniston	Alabama	United States	36202
2	University of Alabama at Birmingham Cancer Center	Birmingham	Alabama	United States	35233
3	Clearview Cancer Institute	Huntsville	Alabama	United States	35805
4	Mobile Infirmary Medical Center	Mobile	Alabama	United States	36607
5	Providence Hospital	Mobile	Alabama	United States	36608
6	Providence Alaska Medical Center	Anchorage	Alaska	United States	99508
7	Mayo Clinic in Arizona	Scottsdale	Arizona	United States	85259
8	Banner University Medical Center - Tucson	Tucson	Arizona	United States	85719
9	Mercy Hospital Fort Smith	Fort Smith	Arkansas	United States	72903
10	NEA Baptist Memorial Hospital	Jonesboro	Arkansas	United States	72401
11	Alta Bates Summit Medical Center-Herrick Campus	Berkeley	California	United States	94704
12	Providence Saint Joseph Medical Center/Disney Family Cancer Center	Burbank	California	United States	91505
13	Mills-Peninsula Medical Center	Burlingame	California	United States	94010
14	East Bay Radiation Oncology Center	Castro Valley	California	United States	94546
15	Eden Hospital Medical Center	Castro Valley	California	United States	94546
16	Valley Medical Oncology Consultants-Castro Valley	Castro Valley	California	United States	94546
17	John Muir Medical Center-Concord Campus	Concord	California	United States	94520
18	City of Hope Comprehensive Cancer Center	Duarte	California	United States	91010
19	Bay Area Breast Surgeons Inc	Emeryville	California	United States	94608
20	Valley Medical Oncology Consultants-Fremont	Fremont	California	United States	94538
21	Washington Hospital	Fremont	California	United States	94538
22	Saint Jude Medical Center	Fullerton	California	United States	92835
23	Glendale Memorial Hospital and Health Center	Glendale	California	United States	91204
24	Marin Cancer Care Inc	Greenbrae	California	United States	94904
25	Marin General Hospital	Greenbrae	California	United States	94904
26	Saint Rose Hospital	Hayward	California	United States	94545
27	Loma Linda University Medical Center	Loma Linda	California	United States	92354
28	Veterans Affairs Loma Linda Healthcare System	Loma Linda	California	United States	92357
29	USC / Norris Comprehensive Cancer Center	Los Angeles	California	United States	90033
30	Contra Costa Regional Medical Center	Martinez	California	United States	94553-3156
31	Fremont - Rideout Cancer Center	Marysville	California	United States	95901
32	Providence Holy Cross Medical Center	Mission Hills	California	United States	91346-9600
33	Memorial Medical Center	Modesto	California	United States	95355
34	El Camino Hospital	Mountain View	California	United States	94040
35	Palo Alto Medical Foundation-Camino Division	Mountain View	California	United States	94040
36	Sutter Cancer Research Consortium	Novato	California	United States	94945
37	Highland General Hospital	Oakland	California	United States	94602
38	Alta Bates Summit Medical Center - Summit Campus	Oakland	California	United States	94609
39	Bay Area Tumor Institute	Oakland	California	United States	94609
40	Hematology and Oncology Associates-Oakland	Oakland	California	United States	94609
41	Tom K Lee Inc	Oakland	California	United States	94609
42	Saint Joseph Hospital - Orange	Orange	California	United States	92868
43	Desert Regional Medical Center	Palm Springs	California	United States	92262
44	Palo Alto Medical Foundation Health Care	Palo Alto	California	United States	94301
45	Stanford Cancer Institute Palo Alto	Palo Alto	California	United States	94304
46	VA Palo Alto Health Care System	Palo Alto	California	United States	94304
47	Valley Care Health System - Pleasanton	Pleasanton	California	United States	94588
48	Valley Medical Oncology Consultants	Pleasanton	California	United States	94588
49	Eisenhower Medical Center	Rancho Mirage	California	United States	92270
50	Sutter Roseville Medical Center	Roseville	California	United States	95661
51	Sutter Medical Center Sacramento	Sacramento	California	United States	95816
52	University of California Davis Comprehensive Cancer Center	Sacramento	California	United States	95817
53	Salinas Valley Memorial	Salinas	California	United States	93901
54	UC San Diego Medical Center - Hillcrest	San Diego	California	United States	92103
55	Kaiser Permanente-San Diego Mission	San Diego	California	United States	92108
56	Sharp Memorial Hospital	San Diego	California	United States	92123
57	San Diego VA Medical Center	San Diego	California	United States	92161
58	Zuckerberg San Francisco General Hospital	San Francisco	California	United States	94110
59	California Pacific Medical Center-Pacific Campus	San Francisco	California	United States	94115
60	UCSF Medical Center-Mount Zion	San Francisco	California	United States	94115
61	Doctors Medical Center- JC Robinson Regional Cancer Center	San Pablo	California	United States	94806
62	Providence Santa Rosa Memorial Hospital	Santa Rosa	California	United States	95405
63	Gene Upshaw Memorial Tahoe Forest Cancer Center	Truckee	California	United States	96161
64	Northbay Cancer Center	Vacaville	California	United States	95687
65	Sutter Solano Medical Center/Cancer Center	Vallejo	California	United States	94589
66	John Muir Medical Center-Walnut Creek	Walnut Creek	California	United States	94598
67	The Medical Center of Aurora	Aurora	Colorado	United States	80012
68	Rocky Mountain Regional VA Medical Center	Aurora	Colorado	United States	80045
69	University of Colorado Hospital	Aurora	Colorado	United States	80045
70	Boulder Community Hospital	Boulder	Colorado	United States	80301
71	Penrose-Saint Francis Healthcare	Colorado Springs	Colorado	United States	80907
72	UCHealth Memorial Hospital Central	Colorado Springs	Colorado	United States	80909
73	Denver Health Medical Center	Denver	Colorado	United States	80204
74	Porter Adventist Hospital	Denver	Colorado	United States	80210
75	University of Colorado	Denver	Colorado	United States	80217-3364
76	Presbyterian - Saint Lukes Medical Center - Health One	Denver	Colorado	United States	80218
77	SCL Health Saint Joseph Hospital	Denver	Colorado	United States	80218
78	Rose Medical Center	Denver	Colorado	United States	80220
79	Western States Cancer Research NCORP	Denver	Colorado	United States	80222
80	Shaw Cancer Center	Edwards	Colorado	United States	81632
81	Swedish Medical Center	Englewood	Colorado	United States	80113
82	Poudre Valley Hospital	Fort Collins	Colorado	United States	80524
83	Valley View Hospital Cancer Center	Glenwood Springs	Colorado	United States	81601
84	Saint Mary's Hospital and Regional Medical Center	Grand Junction	Colorado	United States	81501
85	North Colorado Medical Center	Greeley	Colorado	United States	80631
86	Saint Anthony Hospital	Lakewood	Colorado	United States	80228
87	Sky Ridge Medical Center	Lone Tree	Colorado	United States	80124
88	Longmont United Hospital	Longmont	Colorado	United States	80501
89	McKee Medical Center	Loveland	Colorado	United States	80539
90	Montrose Memorial Hospital	Montrose	Colorado	United States	81401
91	Saint Mary Corwin Medical Center	Pueblo	Colorado	United States	81004
92	North Suburban Medical Center	Thornton	Colorado	United States	80229
93	SCL Health Lutheran Medical Center	Wheat Ridge	Colorado	United States	80033
94	Bridgeport Hospital	Bridgeport	Connecticut	United States	06610
95	Danbury Hospital	Danbury	Connecticut	United States	06810
96	Hartford Hospital	Hartford	Connecticut	United States	06102
97	Smilow Cancer Hospital Care Center at Saint Francis	Hartford	Connecticut	United States	06105
98	The Hospital of Central Connecticut	New Britain	Connecticut	United States	06050
99	Norwalk Hospital	Norwalk	Connecticut	United States	06856
100	Eastern Connecticut Hematology and Oncology Associates	Norwich	Connecticut	United States	06360
101	Stamford Hospital/Bennett Cancer Center	Stamford	Connecticut	United States	06904
102	Bayhealth Hospital Kent Campus	Dover	Delaware	United States	19901
103	Beebe Medical Center	Lewes	Delaware	United States	19958
104	Christiana Care Health System-Christiana Hospital	Newark	Delaware	United States	19718
105	MedStar Georgetown University Hospital	Washington	District of Columbia	United States	20007
106	Sibley Memorial Hospital	Washington	District of Columbia	United States	20016
107	Howard University Hospital	Washington	District of Columbia	United States	20060
108	Boca Raton Regional Hospital	Boca Raton	Florida	United States	33486
109	Broward Health North	Deerfield Beach	Florida	United States	33064
110	Holy Cross Hospital	Fort Lauderdale	Florida	United States	33308
111	Broward Health Medical Center	Fort Lauderdale	Florida	United States	33316
112	Memorial Regional Hospital/Joe DiMaggio Children's Hospital	Hollywood	Florida	United States	33021
113	Baptist MD Anderson Cancer Center	Jacksonville	Florida	United States	32207
114	Mayo Clinic in Florida	Jacksonville	Florida	United States	32224-9980
115	Jupiter Medical Center	Jupiter	Florida	United States	33458
116	Lakeland Regional Health Hollis Cancer Center	Lakeland	Florida	United States	33805
117	Cancer Centers of Central Florida PA	Leesburg	Florida	United States	34788
118	Mount Sinai Medical Center	Miami Beach	Florida	United States	33140
119	University of Miami Miller School of Medicine-Sylvester Cancer Center	Miami	Florida	United States	33136
120	21st Century Oncology-Orange Park	Orange Park	Florida	United States	32073
121	AdventHealth Orlando	Orlando	Florida	United States	32803
122	Cleveland Clinic-Weston	Weston	Florida	United States	33331
123	Phoebe Putney Memorial Hospital	Albany	Georgia	United States	31701
124	University Cancer and Blood Center LLC	Athens	Georgia	United States	30607
125	Piedmont Hospital	Atlanta	Georgia	United States	30309
126	Emory University Hospital/Winship Cancer Institute	Atlanta	Georgia	United States	30322
127	Atlanta Regional CCOP	Atlanta	Georgia	United States	30342
128	Emory Saint Joseph's Hospital	Atlanta	Georgia	United States	30342
129	Northside Hospital	Atlanta	Georgia	United States	30342
130	Augusta Oncology Associates PC-D'Antignac	Augusta	Georgia	United States	30901
131	Augusta University Medical Center	Augusta	Georgia	United States	30912
132	WellStar Cobb Hospital	Austell	Georgia	United States	30106
133	John B Amos Cancer Center	Columbus	Georgia	United States	31904
134	Atlanta VA Medical Center	Decatur	Georgia	United States	30033
135	Dekalb Medical Center	Decatur	Georgia	United States	30033
136	Northeast Georgia Medical Center-Gainesville	Gainesville	Georgia	United States	30501
137	Northside Hospital - Gwinnett	Lawrenceville	Georgia	United States	30046
138	Wellstar Kennestone Hospital	Marietta	Georgia	United States	30060
139	Southern Regional Medical Center	Riverdale	Georgia	United States	30274
140	Harbin Clinic Medical Oncology and Clinical Research	Rome	Georgia	United States	30165
141	Memorial Health University Medical Center	Savannah	Georgia	United States	31404
142	Lewis Cancer and Research Pavilion at Saint Joseph's/Candler	Savannah	Georgia	United States	31405
143	South Georgia Medical Center/Pearlman Cancer Center	Valdosta	Georgia	United States	31602
144	Pali Momi Medical Center	'Aiea	Hawaii	United States	96701
145	Hawaii Cancer Care Inc - Waterfront Plaza	Honolulu	Hawaii	United States	96813
146	Queen's Medical Center	Honolulu	Hawaii	United States	96813
147	Straub Clinic and Hospital	Honolulu	Hawaii	United States	96813
148	University of Hawaii Cancer Center	Honolulu	Hawaii	United States	96813
149	Queen's Cancer Center - Kuakini	Honolulu	Hawaii	United States	96817
150	The Cancer Center of Hawaii-Liliha	Honolulu	Hawaii	United States	96817
151	Kapiolani Medical Center for Women and Children	Honolulu	Hawaii	United States	96826
152	Tripler Army Medical Center	Honolulu	Hawaii	United States	96859
153	Maui Memorial Medical Center	Wailuku	Hawaii	United States	96793
154	Pacific Cancer Institute of Maui	Wailuku	Hawaii	United States	96793
155	Saint Luke's Cancer Institute - Boise	Boise	Idaho	United States	83712
156	Portneuf Medical Center	Pocatello	Idaho	United States	83201
157	Kootenai Clinic Cancer Services - Post Falls	Post Falls	Idaho	United States	83854
158	Saint Anthony's Health	Alton	Illinois	United States	62002
159	Rush - Copley Medical Center	Aurora	Illinois	United States	60504
160	Saint Joseph Medical Center	Bloomington	Illinois	United States	61701
161	Illinois CancerCare-Bloomington	Bloomington	Illinois	United States	61704
162	Graham Hospital Association	Canton	Illinois	United States	61520
163	Illinois CancerCare-Canton	Canton	Illinois	United States	61520
164	Illinois CancerCare-Carthage	Carthage	Illinois	United States	62321
165	Memorial Hospital	Carthage	Illinois	United States	62321
166	Mount Sinai Hospital Medical Center	Chicago	Illinois	United States	60608
167	Hematology and Oncology Associates	Chicago	Illinois	United States	60611
168	Northwestern University	Chicago	Illinois	United States	60611
169	Jesse Brown Veterans Affairs Medical Center	Chicago	Illinois	United States	60612
170	John H Stroger Jr Hospital of Cook County	Chicago	Illinois	United States	60612
171	Rush University Medical Center	Chicago	Illinois	United States	60612
172	University of Illinois	Chicago	Illinois	United States	60612
173	Mercy Hospital and Medical Center	Chicago	Illinois	United States	60616
174	Swedish Covenant Hospital	Chicago	Illinois	United States	60625
175	Presence Resurrection Medical Center	Chicago	Illinois	United States	60631
176	University of Chicago Comprehensive Cancer Center	Chicago	Illinois	United States	60637
177	Weiss Memorial Hospital	Chicago	Illinois	United States	60640
178	Advocate Illinois Masonic Medical Center	Chicago	Illinois	United States	60657
179	Decatur Memorial Hospital	Decatur	Illinois	United States	62526
180	Heartland Cancer Research NCORP	Decatur	Illinois	United States	62526
181	Advocate Good Samaritan Hospital	Downers Grove	Illinois	United States	60515
182	Advocate Sherman Hospital	Elgin	Illinois	United States	60123
183	Elmhurst Memorial Hospital	Elmhurst	Illinois	United States	60126
184	Eureka Hospital	Eureka	Illinois	United States	61530
185	Illinois CancerCare-Eureka	Eureka	Illinois	United States	61530
186	NorthShore University HealthSystem-Evanston Hospital	Evanston	Illinois	United States	60201
187	Saint Francis Hospital	Evanston	Illinois	United States	60202
188	Galesburg Cottage Hospital	Galesburg	Illinois	United States	61401
189	Illinois CancerCare-Cottage	Galesburg	Illinois	United States	61401
190	Illinois CancerCare-Galesburg	Galesburg	Illinois	United States	61401
191	LaGrange Oncology Associates	Geneva	Illinois	United States	60134
192	Northwestern Medicine Cancer Center Delnor	Geneva	Illinois	United States	60134
193	Ingalls Memorial Hospital	Harvey	Illinois	United States	60426
194	Illinois CancerCare-Havana	Havana	Illinois	United States	62644
195	Mason District Hospital	Havana	Illinois	United States	62644
196	Edward Hines Jr VA Hospital	Hines	Illinois	United States	60141
197	Hinsdale Hematology Oncology Associates Incorporated	Hinsdale	Illinois	United States	60521
198	Hopedale Medical Complex - Hospital	Hopedale	Illinois	United States	61747
199	Midwest Center for Hematology Oncology	Joliet	Illinois	United States	60432
200	Duly Health and Care Joliet	Joliet	Illinois	United States	60435
201	Presence Saint Mary's Hospital	Kankakee	Illinois	United States	60901
202	Illinois CancerCare-Kewanee Clinic	Kewanee	Illinois	United States	61443
203	Kewanee Hospital	Kewanee	Illinois	United States	61443
204	AMITA Health Adventist Medical Center	La Grange	Illinois	United States	60525
205	AMG Libertyville - Oncology	Libertyville	Illinois	United States	60048
206	Illinois CancerCare-Macomb	Macomb	Illinois	United States	61455
207	Mcdonough District Hospital	Macomb	Illinois	United States	61455
208	Loyola University Medical Center	Maywood	Illinois	United States	60153
209	Garneau, Stewart C MD (UIA Investigator)	Moline	Illinois	United States	61265
210	Porubcin, Michael MD (UIA Investigator)	Moline	Illinois	United States	61265
211	Sharis, Christine M MD (UIA Investigator)	Moline	Illinois	United States	61265
212	Stoffel, Thomas J MD (UIA Investigator)	Moline	Illinois	United States	61265
213	Vigliotti, Antonio, P.G. M.D. (UIA Investigator)	Moline	Illinois	United States	61265
214	Holy Family Medical Center	Monmouth	Illinois	United States	61462
215	Illinois CancerCare-Monmouth	Monmouth	Illinois	United States	61462
216	Good Samaritan Regional Health Center	Mount Vernon	Illinois	United States	62864
217	Edward Hospital/Cancer Center	Naperville	Illinois	United States	60540
218	DuPage Medical Group-Ogden	Naperville	Illinois	United States	60563
219	Illinois Cancer Specialists-Niles	Niles	Illinois	United States	60714
220	Bromenn Regional Medical Center	Normal	Illinois	United States	61761
221	Carle Cancer Institute Normal	Normal	Illinois	United States	61761
222	Illinois CancerCare-Community Cancer Center	Normal	Illinois	United States	61761
223	Franciscan St. James Health-Olympia Fields Campus	Olympia Fields	Illinois	United States	60461
224	Illinois CancerCare-Ottawa Clinic	Ottawa	Illinois	United States	61350
225	Ottawa Regional Hospital and Healthcare Center	Ottawa	Illinois	United States	61350
226	Illinois CancerCare-Pekin	Pekin	Illinois	United States	61554
227	OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center	Pekin	Illinois	United States	61554
228	Pekin Hospital	Pekin	Illinois	United States	61554
229	Proctor Hospital	Peoria	Illinois	United States	61614
230	Illinois CancerCare-Peoria	Peoria	Illinois	United States	61615
231	Methodist Medical Center of Illinois	Peoria	Illinois	United States	61636
232	OSF Saint Francis Medical Center	Peoria	Illinois	United States	61637
233	Illinois CancerCare-Peru	Peru	Illinois	United States	61354
234	Illinois Valley Hospital	Peru	Illinois	United States	61354
235	Illinois CancerCare-Princeton	Princeton	Illinois	United States	61356
236	Perry Memorial Hospital	Princeton	Illinois	United States	61356
237	Swedish American Hospital	Rockford	Illinois	United States	61104
238	OSF Saint Anthony Medical Center	Rockford	Illinois	United States	61108
239	Edward H Kaplan MD and Associates	Skokie	Illinois	United States	60076
240	Hematology Oncology Associates of Illinois - Skokie	Skokie	Illinois	United States	60076
241	Midwest Cancer Research Group Incorporated	Skokie	Illinois	United States	60077
242	Illinois CancerCare-Spring Valley	Spring Valley	Illinois	United States	61362
243	Saint Margaret's Hospital	Spring Valley	Illinois	United States	61362
244	Memorial Medical Center	Springfield	Illinois	United States	62781
245	Carle Cancer Center	Urbana	Illinois	United States	61801
246	Northwestern Medicine Cancer Center Warrenville	Warrenville	Illinois	United States	60555
247	Northwestern Medicine Central DuPage Hospital	Winfield	Illinois	United States	60190
248	Franciscan Saint Francis Health-Beech Grove	Beech Grove	Indiana	United States	46107
249	Elkhart Clinic	Elkhart	Indiana	United States	46514-2098
250	Michiana Hematology Oncology PC-Elkhart	Elkhart	Indiana	United States	46514
251	Elkhart General Hospital	Elkhart	Indiana	United States	46515
252	Fort Wayne Medical Oncology and Hematology Inc-Parkview	Fort Wayne	Indiana	United States	46845
253	Indiana University/Melvin and Bren Simon Cancer Center	Indianapolis	Indiana	United States	46202
254	Richard L. Roudebush Veterans Affairs Medical Center	Indianapolis	Indiana	United States	46202
255	Sidney and Lois Eskenazi Hospital	Indianapolis	Indiana	United States	46202
256	Franciscan Health Indianapolis	Indianapolis	Indiana	United States	46237
257	Saint Vincent Hospital and Health Care Center	Indianapolis	Indiana	United States	46260
258	Community Howard Regional Health	Kokomo	Indiana	United States	46904
259	IU Health La Porte Hospital	La Porte	Indiana	United States	46350
260	IU Health Arnett Cancer Care	Lafayette	Indiana	United States	47904
261	Franciscan Saint Anthony Health-Michigan City	Michigan City	Indiana	United States	46360
262	Michiana Hematology Oncology PC-Mishawaka	Mishawaka	Indiana	United States	46545
263	Saint Joseph Regional Medical Center-Mishawaka	Mishawaka	Indiana	United States	46545
264	Michiana Hematology Oncology PC-Plymouth	Plymouth	Indiana	United States	46563
265	Reid Health	Richmond	Indiana	United States	47374
266	Memorial Hospital of South Bend	South Bend	Indiana	United States	46601
267	Michiana Hematology Oncology PC-South Bend	South Bend	Indiana	United States	46601
268	South Bend Clinic	South Bend	Indiana	United States	46617
269	Northern Indiana Cancer Research Consortium	South Bend	Indiana	United States	46628
270	Michiana Hematology Oncology PC-Westville	Westville	Indiana	United States	46391
271	McFarland Clinic PC - Ames	Ames	Iowa	United States	50010
272	Constantinou, Costas L MD (UIA Investigator)	Bettendorf	Iowa	United States	52722
273	University of Iowa Healthcare Cancer Services Quad Cities	Bettendorf	Iowa	United States	52722
274	Mercy Hospital	Cedar Rapids	Iowa	United States	52403
275	Oncology Associates at Mercy Medical Center	Cedar Rapids	Iowa	United States	52403
276	Medical Oncology and Hematology Associates-West Des Moines	Clive	Iowa	United States	50325
277	Genesis Medical Center - East Campus	Davenport	Iowa	United States	52803
278	Genesis Cancer Care Institute	Davenport	Iowa	United States	52804
279	Mercy Capitol	Des Moines	Iowa	United States	50307
280	Iowa Methodist Medical Center	Des Moines	Iowa	United States	50309
281	Iowa-Wide Oncology Research Coalition NCORP	Des Moines	Iowa	United States	50309
282	Medical Oncology and Hematology Associates-Des Moines	Des Moines	Iowa	United States	50309
283	Medical Oncology and Hematology Associates-Laurel	Des Moines	Iowa	United States	50314
284	Mercy Medical Center - Des Moines	Des Moines	Iowa	United States	50314
285	Iowa Lutheran Hospital	Des Moines	Iowa	United States	50316
286	University of Iowa/Holden Comprehensive Cancer Center	Iowa City	Iowa	United States	52242
287	Mercy Medical Center - North Iowa	Mason City	Iowa	United States	50401
288	Ottumwa Regional Health Center	Ottumwa	Iowa	United States	52501
289	Siouxland Regional Cancer Center	Sioux City	Iowa	United States	51101
290	Mercy Medical Center-Sioux City	Sioux City	Iowa	United States	51102
291	Saint Luke's Regional Medical Center	Sioux City	Iowa	United States	51104
292	Cancer Center of Kansas - Chanute	Chanute	Kansas	United States	66720
293	Cancer Center of Kansas - Dodge City	Dodge City	Kansas	United States	67801
294	Cancer Center of Kansas - El Dorado	El Dorado	Kansas	United States	67042
295	Cancer Center of Kansas - Fort Scott	Fort Scott	Kansas	United States	66701
296	HaysMed University of Kansas Health System	Hays	Kansas	United States	67601
297	Hutchinson Regional Medical Center	Hutchinson	Kansas	United States	67502
298	Cancer Center of Kansas-Independence	Independence	Kansas	United States	67301
299	University of Kansas Cancer Center	Kansas City	Kansas	United States	66160
300	Cancer Center of Kansas-Kingman	Kingman	Kansas	United States	67068
301	Lawrence Memorial Hospital	Lawrence	Kansas	United States	66044
302	Southwest Medical Center	Liberal	Kansas	United States	67901
303	Cancer Center of Kansas-Liberal	Liberal	Kansas	United States	67905
304	Cancer Center of Kansas - Newton	Newton	Kansas	United States	67114
305	Olathe Cancer Center	Olathe	Kansas	United States	66061
306	Cancer Center of Kansas - Parsons	Parsons	Kansas	United States	67357
307	Ascension Via Christi - Pittsburg	Pittsburg	Kansas	United States	66762
308	Cancer Center of Kansas - Pratt	Pratt	Kansas	United States	67124
309	Cancer Center of Kansas - Salina	Salina	Kansas	United States	67401
310	Cotton O'Neil Cancer Center / Stormont Vail Health	Topeka	Kansas	United States	66606
311	University of Kansas Health System Saint Francis Campus	Topeka	Kansas	United States	66606
312	Cancer Center of Kansas - Wellington	Wellington	Kansas	United States	67152
313	Associates In Womens Health	Wichita	Kansas	United States	67208
314	Cancer Center of Kansas-Wichita Medical Arts Tower	Wichita	Kansas	United States	67208
315	Ascension Via Christi Hospitals Wichita	Wichita	Kansas	United States	67214
316	Cancer Center of Kansas - Wichita	Wichita	Kansas	United States	67214
317	Wichita NCI Community Oncology Research Program	Wichita	Kansas	United States	67214
318	Cancer Center of Kansas - Winfield	Winfield	Kansas	United States	67156
319	Our Lady Bellefonte Hospital	Ashland	Kentucky	United States	41101
320	Baptist Health Lexington	Lexington	Kentucky	United States	40503
321	The James Graham Brown Cancer Center at University of Louisville	Louisville	Kentucky	United States	40202
322	Baptist Health Madisonville/Merle Mahr Cancer Center	Madisonville	Kentucky	United States	42431
323	Baton Rouge General Medical Center	Baton Rouge	Louisiana	United States	70806
324	Mary Bird Perkins Cancer Center	Baton Rouge	Louisiana	United States	70809
325	Ochsner Health Center-Summa	Baton Rouge	Louisiana	United States	70809
326	Ochsner Health Center-Covington	Covington	Louisiana	United States	70433
327	DeSoto Regional Health System	Mansfield	Louisiana	United States	71052
328	Ochsner LSU Health Monroe Medical Center	Monroe	Louisiana	United States	71202
329	Louisiana State University Health Science Center	New Orleans	Louisiana	United States	70112
330	University Medical Center New Orleans	New Orleans	Louisiana	United States	70112
331	Ochsner Medical Center Jefferson	New Orleans	Louisiana	United States	70121
332	LSU Health Sciences Center at Shreveport	Shreveport	Louisiana	United States	71103
333	Highland Clinic	Shreveport	Louisiana	United States	71105
334	Saint Mary's Regional Medical Center	Lewiston	Maine	United States	04240
335	Maine Center for Cancer Medicine-Scarborough	Scarborough	Maine	United States	04074
336	Maine Medical Center- Scarborough Campus	Scarborough	Maine	United States	04074
337	York Hospital	York	Maine	United States	03909
338	Anne Arundel Medical Center	Annapolis	Maryland	United States	21401
339	Greater Baltimore Medical Center	Baltimore	Maryland	United States	21204
340	Sinai Hospital of Baltimore	Baltimore	Maryland	United States	21215
341	Saint Agnes Hospital	Baltimore	Maryland	United States	21229
342	MedStar Franklin Square Medical Center/Weinberg Cancer Institute	Baltimore	Maryland	United States	21237
343	Johns Hopkins University/Sidney Kimmel Cancer Center	Baltimore	Maryland	United States	21287
344	Suburban Hospital	Bethesda	Maryland	United States	20814
345	University of Maryland Shore Medical Center at Easton	Easton	Maryland	United States	21601
346	Christiana Care - Union Hospital	Elkton	Maryland	United States	21921
347	Frederick Memorial Hospital	Frederick	Maryland	United States	21701
348	Meritus Medical Center	Hagerstown	Maryland	United States	21742
349	UM Saint Joseph Medical Center	Towson	Maryland	United States	21204
350	Massachusetts General Hospital Cancer Center	Boston	Massachusetts	United States	02114
351	Beth Israel Deaconess Medical Center	Boston	Massachusetts	United States	02215
352	Steward Saint Elizabeth's Medical Center	Brighton	Massachusetts	United States	02135
353	Commonwealth Hematology Oncology PC-Concord	Concord	Massachusetts	United States	01742
354	Dana Farber Community Cancer Care-Haverhill	Haverhill	Massachusetts	United States	01830
355	Saints Memorial Medical Center	Lowell	Massachusetts	United States	01852
356	Lawrence Memorial	Medford	Massachusetts	United States	02155
357	Dana Farber-Merrimack Valley	Methuen	Massachusetts	United States	01844
358	Holy Family Hospital	Methuen	Massachusetts	United States	01844
359	Norwood Hospital	Norwood	Massachusetts	United States	02062
360	Dana Farber Community Cancer Care-Quincy	Quincy	Massachusetts	United States	02169
361	Dana Farber Community Cancer Care-Stoneham	Stoneham	Massachusetts	United States	02180
362	Morton Hospital and Medical Center	Taunton	Massachusetts	United States	02780
363	Dana Farber Community Cancer Care-Weymouth	Weymouth	Massachusetts	United States	02189
364	Commonwealth Hematology Oncology PC-Worcester	Worcester	Massachusetts	United States	01605
365	Reliant Medical Group Inc	Worcester	Massachusetts	United States	01606
366	UMass Memorial Medical Center - University Campus	Worcester	Massachusetts	United States	01655
367	Bixby Medical Center	Adrian	Michigan	United States	49221
368	Hickman Cancer Center	Adrian	Michigan	United States	49221
369	Michigan Cancer Research Consortium NCORP	Ann Arbor	Michigan	United States	48106
370	Saint Joseph Mercy Hospital	Ann Arbor	Michigan	United States	48106
371	University of Michigan Comprehensive Cancer Center	Ann Arbor	Michigan	United States	48109
372	Bronson Battle Creek	Battle Creek	Michigan	United States	49017
373	McLaren Cancer Institute-Bay City	Bay City	Michigan	United States	48706
374	Spectrum Health Big Rapids Hospital	Big Rapids	Michigan	United States	49307
375	Beaumont Hospital - Dearborn	Dearborn	Michigan	United States	48124
376	Wayne State University/Karmanos Cancer Institute	Detroit	Michigan	United States	48201
377	Ascension Saint John Hospital	Detroit	Michigan	United States	48236
378	Michigan State University Clinical Center	East Lansing	Michigan	United States	48824-7016
379	Green Bay Oncology - Escanaba	Escanaba	Michigan	United States	49829
380	Genesys Hurley Cancer Institute	Flint	Michigan	United States	48503
381	Hurley Medical Center	Flint	Michigan	United States	48503
382	Genesys Regional Medical Center-West Flint Campus	Flint	Michigan	United States	48532
383	McLaren Cancer Institute-Flint	Flint	Michigan	United States	48532
384	Cancer Research Consortium of West Michigan NCORP	Grand Rapids	Michigan	United States	49503
385	Mercy Health Saint Mary's	Grand Rapids	Michigan	United States	49503
386	Spectrum Health at Butterworth Campus	Grand Rapids	Michigan	United States	49503
387	Holland Community Hospital	Holland	Michigan	United States	49423
388	Green Bay Oncology - Iron Mountain	Iron Mountain	Michigan	United States	49801
389	Allegiance Health	Jackson	Michigan	United States	49201
390	Bronson Methodist Hospital	Kalamazoo	Michigan	United States	49007
391	West Michigan Cancer Center	Kalamazoo	Michigan	United States	49007
392	Borgess Medical Center	Kalamazoo	Michigan	United States	49048
393	Karmanos Cancer Institute at McLaren Greater Lansing	Lansing	Michigan	United States	48910
394	Sparrow Hospital	Lansing	Michigan	United States	48912
395	Lapeer Regional Hospital	Lapeer	Michigan	United States	48446
396	Saint Mary Mercy Hospital	Livonia	Michigan	United States	48154
397	Mercy Memorial Hospital	Monroe	Michigan	United States	48162
398	Toledo Clinic Cancer Centers-Monroe	Monroe	Michigan	United States	48162
399	McLaren Cancer Institute-Macomb	Mount Clemens	Michigan	United States	48043
400	Mercy Health Partners-Hackley Campus	Muskegon	Michigan	United States	49442
401	Mercy Health Mercy Campus	Muskegon	Michigan	United States	49444
402	Lakeland Hospital Niles	Niles	Michigan	United States	49120
403	McLaren Cancer Institute-Northern Michigan	Petoskey	Michigan	United States	49770
404	Saint Joseph Mercy Oakland	Pontiac	Michigan	United States	48341
405	Lake Huron Medical Center	Port Huron	Michigan	United States	48060
406	William Beaumont Hospital-Royal Oak	Royal Oak	Michigan	United States	48073
407	Ascension Saint Mary's Hospital	Saginaw	Michigan	United States	48601
408	Lakeland Medical Center Saint Joseph	Saint Joseph	Michigan	United States	49085
409	Marie Yeager Cancer Center	Saint Joseph	Michigan	United States	49085
410	Oncology Care Associates PLLC	Saint Joseph	Michigan	United States	49085
411	Ascension Providence Hospitals - Southfield	Southfield	Michigan	United States	48075
412	Munson Medical Center	Traverse City	Michigan	United States	49684
413	Saint John Macomb-Oakland Hospital	Warren	Michigan	United States	48093
414	Metro Health Hospital	Wyoming	Michigan	United States	49519
415	Medini, Eitan MD (UIA Investigator)	Alexandria	Minnesota	United States	56308
416	Sanford Joe Lueken Cancer Center	Bemidji	Minnesota	United States	56601
417	Fairview Ridges Hospital	Burnsville	Minnesota	United States	55337
418	Mercy Hospital	Coon Rapids	Minnesota	United States	55433
419	Essentia Health Cancer Center	Duluth	Minnesota	United States	55805
420	Essentia Health Saint Mary's Medical Center	Duluth	Minnesota	United States	55805
421	Miller-Dwan Hospital	Duluth	Minnesota	United States	55805
422	Saint Luke's Hospital of Duluth	Duluth	Minnesota	United States	55805
423	Fairview Southdale Hospital	Edina	Minnesota	United States	55435
424	Etzell, Paul S MD (UIA Investigator)	Fergus Falls	Minnesota	United States	56537
425	Lake Region Healthcare Corporation-Cancer Care	Fergus Falls	Minnesota	United States	56537
426	Swenson, Wade II, MD (UIA Investigator)	Fergus Falls	Minnesota	United States	56537
427	Unity Hospital	Fridley	Minnesota	United States	55432
428	Hutchinson Area Health Care	Hutchinson	Minnesota	United States	55350
429	Meeker County Memorial Hospital	Litchfield	Minnesota	United States	55355
430	Mayo Clinic Health Systems-Mankato	Mankato	Minnesota	United States	56001
431	Minnesota Oncology Hematology PA-Maplewood	Maplewood	Minnesota	United States	55109
432	Saint John's Hospital - Healtheast	Maplewood	Minnesota	United States	55109
433	Abbott-Northwestern Hospital	Minneapolis	Minnesota	United States	55407
434	Virginia Piper Cancer Institute	Minneapolis	Minnesota	United States	55407
435	Hennepin County Medical Center	Minneapolis	Minnesota	United States	55415
436	Minneapolis VA Medical Center	Minneapolis	Minnesota	United States	55417
437	University of Minnesota/Masonic Cancer Center	Minneapolis	Minnesota	United States	55455
438	North Memorial Medical Health Center	Robbinsdale	Minnesota	United States	55422
439	Mayo Clinic in Rochester	Rochester	Minnesota	United States	55905
440	Coborn Cancer Center at Saint Cloud Hospital	Saint Cloud	Minnesota	United States	56303
441	Saint Cloud Hospital	Saint Cloud	Minnesota	United States	56303
442	Metro Minnesota Community Oncology Research Consortium	Saint Louis Park	Minnesota	United States	55416
443	Park Nicollet Clinic - Saint Louis Park	Saint Louis Park	Minnesota	United States	55416
444	Regions Hospital	Saint Paul	Minnesota	United States	55101
445	Saint Joseph's Hospital - Healtheast	Saint Paul	Minnesota	United States	55102
446	United Hospital	Saint Paul	Minnesota	United States	55102
447	Saint Francis Regional Medical Center	Shakopee	Minnesota	United States	55379
448	Ridgeview Medical Center	Waconia	Minnesota	United States	55387
449	Rice Memorial Hospital	Willmar	Minnesota	United States	56201
450	Minnesota Oncology Hematology PA-Woodbury	Woodbury	Minnesota	United States	55125
451	Woodwinds Health Campus	Woodbury	Minnesota	United States	55125
452	Hattiesburg Clinic - Hematology/Oncology Clinic	Hattiesburg	Mississippi	United States	39401
453	Hematology and Oncology Clinic	Hattiesburg	Mississippi	United States	39402
454	University of Mississippi Medical Center	Jackson	Mississippi	United States	39216
455	Singing River Hospital	Pascagoula	Mississippi	United States	39581
456	Central Care Cancer Center - Bolivar	Bolivar	Missouri	United States	65613
457	Cox Cancer Center Branson	Branson	Missouri	United States	65616
458	Southeast Missouri Hospital	Cape Girardeau	Missouri	United States	63701
459	Saint Francis Medical Center	Cape Girardeau	Missouri	United States	63703
460	Saint Luke's Hospital	Chesterfield	Missouri	United States	63017
461	Missouri Cancer Associates	Columbia	Missouri	United States	65201
462	Veterans Administration	Columbia	Missouri	United States	65201
463	University of Missouri - Ellis Fischel	Columbia	Missouri	United States	65212
464	Freeman Health System	Joplin	Missouri	United States	64804
465	SSM Health Saint Louis University Hospital	Saint Louis	Missouri	United States	63104
466	Saint Louis Cancer and Breast Institute-South City	Saint Louis	Missouri	United States	63109
467	Washington University School of Medicine	Saint Louis	Missouri	United States	63110
468	Mercy Hospital South	Saint Louis	Missouri	United States	63128
469	Missouri Baptist Medical Center	Saint Louis	Missouri	United States	63131
470	Center for Cancer Care and Research	Saint Louis	Missouri	United States	63141
471	Mercy Hospital Saint Louis	Saint Louis	Missouri	United States	63141
472	Saint Louis-Cape Girardeau CCOP	Saint Louis	Missouri	United States	63141
473	Cancer Research for the Ozarks NCORP	Springfield	Missouri	United States	65804
474	Mercy Hospital Springfield	Springfield	Missouri	United States	65804
475	CoxHealth South Hospital	Springfield	Missouri	United States	65807
476	Billings Clinic Cancer Center	Billings	Montana	United States	59101
477	Northern Rockies Radiation Oncology Center	Billings	Montana	United States	59101
478	Saint Vincent Healthcare	Billings	Montana	United States	59101
479	Montana Cancer Consortium NCORP	Billings	Montana	United States	59102
480	Saint Vincent Frontier Cancer Center	Billings	Montana	United States	59102
481	Deaconess Medical Center	Billings	Montana	United States	59107
482	Bozeman Deaconess Hospital	Bozeman	Montana	United States	59715
483	Internal Medicine of Bozeman	Bozeman	Montana	United States	59715
484	Saint James Community Hospital and Cancer Treatment Center	Butte	Montana	United States	59701
485	Benefis Healthcare- Sletten Cancer Institute	Great Falls	Montana	United States	59405
486	Berdeaux, Donald MD (UIA Investigator)	Great Falls	Montana	United States	59405
487	Great Falls Clinic	Great Falls	Montana	United States	59405
488	Northern Montana Hospital	Havre	Montana	United States	59501
489	Saint Peter's Community Hospital	Helena	Montana	United States	59601
490	Glacier Oncology PLLC	Kalispell	Montana	United States	59901
491	Kalispell Medical Oncology	Kalispell	Montana	United States	59901
492	Kalispell Regional Medical Center	Kalispell	Montana	United States	59901
493	Eastern Montana Cancer Center	Miles City	Montana	United States	59301
494	Montana Cancer Specialists	Missoula	Montana	United States	59802
495	Saint Patrick Hospital - Community Hospital	Missoula	Montana	United States	59802
496	Community Medical Hospital	Missoula	Montana	United States	59804
497	Guardian Oncology and Center for Wellness	Missoula	Montana	United States	59804
498	CHI Health Saint Francis	Grand Island	Nebraska	United States	68803
499	CHI Health Good Samaritan	Kearney	Nebraska	United States	68847
500	Nebraska Cancer Research Center	Lincoln	Nebraska	United States	68510
501	Cancer Alliance of Nebraska	Omaha	Nebraska	United States	68106
502	Missouri Valley Cancer Consortium	Omaha	Nebraska	United States	68106
503	Nebraska Methodist Hospital	Omaha	Nebraska	United States	68114
504	Alegent Health Immanuel Medical Center	Omaha	Nebraska	United States	68122
505	Alegent Health Bergan Mercy Medical Center	Omaha	Nebraska	United States	68124
506	Creighton University Medical Center	Omaha	Nebraska	United States	68131
507	University of Nebraska Medical Center	Omaha	Nebraska	United States	68198
508	Carson-Tahoe Specialty Medical Center	Carson City	Nevada	United States	89703
509	University Medical Center of Southern Nevada	Las Vegas	Nevada	United States	89102
510	Nevada Cancer Institute-Summerlin Campus	Las Vegas	Nevada	United States	89135
511	Nevada Cancer Research Foundation NCORP	Las Vegas	Nevada	United States	89169
512	Renown Regional Medical Center	Reno	Nevada	United States	89502
513	New Hampshire Oncology Hematology PA-Concord	Concord	New Hampshire	United States	03301
514	LRGHealthcare-Lakes Region General Hospital	Laconia	New Hampshire	United States	03246
515	Elliot Hospital	Manchester	New Hampshire	United States	03103
516	Solinsky Center for Cancer Care	Manchester	New Hampshire	United States	03103
517	Portsmouth Regional Hospital	Portsmouth	New Hampshire	United States	03802
518	Ocean Medical Center	Brick	New Jersey	United States	08724
519	Cooper Hospital University Medical Center	Camden	New Jersey	United States	08103
520	Veterans Adminstration New Jersey Health Care System	East Orange	New Jersey	United States	07018-1095
521	John F Kennedy Medical Center	Edison	New Jersey	United States	08818
522	AtlantiCare Surgery Center	Egg Harbor Township	New Jersey	United States	08234
523	Hunterdon Medical Center	Flemington	New Jersey	United States	08822
524	CentraState Medical Center	Freehold	New Jersey	United States	07728
525	Hackensack University Medical Center	Hackensack	New Jersey	United States	07601
526	The Cancer Institute of New Jersey Hamilton	Hamilton	New Jersey	United States	08690
527	Saint Barnabas Medical Center	Livingston	New Jersey	United States	07039
528	Mountainside Hospital	Montclair	New Jersey	United States	07042
529	Morristown Medical Center	Morristown	New Jersey	United States	07960
530	Virtua Memorial	Mount Holly	New Jersey	United States	08060
531	Jersey Shore Medical Center	Neptune	New Jersey	United States	07753
532	Saint Peter's University Hospital	New Brunswick	New Jersey	United States	08901
533	Rutgers Cancer Institute of New Jersey	New Brunswick	New Jersey	United States	08903
534	Rutgers New Jersey Medical School	Newark	New Jersey	United States	07101
535	Saint Luke's Hospital-Warren Campus	Phillipsburg	New Jersey	United States	08865
536	AtlantiCare Regional Medical Center -Main Campus	Pomona	New Jersey	United States	08240
537	Riverview Medical Center/Booker Cancer Center	Red Bank	New Jersey	United States	07701
538	Valley Hospital	Ridgewood	New Jersey	United States	07450
539	Robert Wood Johnson University Hospital Somerset	Somerville	New Jersey	United States	08876
540	Sparta Cancer Treatment Center	Sparta	New Jersey	United States	07871
541	Overlook Hospital	Summit	New Jersey	United States	07902
542	Community Medical Center	Toms River	New Jersey	United States	08755
543	Saint Francis Medical Center	Trenton	New Jersey	United States	08629
544	Inspira Medical Center Vineland	Vineland	New Jersey	United States	08360
545	Virtua Voorhees	Voorhees	New Jersey	United States	08043
546	Lincoln Medical and Mental Health Center	Bronx	New York	United States	10451
547	Montefiore Medical Center-Weiler Hospital	Bronx	New York	United States	10461
548	Montefiore Medical Center-Wakefield Campus	Bronx	New York	United States	10466
549	Montefiore Medical Center - Moses Campus	Bronx	New York	United States	10467
550	Veteran Affairs New York Harbor Healthcare System-Brooklyn Campus	Brooklyn	New York	United States	11209
551	Veterans Affairs Western New York Health Care System-Buffalo	Buffalo	New York	United States	14215
552	Roswell Park Cancer Institute	Buffalo	New York	United States	14263
553	Finger Lakes Hematology and Oncology	Clifton Springs	New York	United States	14432
554	Mary Imogene Bassett Hospital	Cooperstown	New York	United States	13326
555	Garnet Health Medical Center	Middletown	New York	United States	10940
556	NYU Winthrop Hospital	Mineola	New York	United States	11501
557	Mount Sinai Union Square	New York	New York	United States	10003
558	Laura and Isaac Perlmutter Cancer Center at NYU Langone	New York	New York	United States	10016
559	Mount Sinai West	New York	New York	United States	10019
560	NYP/Weill Cornell Medical Center	New York	New York	United States	10065
561	Nyack Hospital	Nyack	New York	United States	10960
562	Rochester General Hospital	Rochester	New York	United States	14621
563	Interlakes Foundation Inc-Rochester	Rochester	New York	United States	14623
564	University of Rochester	Rochester	New York	United States	14642
565	Staten Island University Hospital	Staten Island	New York	United States	10305
566	Stony Brook University Medical Center	Stony Brook	New York	United States	11794
567	State University of New York Upstate Medical University	Syracuse	New York	United States	13210
568	Syracuse Veterans Administration Medical Center	Syracuse	New York	United States	13210
569	Faxton-Saint Luke's Healthcare	Utica	New York	United States	13502
570	Randolph Hospital	Asheboro	North Carolina	United States	27203
571	Mission Hospital	Asheville	North Carolina	United States	28801
572	Cone Health Cancer Center at Alamance Regional	Burlington	North Carolina	United States	27215
573	Waverly Hematology Oncology	Cary	North Carolina	United States	27518
574	UNC Lineberger Comprehensive Cancer Center	Chapel Hill	North Carolina	United States	27599
575	Carolinas Medical Center/Levine Cancer Institute	Charlotte	North Carolina	United States	28203
576	Novant Health Presbyterian Medical Center	Charlotte	North Carolina	United States	28204
577	Atrium Health Cabarrus/LCI-Concord	Concord	North Carolina	United States	28025
578	Duke University Medical Center	Durham	North Carolina	United States	27710
579	Southeastern Medical Oncology Center-Goldsboro	Goldsboro	North Carolina	United States	27534
580	Wayne Memorial Hospital	Goldsboro	North Carolina	United States	27534
581	Wayne Radiation Oncology	Goldsboro	North Carolina	United States	27534
582	Cone Health Cancer Center	Greensboro	North Carolina	United States	27403
583	East Carolina University	Greenville	North Carolina	United States	27834
584	Maria Parham Hospital	Henderson	North Carolina	United States	27536
585	Lenoir Memorial Hospital	Kinston	North Carolina	United States	28501
586	Vidant Oncology-Kinston	Kinston	North Carolina	United States	28501
587	Southeastern Regional Medical Center	Lumberton	North Carolina	United States	28358
588	Granville Medical Center	Oxford	North Carolina	United States	27565
589	UNC Rex Cancer Center	Raleigh	North Carolina	United States	27607
590	Duke Raleigh Hospital	Raleigh	North Carolina	United States	27609
591	Annie Penn Memorial Hospital	Reidsville	North Carolina	United States	27320
592	Person Memorial Hospital	Roxboro	North Carolina	United States	27573
593	Rutherford Hospital	Rutherfordton	North Carolina	United States	28139
594	Iredell Memorial Hospital	Statesville	North Carolina	United States	28677
595	Marion L Shepard Cancer Center at Vidant Beaufort Hospital	Washington	North Carolina	United States	27889
596	Wilson Medical Center	Wilson	North Carolina	United States	27893
597	Southeast Clinical Oncology Research Consortium NCORP	Winston-Salem	North Carolina	United States	27104
598	Wake Forest University Health Sciences	Winston-Salem	North Carolina	United States	27157
599	Mid Dakota Clinic	Bismarck	North Dakota	United States	58501
600	Saint Alexius Medical Center	Bismarck	North Dakota	United States	58501
601	Sanford Bismarck Medical Center	Bismarck	North Dakota	United States	58501
602	Essentia Health Cancer Center-South University Clinic	Fargo	North Dakota	United States	58103
603	Sanford Broadway Medical Center	Fargo	North Dakota	United States	58122
604	Sanford Clinic North-Fargo	Fargo	North Dakota	United States	58122
605	Altru Cancer Center	Grand Forks	North Dakota	United States	58201
606	Trinity Cancer Care Center	Minot	North Dakota	United States	58701
607	Summa Health System - Akron Campus	Akron	Ohio	United States	44304
608	Cleveland Clinic Akron General	Akron	Ohio	United States	44307
609	Summa Health System - Barberton Campus	Barberton	Ohio	United States	44203
610	Mary Rutan Hospital	Bellefontaine	Ohio	United States	43311
611	Toledo Clinic Cancer Centers-Bowling Green	Bowling Green	Ohio	United States	43402
612	Cleveland Clinic Mercy Hospital	Canton	Ohio	United States	44708
613	Aultman Health Foundation	Canton	Ohio	United States	44710
614	Adena Regional Medical Center	Chillicothe	Ohio	United States	45601
615	Case Western Reserve University	Cleveland	Ohio	United States	44106
616	MetroHealth Medical Center	Cleveland	Ohio	United States	44109
617	Cleveland Clinic Foundation	Cleveland	Ohio	United States	44195
618	North Coast Cancer Care-Clyde	Clyde	Ohio	United States	43410
619	Ohio State University Comprehensive Cancer Center	Columbus	Ohio	United States	43210
620	Riverside Methodist Hospital	Columbus	Ohio	United States	43214
621	Columbus NCI Community Oncology Research Program	Columbus	Ohio	United States	43215
622	Grant Medical Center	Columbus	Ohio	United States	43215
623	Mount Carmel Health Center West	Columbus	Ohio	United States	43222
624	Doctors Hospital	Columbus	Ohio	United States	43228
625	Grandview Hospital	Dayton	Ohio	United States	45405
626	Good Samaritan Hospital - Dayton	Dayton	Ohio	United States	45406
627	Miami Valley Hospital	Dayton	Ohio	United States	45409
628	Miami Valley Hospital North	Dayton	Ohio	United States	45415
629	Dayton Veterans Affairs Medical Center	Dayton	Ohio	United States	45428
630	Dayton NCI Community Oncology Research Program	Dayton	Ohio	United States	45459
631	Grady Memorial Hospital	Delaware	Ohio	United States	43015
632	Hematology Oncology Center Incorporated	Elyria	Ohio	United States	44035
633	Mercy Cancer Center-Elyria	Elyria	Ohio	United States	44035
634	Blanchard Valley Hospital	Findlay	Ohio	United States	45840
635	Atrium Medical Center-Middletown Regional Hospital	Franklin	Ohio	United States	45005-1066
636	Fremont Memorial Hospital	Fremont	Ohio	United States	43420
637	Wayne Hospital	Greenville	Ohio	United States	45331
638	Cleveland Clinic Cancer Center Independence	Independence	Ohio	United States	44131
639	Cole, Sharon, K. M.D. (UIA Investigator)	Kenton	Ohio	United States	43326
640	Kettering Medical Center	Kettering	Ohio	United States	45429
641	Fairfield Medical Center	Lancaster	Ohio	United States	43130
642	Saint Rita's Medical Center	Lima	Ohio	United States	45801
643	Lima Memorial Hospital	Lima	Ohio	United States	45804
644	OhioHealth Mansfield Hospital	Mansfield	Ohio	United States	44903
645	Marietta Memorial Hospital	Marietta	Ohio	United States	45750
646	Saint Luke's Hospital	Maumee	Ohio	United States	43537
647	Toledo Clinic Cancer Centers-Maumee	Maumee	Ohio	United States	43537
648	Toledo Radiation Oncology at Northwest Ohio Onocolgy Center	Maumee	Ohio	United States	43537
649	Knox Community Hospital	Mount Vernon	Ohio	United States	43050
650	Licking Memorial Hospital	Newark	Ohio	United States	43055
651	Fisher-Titus Medical Center	Norwalk	Ohio	United States	44857
652	Saint Charles Hospital	Oregon	Ohio	United States	43616
653	Toledo Clinic Cancer Centers-Oregon	Oregon	Ohio	United States	43616
654	Firelands Regional Medical Center	Sandusky	Ohio	United States	44870
655	North Coast Cancer Care	Sandusky	Ohio	United States	44870
656	Springfield Regional Medical Center	Springfield	Ohio	United States	45505
657	ProMedica Flower Hospital	Sylvania	Ohio	United States	43560
658	Mercy Hospital of Tiffin	Tiffin	Ohio	United States	44883
659	ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital	Toledo	Ohio	United States	43606
660	Saint Vincent Mercy Medical Center	Toledo	Ohio	United States	43608
661	University of Toledo	Toledo	Ohio	United States	43614
662	Toledo Community Hospital Oncology Program CCOP	Toledo	Ohio	United States	43617
663	Mercy Health - Saint Anne Hospital	Toledo	Ohio	United States	43623
664	Stark, Michael, Edward. M.D. (UIA Investigator)	Toledo	Ohio	United States	43623
665	Toledo Clinic Cancer Centers-Toledo	Toledo	Ohio	United States	43623
666	Upper Valley Medical Center	Troy	Ohio	United States	45373
667	Fulton County Health Center	Wauseon	Ohio	United States	43567
668	Saint Ann's Hospital	Westerville	Ohio	United States	43081
669	Clinton Memorial Hospital	Wilmington	Ohio	United States	45177
670	Cleveland Clinic Wooster Family Health and Surgery Center	Wooster	Ohio	United States	44691
671	Wright-Patterson Medical Center	Wright-Patterson Air Force Base	Ohio	United States	45433
672	Greene Memorial Hospital	Xenia	Ohio	United States	45385
673	Genesis Healthcare System Cancer Care Center	Zanesville	Ohio	United States	43701
674	Cancer Centers of Southwest Oklahoma Research	Lawton	Oklahoma	United States	73505
675	University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	United States	73104
676	Cancer Care Associates	Oklahoma City	Oklahoma	United States	73120
677	Integris Cancer Institute of Oklahoma	Oklahoma City	Oklahoma	United States	73142
678	Saint John Medical Center	Tulsa	Oklahoma	United States	74104
679	Natalie Warren Bryant Cancer Center at Saint Francis	Tulsa	Oklahoma	United States	74136
680	Saint Charles Health System	Bend	Oregon	United States	97701
681	Bay Area Hospital	Coos Bay	Oregon	United States	97420
682	Legacy Mount Hood Medical Center	Gresham	Oregon	United States	97030
683	Providence Milwaukie Hospital	Milwaukie	Oregon	United States	97222
684	Legacy Good Samaritan Hospital and Medical Center	Portland	Oregon	United States	97210
685	Providence Portland Medical Center	Portland	Oregon	United States	97213
686	Adventist Medical Center	Portland	Oregon	United States	97216
687	Providence Saint Vincent Medical Center	Portland	Oregon	United States	97225
688	Legacy Emanuel Hospital and Health Center	Portland	Oregon	United States	97227
689	Oregon Health and Science University	Portland	Oregon	United States	97239
690	Salem Hospital	Salem	Oregon	United States	97301
691	Legacy Meridian Park Hospital	Tualatin	Oregon	United States	97062
692	Jefferson Abington Hospital	Abington	Pennsylvania	United States	19001
693	Lehigh Valley Hospital-Cedar Crest	Allentown	Pennsylvania	United States	18103
694	Saint Luke's University Hospital-Bethlehem Campus	Bethlehem	Pennsylvania	United States	18015
695	Bryn Mawr Hospital	Bryn Mawr	Pennsylvania	United States	19010
696	Geisinger Medical Center	Danville	Pennsylvania	United States	17822
697	Mercy Fitzgerald Hospital	Darby	Pennsylvania	United States	19023-1291
698	Doylestown Hospital	Doylestown	Pennsylvania	United States	18901
699	Delaware County Memorial Hospital	Drexel Hill	Pennsylvania	United States	19026
700	Oncology Hematology Associates of Northern Pennsylvania	DuBois	Pennsylvania	United States	15801
701	Pocono Medical Center	East Stroudsburg	Pennsylvania	United States	18301
702	Easton Hospital	Easton	Pennsylvania	United States	18042
703	Ephrata Cancer Center	Ephrata	Pennsylvania	United States	17522
704	UPMC Hillman Cancer Center Erie	Erie	Pennsylvania	United States	16505
705	UPMC Hamot	Erie	Pennsylvania	United States	16550
706	UPMC Pinnacle Cancer Center/Community Osteopathic Campus	Harrisburg	Pennsylvania	United States	17109
707	Geisinger Medical Center-Cancer Center Hazleton	Hazleton	Pennsylvania	United States	18201
708	Penn State Milton S Hershey Medical Center	Hershey	Pennsylvania	United States	17033-0850
709	Armstrong Center for Medicine and Health	Kittanning	Pennsylvania	United States	16201
710	Lancaster General Hospital	Lancaster	Pennsylvania	United States	17602
711	Saint Mary Medical and Regional Cancer Center	Langhorne	Pennsylvania	United States	19047
712	Lewistown Hospital	Lewistown	Pennsylvania	United States	17044
713	Riddle Memorial Hospital	Media	Pennsylvania	United States	19063
714	Paoli Memorial Hospital	Paoli	Pennsylvania	United States	19301
715	University of Pennsylvania/Abramson Cancer Center	Philadelphia	Pennsylvania	United States	19104
716	Pennsylvania Hospital	Philadelphia	Pennsylvania	United States	19107
717	Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	United States	19107
718	Fox Chase Cancer Center	Philadelphia	Pennsylvania	United States	19111
719	Jefferson Torresdale Hospital	Philadelphia	Pennsylvania	United States	19114
720	Chestnut Hill Health System	Philadelphia	Pennsylvania	United States	19118
721	Einstein Medical Center Philadelphia	Philadelphia	Pennsylvania	United States	19141
722	Phoenixville Hospital	Phoenixville	Pennsylvania	United States	19460
723	Allegheny General Hospital	Pittsburgh	Pennsylvania	United States	15212
724	University of Pittsburgh Cancer Institute (UPCI)	Pittsburgh	Pennsylvania	United States	15232
725	Pottstown Hospital	Pottstown	Pennsylvania	United States	19464
726	Guthrie Medical Group PC-Robert Packer Hospital	Sayre	Pennsylvania	United States	18840
727	Mercy Hospital	Scranton	Pennsylvania	United States	18501
728	Hematology and Oncology Associates of North East Pennsylvania	Scranton	Pennsylvania	United States	18508
729	Scranton Hematology Oncology	Scranton	Pennsylvania	United States	18510
730	Grand View Hospital	Sellersville	Pennsylvania	United States	18960
731	Geisinger Medical Group	State College	Pennsylvania	United States	16801
732	Mount Nittany Medical Center	State College	Pennsylvania	United States	16803
733	Associates In Hematology Oncology PC-Upland	Upland	Pennsylvania	United States	19013
734	Chester County Hospital	West Chester	Pennsylvania	United States	19380
735	Jennersville Regional Hospital	West Grove	Pennsylvania	United States	19390
736	Reading Hospital	West Reading	Pennsylvania	United States	19611
737	Geisinger Wyoming Valley/Henry Cancer Center	Wilkes-Barre	Pennsylvania	United States	18711
738	UPMC Susquehanna	Williamsport	Pennsylvania	United States	17701
739	Lankenau Medical Center	Wynnewood	Pennsylvania	United States	19096
740	Main Line Health NCORP	Wynnewood	Pennsylvania	United States	19096
741	WellSpan Health-York Hospital	York	Pennsylvania	United States	17403
742	Hematology and Oncology Associates of Rhode Island Inc	Cranston	Rhode Island	United States	02920
743	Roger Williams Medical Center	Providence	Rhode Island	United States	02908
744	Kent Hospital	Warwick	Rhode Island	United States	02886
745	AnMed Health Cancer Center	Anderson	South Carolina	United States	29621
746	AnMed Health Hospital	Anderson	South Carolina	United States	29621
747	Beaufort Memorial Hospital	Beaufort	South Carolina	United States	29902
748	Prisma Health Cancer Institute - Spartanburg	Boiling Springs	South Carolina	United States	29316
749	Roper Hospital	Charleston	South Carolina	United States	29401
750	Prisma Health Cancer Institute - Easley	Easley	South Carolina	United States	29640
751	Tidelands Georgetown Memorial Hospital	Georgetown	South Carolina	United States	29440
752	Greenville Health System Cancer Institute-Andrews	Greenville	South Carolina	United States	29601
753	Saint Francis Hospital	Greenville	South Carolina	United States	29601
754	Prisma Health Cancer Institute - Butternut	Greenville	South Carolina	United States	29605
755	Prisma Health Cancer Institute - Faris	Greenville	South Carolina	United States	29605
756	Prisma Health Greenville Memorial Hospital	Greenville	South Carolina	United States	29605
757	Prisma Health Cancer Institute - Eastside	Greenville	South Carolina	United States	29615
758	Self Regional Healthcare	Greenwood	South Carolina	United States	29646
759	Prisma Health Cancer Institute - Greer	Greer	South Carolina	United States	29650
760	Prisma Health Cancer Institute - Seneca	Seneca	South Carolina	United States	29672
761	Spartanburg Medical Center	Spartanburg	South Carolina	United States	29303
762	Sanford Cancer Center Oncology Clinic	Sioux Falls	South Dakota	United States	57104
763	Avera Cancer Institute	Sioux Falls	South Dakota	United States	57105
764	Medical X-Ray Center	Sioux Falls	South Dakota	United States	57105
765	Avera McKennan Hospital and University Health Center	Sioux Falls	South Dakota	United States	57117-5045
766	Sanford USD Medical Center - Sioux Falls	Sioux Falls	South Dakota	United States	57117-5134
767	Erlanger Medical Center	Chattanooga	Tennessee	United States	37403
768	Vanderbilt-Ingram Cancer Center Cool Springs	Franklin	Tennessee	United States	37067
769	Jones Clinic	Germantown	Tennessee	United States	38138
770	Wellmont Holston Valley Hospital and Medical Center	Kingsport	Tennessee	United States	37660
771	Tennessee Cancer Specialists-Dowell Springs	Knoxville	Tennessee	United States	37909
772	Thompson Cancer Survival Center	Knoxville	Tennessee	United States	37916
773	East Tennessee Baptist Hospital-Mercy Health Partners	Knoxville	Tennessee	United States	37920
774	University of Tennessee - Knoxville	Knoxville	Tennessee	United States	37920
775	Nashville Oncology Associates PC	Nashville	Tennessee	United States	37203
776	Meharry Medical College	Nashville	Tennessee	United States	37208
777	Vanderbilt University/Ingram Cancer Center	Nashville	Tennessee	United States	37232
778	The Don and Sybil Harrington Cancer Center	Amarillo	Texas	United States	79106
779	Texas Oncology-Austin Midtown	Austin	Texas	United States	78705
780	Texas Oncology - Central Austin Cancer Center	Austin	Texas	United States	78731
781	Texas Oncology - South Austin Cancer Center	Austin	Texas	United States	78745
782	Texas Oncology-Austin North	Austin	Texas	United States	78758
783	Texas Oncology Seton Northwest	Austin	Texas	United States	78759
784	Texas Oncology-Cedar Park	Cedar Park	Texas	United States	78613
785	Medical City Dallas Hospital	Dallas	Texas	United States	75230
786	Parkland Memorial Hospital	Dallas	Texas	United States	75235
787	Clements University Hospital	Dallas	Texas	United States	75390
788	UT Southwestern/Simmons Cancer Center-Dallas	Dallas	Texas	United States	75390
789	Brooke Army Medical Center	Fort Sam Houston	Texas	United States	78234
790	Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center	Houston	Texas	United States	77030
791	Baylor Saint Luke's Medical Center	Houston	Texas	United States	77030
792	Ben Taub General Hospital	Houston	Texas	United States	77030
793	Houston Methodist Hospital	Houston	Texas	United States	77030
794	M D Anderson Cancer Center	Houston	Texas	United States	77030
795	Michael E DeBakey VA Medical Center	Houston	Texas	United States	77030
796	Wilford Hall Medical Center	Lackland Air Force Base	Texas	United States	78236
797	Doctor's Hospital of Laredo	Laredo	Texas	United States	78041
798	Texas Oncology-Seton Williamson	Round Rock	Texas	United States	78665
799	Texas Oncology - Round Rock Cancer Center	Round Rock	Texas	United States	78681
800	Audie L Murphy VA Hospital	San Antonio	Texas	United States	78229
801	Cancer Therapy and Research Center at The UT Health Science Center at San Antonio	San Antonio	Texas	United States	78229
802	University Hospital	San Antonio	Texas	United States	78229
803	University of Texas Health Science Center at San Antonio	San Antonio	Texas	United States	78229
804	Texas Oncology- San Marcos	San Marcos	Texas	United States	78666
805	Scott and White Memorial Hospital	Temple	Texas	United States	76508
806	American Fork Hospital / Huntsman Intermountain Cancer Center	American Fork	Utah	United States	84003
807	Sandra L Maxwell Cancer Center	Cedar City	Utah	United States	84720
808	Logan Regional Hospital	Logan	Utah	United States	84321
809	Cottonwood Hospital Medical Center	Murray	Utah	United States	84107
810	Intermountain Medical Center	Murray	Utah	United States	84107
811	McKay-Dee Hospital Center	Ogden	Utah	United States	84403
812	Utah Valley Regional Medical Center	Provo	Utah	United States	84604
813	Dixie Medical Center Regional Cancer Center	Saint George	Utah	United States	84770
814	Intermountain Health Care	Salt Lake City	Utah	United States	84103
815	Utah Cancer Specialists-Salt Lake City	Salt Lake City	Utah	United States	84106
816	Huntsman Cancer Institute/University of Utah	Salt Lake City	Utah	United States	84112
817	LDS Hospital	Salt Lake City	Utah	United States	84143
818	Southwestern Vermont Medical Center	Bennington	Vermont	United States	05201
819	Mount Ascutney Hospital and Health Center	Windsor	Vermont	United States	05089
820	Sentara Martha Jefferson Hospital	Charlottesville	Virginia	United States	22901
821	University of Virginia Cancer Center	Charlottesville	Virginia	United States	22908
822	Danville Regional Medical Center	Danville	Virginia	United States	24541
823	Fredericksburg Oncology Inc	Fredericksburg	Virginia	United States	22401
824	Virginia Oncology Associates-Hampton	Hampton	Virginia	United States	23666
825	Centra Lynchburg Hematology-Oncology Clinic Inc	Lynchburg	Virginia	United States	24501
826	Peninsula Cancer Institute-Newport News	Newport News	Virginia	United States	23601
827	Southwest VA Regional Cancer Center	Norton	Virginia	United States	24273
828	MultiCare Auburn Medical Center	Auburn	Washington	United States	98001
829	PeaceHealth Saint Joseph Medical Center	Bellingham	Washington	United States	98225
830	Harrison HealthPartners Hematology and Oncology-Bremerton	Bremerton	Washington	United States	98310
831	Providence Regional Cancer System-Centralia	Centralia	Washington	United States	98531
832	Saint Francis Hospital	Federal Way	Washington	United States	98003
833	Kadlec Clinic Hematology and Oncology	Kennewick	Washington	United States	99336
834	Saint Clare Hospital	Lakewood	Washington	United States	98499
835	Skagit Valley Hospital	Mount Vernon	Washington	United States	98274
836	Providence - Saint Peter Hospital	Olympia	Washington	United States	98506-5166
837	Capital Medical Center	Olympia	Washington	United States	98507
838	Harrison HealthPartners Hematology and Oncology-Poulsbo	Poulsbo	Washington	United States	98370
839	MultiCare Good Samaritan Hospital	Puyallup	Washington	United States	98372
840	Minor and James Medical PLLC	Seattle	Washington	United States	98104
841	VA Puget Sound Health Care System	Seattle	Washington	United States	98108
842	Kaiser Permanente Washington	Seattle	Washington	United States	98112
843	Swedish Medical Center-First Hill	Seattle	Washington	United States	98122-4307
844	University of Washington Medical Center - Montlake	Seattle	Washington	United States	98195
845	Cancer Care Northwest - Spokane South	Spokane	Washington	United States	99202
846	Providence Sacred Heart Medical Center and Children's Hospital	Spokane	Washington	United States	99204
847	Providence Holy Family Hospital	Spokane	Washington	United States	99208
848	Evergreen Hematology and Oncology PS	Spokane	Washington	United States	99218
849	Rockwood Clinic	Spokane	Washington	United States	99220
850	MultiCare Allenmore Hospital	Tacoma	Washington	United States	98405
851	MultiCare Tacoma General Hospital	Tacoma	Washington	United States	98405
852	Northwest NCI Community Oncology Research Program	Tacoma	Washington	United States	98405
853	Saint Joseph Medical Center	Tacoma	Washington	United States	98405
854	Madigan Army Medical Center	Tacoma	Washington	United States	98431
855	PeaceHealth Southwest Medical Center	Vancouver	Washington	United States	98664
856	Wenatchee Valley Hospital and Clinics	Wenatchee	Washington	United States	98801
857	North Star Lodge Cancer Center at Yakima Valley Memorial Hospital	Yakima	Washington	United States	98902
858	West Virginia University Charleston Division	Charleston	West Virginia	United States	25304
859	Edwards Comprehensive Cancer Center	Huntington	West Virginia	United States	25701
860	Marshall University Medical Center	Huntington	West Virginia	United States	25701
861	Saint Mary's Medical Center	Huntington	West Virginia	United States	25702
862	West Virginia University Healthcare	Morgantown	West Virginia	United States	26506
863	Camden Clark Medical Center	Parkersburg	West Virginia	United States	26101
864	Princeton Community Hospital	Princeton	West Virginia	United States	24740
865	Aurora Cancer Care-Southern Lakes VLCC	Burlington	Wisconsin	United States	53105
866	Marshfield Clinic-Chippewa Center	Chippewa Falls	Wisconsin	United States	54729
867	HSHS Sacred Heart Hospital	Eau Claire	Wisconsin	United States	54701
868	Marshfield Clinic Cancer Center at Sacred Heart	Eau Claire	Wisconsin	United States	54701
869	Saint Agnes Hospital/Agnesian Cancer Center	Fond Du Lac	Wisconsin	United States	54935
870	Aurora Cancer Care-Franklin	Franklin	Wisconsin	United States	53132
871	Aurora Health Care Germantown Health Center	Germantown	Wisconsin	United States	53022
872	Aurora Cancer Care-Glendale	Glendale	Wisconsin	United States	53212
873	Green Bay Oncology at Saint Vincent Hospital	Green Bay	Wisconsin	United States	54301-3526
874	Saint Vincent Hospital Cancer Center Green Bay	Green Bay	Wisconsin	United States	54301
875	Green Bay Oncology Limited at Saint Mary's Hospital	Green Bay	Wisconsin	United States	54303
876	Saint Vincent Hospital Cancer Center at Saint Mary's	Green Bay	Wisconsin	United States	54303
877	Aurora BayCare Medical Center	Green Bay	Wisconsin	United States	54311
878	Mercyhealth Hospital and Cancer Center - Janesville	Janesville	Wisconsin	United States	53548
879	UW Cancer Center Johnson Creek	Johnson Creek	Wisconsin	United States	53038
880	Aurora Cancer Care-Kenosha South	Kenosha	Wisconsin	United States	53142
881	Gundersen Lutheran Medical Center	La Crosse	Wisconsin	United States	54601
882	Mayo Clinic Health System-Franciscan Healthcare	La Crosse	Wisconsin	United States	54601
883	UW Health Oncology-One South Park	Madison	Wisconsin	United States	53715
884	Dean Hematology and Oncology Clinic	Madison	Wisconsin	United States	53717
885	University of Wisconsin Hospital and Clinics	Madison	Wisconsin	United States	53792
886	Holy Family Memorial Hospital	Manitowoc	Wisconsin	United States	54221
887	Aurora Bay Area Medical Group-Marinette	Marinette	Wisconsin	United States	54143
888	Bay Area Medical Center	Marinette	Wisconsin	United States	54143
889	Marshfield Medical Center-Marshfield	Marshfield	Wisconsin	United States	54449
890	Marshfield Medical Center	Marshfield	Wisconsin	United States	54449
891	Ascension Southeast Wisconsin Hospital - Saint Joseph Campus	Milwaukee	Wisconsin	United States	53210
892	Aurora Saint Luke's Medical Center	Milwaukee	Wisconsin	United States	53215
893	Medical College of Wisconsin	Milwaukee	Wisconsin	United States	53226
894	Aurora Sinai Medical Center	Milwaukee	Wisconsin	United States	53233
895	Marshfield Clinic-Minocqua Center	Minocqua	Wisconsin	United States	54548
896	ProHealth Oconomowoc Memorial Hospital	Oconomowoc	Wisconsin	United States	53066
897	Saint Vincent Hospital Cancer Center at Oconto Falls	Oconto Falls	Wisconsin	United States	54154
898	Vince Lombardi Cancer Clinic - Oshkosh	Oshkosh	Wisconsin	United States	54904
899	Ascension All Saints Hospital	Racine	Wisconsin	United States	53405
900	Aurora Cancer Care-Racine	Racine	Wisconsin	United States	53406
901	Ascension Saint Mary's Hospital	Rhinelander	Wisconsin	United States	54501
902	Marshfield Medical Center-Rice Lake	Rice Lake	Wisconsin	United States	54868
903	Vince Lombardi Cancer Clinic-Sheboygan	Sheboygan	Wisconsin	United States	53081
904	Vince Lombardi Cancer Clinic - Slinger	Slinger	Wisconsin	United States	53086
905	Ascension Saint Michael's Hospital	Stevens Point	Wisconsin	United States	54481
906	Green Bay Oncology - Sturgeon Bay	Sturgeon Bay	Wisconsin	United States	54235
907	Aurora Medical Center in Summit	Summit	Wisconsin	United States	53066
908	Vince Lombardi Cancer Clinic-Two Rivers	Two Rivers	Wisconsin	United States	54241
909	Aurora Cancer Care-Waukesha	Waukesha	Wisconsin	United States	53188
910	ProHealth Waukesha Memorial Hospital	Waukesha	Wisconsin	United States	53188
911	Aspirus Regional Cancer Center	Wausau	Wisconsin	United States	54401
912	Marshfield Clinic-Wausau Center	Wausau	Wisconsin	United States	54401
913	Aurora Cancer Care-Milwaukee West	Wauwatosa	Wisconsin	United States	53226
914	Marshfield Medical Center - Weston	Weston	Wisconsin	United States	54476
915	Aspirus Cancer Care - Wisconsin Rapids	Wisconsin Rapids	Wisconsin	United States	54494
916	Marshfield Clinic - Wisconsin Rapids Center	Wisconsin Rapids	Wisconsin	United States	54494
917	Rocky Mountain Oncology	Casper	Wyoming	United States	82609
918	Welch Cancer Center	Sheridan	Wyoming	United States	82801
919	Cross Cancer Institute	Edmonton	Alberta	Canada	T6G 1Z2
920	BCCA-Vancouver Cancer Centre	Vancouver	British Columbia	Canada	V5Z 4E6
921	Atlantic Health Sciences Corporation-Saint John Regional Hospital	Saint John	New Brunswick	Canada	E2L 4L2
922	London Regional Cancer Program	London	Ontario	Canada	N6A 4L6
923	Lakeridge Health Oshawa	Oshawa	Ontario	Canada	L1G 2B9
924	Ottawa Hospital and Cancer Center-General Campus	Ottawa	Ontario	Canada	K1H 8L6
925	Health Sciences North	Sudbury	Ontario	Canada	P3E 5J1
926	Thunder Bay Regional Health Science Centre	Thunder Bay	Ontario	Canada	P7B 6V4
927	Odette Cancer Centre- Sunnybrook Health Sciences Centre	Toronto	Ontario	Canada	M4N 3M5
928	Saint Michael's Hospital	Toronto	Ontario	Canada	M5B 1W8
929	PEI Cancer Treatment Centre-Queen Elizabeth Hospital	Charlottetown	Prince Edward Island	Canada	C1A 8T5
930	Allan Blair Cancer Centre	Regina	Saskatchewan	Canada	S4T 7T1
931	Instituto Nacional de Enfermedades Neoplasicas	Lima		Peru	Lima 34
932	Andres Grillasca Hospital	Ponce		Puerto Rico	00733
933	San Juan Community Oncology Group	San Juan		Puerto Rico	00917
934	San Juan Veterans Affairs Medical Center	San Juan		Puerto Rico	00921-3201
935	San Juan City Hospital	San Juan		Puerto Rico	00936
936	University Of Pretoria	Pretoria		South Africa	0002

Sponsors and Collaborators

• National Cancer Institute (NCI)

Investigators

• Principal Investigator: Al B Benson, ECOG-ACRIN Cancer Research Group

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: National Cancer Institute (NCI)
• ClinicalTrials.gov Identifier: NCT00217737
• Other Study ID Numbers: NCI-2009-00562; NCI-2009-00562; 05-198; CDR0000443410; E5202; ECOG-E5202; E5202; E5202; U10CA180820; U10CA021115
• First Posted: Sep 22, 2005
• Last Update Posted: Mar 11, 2022
• Last Verified: Mar 1, 2022

• Additional relevant MeSH terms: Adenocarcinoma; Colonic Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis; Adenocarcinoma, Mucinous; Cystadenocarcinoma; Carcinoma, Signet Ring Cell; Calcium, Dietary; Leucovorin; Folic Acid; Bevacizumab; Antineoplastic Agents, Immunological; Fluorouracil; Oxaliplatin; Endothelial Growth Factors; Antibodies; Immunoglobulins; Antibodies, Monoclonal; Immunoglobulin G; Calcium; Levoleucovorin

Study Results

No Results Posted as of Mar 11, 2022