Clinical Outcomes After EMR or ESD of Colorectal Neoplasms - A Multicenter Registry
Study Details
Study Description
Brief Summary
This study aims to establish a multicenter registry platform to capture clinical data from subjects undergoing colorectal EMR and ESD.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Colorectal cancer (CRC) is one of the most common causes of cancer-related death, however its morbidity and mortality can be reduced by colonoscopy screening and endoscopic removal of adenomas or early cancers.[1] Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are two main endoscopic treatment options for colorectal neoplasms. Despite being a safe and convenient procedure, insufficient resection by EMR can result in a high risk of local recurrence, particularly in lesions ≥ 20 mm. Compared with EMR, ESD facilitates a higher rate of en bloc resection and a lower rate of local recurrence. A recent meta-analysis revealed that the local recurrence rate after colorectal ESD was 1% during a 2-year follow-up period. In addition, ESD can facilitate precise pathological diagnosis to assess the risk of lymph node metastasis of early CRC to judge whether salvage surgery is needed. Although the efficacy of colorectal ESD has been demonstrated, its usage is largely limited by its technical difficulty and risk of complications.
Both short- and long-term data on clinical outcomes and safety profiles for colorectal EMR and ESD are needed. Therefore, this study aims to establish a multicenter registry platform to capture clinical data from subjects undergoing colorectal EMR and ESD.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Subjects who undergo EMR or ESD Subjects who undergo EMR or ESD for colorectal lesions |
Other: EMR or ESD
Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are two main endoscopic treatment options for colorectal neoplasms
|
Outcome Measures
Primary Outcome Measures
- Curative resection rate of EMR or ESD for colorectal neoplasms [10 years]
The short- and long-term clinical efficacy outcomes of colorectal EMR or ESD
- Adverse event rate of EMR or ESD for colorectal neoplasms [10 years]
The short- and long-term clinical safety outcomes of colorectal EMR or ESD
Eligibility Criteria
Criteria
Inclusion Criteria:
- Subjects who undergo EMR or ESD for colorectal lesions.
Exclusion Criteria:
- Not applicable.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Prince of Wales Hospital | Shatin | New Territories | Hong Kong |
Sponsors and Collaborators
- Chinese University of Hong Kong
Investigators
- Principal Investigator: Louis Lau, Prince of Wales Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2022.474