Rosuvastatin in Treating Patients With Stage I or Stage II Colon Cancer That Was Removed By Surgery
Sponsor
NSABP Foundation Inc (Other)
Overall Status
Terminated
CT.gov ID
NCT01011478
Collaborator
National Cancer Institute (NCI) (NIH)
406
587
2
59.1
0.7
0
Study Details
Study Description
Brief Summary
RATIONALE: Rosuvastatin may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving rosuvastatin after surgery may kill any tumor cells that remain after surgery. It may also keep polyps from forming or colon cancer from coming back. It is not yet known whether rosuvastatin is more effective than a placebo in treating colon cancer that was removed by surgery.
PURPOSE: This randomized phase III trial is studying rosuvastatin to see how well it works compared with placebo in treating patients with stage I or stage II colon cancer that was removed by surgery.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 3 |
Detailed Description
OBJECTIVES:
Primary
- To compare the effect of rosuvastatin vs placebo on the 5-year occurrence of adenomatous polyps of the colon or rectum, metachronous colorectal carcinoma, or colon cancer recurrence (APMC+R) in patients with resected stage I or II colon cancer.
Secondary
-
To determine whether the effect of rosuvastatin vs placebo is of the same magnitude in patients taking aspirin (regardless of dose) compared to patients not taking aspirin.
-
To determine whether taking aspirin (regardless of dose) vs no aspirin will decrease the occurrence or APMC+R and, if there is an effect, to explore the relationship to dose.
-
To determine the effect of rosuvastatin in patients with familial colorectal cancer.
-
To determine the effect of rosuvastatin in patients with microsatellite unstable tumors (i.e., tumors displaying loss of MLH1 or MSH2 expression by IHC).
-
To determine the relationship between rosuvastatin therapy and features of colorectal adenomas as well as the size and number of colorectal adenomas.
-
To compare the time to APMC+R in patients treated with rosuvastatin vs placebo.
-
To compare the disease-free survival of patients treated with rosuvastatin vs placebo.
-
To compare the overall survival of patients treated with rosuvastatin vs placebo.
-
To compare the rate of recurrence of colon cancer in patients treated with rosuvastatin vs placebo.
-
To compare the rate of second non-colorectal primary cancers in patients treated with rosuvastatin vs placebo.
-
To determine the effect of rosuvastatin on health-related quality of life, global quality of life, and self-reported symptoms.
-
To compare the incidence and severity of adverse events associated with rosuvastatin vs placebo.
-
To assess relevant tumor and blood markers that may affect the metabolism, activity, or effect of the study drugs, such as HMG-CoA reductase, UGT1A6, P450-2C9, PTGS2 (COX-2), and other possible markers.
OUTLINE: This is a multicenter study. Patients are stratified according to family history of a first-degree relative with colorectal cancer (yes vs no), intended aspirin dose (none vs 81 mg vs 325 mg), and adjuvant therapy for colon cancer (yes vs no). Patients are randomized to 1 of 2 treatment arms.
-
Group 1: Patients receive oral placebo once daily for 5 years.
-
Group 2: Patients receive oral rosuvastatin once daily for 5 years.
Patients may complete a quality-of-life questionnaire at baseline and at 6, 12, 36, 60, and 84 months.
Tumor tissue, serum, and blood samples may be collected periodically for biomarker and other analyses.
After completion of study treatment, patients are followed up periodically for up to 2 years.
Study Design
Study Type:
Interventional
Actual Enrollment
:
406 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose:
Treatment
Official Title:
Statin Polyp Prevention Trial in Patients With Resected Colon Cancer
Study Start Date
:
Mar 1, 2010
Actual Primary Completion Date
:
Dec 1, 2014
Actual Study Completion Date
:
Feb 1, 2015
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Placebo Comparator: Group 1: placebo Patients receive oral placebo once daily for 5 years. |
Other: placebo
|
| Experimental: Group 2: rosuvastatin Patients receive oral rosuvastatin once daily for 5 years. |
Drug: rosuvastatin
Other Names:
|
Outcome Measures
Primary Outcome Measures
- Occurrence of ≥ 1 adenomatous polyp of the colon or rectum, metachronous colorectal carcinoma, or colon cancer recurrence (APMC+R) [From start of study through 5 years]
Secondary Outcome Measures
- Size, number, and features of colorectal adenomas, including advanced adenomas [From start of study through 7 years]
- Disease -free survival [Time from randomization to colon cancer recurrence,second primary cancer, or death from any cause through 7 years]
- Overall Survival: Time from randomization to death from any cause [Time from randomization to death from any cause through 7 years]
- Recurrence-free interval: Time from randomization to first recurrence of colon cancer [Time from randomization to first recurrence of colon cancer through 7 years]
- Second non-colorectal primary cancer-free interval [Time from randomization to first occurrence of non-colorectal primary cancer through 7 years]
- Behavioral and Health Outcomes as measured by SF-12 component scores, global quality-of-life scale, and symptom checklist [Assessed at 6, 12, 36, 60, and 84 months]
- Occurrence and grade of reported toxicities [From start of study through 7 years]
- Measurements of relevant tumor and blood markers [Samples collected at start of study]
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria
-
Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
-
Patients must have the ability to swallow oral medication.
-
Patients must have resected adenocarcinoma of the colon staged as American Joint Committee on Cancer (AJCC) Stage 0, I, II, or III.
-
Patients must have had surgical resection of the colon adenocarcinoma with curative intent within 1 year prior to randomization. (Laparoscopically-assisted colectomy is permitted.)
-
Patients must have completed any adjuvant therapy prior to randomization.
-
Patients who are taking cardioprotective low-dose aspirin at study entry must not have clinically significant toxicity, as determined by the investigator, that precludes continuation of aspirin, and the patient must be willing to continue aspirin therapy (81 mg or 325 mg) throughout study therapy.
-
Colonoscopy requirements within 180 days prior to randomization:
-
The patient must have either undergone a preoperative or postoperative documented colonoscopy to the cecum (or small bowel anastomosis) with adequate bowel preparation.
-
All observed polyps must have been removed. (Polyps can be removed during colonoscopy or surgery performed prior to randomization.)
-
Postoperative serum creatinine performed within 90 days prior to randomization must be less than or equal to 1.5 x upper limit of normal (ULN) for the lab.
-
The following criteria for evidence of adequate hepatic function based on postoperative testing performed within 90 days prior to randomization must be met: aspartate aminotransferase (AST) or alanine aminotransferase (ALT) less than or equal to 3.0 x ULN for the lab, and Total bilirubin less than or equal to 1.5 x ULN for the lab
Exclusion Criteria
-
Tumor with the distal border located less than 12 cm from the anal verge.
-
Total colectomy or total proctocolectomy.
-
Classic Familial Adenomatous Polyposis, Attenuated Familial Adenomatous Polyposis (i.e., 20 or more adenomas, either synchronous or metachronous), or Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome).
-
Malabsorption syndrome, ulcerative colitis, inflammatory bowel disease, resection of the stomach or small bowel, or other disease significantly affecting gastrointestinal function.
-
History of documented upper GI bleeding or upper GI ulcerative disease.
-
Statin use within 30 days prior to randomization.
-
Hyperlipidemia with clinical indication for statin therapy or other prescribed medication. Determination of acceptable fasting lipid values, within 90 days prior to randomization, should be in accordance with current dyslipidemia management guidelines.
-
Unwillingness to discontinue chronic use of nonsteroidal antiinflammatory drugs (NSAIDs) (other than cardioprotective low-dose aspirin 81 mg or 325 mg) prior to randomization.
-
Anticipated need for chronic use of NSAIDs (other than cardioprotective low-dose aspirin 81 mg or 325 mg).
-
Inadequately treated hypothyroidism, as determined by the investigator.
-
History of myopathy or rhabdomyolysis.
-
Hypersensitivity or intolerance to statins.
-
Chronic drug therapy with cyclosporine, coumarin anticoagulants, gemfibrozil, some other lipid-lowering therapies (fibrates or niacin), lopinavir/ritonavir, or drugs (such as ketoconazole, spironolactone, or cimetidine) that lower levels or activity of steroid hormones.
-
Pregnancy or lactation at the time of study entry. (Pregnancy testing must be performed within 14 days prior to randomization according to institutional standards for women of childbearing potential.)
-
Previous malignancies unless the patient has been disease-free for 5 or more years prior to randomization and is deemed by the physician to be at low risk for recurrence. Patients with the following cancers are eligible if diagnosed and treated within the past 5 years: all in situ cancers and basal cell and squamous cell carcinoma of the skin.
-
Other non-malignant systemic disease that would preclude a patient from receiving rosuvastatin or would prevent prolonged follow-up.
-
Administration of any investigational agent within 30 days before randomization.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Regional Medical Center | Anniston | Alabama | United States | 36207 |
| 2 | Providence Cancer Center at Providence Hospital | Mobile | Alabama | United States | 36608 |
| 3 | Hembree Mercy Cancer Center at St. Edward Mercy Medical Center | Fort Smith | Arkansas | United States | 72903 |
| 4 | Arkansas Cancer Research Center at University of Arkansas for Medical Sciences | Little Rock | Arkansas | United States | 72205 |
| 5 | Little Rock | Arkansas | United States | 72205 | |
| 6 | Kaiser Permanente Medical Center - Anaheim/Orange County | Anaheim | California | United States | 92807 |
| 7 | Kaiser Permanente - Deer Valley | Antioch | California | United States | 94531 |
| 8 | Kaiser Permanente Medical Center - Baldwin Park | Baldwin Park | California | United States | 91706 |
| 9 | Kaiser Permanente Medical Center - Bellflower | Bellflower | California | United States | 90706 |
| 10 | East Bay Radiation Oncology Center | Castro Valley | California | United States | 94546 |
| 11 | Valley Medical Oncology Consultants - Castro Valley | Castro Valley | California | United States | 94546 |
| 12 | North Bay Cancer Center | Fairfield | California | United States | 94533 |
| 13 | Kaiser Permanente Medical Center - Fontana | Fontana | California | United States | 92335 |
| 14 | Kaiser Permanente - Fremont | Fremont | California | United States | 94538 |
| 15 | Valley Medical Oncology | Fremont | California | United States | 94538 |
| 16 | Virginia K. Crosson Cancer Center at St. Jude Medical Center | Fullerton | California | United States | 92835 |
| 17 | Glendale Memorial Hospital Comprehensive Cancer Center | Glendale | California | United States | 91204 |
| 18 | Kaiser Permanente Medical Center - Harbor City | Harbor City | California | United States | 90710 |
| 19 | Kaiser Permanente Medical Center - Hayward | Hayward | California | United States | 94545 |
| 20 | Kaiser Permanente - Irvine | Irvine | California | United States | 92618 |
| 21 | Kaiser Permanente Medical Center - Los Angeles | Los Angeles | California | United States | 90027 |
| 22 | Kaiser Foundation Hospital - West Los Angeles | Los Angeles | California | United States | 90034 |
| 23 | Contra Costa Regional Medical Center | Martinez | California | United States | 94553-3156 |
| 24 | Memorial Medical Center | Modesto | California | United States | 95355 |
| 25 | Camino Medical Group - Treatment Center | Mountain View | California | United States | 94040 |
| 26 | El Camino Hospital Cancer Center | Mountain View | California | United States | 94040 |
| 27 | Highland General Hospital | Oakland | California | United States | 94602 |
| 28 | Alta Bates Summit Medical Center - Summit Campus | Oakland | California | United States | 94609 |
| 29 | Bay Area Breast Surgeons, Incorporated | Oakland | California | United States | 94609 |
| 30 | CCOP - Bay Area Tumor Institute | Oakland | California | United States | 94609 |
| 31 | Larry G Strieff MD Medical Corporation | Oakland | California | United States | 94609 |
| 32 | Tom K Lee, Incorporated | Oakland | California | United States | 94609 |
| 33 | Kaiser Permanente Medical Center - Oakland | Oakland | California | United States | 94611 |
| 34 | Epic Care - Oakland | Oakland | California | United States | 94612 |
| 35 | Kaiser Permanente - Ontario Vineyard Medical Offices and Ambulatory SurgiCenter | Ontario | California | United States | 91761 |
| 36 | St. Joseph Hospital Regional Cancer Center - Orange | Orange | California | United States | 92868 |
| 37 | Palo Alto Medical Foundation | Palo Alto | California | United States | 94301 |
| 38 | Kaiser Permanente Medical Group | Panorama City | California | United States | 91402 |
| 39 | Lucy Curci Cancer Center at Eisenhower Memorial Hospital and Medical Center | Rancho Mirage | California | United States | 92270 |
| 40 | Kaiser Permanente Medical Center - Redwood City | Redwood City | California | United States | 94063 |
| 41 | Kaiser Permanente Medical Center - Richmond | Richmond | California | United States | 94801 |
| 42 | Kaiser Permanente Medical Center - Riverside | Riverside | California | United States | 92505 |
| 43 | Kaiser Permanente Medical Center - Roseville | Roseville | California | United States | 95661 |
| 44 | South Sacramento Kaiser-Permanente Medical Center | Sacramento | California | United States | 95823 |
| 45 | Kaiser Permanente Medical Center - Sacramento | Sacramento | California | United States | 95825 |
| 46 | Salinas Valley Memorial Hospital | Salinas | California | United States | 93901 |
| 47 | Kaiser Permanente Medical Office -Vandever Medical Office | San Diego | California | United States | 92108 |
| 48 | Kaiser Permanente Medical Center - Kaiser Foundation Hospital - San Diego | San Diego | California | United States | 92120 |
| 49 | Kaiser Permanente Medical Center - San Francisco Geary Campus | San Francisco | California | United States | 94115 |
| 50 | Kaiser Permanente Medical Center - Santa Teresa | San Jose | California | United States | 95119 |
| 51 | Kaiser Permanente Health Care | San Marcos | California | United States | 92078 |
| 52 | Doctors Medical Center - San Pablo Campus | San Pablo | California | United States | 94806 |
| 53 | Kaiser Foundation Hospital - San Rafael | San Rafael | California | United States | 94903 |
| 54 | Kaiser Permanente Medical Center - Santa Clara Kiely Campus | Santa Clara | California | United States | 95051 |
| 55 | Kaiser Permanente Medical Center - Santa Rosa | Santa Rosa | California | United States | 95403 |
| 56 | Kaiser Permanente Medical Center - South San Francisco | South San Francisco | California | United States | 94080 |
| 57 | Stanford Cancer Center | Stanford | California | United States | 94305-5824 |
| 58 | Kaiser Permanente Medical Facility - Stockton | Stockton | California | United States | 95210 |
| 59 | Kaiser Permanente Medical Center - Vacaville | Vacaville | California | United States | 95688 |
| 60 | Kaiser Permanente Medical Center - Vallejo | Vallejo | California | United States | 94589 |
| 61 | Kaiser Permanente Medical Center - Walnut Creek | Walnut Creek | California | United States | 94596 |
| 62 | Kaiser Permanente Medical Cener - Woodland Hills | Woodland Hills | California | United States | 91367 |
| 63 | Aurora Presbyterian Hospital | Aurora | Colorado | United States | 80012 |
| 64 | Boulder Community Hospital | Boulder | Colorado | United States | 80301-9019 |
| 65 | Penrose Cancer Center at Penrose Hospital | Colorado Springs | Colorado | United States | 80933 |
| 66 | St. Anthony Central Hospital | Denver | Colorado | United States | 80204 |
| 67 | Kaiser Permanente - Denver | Denver | Colorado | United States | 80205 |
| 68 | Porter Adventist Hospital | Denver | Colorado | United States | 80210 |
| 69 | Presbyterian - St. Luke's Medical Center | Denver | Colorado | United States | 80218 |
| 70 | St. Joseph Hospital | Denver | Colorado | United States | 80218 |
| 71 | Rose Medical Center | Denver | Colorado | United States | 80220 |
| 72 | CCOP - Colorado Cancer Research Program | Denver | Colorado | United States | 80222 |
| 73 | Swedish Medical Center | Englewood | Colorado | United States | 80110 |
| 74 | Poudre Valley Hospital | Fort Collins | Colorado | United States | 80524 |
| 75 | Front Range Cancer Specialists | Fort Collins | Colorado | United States | 80528 |
| 76 | St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center | Grand Junction | Colorado | United States | 81502 |
| 77 | North Colorado Medical Center | Greeley | Colorado | United States | 80631 |
| 78 | Kaiser Permanente - Lafayette | Lafayette | Colorado | United States | 80026 |
| 79 | Littleton Adventist Hospital | Littleton | Colorado | United States | 80122 |
| 80 | Sky Ridge Medical Center | Lone Tree | Colorado | United States | 80124 |
| 81 | Hope Cancer Care Center at Longmont United Hospital | Longmont | Colorado | United States | 80501 |
| 82 | McKee Medical Center | Loveland | Colorado | United States | 80539 |
| 83 | Parker Adventist Hospital | Parker | Colorado | United States | 80138 |
| 84 | St. Mary - Corwin Regional Medical Center | Pueblo | Colorado | United States | 81004 |
| 85 | North Suburban Medical Center | Thornton | Colorado | United States | 80229 |
| 86 | Exempla Lutheran Medical Center | Wheat Ridge | Colorado | United States | 80033 |
| 87 | Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center | Farmington | Connecticut | United States | 06360-2875 |
| 88 | Bendheim Cancer Center at Greenwich Hospital | Greenwich | Connecticut | United States | 06830 |
| 89 | Helen and Harry Gray Cancer Center at Hartford Hospital | Hartford | Connecticut | United States | 06102-5037 |
| 90 | Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center | Hartford | Connecticut | United States | 06105 |
| 91 | Middlesex Hospital Cancer Center | Middletown | Connecticut | United States | 06457 |
| 92 | Carl and Dorothy Bennett Cancer Center at Stamford Hospital | Stamford | Connecticut | United States | 06904 |
| 93 | Kent General Hospital | Dover | Delaware | United States | 19901 |
| 94 | Tunnell Cancer Center at Beebe Medical Center | Lewes | Delaware | United States | 19958 |
| 95 | CCOP - Christiana Care Health Services | Newark | Delaware | United States | 19713 |
| 96 | Kaiser Permanente at Capitol Hill Medical Center | Washington | District of Columbia | United States | 20002 |
| 97 | Washington Cancer Institute at Washington Hospital Center | Washington | District of Columbia | United States | 20010 |
| 98 | Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital | Fort Lauderdale | Florida | United States | 33308 |
| 99 | University of Florida Shands Cancer Center | Gainesville | Florida | United States | 32610-0232 |
| 100 | St. Vincent's Medical Center | Jacksonville | Florida | United States | 32204 |
| 101 | Baptist Cancer Institute - Jacksonville | Jacksonville | Florida | United States | 32207 |
| 102 | Ella Milbank Foshay Cancer Center at Jupiter Medical Center | Jupiter | Florida | United States | 33458 |
| 103 | CCOP - Mount Sinai Medical Center | Miami Beach | Florida | United States | 33140 |
| 104 | Florida Cancer Specialists - Sarasota Downtown | Sarasota | Florida | United States | 34236 |
| 105 | Cleveland Clinic Florida - Weston | Weston | Florida | United States | 33331 |
| 106 | Phoebe Cancer Center at Phoebe Putney Memorial Hospital | Albany | Georgia | United States | 31701 |
| 107 | Piedmont Hospital | Atlanta | Georgia | United States | 30309 |
| 108 | Northside Hospital Cancer Center | Atlanta | Georgia | United States | 30342-1611 |
| 109 | Saint Joseph's Hospital of Atlanta | Atlanta | Georgia | United States | 30342-1701 |
| 110 | CCOP - Atlanta Regional | Atlanta | Georgia | United States | 30342 |
| 111 | MBCCOP - Medical College of Georgia Cancer Center | Augusta | Georgia | United States | 30912 |
| 112 | WellStar Cobb Hospital | Austell | Georgia | United States | 30106 |
| 113 | John B. Amos Cancer Center | Columbus | Georgia | United States | 31904 |
| 114 | Charles B. Eberhart Cancer Center at DeKalb Medical Center | Decatur | Georgia | United States | 30033 |
| 115 | Piedmont Fayette Hospital | Fayetteville | Georgia | United States | 30214 |
| 116 | Gwinnett Medical Center | Lawrenceville | Georgia | United States | 30045 |
| 117 | Kennestone Cancer Center at Wellstar Kennestone Hospital | Marietta | Georgia | United States | 30060 |
| 118 | Southern Regional Medical Center | Riverdale | Georgia | United States | 30274-2600 |
| 119 | Harbin Clinic Cancer Center - Medical Oncology | Rome | Georgia | United States | 30165 |
| 120 | Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler | Savannah | Georgia | United States | 31405 |
| 121 | Cancer Research Center of Hawaii | Honolulu | Hawaii | United States | 96813 |
| 122 | OnCare Hawaii, Incorporated - Lusitana | Honolulu | Hawaii | United States | 96813 |
| 123 | Queen's Cancer Institute at Queen's Medical Center | Honolulu | Hawaii | United States | 96813 |
| 124 | Straub Clinic and Hospital, Incorporated | Honolulu | Hawaii | United States | 96813 |
| 125 | OnCare Hawaii, Incorporated - Kuakini | Honolulu | Hawaii | United States | 96817 |
| 126 | Kaiser Permanente - Moanalua Medical Center and Clinic | Honolulu | Hawaii | United States | 96819 |
| 127 | Tripler Army Medical Center | Honolulu | Hawaii | United States | 96859 |
| 128 | Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center | Boise | Idaho | United States | 83706 |
| 129 | St. Joseph Regional Medical Center | Lewiston | Idaho | United States | 83501 |
| 130 | Rush-Copley Cancer Care Center | Aurora | Illinois | United States | 60504 |
| 131 | Illinois CancerCare - Bloomington | Bloomington% | Illinois | United States | 61701 |
| 132 | St. Joseph Medical Center | Bloomington | Illinois | United States | 61701 |
| 133 | Graham Hospital | Canton | Illinois | United States | 61520 |
| 134 | Illinois CancerCare - Canton | Canton | Illinois | United States | 61520 |
| 135 | Illinois CancerCare - Carthage | Carthage | Illinois | United States | 62321 |
| 136 | Memorial Hospital | Carthage | Illinois | United States | 62321 |
| 137 | Mount Sinai Hospital Medical Center | Chicago | Illinois | United States | 60608 |
| 138 | Resurrection Medical Center | Chicago | Illinois | United States | 60631 |
| 139 | Louis A. Weiss Memorial Hospital | Chicago | Illinois | United States | 60640 |
| 140 | Decatur Memorial Hospital Cancer Care Institute | Decatur | Illinois | United States | 62526 |
| 141 | Sherman Hospital | Elgin | Illinois | United States | 60123 |
| 142 | Alexian Brothers Radiation Oncology | Elk Grove Village | Illinois | United States | 60007 |
| 143 | Elmhurst Memorial Hospital | Elmhurst | Illinois | United States | 60126 |
| 144 | Eureka Community Hospital | Eureka | Illinois | United States | 61530 |
| 145 | Illinois CancerCare - Eureka | Eureka | Illinois | United States | 61530 |
| 146 | Galesburg Clinic, PC | Galesburg | Illinois | United States | 61401 |
| 147 | Illinois CancerCare - Galesburg | Galesburg | Illinois | United States | 61401 |
| 148 | Ingalls Cancer Care Center at Ingalls Memorial Hospital | Harvey | Illinois | United States | 60426 |
| 149 | Illinois CancerCare - Havana | Havana | Illinois | United States | 62644 |
| 150 | Mason District Hospital | Havana | Illinois | United States | 62644 |
| 151 | Hinsdale Hematology Oncology Associates | Hinsdale | Illinois | United States | 60521 |
| 152 | Joliet Oncology-Hematology Associates, Limited - West | Joliet | Illinois | United States | 60435 |
| 153 | Illinois CancerCare - Kewanee Clinic | Kewanee | Illinois | United States | 61443 |
| 154 | La Grange Memorial Hospital | La Grange | Illinois | United States | 60525 |
| 155 | Illinois CancerCare - Macomb | Macomb | Illinois | United States | 61455 |
| 156 | McDonough District Hospital | Macomb | Illinois | United States | 61455 |
| 157 | Trinity Cancer Center at Trinity Medical Center - 7th Street Campus | Moline | Illinois | United States | 61265 |
| 158 | Moline | Illinois | United States | 61265 | |
| 159 | Illinois CancerCare - Monmouth | Monmouth | Illinois | United States | 61462 |
| 160 | OSF Holy Family Medical Center | Monmouth | Illinois | United States | 61462 |
| 161 | Edward Hospital Cancer Center | Naperville | Illinois | United States | 60540 |
| 162 | BroMenn Regional Medical Center | Normal | Illinois | United States | 61761 |
| 163 | Community Cancer Center | Normal | Illinois | United States | 61761 |
| 164 | Illinois CancerCare - Community Cancer Center | Normal | Illinois | United States | 61761 |
| 165 | Advocate Christ Medical Center | Oak Lawn | Illinois | United States | 60453-2699 |
| 166 | Community Hospital of Ottawa | Ottawa | Illinois | United States | 61350 |
| 167 | Oncology Hematology Associates of Central Illinois, PC - Ottawa | Ottawa | Illinois | United States | 61350 |
| 168 | Advocate Lutheran General Cancer Care Center | Park Ridge | Illinois | United States | 60068-1174 |
| 169 | Cancer Treatment Center at Pekin Hospital | Pekin | Illinois | United States | 61554 |
| 170 | Illinois CancerCare - Pekin | Pekin | Illinois | United States | 61603 |
| 171 | Proctor Hospital | Peoria | Illinois | United States | 61614 |
| 172 | CCOP - Illinois Oncology Research Association | Peoria | Illinois | United States | 61615 |
| 173 | Oncology Hematology Associates of Central Illinois, PC - Peoria | Peoria | Illinois | United States | 61615 |
| 174 | Methodist Medical Center of Illinois | Peoria | Illinois | United States | 61636 |
| 175 | OSF St. Francis Medical Center | Peoria | Illinois | United States | 61637 |
| 176 | Illinois CancerCare - Peru | Peru | Illinois | United States | 61354 |
| 177 | Illinois Valley Community Hospital | Peru | Illinois | United States | 61354 |
| 178 | Illinois CancerCare - Princeton | Princeton | Illinois | United States | 61356 |
| 179 | Perry Memorial Hospital | Princeton | Illinois | United States | 61356 |
| 180 | West Suburban Center for Cancer Care | River Forest | Illinois | United States | 60305 |
| 181 | Swedish-American Regional Cancer Center | Rockford | Illinois | United States | 61104-2315 |
| 182 | Center for Cancer Care at OSF Saint Anthony Medical Center | Rockford | Illinois | United States | 61108 |
| 183 | Illinois CancerCare - Spring Valley | Spring Valley | Illinois | United States | 61362 |
| 184 | Regional Cancer Center at Memorial Medical Center | Springfield | Illinois | United States | 62781-0001 |
| 185 | CCOP - Carle Cancer Center | Urbana | Illinois | United States | 61801 |
| 186 | St. Francis Hospital and Health Centers - Beech Grove Campus | Beech Grove | Indiana | United States | 46107 |
| 187 | Elkhart Clinic, LLC | Elkhart | Indiana | United States | 46514-2098 |
| 188 | Michiana Hematology-Oncology, PC - Elkhart | Elkhart | Indiana | United States | 46514 |
| 189 | Elkhart General Hospital | Elkhart | Indiana | United States | 46515 |
| 190 | St. Vincent Indianapolis Hospital | Indianapolis | Indiana | United States | 46260 |
| 191 | Howard Community Hospital | Kokomo | Indiana | United States | 46904 |
| 192 | Center for Cancer Therapy at LaPorte Hospital and Health Services | La Porte | Indiana | United States | 46350 |
| 193 | Saint Anthony Memorial Health Centers | Michigan City | Indiana | United States | 46360 |
| 194 | Michiana Hematology-Oncology, PC - South Bend | Mishawaka | Indiana | United States | 46545-1470 |
| 195 | Saint Joseph Regional Medical Center | Mishawaka | Indiana | United States | 46545-1470 |
| 196 | Community Hospital | Munster | Indiana | United States | 46321 |
| 197 | Michiana Hematology Oncology PC - Plymouth | Plymouth | Indiana | United States | 46563 |
| 198 | Reid Hospital & Health Care Services | Richmond | Indiana | United States | 47374 |
| 199 | CCOP - Northern Indiana CR Consortium | South Bend | Indiana | United States | 46601 |
| 200 | Memorial Hospital of South Bend | South Bend | Indiana | United States | 46601 |
| 201 | Michiana Hematology Oncology PC - La Porte | Westville | Indiana | United States | 46391 |
| 202 | McFarland Clinic, PC | Ames | Iowa | United States | 50010 |
| 203 | Hematology Oncology Associates of the Quad Cities | Bettendorf | Iowa | United States | 52722 |
| 204 | Bettendorf | Iowa | United States | 52722 | |
| 205 | Cedar Rapids Oncology Associates | Cedar Rapids | Iowa | United States | 52403 |
| 206 | Mercy Regional Cancer Center at Mercy Medical Center | Cedar Rapids | Iowa | United States | 52403 |
| 207 | Medical Oncology and Hematology Associates - West Des Moines | Clive | Iowa | United States | 50325 |
| 208 | Mercy Cancer Center - West Lakes | Clive | Iowa | United States | 50325 |
| 209 | Genesis Regional Cancer Center at Genesis Medical Center | Davenport | Iowa | United States | 52803 |
| 210 | CCOP - Iowa Oncology Research Association | Des Moines | Iowa | United States | 50309 |
| 211 | John Stoddard Cancer Center at Iowa Methodist Medical Center | Des Moines | Iowa | United States | 50309 |
| 212 | Medical Oncology and Hematology Associates at John Stoddard Cancer Center | Des Moines | Iowa | United States | 50309 |
| 213 | Medical Oncology and Hematology Associates at Mercy Cancer Center | Des Moines | Iowa | United States | 50314 |
| 214 | Mercy Cancer Center at Mercy Medical Center - Des Moines | Des Moines | Iowa | United States | 50314 |
| 215 | John Stoddard Cancer Center at Iowa Lutheran Hospital | Des Moines | Iowa | United States | 50316 |
| 216 | Holden Comprehensive Cancer Center at University of Iowa | Iowa City | Iowa | United States | 52242-1002 |
| 217 | Mercy Cancer Center at Mercy Medical Center - North Iowa | Mason City | Iowa | United States | 50401 |
| 218 | McCreery Cancer Center at Ottumwa Regional | Ottumwa | Iowa | United States | 52501 |
| 219 | Siouxland Hematology-Oncology Associates, LLP | Sioux City | Iowa | United States | 51101 |
| 220 | Mercy Medical Center - Sioux City | Sioux City | Iowa | United States | 51102 |
| 221 | St. Luke's Regional Medical Center | Sioux City | Iowa | United States | 51104 |
| 222 | Covenant Cancer Treatment Center | Waterloo | Iowa | United States | 50702 |
| 223 | Methodist West Hospital | West Des Moines | Iowa | United States | 50266-7700 |
| 224 | Cancer Center of Kansas, PA - Chanute | Chanute | Kansas | United States | 66720 |
| 225 | Cancer Center of Kansas, PA - Dodge City | Dodge City | Kansas | United States | 67801 |
| 226 | Cancer Center of Kansas, PA - El Dorado | El Dorado | Kansas | United States | 67042 |
| 227 | Cancer Center of Kansas - Fort Scott | Fort Scott | Kansas | United States | 66701 |
| 228 | Cancer Center of Kansas-Independence | Independence | Kansas | United States | 67301 |
| 229 | Cancer Center of Kansas, PA - Kingman | Kingman | Kansas | United States | 67068 |
| 230 | Lawrence Memorial Hospital | Lawrence | Kansas | United States | 66044 |
| 231 | Cancer Center of Kansas, PA - Liberal | Liberal | Kansas | United States | 67901 |
| 232 | Cancer Center of Kansas, PA - McPherson | McPherson | Kansas | United States | 67460 |
| 233 | Cancer Center of Kansas, PA - Newton | Newton | Kansas | United States | 67114 |
| 234 | Menorah Medical Center | Overland Park | Kansas | United States | 66209 |
| 235 | Saint Luke's Hospital - South | Overland Park | Kansas | United States | 66213 |
| 236 | Cancer Center of Kansas, PA - Parsons | Parsons | Kansas | United States | 67357 |
| 237 | CCOP - Kansas City | Prairie Village | Kansas | United States | 66208 |
| 238 | Cancer Center of Kansas, PA - Pratt | Pratt | Kansas | United States | 67124 |
| 239 | Cancer Center of Kansas, PA - Salina | Salina | Kansas | United States | 67401 |
| 240 | Cotton-O'Neil Cancer Center | Topeka | Kansas | United States | 66606 |
| 241 | Cancer Center of Kansas, PA - Wellington | Wellington | Kansas | United States | 67152 |
| 242 | Associates in Womens Health, PA - North Review | Wichita | Kansas | United States | 67208 |
| 243 | Cancer Center of Kansas, PA - Medical Arts Tower | Wichita | Kansas | United States | 67208 |
| 244 | Cancer Center of Kansas, PA - Wichita | Wichita | Kansas | United States | 67214 |
| 245 | CCOP - Wichita | Wichita | Kansas | United States | 67214 |
| 246 | Via Christi Cancer Center at Via Christi Regional Medical Center | Wichita | Kansas | United States | 67214 |
| 247 | Cancer Center of Kansas, PA - Winfield | Winfield | Kansas | United States | 67156 |
| 248 | Central Baptist Hospital | Lexington | Kentucky | United States | 40503-9985 |
| 249 | Louisville Oncology at Norton Cancer Institute - Louisville | Louisville | Kentucky | United States | 40202 |
| 250 | CHRISTUS Cabrini Cancer Center | Alexandria | Louisiana | United States | 71301 |
| 251 | Tulane Cancer Center Office of Clinical Research | Alexandria | Louisiana | United States | 71315-3198 |
| 252 | Hematology-Oncology Clinic | Baton Rouge | Louisiana | United States | 70809 |
| 253 | Mary Bird Perkins Cancer Center - Baton Rouge | Baton Rouge | Louisiana | United States | 70809 |
| 254 | Louisiana State University Health Sciences Center - Monroe | Monroe | Louisiana | United States | 71210 |
| 255 | MBCCOP - LSU Health Sciences Center | New Orleans | Louisiana | United States | 70112 |
| 256 | Medical Center of Louisiana - New Orleans | New Orleans | Louisiana | United States | 70112 |
| 257 | CCOP - Ochsner | New Orleans | Louisiana | United States | 70121 |
| 258 | Ochsner Cancer Institute at Ochsner Clinic Foundation | New Orleans | Louisiana | United States | 70121 |
| 259 | Highland Clinic | Shreveport | Louisiana | United States | 71105 |
| 260 | Feist-Weiller Cancer Center at Louisiana State University Health Sciences | Shreveport | Louisiana | United States | 71130-3932 |
| 261 | Harold Alfond Center for Cancer Care | Augusta | Maine | United States | 04330 |
| 262 | CancerCare of Maine at Eastern Maine Medical Center | Bangor | Maine | United States | 04401 |
| 263 | Mercy Hospital | Portland | Maine | United States | 04101 |
| 264 | Harry and Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center | Baltimore | Maryland | United States | 21237 |
| 265 | Kaiser Permanente at Woodlawn Medical Center | Baltimore | Maryland | United States | 21244 |
| 266 | Shore Regional Cancer Center at Memorial Hospital - Easton | Easton | Maryland | United States | 21601 |
| 267 | Union Hospital of Cecil County | Elkton MD | Maryland | United States | 21921 |
| 268 | Frederick Memorial Hospital Regional Cancer Therapy Center | Frederick | Maryland | United States | 21701 |
| 269 | Kaiser Permanente - Gaithersburg Medical Center | Gaithersburg | Maryland | United States | 20879 |
| 270 | Kaiser Permanente Mid-Atlantic Medical Group-Largo Medical Facility | Largo | Maryland | United States | 20774 |
| 271 | Peninsula Regional Medical Center | Salisbury | Maryland | United States | 21801 |
| 272 | Boston University Cancer Research Center | Boston | Massachusetts | United States | 02118 |
| 273 | Lahey Clinic Medical Center - Burlington | Burlington | Massachusetts | United States | 01805 |
| 274 | Southcoast Center for Cancer Care | Fairhaven | Massachusetts | United States | 02719 |
| 275 | Hudner Oncology Center at Saint Anne's Hospital - Fall River | Fall River | Massachusetts | United States | 02721 |
| 276 | Berkshire Hematology Oncology, PC | Pittsfield | Massachusetts | United States | 01201 |
| 277 | Saint Joseph Mercy Cancer Center | Ann Arbor | Michigan | United States | 48106-0995 |
| 278 | CCOP - Michigan Cancer Research Consortium | Ann Arbor | Michigan | United States | 48106 |
| 279 | Battle Creek Health System Cancer Care Center | Battle Creek | Michigan | United States | 49017 |
| 280 | Mecosta County Medical Center | Big Rapids | Michigan | United States | 49307 |
| 281 | Oakwood Cancer Center at Oakwood Hospital and Medical Center | Dearborn | Michigan | United States | 48123-2500 |
| 282 | Josephine Ford Cancer Center at Henry Ford Hospital | Detroit | Michigan | United States | 48202 |
| 283 | Green Bay Oncology, Limited - Escanaba | Escanaba | Michigan | United States | 49431 |
| 284 | Genesys Hurley Cancer Institute | Flint | Michigan | United States | 48503 |
| 285 | Hurley Medical Center | Flint | Michigan | United States | 48503 |
| 286 | Butterworth Hospital at Spectrum Health | Grand Rapids | Michigan | United States | 49503 |
| 287 | CCOP - Grand Rapids | Grand Rapids | Michigan | United States | 49503 |
| 288 | Lacks Cancer Center at Saint Mary's Health Care | Grand Rapids | Michigan | United States | 49503 |
| 289 | Van Elslander Cancer Center at St. John Hospital and Medical Center | Grosse Pointe Woods | Michigan | United States | 48236 |
| 290 | Dickinson County Healthcare System | Iron Mountain | Michigan | United States | 49801 |
| 291 | Foote Memorial Hospital | Jackson | Michigan | United States | 49201 |
| 292 | Borgess Medical Center | Kalamazoo | Michigan | United States | 49001 |
| 293 | West Michigan Cancer Center | Kalamazoo | Michigan | United States | 49007-3731 |
| 294 | Bronson Methodist Hospital | Kalamazoo | Michigan | United States | 49007 |
| 295 | Breslin Cancer Center at Ingham Regional Medical Center | Lansing | Michigan | United States | 48910 |
| 296 | Sparrow Regional Cancer Center | Lansing | Michigan | United States | 48912-1811 |
| 297 | St. Mary Mercy Hospital | Livonia | Michigan | United States | 48154 |
| 298 | Upper Michigan Cancer Center at Marquette General Hospital | Marquette | Michigan | United States | 49855 |
| 299 | Mercy General Health Partners | Muskegon | Michigan | United States | 49444 |
| 300 | St. Joseph Mercy Oakland | Pontiac | Michigan | United States | 48341-2985 |
| 301 | Mercy Regional Cancer Center at Mercy Hospital | Port Huron | Michigan | United States | 48060 |
| 302 | Spectrum Health Reed City Hospital | Reed City | Michigan | United States | 49677 |
| 303 | William Beaumont Hospital - Royal Oak Campus | Royal Oak | Michigan | United States | 48073 |
| 304 | Seton Cancer Institute at Saint Mary's - Saginaw | Saginaw | Michigan | United States | 48601 |
| 305 | Lakeland Regional Cancer Care Center - St. Joseph | Saint Joseph | Michigan | United States | 49085 |
| 306 | Lakeside Cancer Specialists, PLLC | Saint Joseph | Michigan | United States | 49085 |
| 307 | Munson Medical Center | Traverse City | Michigan | United States | 49684 |
| 308 | St. John Macomb Hospital | Warren | Michigan | United States | 48093 |
| 309 | St. Joseph's Medical Center | Brainerd | Minnesota | United States | 56401 |
| 310 | Fairview Ridges Hospital | Burnsville | Minnesota | United States | 55337 |
| 311 | Mercy and Unity Cancer Center at Mercy Hospital | Coon Rapids | Minnesota | United States | 55433 |
| 312 | Duluth Clinic Cancer Center - Duluth | Duluth | Minnesota | United States | 55805-1983 |
| 313 | CCOP - Duluth | Duluth | Minnesota | United States | 55805 |
| 314 | Miller - Dwan Medical Center | Duluth | Minnesota | United States | 55805 |
| 315 | St. Luke's Hospital Cancer Care Center | Duluth | Minnesota | United States | 55805 |
| 316 | Fairview Southdale Hospital | Edina | Minnesota | United States | 55435 |
| 317 | Mercy and Unity Cancer Center at Unity Hospital | Fridley | Minnesota | United States | 55432 |
| 318 | Hutchinson Area Health Care | Hutchinson | Minnesota | United States | 55350 |
| 319 | Immanuel St. Joseph's | Mankato | Minnesota | United States | 56002 |
| 320 | HealthEast Cancer Care at St. John's Hospital | Maplewood | Minnesota | United States | 55109 |
| 321 | Minnesota Oncology - Maplewood | Maplewood | Minnesota | United States | 55109 |
| 322 | Virginia Piper Cancer Institute at Abbott - Northwestern Hospital | Minneapolis | Minnesota | United States | 55407 |
| 323 | Hennepin County Medical Center - Minneapolis | Minneapolis | Minnesota | United States | 55415 |
| 324 | New Ulm Medical Center | New Ulm | Minnesota | United States | 56073 |
| 325 | Humphrey Cancer Center at North Memorial Outpatient Center | Robbinsdale | Minnesota | United States | 55422-2900 |
| 326 | Mayo Clinic Cancer Center | Rochester | Minnesota | United States | 55905 |
| 327 | CCOP - Metro-Minnesota | Saint Louis Park | Minnesota | United States | 55416 |
| 328 | Park Nicollet Cancer Center | Saint Louis Park | Minnesota | United States | 55416 |
| 329 | United Hospital | Saint Paul | Minnesota | United States | 55102 |
| 330 | St. Francis Cancer Center at St. Francis Medical Center | Shakopee | Minnesota | United States | 55379 |
| 331 | Regions Hospital Cancer Care Center | St. Paul | Minnesota | United States | 55101 |
| 332 | Lakeview Hospital | Stillwater | Minnesota | United States | 55082 |
| 333 | Ridgeview Medical Center | Waconia | Minnesota | United States | 55387 |
| 334 | Willmar Cancer Center at Rice Memorial Hospital | Willmar | Minnesota | United States | 56201 |
| 335 | Minnesota Oncology - Woodbury | Woodbury | Minnesota | United States | 55125 |
| 336 | Central Care Cancer Center at Carrie J. Babb Cancer Center | Bolivar | Missouri | United States | 65613 |
| 337 | Southeast Cancer Center | Cape Girardeau | Missouri | United States | 63703 |
| 338 | Saint Luke's Hospital | Chesterfield | Missouri | United States | 63017 |
| 339 | Goldschmidt Cancer Center | Jefferson City | Missouri | United States | 65109 |
| 340 | Saint Luke's Cancer Institute at Saint Luke's Hospital | Kansas City | Missouri | United States | 64111 |
| 341 | North Kansas City Hospital | Kansas City | Missouri | United States | 64116 |
| 342 | Heartland Hematology Oncology Associates, Incorporated | Kansas City | Missouri | United States | 64118 |
| 343 | Research Medical Center | Kansas City | Missouri | United States | 64132 |
| 344 | Saint Luke's East - Lee's Summit | Lee's Summit | Missouri | United States | 64086 |
| 345 | Parvin Radiation Oncology | Liberty | Missouri | United States | 64068 |
| 346 | Phelps County Regional Medical Center | Rolla | Missouri | United States | 65401 |
| 347 | Heartland Regional Medical Center | Saint Joseph | Missouri | United States | 64506 |
| 348 | Saint Joseph Oncology, Incorporated | Saint Joseph | Missouri | United States | 64507 |
| 349 | Saint Louis University Cancer Center | Saint Louis | Missouri | United States | 63110 |
| 350 | Missouri Baptist Cancer Center | Saint Louis | Missouri | United States | 63131 |
| 351 | CCOP - Cancer Research for the Ozarks | Springfield | Missouri | United States | 65802 |
| 352 | St. John's Regional Health Center | Springfield | Missouri | United States | 65804 |
| 353 | Hulston Cancer Center at Cox Medical Center South | Springfield | Missouri | United States | 65807 |
| 354 | CCOP - Montana Cancer Consortium | Billings | Montana | United States | 59101 |
| 355 | St. Vincent Healthcare Cancer Care Services | Billings | Montana | United States | 59101 |
| 356 | Hematology-Oncology Centers of the Northern Rockies - Billings | Billings | Montana | United States | 59102 |
| 357 | Billings Clinic - Downtown | Billings | Montana | United States | 59107-7000 |
| 358 | Bozeman Deaconess Cancer Center | Bozeman | Montana | United States | 59715 |
| 359 | St. James Healthcare Cancer Care | Butte | Montana | United States | 59701 |
| 360 | Big Sky Oncology | Great Falls | Montana | United States | 59405-5309 |
| 361 | Great Falls Clinic - Main Facility | Great Falls | Montana | United States | 59405 |
| 362 | Sletten Cancer Institute at Benefis Healthcare | Great Falls | Montana | United States | 59405 |
| 363 | St. Peter's Hospital | Helena | Montana | United States | 59601 |
| 364 | Glacier Oncology, PLLC | Kalispell | Montana | United States | 59901 |
| 365 | Kalispell Medical Oncology at KRMC | Kalispell | Montana | United States | 59901 |
| 366 | Kalispell Regional Medical Center | Kalispell | Montana | United States | 59901 |
| 367 | Montana Cancer Specialists at Montana Cancer Center | Missoula | Montana | United States | 59807-7877 |
| 368 | Montana Cancer Center at St. Patrick Hospital and Health Sciences Center | Missoula | Montana | United States | 59807 |
| 369 | Cancer Resource Center - Lincoln | Lincoln | Nebraska | United States | 68510 |
| 370 | CCOP - Missouri Valley Cancer Consortium | Omaha | Nebraska | United States | 68106 |
| 371 | Methodist Estabrook Cancer Center | Omaha | Nebraska | United States | 68114 |
| 372 | Immanuel Medical Center | Omaha | Nebraska | United States | 68122 |
| 373 | Alegant Health Cancer Center at Bergan Mercy Medical Center | Omaha | Nebraska | United States | 68124 |
| 374 | Lakeside Hospital | Omaha | Nebraska | United States | 68130 |
| 375 | Creighton University Medical Center | Omaha | Nebraska | United States | 68131-2197 |
| 376 | University Medical Center of Southern Nevada | Las Vegas | Nevada | United States | 89102 |
| 377 | CCOP - Nevada Cancer Research Foundation | Las Vegas | Nevada | United States | 89106 |
| 378 | New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care | Concord | New Hampshire | United States | 03301 |
| 379 | Center for Cancer Care at Exeter Hospital | Exeter | New Hampshire | United States | 03833 |
| 380 | New Hampshire Oncology - Hematology, PA - Hooksett | Hooksett | New Hampshire | United States | 03106 |
| 381 | Lakes Region General Hospital | Laconia | New Hampshire | United States | 03246 |
| 382 | Hunterdon Regional Cancer Center at Hunterdon Medical Center | Flemington | New Jersey | United States | 08822 |
| 383 | CCOP - Northern New Jersey | Hackensack | New Jersey | United States | 07601 |
| 384 | St. Barnabas Medical Center Cancer Center | Livingston | New Jersey | United States | 07039 |
| 385 | Monmouth Medical Center | Long Branch | New Jersey | United States | 07740-6395 |
| 386 | Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton | Marlton | New Jersey | United States | 08053 |
| 387 | Newark Beth Israel Medical Center | Newark | New Jersey | United States | 07112 |
| 388 | Capital Health Regional Cancer Center | Pennington | New Jersey | United States | 08534 |
| 389 | Somerset Medical Center | Somerville | New Jersey | United States | 08876 |
| 390 | Frederick R. and Betty M. Smith Cancer Treatment Center | Sparta | New Jersey | United States | 07871 |
| 391 | J. Phillip Citta Regional Cancer Center at Community Medical Center | Toms River | New Jersey | United States | 08755 |
| 392 | Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare | Vineland | New Jersey | United States | 08360 |
| 393 | Cancer Institute of New Jersey at Cooper - Voorhees | Voorhees | New Jersey | United States | 08043 |
| 394 | Fox Chase Virtua Health Cancer Program at Virtua West Jersey | Voorhees | New Jersey | United States | 08043 |
| 395 | Lovelace Medical Center - Downtown | Albuquerque | New Mexico | United States | 87102 |
| 396 | Hematology Oncology Associates, PC | Albuquerque | New Mexico | United States | 87106 |
| 397 | University of New Mexico Cancer Center | Albuquerque | New Mexico | United States | 87131-5636 |
| 398 | Veterans Affairs Medical Center - Buffalo | Buffalo | New York | United States | 14215 |
| 399 | CCOP - Hematology-Oncology Associates of Central New York | East Syracuse | New York | United States | 13057 |
| 400 | Elmhurst Hospital Center | Elmhurst | New York | United States | 11373 |
| 401 | Queens Cancer Center of Queens Hospital | Jamaica | New York | United States | 11432 |
| 402 | Monter Cancer Center of the North Shore-LIJ Health System | Lake Success | New York | United States | 11042 |
| 403 | CCOP - North Shore University Hospital | Manhasset | New York | United States | 11030 |
| 404 | Don Monti Comprehensive Cancer Center at North Shore University Hospital | Manhasset | New York | United States | 11030 |
| 405 | Tucker Center for Cancer Care at Orange Regional Medical Center | Middletown | New York | United States | 10940-4199 |
| 406 | Long Island Jewish Medical Center | New Hyde Park | New York | United States | 11040 |
| 407 | Nalitt Cancer Institute at Staten Island University Hospital | Staten Island | New York | United States | 10305 |
| 408 | SUNY Upstate Medical University Hospital | Syracuse | New York | United States | 13210 |
| 409 | Randolph Hospital | Asheboro | North Carolina | United States | 27203-5400 |
| 410 | Mission Hospitals - Memorial Campus | Asheville | North Carolina | United States | 28801 |
| 411 | Alamance Cancer Center at Alamance Regional Medical Center | Burlington | North Carolina | United States | 27216 |
| 412 | Blumenthal Cancer Center at Carolinas Medical Center | Charlotte | North Carolina | United States | 28232-2861 |
| 413 | Wayne Memorial Hospital, Incorporated | Goldsboro | North Carolina | United States | 27534 |
| 414 | Moses Cone Regional Cancer Center at Wesley Long Community Hospital | Greensboro | North Carolina | United States | 27403-1198 |
| 415 | Pardee Memorial Hospital | Hendersonville | North Carolina | United States | 28791 |
| 416 | Kinston Medical Specialists | Kinston | North Carolina | United States | 28501 |
| 417 | FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center | Pinehurst | North Carolina | United States | 28374 |
| 418 | Annie Penn Cancer Center | Reidsville | North Carolina | United States | 27320 |
| 419 | Rutherford Hospital | Rutherfordton | North Carolina | United States | 28139 |
| 420 | Iredell Memorial Hospital | Statesville | North Carolina | United States | 28677 |
| 421 | Forsyth Regional Cancer Center at Forsyth Medical Center | Winston-Salem | North Carolina | United States | 27103 |
| 422 | Medcenter One Hospital Cancer Care Center | Bismarck | North Dakota | United States | 58501 |
| 423 | Mid Dakota Clinic, PC | Bismarck | North Dakota | United States | 58501 |
| 424 | St. Alexius Medical Center Cancer Center | Bismarck | North Dakota | United States | 58502 |
| 425 | Dakota Cancer Institute at Dakota Clinic - South University | Fargo | North Dakota | United States | 58103 |
| 426 | Altru Cancer Center at Altru Hospital | Grand Forks | North Dakota | United States | 58201 |
| 427 | Trinity CancerCare Center | Minot | North Dakota | United States | 58701 |
| 428 | McDowell Cancer Center at Akron General Medical Center | Akron | Ohio | United States | 44307 |
| 429 | Summa Center for Cancer Care at Akron City Hospital | Akron | Ohio | United States | 44309-2090 |
| 430 | Mercy Cancer Center at Mercy Medical Center | Canton | Ohio | United States | 44708 |
| 431 | Aultman Cancer Center at Aultman Hospital | Canton | Ohio | United States | 44710-1799 |
| 432 | Adena Regional Medical Center | Chillicothe | Ohio | United States | 45601 |
| 433 | Christ Hospital Cancer Center | Cincinnati | Ohio | United States | 45219 |
| 434 | Charles M. Barrett Cancer Center at University Hospital | Cincinnati | Ohio | United States | 45267 |
| 435 | Riverside Methodist Hospital Cancer Care | Columbus | Ohio | United States | 43214-3998 |
| 436 | CCOP - Columbus | Columbus | Ohio | United States | 43215 |
| 437 | Grant Medical Center Cancer Care | Columbus | Ohio | United States | 43215 |
| 438 | Mount Carmel Health - West Hospital | Columbus | Ohio | United States | 43222 |
| 439 | Doctors Hospital at Ohio Health | Columbus | Ohio | United States | 43228 |
| 440 | Grandview Hospital | Dayton | Ohio | United States | 45405 |
| 441 | Good Samaritan Hospital | Dayton | Ohio | United States | 45406 |
| 442 | David L. Rike Cancer Center at Miami Valley Hospital | Dayton | Ohio | United States | 45409 |
| 443 | Samaritan North Cancer Care Center | Dayton | Ohio | United States | 45415 |
| 444 | CCOP - Dayton | Dayton | Ohio | United States | 45420 |
| 445 | Grady Memorial Hospital | Delaware | Ohio | United States | 43015 |
| 446 | Blanchard Valley Medical Associates | Findlay | Ohio | United States | 45840 |
| 447 | Middletown Regional Hospital | Franklin | Ohio | United States | 45005-1066 |
| 448 | Wayne Hospital | Greenville | Ohio | United States | 45331 |
| 449 | Charles F. Kettering Memorial Hospital | Kettering | Ohio | United States | 45429 |
| 450 | Fairfield Medical Center | Lancaster | Ohio | United States | 43130 |
| 451 | St. Rita's Medical Center | Lima | Ohio | United States | 45801 |
| 452 | Strecker Cancer Center at Marietta Memorial Hospital | Marietta | Ohio | United States | 45750 |
| 453 | Knox Community Hospital | Mount Vernon | Ohio | United States | 43050 |
| 454 | Licking Memorial Cancer Care Program at Licking Memorial Hospital | Newark | Ohio | United States | 43055 |
| 455 | Community Hospital of Springfield and Clark County | Springfield | Ohio | United States | 45505 |
| 456 | UVMC Cancer Care Center at Upper Valley Medical Center | Troy | Ohio | United States | 45373-1300 |
| 457 | Mount Carmel St. Ann's Cancer Center | Westerville | Ohio | United States | 43081 |
| 458 | United States Air Force Medical Center - Wright-Patterson | Wright-Patterson Afb | Ohio | United States | 45433-5529 |
| 459 | Ruth G. McMillan Cancer Center at Greene Memorial Hospital | Xenia | Ohio | United States | 45385 |
| 460 | Genesis - Good Samaritan Hospital | Zanesville | Ohio | United States | 43701 |
| 461 | Cancer Care Associates - Norman | Norman | Oklahoma | United States | 73071 |
| 462 | Cancer Care Associates - Mercy Campus | Oklahoma City | Oklahoma | United States | 73120 |
| 463 | Natalie Warren Bryant Cancer Center at St. Francis Hospital | Tulsa | Oklahoma | United States | 74136 |
| 464 | Clackamas Radiation Oncology Center | Clackamas | Oregon | United States | 97015 |
| 465 | Providence Milwaukie Hospital | Milwaukie | Oregon | United States | 97222 |
| 466 | Providence Newberg Medical Center | Newberg | Oregon | United States | 97132 |
| 467 | Willamette Falls Hospital | Oregon City | Oregon | United States | 97045 |
| 468 | Providence Cancer Center at Providence Portland Medical Center | Portland | Oregon | United States | 97213-2967 |
| 469 | CCOP - Columbia River Oncology Program | Portland | Oregon | United States | 97225 |
| 470 | Providence St. Vincent Medical Center | Portland | Oregon | United States | 97225 |
| 471 | Kaiser Permanente Health Care - Portland | Portland | Oregon | United States | 97227 |
| 472 | Salem Hospital Regional Cancer Care Services | Salem | Oregon | United States | 97309-5014 |
| 473 | Celilo Cancer Center at Mid-Columbia Medical Center | The Dalles | Oregon | United States | 97058 |
| 474 | Rosenfeld Cancer Center at Abington Memorial Hospital | Abington | Pennsylvania | United States | 19001 |
| 475 | Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest | Allentown | Pennsylvania | United States | 18105 |
| 476 | Lehigh Valley Hospital - Muhlenberg | Bethlehem | Pennsylvania | United States | 18017 |
| 477 | Geisinger Cancer Institute at Geisinger Health | Danville | Pennsylvania | United States | 17822-0001 |
| 478 | Mercy Fitzgerald Hospital | Darby | Pennsylvania | United States | 19023 |
| 479 | Doylestown Hospital Cancer Center | Doylestown | Pennsylvania | United States | 18901 |
| 480 | Delaware County Regional Cancer Center at Delaware County Memorial Hospital | Drexel Hill | Pennsylvania | United States | 19026 |
| 481 | Oncology Hematology Associates of Northern Pennsylvania, PC at Hahne Regional Cancer Center | Dubois | Pennsylvania | United States | 15801 |
| 482 | Dale and Frances Hughes Cancer Center at Pocono Medical Center | East Stroudsburg | Pennsylvania | United States | 18301 |
| 483 | Ephrata Cancer Center at Ephrata Community Hospital | Ephrata | Pennsylvania | United States | 17522 |
| 484 | Adams Cancer Center | Gettysburg | Pennsylvania | United States | 17325 |
| 485 | Cherry Tree Cancer Center | Hanover | Pennsylvania | United States | 17331 |
| 486 | PinnacleHealth Regional Cancer Center at Polyclinic Hospital | Harrisburg | Pennsylvania | United States | 17110-2098 |
| 487 | Geisinger Hazleton Cancer Center | Hazleton | Pennsylvania | United States | 18201 |
| 488 | Riddle Memorial Hospital Cancer Center | Media | Pennsylvania | United States | 19063 |
| 489 | Forbes Regional Hospital | Monroeville | Pennsylvania | United States | 15146 |
| 490 | Kimmel Cancer Center at Thomas Jefferson University - Philadelphia | Philadelphia | Pennsylvania | United States | 19107-5541 |
| 491 | Allegheny Cancer Center at Allegheny General Hospital | Pittsburgh | Pennsylvania | United States | 15212 |
| 492 | Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital | Pittsburgh | Pennsylvania | United States | 15224-1791 |
| 493 | Pottstown Memorial Regional Cancer Center | Pottstown | Pennsylvania | United States | 19464 |
| 494 | Mercy Hospital Cancer Center - Scranton | Scranton | Pennsylvania | United States | 18501 |
| 495 | Hematology and Oncology Associates of Northeastern Pennsylvania | Scranton | Pennsylvania | United States | 18510 |
| 496 | Geisinger Medical Group - Scenery Park | State College | Pennsylvania | United States | 16801 |
| 497 | Associates in Hematology-Oncology, PC at Crozer Regional Cancer Center | Upland | Pennsylvania | United States | 19013 |
| 498 | Jennersville Regional Hospital | West Grove | Pennsylvania | United States | 19390-9499 |
| 499 | Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center | Wilkes-Barre | Pennsylvania | United States | 18711 |
| 500 | Susquehanna Cancer Center at Divine Providence Hospital | Williamsport | Pennsylvania | United States | 17701 |
| 501 | York Cancer Center at Apple Hill Medical Center | York | Pennsylvania | United States | 17405 |
| 502 | AnMed Cancer Center | Anderson | South Carolina | United States | 29621 |
| 503 | Roper St. Francis Cancer Center at Roper Hospital | Charleston | South Carolina | United States | 29401 |
| 504 | Hollings Cancer Center at Medical University of South Carolina | Charleston | South Carolina | United States | 29425 |
| 505 | McLeod Regional Medical Center | Florence | South Carolina | United States | 29501 |
| 506 | Bon Secours St. Francis Health System | Greenville | South Carolina | United States | 29601 |
| 507 | Cancer Centers of the Carolinas - Faris Road | Greenville | South Carolina | United States | 29605 |
| 508 | Cancer Centers of the Carolinas - Grove Commons | Greenville | South Carolina | United States | 29605 |
| 509 | Greenville Hospital Cancer Center | Greenville | South Carolina | United States | 29605 |
| 510 | CCOP - Greenville | Greenville | South Carolina | United States | 29615 |
| 511 | Cancer Centers of the Carolinas - Greer Medical Oncology | Greer | South Carolina | United States | 29650 |
| 512 | Cancer Centers of the Carolinas - Seneca | Seneca | South Carolina | United States | 29672 |
| 513 | CCOP - Upstate Carolina | Spartanburg | South Carolina | United States | 29303 |
| 514 | Gibbs Regional Cancer Center at Spartanburg Regional Medical Center | Spartanburg | South Carolina | United States | 29303 |
| 515 | Cancer Centers of the Carolinas - Spartanburg | Spartanburg | South Carolina | United States | 29307 |
| 516 | Oncology Services of Aberdeen | Aberdeen | South Dakota | United States | 57401 |
| 517 | Rapid City Regional Hospital | Rapid City | South Dakota | United States | 57701 |
| 518 | Avera Cancer Institute | Sioux Falls | South Dakota | United States | 57105 |
| 519 | Sanford Cancer Center at Sanford USD Medical Center | Sioux Falls | South Dakota | United States | 57117-5039 |
| 520 | Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center | Kingsport | Tennessee | United States | 37662 |
| 521 | Thompson Cancer Survival Center | Knoxville | Tennessee | United States | 37916 |
| 522 | M. D. Anderson Cancer Center at University of Texas | Houston | Texas | United States | 77030-4009 |
| 523 | Doctor's Hospital of Laredo | Laredo | Texas | United States | 78045 |
| 524 | Joe Arrington Cancer Research and Treatment Center | Lubbock | Texas | United States | 79410-1894 |
| 525 | University of Texas Health Science Center at San Antonio | San Antonio | Texas | United States | 78229-3900 |
| 526 | American Fork Hospital | American Fork | Utah | United States | 84003 |
| 527 | Sandra L. Maxwell Cancer Center | Cedar City | Utah | United States | 84720 |
| 528 | Logan Regional Hospital | Logan | Utah | United States | 84321 |
| 529 | Jon and Karen Huntsman Cancer Center at Intermountain Medical Center | Murray | Utah | United States | 84157 |
| 530 | Val and Ann Browning Cancer Center at McKay-Dee Hospital Center | Ogden | Utah | United States | 84403 |
| 531 | Utah Valley Regional Medical Center - Provo | Provo | Utah | United States | 84604 |
| 532 | Dixie Regional Medical Center - East Campus | Saint George | Utah | United States | 84770 |
| 533 | Utah Cancer Specialists at UCS Cancer Center | Salt Lake City | Utah | United States | 84106 |
| 534 | LDS Hospital | Salt Lake City | Utah | United States | 84143 |
| 535 | Kaiser Permanente Medical Center - Fair Oaks | Fairfax | Virginia | United States | 22033 |
| 536 | Kaiser Permanente Tysons Corner Medical Center | McLean | Virginia | United States | 22102 |
| 537 | Southwest Virginia Regional Cancer Center at Wellmonth Health | Norton | Virginia | United States | 24273 |
| 538 | Virginia Commonwealth University Massey Cancer Center | Richmond | Virginia | United States | 23298-0037 |
| 539 | Overlake Cancer Center at Overlake Hospital Medical Center | Bellevue | Washington | United States | 98004 |
| 540 | St. Joseph Cancer Center | Bellingham | Washington | United States | 98225 |
| 541 | Olympic Hematology and Oncology | Bremerton | Washington | United States | 98310 |
| 542 | Providence Centralia Hospital | Centralia | Washington | United States | 98531-9027 |
| 543 | Providence Regional Cancer Partnership | Everett | Washington | United States | 98201 |
| 544 | St. Francis Hospital | Federal Way | Washington | United States | 98003 |
| 545 | Skagit Valley Hospital Cancer Care Center | Mount Vernon | Washington | United States | 98274 |
| 546 | Providence St. Peter Hospital Regional Cancer Center | Olympia | Washington | United States | 98506-5166 |
| 547 | Good Samaritan Cancer Center | Puyallup | Washington | United States | 98372 |
| 548 | Fred Hutchinson Cancer Research Center | Seattle | Washington | United States | 98109 |
| 549 | Group Health Central Hospital | Seattle | Washington | United States | 98112 |
| 550 | Swedish Cancer Institute at Swedish Medical Center - First Hill Campus | Seattle | Washington | United States | 98122-4307 |
| 551 | Olympic Medical Cancer Center | Sequim | Washington | United States | 98382 |
| 552 | Rockwood Clinic Cancer Treatment Center | Spokane | Washington | United States | 99204-2967 |
| 553 | Franciscan Cancer Center at St. Joseph Medical Center | Tacoma | Washington | United States | 98405-3004 |
| 554 | Allenmore Hospital | Tacoma | Washington | United States | 98405 |
| 555 | CCOP - Northwest | Tacoma | Washington | United States | 98405 |
| 556 | MultiCare Regional Cancer Center at Tacoma General Hospital | Tacoma | Washington | United States | 98405 |
| 557 | St. Clare Hospital | Tacoma | Washington | United States | 98499 |
| 558 | Southwest Washington Medical Center Cancer Center | Vancouver | Washington | United States | 98664 |
| 559 | St. Mary Regional Cancer Center at St. Mary Medical Center | Walla Walla | Washington | United States | 99362 |
| 560 | Wenatchee Valley Medical Center | Wenatchee | Washington | United States | 98801-2028 |
| 561 | United Hospital Center | Clarksburg | West Virginia | United States | 26301 |
| 562 | St. Mary's Regional Cancer Center at St. Mary's Medical Center | Huntington | West Virginia | United States | 25702 |
| 563 | Princeton Community Hospital | Princeton | West Virginia | United States | 24740 |
| 564 | Langlade Memorial Hospital | Antigo | Wisconsin | United States | 54409 |
| 565 | Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center | Green Bay | Wisconsin | United States | 54301-3526 |
| 566 | Bellin Memorial Hospital | Green Bay | Wisconsin | United States | 54301 |
| 567 | Green Bay Oncology, Limited at St. Mary's Hospital | Green Bay | Wisconsin | United States | 54303 |
| 568 | St. Mary's Hospital Medical Center - Green Bay | Green Bay | Wisconsin | United States | 54303 |
| 569 | St. Vincent Hospital Regional Cancer Center | Green Bay | Wisconsin | United States | 54307-3508 |
| 570 | Mercy Regional Cancer Center | Janesville | Wisconsin | United States | 53547 |
| 571 | Dean Medical Center - Madison | Madison | Wisconsin | United States | 53717 |
| 572 | Holy Family Memorial Medical Center Cancer Care Center | Manitowoc | Wisconsin | United States | 54221-1450 |
| 573 | Bay Area Cancer Care Center at Bay Area Medical Center | Marinette | Wisconsin | United States | 54143 |
| 574 | Marshfield Clinic - Marshfield Center | Marshfield | Wisconsin | United States | 54449 |
| 575 | D.N. Greenwald Center | Mukwonago | Wisconsin | United States | 53149 |
| 576 | Regional Cancer Center at Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin | United States | 53066 |
| 577 | Green Bay Oncology, Limited - Oconto Falls | Oconto Falls | Wisconsin | United States | 54154 |
| 578 | Marshfield Clinic - Indianhead Center | Rice Lake | Wisconsin | United States | 54868 |
| 579 | St. Nicholas Hospital | Sheboygan | Wisconsin | United States | 53081 |
| 580 | Green Bay Oncology, Limited - Sturgeon Bay | Sturgeon Bay | Wisconsin | United States | 54235 |
| 581 | Waukesha Memorial Hospital Regional Cancer Center | Waukesha | Wisconsin | United States | 53188 |
| 582 | University of Wisconcin Cancer Center at Aspirus Wausau Hospital | Wausau | Wisconsin | United States | 54401 |
| 583 | Riverview UW Cancer Center at Riverview Hospital | Wisconsin Rapids | Wisconsin | United States | 54494 |
| 584 | Rocky Mountain Oncology | Casper | Wyoming | United States | 82609 |
| 585 | Cancer Centre of Southeastern Ontario at Kingston General Hospital | Kingston | Ontario | Canada | K7L 5P9 |
| 586 | Royal Victoria Hospital - Montreal | Montreal | Quebec | Canada | H3A 1A1 |
| 587 | Hopital du Saint-Sacrement - Quebec | Quebec City | Quebec | Canada | G1S 4L8 |
Sponsors and Collaborators
- NSABP Foundation Inc
- National Cancer Institute (NCI)
Investigators
- Principal Investigator: Norman Wolmark, MD, NSABP Foundation Inc
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
NSABP Foundation Inc
ClinicalTrials.gov Identifier:
NCT01011478
Other Study ID Numbers:
- NSABP-P-5
- NSABP P-5
- NCI-2011-09183
First Posted:
Nov 11, 2009
Last Update Posted:
Apr 11, 2016
Last Verified:
Apr 1, 2016
Keywords provided by NSABP Foundation Inc
Additional relevant MeSH terms: