Early Lymph Node Metastasis in T1/2 Stage Colorectal Cancer: Molecular and Clinical Insights
Study Details
Study Description
Brief Summary
The prognostic implications of lymph node metastasis in colorectal cancer patients at an early stage, specifically T1/2 stage, are relatively unfavorable. Therefore, understanding the clinical and molecular traits relevant to metastasis in T1/2 stage are of substantial clinical importance.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Patients were classified based on their lymph node staging, with an ancillary categorization into MSI-H and MSS subgroups. A comparative mutational study was performed among these groups, incorporating risk stratification and Receiver Operating Characteristic curve analysis, with the aim of discerning the predictability of clinical features integrated with molecular characteristics for early metastasis in T1/2 stage colorectal cancer.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Patients with lymph node metastasis T1/2N+ patients |
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Patients without lymph node metastasis T1/2N- patients |
Outcome Measures
Primary Outcome Measures
- MSI status [through study completion, an average of 1 year]
(I) MSI-High (MSI-H) if two or more mononucleotide markers in tumor tissue had size variations of ≥3bp compared to normal tissue; (II) MSI-Low (MSI-L) if a single mononucleotide marker in tumor tissue exhibited a size variation of ≥3bp compared to normal tissue; (III) Microsatellite Stable (MSS) if there were no size variations of ≥3bp in mononucleotide markers in tumor tissue compared to normal tissue.
Secondary Outcome Measures
- Somatic Mutation Distribution [through study completion, an average of 1 year]
targeted NGS
- Tumor Mutation Burden (TMB) [through study completion, an average of 1 year]
targeted NGS
Eligibility Criteria
Criteria
Inclusion Criteria:
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Men and women aged 18-75 years old;
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Clinical staged T2;
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Histologically proven colon or rectal adenocarcinoma.
Exclusion Criteria:
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Patients over 80 years of age;
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Recurrent colorectal cancer;
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Multiple primary tumors;
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Distant metastasis.
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- The First Affiliated Hospital with Nanjing Medical University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- PRSYM202311