Radiation Therapy Plus Chemotherapy Followed by Surgery in Treating Patients With Locally Advanced Cancer of the Rectum
Sponsor
Radiation Therapy Oncology Group (Other)
Overall Status
Completed
CT.gov ID
NCT00006366
Collaborator
National Cancer Institute (NCI) (NIH)
235
Study Details
Study Description
Brief Summary
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known which regimen of radiation therapy plus chemotherapy is more effective for rectal cancer.
PURPOSE: Randomized phase II trial to compare two regimens of radiation therapy plus chemotherapy followed by surgery in treating patients who have locally advanced cancer of the rectum.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 2 |
Detailed Description
OBJECTIVES:
- Compare the pathological complete response, acute and late normal tissue morbidity, patterns of failure, and complete resection rates in patients with locally advanced adenocarcinoma of the distal rectum treated with neoadjuvant chemoradiotherapy comprised of hyperfractionated radiotherapy and fluorouracil vs conventional radiotherapy, fluorouracil, and irinotecan, followed by radical resection.
OUTLINE: This is a randomized study. Patients are stratified according to clinical stage (T3 vs T4). Patients are randomized to 1 of 2 treatment arms.
-
Arm I: Patients receive hyperfractionated radiotherapy (RT) twice daily, 5 days a week for 19 days. Patients receive fluorouracil IV continuously over 7 days a week concurrently with RT. Patients with clinical stage T3 or fixed T4 disease also receive a higher boost dose of RT to tumor.
-
Arm II: Patients receive conventional RT once daily, 5 days a week for 25 days. Patients receive fluorouracil IV continuously over 5 days a week concurrently with RT. Patients receive irinotecan IV over 1 hour (immediately prior to RT dose) once weekly for 4 weeks. Patients with clinical stage T3 or fixed T4 disease also receive a lower boost dose of RT to tumor.
Within 4-10 weeks after completion of chemoradiotherapy, patients on both arms undergo radical anterior resection or radical abdominal perineal resection with preferably a total mesorectal resection.
Patients are followed every 3 months for 2 years, every 6 months for 3 years, and then annually thereafter.
PROJECTED ACCRUAL: A total of 100 patients (50 per arm) will be accrued for this study within 18 months.
Study Design
Study Type:
Interventional
Allocation:
Randomized
Primary Purpose:
Treatment
Official Title:
Randomized Phase II Trial of Preoperative Combined Modality Chemoradiation for Distal Rectal Cancer
Study Start Date
:
Feb 1, 2001
Actual Primary Completion Date
:
Dec 1, 2003
Outcome Measures
Primary Outcome Measures
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
DISEASE CHARACTERISTICS:
-
Histologically confirmed adenocarcinoma of the distal rectum
-
Located 0-9 cm from the dentate line (3-12 cm from the anal verge)
-
No extension of malignant disease into the anal canal
-
Lesions may be mobile stage T3 by endorectal ultrasound OR fixed, defined as clinical stage T4, by palpation
-
No evidence of distant metastases
PATIENT CHARACTERISTICS:
Age:
- Over 18
Performance status:
- Zubrod 0-1
Life expectancy:
- Not specified
Hematopoietic:
-
WBC (white blood cell count) greater than 4,000/mm^3
-
Platelet count greater than 130,000/mm^3
Hepatic:
-
Bilirubin no greater than 1.5 times upper limit of normal
-
Alkaline phosphatase, SGOT (serum glutamic oxaloacetic transaminase), and LDH (lactate dehydrogenase) normal
Renal:
- Creatinine normal
Other:
-
Not pregnant or nursing
-
Fertile patients must use effective contraception
-
No other invasive malignancy within the past 5 years except:
-
Inactive nonmelanomatous skin cancer
-
Carcinoma in situ of the cervix
-
Synchronous colonic cancer if tumor is Tis or T1 and has been completely resected
-
No other serious medical illnesses
PRIOR CONCURRENT THERAPY:
Biologic therapy:
- Not specified
Chemotherapy:
- No prior chemotherapy
Endocrine therapy:
- Not specified
Radiotherapy:
- No prior radiotherapy to pelvis
Surgery:
- Not specified
Other:
- No concurrent antiepileptic drugs
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of Alabama at Birmingham Comprehensive Cancer Center | Birmingham | Alabama | United States | 35294-3300 |
| 2 | Comprehensive Cancer Institute of Huntsville | Huntsville | Alabama | United States | 35801 |
| 3 | Huntsville Hospital System | Huntsville | Alabama | United States | 35807 |
| 4 | MBCCOP - Gulf Coast | Mobile | Alabama | United States | 36688 |
| 5 | Alabama Oncology, LLC | Montgomery | Alabama | United States | 36106-3657 |
| 6 | Radiation Oncology Associates of West Alabama | Tuscaloosa | Alabama | United States | 35401 |
| 7 | Foundation for Cancer Research and Education | Phoenix | Arizona | United States | 85013 |
| 8 | Mount Diablo Medical Center | Concord | California | United States | 94524-4110 |
| 9 | City of Hope Comprehensive Cancer Center | Duarte | California | United States | 91010-3000 |
| 10 | Saint Agnes Cancer Center | Fresno | California | United States | 93720 |
| 11 | California Cancer Center | Fresno | California | United States | 93729-5100 |
| 12 | Sutter Health West Cancer Research Group | Greenbrae | California | United States | 94904 |
| 13 | Loma Linda University Medical Center | Loma Linda | California | United States | 92354 |
| 14 | Veterans Affairs Medical Center - Long Beach | Long Beach | California | United States | 90822 |
| 15 | Jonsson Comprehensive Cancer Center, UCLA | Los Angeles | California | United States | 90025-1781 |
| 16 | USC/Norris Comprehensive Cancer Center and Hospital | Los Angeles | California | United States | 90033-0804 |
| 17 | CCOP - Bay Area Tumor Institute | Oakland | California | United States | 94609-3305 |
| 18 | Huntington Cancer Center | Pasadena | California | United States | 91105 |
| 19 | Cancer Care Center | Pomona | California | United States | 91767 |
| 20 | Radiation Oncology Center - Sacramento | Sacramento | California | United States | 95816 |
| 21 | Radiation Medical Group, Inc. | San Diego | California | United States | 92101 |
| 22 | UCSF Cancer Center and Cancer Research Institute | San Francisco | California | United States | 94143-0128 |
| 23 | O'Connor Hospital | San Jose | California | United States | 95128 |
| 24 | CCOP - Santa Rosa Memorial Hospital | Santa Rosa | California | United States | 95403 |
| 25 | David Grant Medical Center | Travis Air Force Base | California | United States | 94535 |
| 26 | Memorial Hospital Cancer Center | Colorado Springs | Colorado | United States | 80909 |
| 27 | University of Colorado Cancer Center | Denver | Colorado | United States | 80010 |
| 28 | Saint Mary's Hospital and Medical Center | Grand Junction | Colorado | United States | 81502-1628 |
| 29 | Hospital of St. Raphael | New Haven | Connecticut | United States | 06511 |
| 30 | CCOP - Christiana Care Health Services | Wilmington | Delaware | United States | 19899 |
| 31 | University of Florida Health Science Center | Gainesville | Florida | United States | 32610-0385 |
| 32 | Florida Radiation Oncology Group | Jacksonville | Florida | United States | 32207 |
| 33 | Health First Holmes Regional Medical Center | Melbourne | Florida | United States | 32901-3276 |
| 34 | CCOP - Mount Sinai Medical Center | Miami Beach | Florida | United States | 33140 |
| 35 | Veterans Affairs Medical Center - Miami | Miami | Florida | United States | 33125 |
| 36 | Sylvester Cancer Center, University of Miami | Miami | Florida | United States | 33136 |
| 37 | Baptist Hospital of Miami | Miami | Florida | United States | 33256-2110 |
| 38 | MD Anderson Cancer Center Orlando | Orlando | Florida | United States | 32806 |
| 39 | Bay Medical Center | Panama City | Florida | United States | 32401 |
| 40 | Gulf Coast Cancer Treatment Center | Panama City | Florida | United States | 32405-4587 |
| 41 | Sarasota Radiation and Medical Oncology Center | Sarasota | Florida | United States | 34233 |
| 42 | Tallahassee Memorial Healthcare | Tallahassee | Florida | United States | 32308 |
| 43 | H. Lee Moffitt Cancer Center and Research Institute | Tampa | Florida | United States | 33612-9497 |
| 44 | Emory University Hospital - Atlanta | Atlanta | Georgia | United States | 30322 |
| 45 | CCOP - Atlanta Regional | Atlanta | Georgia | United States | 30342-1701 |
| 46 | Medical Center/John B. Amos Community Cancer Center | Columbus | Georgia | United States | 31901 |
| 47 | Regional Radiation Oncology Center at Rome | Rome | Georgia | United States | 30165 |
| 48 | MBCCOP - Hawaii | Honolulu | Hawaii | United States | 96813 |
| 49 | Northwest Community Hospital | Arlington Heights | Illinois | United States | 60005 |
| 50 | Northwestern Memorial Hospital | Chicago | Illinois | United States | 60611 |
| 51 | CCOP - Central Illinois | Decatur | Illinois | United States | 62526 |
| 52 | Ingalls Memorial Hospital | Harvey | Illinois | United States | 60426 |
| 53 | Loyola University Medical Center | Maywood | Illinois | United States | 60153 |
| 54 | Lutheran General Cancer Care Center | Park Ridge | Illinois | United States | 60068 |
| 55 | Methodist Medical Center of Illinois | Peoria | Illinois | United States | 61636 |
| 56 | St. John's Medical Center | Anderson | Indiana | United States | 46016 |
| 57 | Bloomington Hospital | Bloomington | Indiana | United States | 47402 |
| 58 | Veterans Affairs Medical Center - Indianapolis (Roudebush) | Indianapolis | Indiana | United States | 46202 |
| 59 | Clarian Health Partners Inc. | Indianapolis | Indiana | United States | 46206-1367 |
| 60 | Regional Cancer Center | Indianapolis | Indiana | United States | 46219 |
| 61 | Ball Memorial Hospital | Muncie | Indiana | United States | 47303-3499 |
| 62 | CCOP - Northern Indiana CR Consortium | South Bend | Indiana | United States | 46601 |
| 63 | Wendt Regional Cancer Center of Finley Hospital | Dubuque | Iowa | United States | 52001 |
| 64 | Central Baptist Hospital | Lexington | Kentucky | United States | 40503 |
| 65 | Albert B. Chandler Medical Center, University of Kentucky | Lexington | Kentucky | United States | 40536-0293 |
| 66 | James Graham Brown Cancer Center | Louisville | Kentucky | United States | 40202 |
| 67 | Louisville Radiation Oncology | Louisville | Kentucky | United States | 40215 |
| 68 | Merle M. Mahr Cancer Center | Madisonville | Kentucky | United States | 42431 |
| 69 | Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | United States | 70809 |
| 70 | Tulane University School of Medicine | New Orleans | Louisiana | United States | 70112-2699 |
| 71 | MBCCOP - LSU Health Sciences Center | New Orleans | Louisiana | United States | 70112 |
| 72 | CCOP - Ochsner | New Orleans | Louisiana | United States | 70121 |
| 73 | Maine Medical Center | Portland | Maine | United States | 04102 |
| 74 | Anne Arundel Oncology Center | Annapolis | Maryland | United States | 21401 |
| 75 | Marlene and Stewart Greenebaum Cancer Center, University of Maryland | Baltimore | Maryland | United States | 21201 |
| 76 | Greater Baltimore Medical Center and Cancer Center | Baltimore | Maryland | United States | 21204 |
| 77 | Harbor Hospital Center | Baltimore | Maryland | United States | 21215-1290 |
| 78 | Sinai Hospital of Baltimore | Baltimore | Maryland | United States | 21215 |
| 79 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Baltimore | Maryland | United States | 21231-2410 |
| 80 | Peninsula Regional Medical Center | Salisbury | Maryland | United States | 21801 |
| 81 | Dana-Farber Cancer Institute | Boston | Massachusetts | United States | 02115 |
| 82 | Cape Cod Hospital | Hyannis | Massachusetts | United States | 02601 |
| 83 | Veterans Affairs Medical Center - Boston (Jamaica Plain) | Jamaica Plain | Massachusetts | United States | 02130 |
| 84 | CCOP - Ann Arbor Regional | Ann Arbor | Michigan | United States | 48106 |
| 85 | University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | United States | 48109-0752 |
| 86 | Barbara Ann Karmanos Cancer Institute | Detroit | Michigan | United States | 48201-1379 |
| 87 | Henry Ford Hospital | Detroit | Michigan | United States | 48202 |
| 88 | Hurley Medical Center | Flint | Michigan | United States | 48503 |
| 89 | McLaren Regional Cancer Center | Flint | Michigan | United States | 48532-3685 |
| 90 | CCOP - Kalamazoo | Kalamazoo | Michigan | United States | 49007-3731 |
| 91 | Marquette General Hospital | Marquette | Michigan | United States | 49855 |
| 92 | MidMichigan Medical Center - Midland | Midland | Michigan | United States | 48670 |
| 93 | CCOP - Beaumont | Royal Oak | Michigan | United States | 48073-6769 |
| 94 | William Beaumont Hospital | Royal Oak | Michigan | United States | 48073 |
| 95 | William Beaumont Hospital - Troy | Troy | Michigan | United States | 48098 |
| 96 | Mayo Clinic Cancer Center | Rochester | Minnesota | United States | 55905 |
| 97 | CCOP - Metro-Minnesota | Saint Louis Park | Minnesota | United States | 55416 |
| 98 | Ellis Fischel Cancer Center - Columbia | Columbia | Missouri | United States | 65203 |
| 99 | CCOP - Kansas City | Kansas City | Missouri | United States | 64131 |
| 100 | Mallinckrodt Institute of Radiology | Saint Louis | Missouri | United States | 63108 |
| 101 | St. Louis University Health Sciences Center | Saint Louis | Missouri | United States | 63110-0250 |
| 102 | Cancer Research for the Ozarks | Springfield | Missouri | United States | 65807 |
| 103 | CCOP - Cancer Research for the Ozarks | Springfield | Missouri | United States | 65807 |
| 104 | CCOP - Montana Cancer Consortium | Billings | Montana | United States | 59101 |
| 105 | CCOP - Missouri Valley Cancer Consortium | Omaha | Nebraska | United States | 68106 |
| 106 | Methodist Cancer Center - Omaha | Omaha | Nebraska | United States | 68114 |
| 107 | Nebraska Health System | Omaha | Nebraska | United States | 68198-7460 |
| 108 | CCOP - Southern Nevada Cancer Research Foundation | Las Vegas | Nevada | United States | 89106 |
| 109 | Norris Cotton Cancer Center | Lebanon | New Hampshire | United States | 03756-0002 |
| 110 | Elliot Regional Cancer Center | Manchester | New Hampshire | United States | 03103 |
| 111 | Veterans Affairs Medical Center - East Orange | East Orange | New Jersey | United States | 07019 |
| 112 | John F. Kennedy Medical Center | Edison | New Jersey | United States | 08818 |
| 113 | Trinitas Hospital - Jersey Street Campus | Elizabeth | New Jersey | United States | 07201 |
| 114 | Monmouth Medical Center | Long Branch | New Jersey | United States | 07740-6395 |
| 115 | South Jersey Regional Cancer Center | Millville | New Jersey | United States | 08332 |
| 116 | Fox Chase Cancer Center at Virtua Memorial Hospital Burlington County | Mount Holly | New Jersey | United States | 08060 |
| 117 | Cancer Institute of New Jersey | New Brunswick | New Jersey | United States | 38103-2807 |
| 118 | Newark Beth Israel Medical Center | Newark | New Jersey | United States | 07112 |
| 119 | Atlantic City Medical Center | Pomona | New Jersey | United States | 08240 |
| 120 | Valley Hospital | Ridgewood | New Jersey | United States | 07450 |
| 121 | Community Medical Center | Toms River | New Jersey | United States | 08755 |
| 122 | St. Francis Medical Center | Trenton | New Jersey | United States | 08629 |
| 123 | Associated Radiologists, P.A. | Warren | New Jersey | United States | 07059 |
| 124 | Radiation Oncology Associates of Albuquerque | Albuquerque | New Mexico | United States | 87109 |
| 125 | Cancer Center of Albany Medical Center | Albany | New York | United States | 12208 |
| 126 | State University of New York Health Science Center at Brooklyn | Brooklyn | New York | United States | 11203 |
| 127 | New York Methodist Hospital | Brooklyn | New York | United States | 11215 |
| 128 | Roswell Park Cancer Institute | Buffalo | New York | United States | 14263-0001 |
| 129 | Finger Lakes Radiation Oncology Center | Clifton Springs | New York | United States | 14432 |
| 130 | CCOP - North Shore University Hospital | Manhasset | New York | United States | 11030 |
| 131 | Herbert Irving Comprehensive Cancer Center | New York | New York | United States | 10032 |
| 132 | Champlain Valley Physicians Hospital Medical Center | Plattsburgh | New York | United States | 12901 |
| 133 | Vassar Brothers Medical Center | Poughkeepsie | New York | United States | 12601 |
| 134 | James P. Wilmot Cancer Center | Rochester | New York | United States | 14642 |
| 135 | CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C. | Syracuse | New York | United States | 13217 |
| 136 | Riverhill Radiation Oncology | Yonkers | New York | United States | 10701 |
| 137 | Lineberger Comprehensive Cancer Center, UNC | Chapel Hill | North Carolina | United States | 27599-7295 |
| 138 | Northeast Medical Center | Concord | North Carolina | United States | 28025 |
| 139 | East Carolina University School of Medicine | Greenville | North Carolina | United States | 27858-4354 |
| 140 | CCOP - Southeast Cancer Control Consortium | Winston-Salem | North Carolina | United States | 27104-4241 |
| 141 | Comprehensive Cancer Center at Wake Forest University | Winston-Salem | North Carolina | United States | 27157-1082 |
| 142 | Trinity Cancer Care Center | Minot | North Dakota | United States | 58701 |
| 143 | Akron General Medical Center | Akron | Ohio | United States | 44302 |
| 144 | Akron City Hospital | Akron | Ohio | United States | 44304 |
| 145 | Christ Hospital | Cincinnati | Ohio | United States | 45219 |
| 146 | Barrett Cancer Center, The University Hospital | Cincinnati | Ohio | United States | 45267-0502 |
| 147 | Ireland Cancer Center | Cleveland | Ohio | United States | 44106-5065 |
| 148 | University Hospitals of Cleveland | Cleveland | Ohio | United States | 44106 |
| 149 | Cleveland Clinic Taussig Cancer Center | Cleveland | Ohio | United States | 44195 |
| 150 | CCOP - Columbus | Columbus | Ohio | United States | 43206 |
| 151 | Arthur G. James Cancer Hospital - Ohio State University | Columbus | Ohio | United States | 43210-1240 |
| 152 | CCOP - Dayton | Kettering | Ohio | United States | 45429 |
| 153 | CCOP - Toledo Community Hospital Oncology Program | Toledo | Ohio | United States | 43623-3456 |
| 154 | St. Anthony Hospital | Oklahoma City | Oklahoma | United States | 73101 |
| 155 | University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | United States | 73104 |
| 156 | St. John Health System | Tulsa | Oklahoma | United States | 74104 |
| 157 | CCOP - Oklahoma | Tulsa | Oklahoma | United States | 74136 |
| 158 | CCOP - Columbia River Program | Portland | Oregon | United States | 97225 |
| 159 | Lehigh Valley Hospital | Allentown | Pennsylvania | United States | 18105 |
| 160 | St. Luke's Hospital Cancer Center | Bethlehem | Pennsylvania | United States | 18015 |
| 161 | Geisinger Medical Center | Danville | Pennsylvania | United States | 17822-2001 |
| 162 | Mercy Fitzgerald Hospital | Darby | Pennsylvania | United States | 19023 |
| 163 | Delaware County Memorial Hospital | Drexel Hill | Pennsylvania | United States | 19026 |
| 164 | Pocono Cancer Center | East Stroudsburg | Pennsylvania | United States | 18301 |
| 165 | Milton S. Hershey Medical Center | Hershey | Pennsylvania | United States | 17033-0850 |
| 166 | University of Pennsylvania Cancer Center | Philadelphia | Pennsylvania | United States | 19104-4283 |
| 167 | Veterans Affairs Medical Center - Philadelphia | Philadelphia | Pennsylvania | United States | 19104 |
| 168 | Kimmel Cancer Center of Thomas Jefferson University - Philadelphia | Philadelphia | Pennsylvania | United States | 19107-5541 |
| 169 | Fox Chase Cancer Center | Philadelphia | Pennsylvania | United States | 19111 |
| 170 | Albert Einstein Cancer Center | Philadelphia | Pennsylvania | United States | 19141-3098 |
| 171 | University of Pittsburgh Cancer Institute | Pittsburgh | Pennsylvania | United States | 15213-3489 |
| 172 | Mercy Hospital of Pittsburgh | Pittsburgh | Pennsylvania | United States | 15219 |
| 173 | Western Pennsylvania Hospital | Pittsburgh | Pennsylvania | United States | 15224 |
| 174 | Reading Hospital and Medical Center | Reading | Pennsylvania | United States | 19612-6052 |
| 175 | Mercy Hospital Cancer Center - Scranton | Scranton | Pennsylvania | United States | 18501 |
| 176 | Wilkes Barre General Hospital | Wilkes-Barre | Pennsylvania | United States | 18764 |
| 177 | York Hospital | York | Pennsylvania | United States | 17315 |
| 178 | Roger Williams Medical Center/BUSM | Providence | Rhode Island | United States | 02908-4735 |
| 179 | CCOP - Greenville | Greenville | South Carolina | United States | 29615 |
| 180 | CCOP - Upstate Carolina | Spartanburg | South Carolina | United States | 29303 |
| 181 | Rapid City Regional Hospital | Rapid City | South Dakota | United States | 57709 |
| 182 | Jackson-Madison County General Hospital | Jackson | Tennessee | United States | 38301-3956 |
| 183 | University of Tennessee Cancer Institute | Memphis | Tennessee | United States | 38103 |
| 184 | Vanderbilt-Ingram Cancer Center | Nashville | Tennessee | United States | 37232-5671 |
| 185 | Harrington Cancer Center | Amarillo | Texas | United States | 79106 |
| 186 | University of Texas Medical Branch | Galveston | Texas | United States | 77555-0209 |
| 187 | University of Texas - MD Anderson Cancer Center | Houston | Texas | United States | 77030-4009 |
| 188 | Wilford Hall Medical Center | Lackland Air Force Base | Texas | United States | 78236-5300 |
| 189 | Joe Arrington Cancer Research and Treatment Center | Lubbock | Texas | United States | 79410-1894 |
| 190 | Bayshore Medical Center | Pasadena | Texas | United States | 77504 |
| 191 | Dixie Regional Medical Center | Saint George | Utah | United States | 84770 |
| 192 | University of Utah Health Sciences Center | Salt Lake City | Utah | United States | 84132 |
| 193 | Latter Day Saints Hospital | Salt Lake City | Utah | United States | 84143 |
| 194 | Vermont Cancer Center | Burlington | Vermont | United States | 05401 |
| 195 | Cancer Center at the University of Virginia | Charlottesville | Virginia | United States | 22908 |
| 196 | RMH Regional Cancer Center | Harrisonburg | Virginia | United States | 22801 |
| 197 | Naval Medical Center, Portsmouth | Portsmouth | Virginia | United States | 23708-2197 |
| 198 | Bon-Secours - St. Mary's Hospital | Richmond | Virginia | United States | 23226 |
| 199 | Massey Cancer Center | Richmond | Virginia | United States | 23298-0037 |
| 200 | Virginia Mason Medical Center | Seattle | Washington | United States | 98111 |
| 201 | Deaconess Medical Center | Spokane | Washington | United States | 99210-0248 |
| 202 | Yakima Valley Memorial Hospital | Yakima | Washington | United States | 98902 |
| 203 | Schiffler Cancer Center | Wheeling | West Virginia | United States | 26003 |
| 204 | CCOP - St. Vincent Hospital Cancer Center, Green Bay | Green Bay | Wisconsin | United States | 54301 |
| 205 | St. Vincent Hospital | Green Bay | Wisconsin | United States | 54307-3508 |
| 206 | Gundersen Lutheran Medical Foundation | La Crosse | Wisconsin | United States | 54601 |
| 207 | Southern Wisconsin Radiotherapy Center | Madison | Wisconsin | United States | 53713 |
| 208 | University of Wisconsin Comprehensive Cancer Center | Madison | Wisconsin | United States | 53792 |
| 209 | Marshfield Clinic | Marshfield | Wisconsin | United States | 54449 |
| 210 | Community Memorial Hospital | Menomonee Falls | Wisconsin | United States | 53051 |
| 211 | Columbia Hospital | Milwaukee | Wisconsin | United States | 53211 |
| 212 | St. Luke's Medical Center | Milwaukee | Wisconsin | United States | 53215 |
| 213 | Medical College of Wisconsin | Milwaukee | Wisconsin | United States | 53226 |
| 214 | Veterans Affairs Medical Center - Milwaukee (Zablocki) | Milwaukee | Wisconsin | United States | 53295 |
| 215 | All Saints Cancer Center | Racine | Wisconsin | United States | 53405 |
| 216 | Waukesha Memorial Hospital | Waukesha | Wisconsin | United States | 53188 |
| 217 | Tom Baker Cancer Center - Calgary | Calgary | Alberta | Canada | T2N 4N2 |
| 218 | Cross Cancer Institute | Edmonton | Alberta | Canada | T6G 1Z2 |
| 219 | Saint John Regional Hospital | Saint John | New Brunswick | Canada | E2L 4L2 |
| 220 | Newfoundland Cancer Treatment and Research Foundation | St. Johns | Newfoundland and Labrador | Canada | A1B 3V6 |
| 221 | Nova Scotia Cancer Centre | Halifax | Nova Scotia | Canada | B3H 1V7 |
| 222 | Cancer Care Ontario-Hamilton Regional Cancer Centre | Hamilton | Ontario | Canada | L8V 5C2 |
| 223 | Kingston Regional Cancer Centre | Kingston | Ontario | Canada | K7L 5P9 |
| 224 | Cancer Care Ontario-London Regional Cancer Centre | London | Ontario | Canada | N6A 4L6 |
| 225 | Ottawa Regional Cancer Centre | Ottawa | Ontario | Canada | K1H 1C4 |
| 226 | Northeastern Ontario Regional Cancer Centre, Sudbury | Sudbury | Ontario | Canada | P3E 5J1 |
| 227 | Northwestern Ontario Regional Cancer Centre, Thunder Bay | Thunder Bay | Ontario | Canada | P7A 7T1 |
| 228 | Toronto Sunnybrook Regional Cancer Centre | Toronto | Ontario | Canada | M4N 3M5 |
| 229 | Princess Margaret Hospital | Toronto | Ontario | Canada | M5G 2M9 |
| 230 | CHUS-Hopital Fleurimont | Fleurimont | Quebec | Canada | J1H 5N4 |
| 231 | Centre Hospitalier de l'Universite de Montreal | Montreal | Quebec | Canada | H2L 4MI |
| 232 | McGill University | Montreal | Quebec | Canada | H2W 1S6 |
| 233 | Centre Hospitalier Universitaire de Quebec | Quebec City | Quebec | Canada | G1R 2J6 |
| 234 | Allan Blair Cancer Centre | Regina | Saskatchewan | Canada | S4T 7T1 |
| 235 | Saskatoon Cancer Centre | Saskatoon | Saskatchewan | Canada | S7N 4H4 |
Sponsors and Collaborators
- Radiation Therapy Oncology Group
- National Cancer Institute (NCI)
Investigators
- Study Chair: Mohammed M. Mohiuddin, MD, Lucille P. Markey Cancer Center at University of Kentucky
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
Radiation Therapy Oncology Group
ClinicalTrials.gov Identifier:
NCT00006366
Other Study ID Numbers:
- RTOG-R-0012
- CDR0000068239
First Posted:
Jan 27, 2003
Last Update Posted:
Oct 22, 2020
Last Verified:
Dec 1, 2002
Keywords provided by Radiation Therapy Oncology Group
Additional relevant MeSH terms: