Color Flow Doppler Ultrasound in Subclinical Thyroid Dysfunction

Sponsor

HaEmek Medical Center, Israel (Other)

Overall Status

Completed

CT.gov ID

NCT00437931

Collaborator

(none)

Enrollment

Location

Duration (Months)

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Overt hyperthyroidism and hypothyroidism are associated with inverted hemodynamic changes.Regional blood flow disturbances (including intrathyroidal) were also reported in these thyroid disorders. The purpose of this study is to investigate the thyroid vascularity and blood flow by Color Flow Doppler Sonography in patients with subclinical thyroid dysfunction

Condition or Disease	Intervention/Treatment	Phase
Subclinical Hypothyroidism Hyperthyroidism Thyroid Dysfunction

Detailed Description

Color Flow Doppler Sonography (CFDS) has become in the last years an increasing procedure to assess the thyroid blood flow. Previous studies showed specific changes of thyroid blood flow in hyperthyroidism, Hashimoto's thyroiditis and thyroid nodules when investigated by CFDS. Subclinical hyperthyroidism and hypothyroidism are common laboratory findings, defined by normal thyroid hormones concentrations along with ,respectively,decreased or increase Thyroid stimulating hormone (TSH) level. We purpose to investigate thyroid vascularity by CFDS in patients with subclinical hyperthyroidism or hypothyroidism and compared them with euthyroid patients.

Study Design

Study Type:

Observational

Actual Enrollment :

60 participants

Observational Model:

Case-Control

Time Perspective:

Prospective

Study Start Date :

Feb 1, 2007

Actual Primary Completion Date :

Feb 1, 2008

Actual Study Completion Date :

Feb 1, 2008

Arms and Interventions

Arm	Intervention/Treatment
A patients with subclinical hypothyroidism
B patients with subclinical hyperthyroidism
C patient with normal thyroid function.

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 75 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

patients with subclinical hypothyroidism or hyperthyroidism
patients with thyroid nodules and normal thyroid function

Exclusion Criteria:

patients who are taking thyroxine, antithyroid drugs, lithium or amiodarone
patients who had thyroid surgery or radioiodine therapy
patients with NYHA class 3 or 4 heart failure

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Haemek Medical Center, Department of Radiology	Afula		Israel	18101

Sponsors and Collaborators

HaEmek Medical Center, Israel

Investigators

Principal Investigator: Avraham Ishay, MD, Haemek Medical Center, Endocrine Institute, Afula, Israel
Study Chair: Leonid Chervinsky, Haemek Medical Center, Department of Radiology, Afula , Israel
Study Chair: Rafael Luboshitzky, MD, Haemek Medical Center, Endocrine Institute, Afula, Israel