Study of Oxaliplatin/5-FU/Leucovorin Plus Vatalanib Versus Oxaliplatin/5-FU/Leucovorin in Patients With Previously Treated Metastatic Colorectal Cancer
Sponsor
Novartis Pharmaceuticals (Industry)
Overall Status
Completed
CT.gov ID
NCT00056446
Collaborator
Bayer (Industry)
855
251
2
48
3.4
0.1
Study Details
Study Description
Brief Summary
The purpose of this study is to compare treatment with oxaliplatin/5-FU/leucovorin plus vatalanib versus oxaliplatin/5-FU/leucovorin plus placebo in patients with colorectal cancer that has spread to other organs and whose disease has worsened after treatment with irinotecan.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
| Phase 3 |
Study Design
Study Type:
Interventional
Actual Enrollment
:
855 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Double
Primary Purpose:
Treatment
Official Title:
A Randomized, Double-blind, Placebo-controlled, Phase III Study of Oxaliplatin/5-fluorouracil/Leucovorin With PTK787/ZK 222584 or Placebo in Patients With Previously Treated Metastatic Adenocarcinoma of the Colon or Rectum
Study Start Date
:
Jan 1, 2003
Actual Primary Completion Date
:
Jan 1, 2007
Actual Study Completion Date
:
Jan 1, 2007
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: 1 Oxaliplatin/5-FU/LV and PTK787/ZK 222584 |
Drug: Vatalanib
Other Names:
|
| Placebo Comparator: 2 Oxaliplatin/5-FU/LV and placebo |
Drug: Vatalanib
Other Names:
|
Outcome Measures
Primary Outcome Measures
- Overall survival [throughout duration of study]
Secondary Outcome Measures
- Progression free survival [throughout duration of study]
- Time to progression [throughout duration of study]
- Time to treatment failure [throughout duration of study]
- Tumor response rate [throughout duration of study]
- Tolerability and safety profile [throughout duration of study]
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion criteria
-
Confirmed adenocarcinoma of the colon or rectum in patients with metastatic disease
-
One prior chemotherapy regimen with irinotecan and 5FU
-
Evidence of progressive disease within 6 months after last dose of irinotecan
-
WHO Performance Status of 0, 1, or 2
-
Measurable tumors
-
Adequate hematologic status, liver and kidney function
-
Life expectancy greater than 12 weeks
-
Written informed consent obtained
Exclusion criteria
-
History or presence of central nervous system disease
-
Patients with a history of another primary cancer within 5 years
-
Prior chemotherapy within 3 weeks before entry to study
-
Major surgery within 4 weeks or minor surgery within 2 weeks before entry to study
-
Investigational drugs within 4 weeks before entry to study
-
Prior therapy with oxaliplatin
-
Peripheral neuropathy with functional impairment
-
Female patients who are pregnant or breast feeding
-
Any severe or uncontrolled medical condition which could prevent participation in study
-
Chronic kidney disease
-
Acute or chronic liver disease
-
Patients taking Coumadin
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Comprehensive Cancer Institute | Huntsville | Alabama | United States | 35801 |
| 2 | Alaska Oncology and Hematology | Anchorage | Alaska | United States | 99508 |
| 3 | Arizona Clinical Research Center | Tucson | Arizona | United States | 85712 |
| 4 | Northeast Arkansas Clinic | Jonesboro | Arkansas | United States | 72401 |
| 5 | Arkansas Cancer Research Center | Little Rock | Arkansas | United States | 72205 |
| 6 | Little Rock Hematology & Oncology | Little Rock | Arkansas | United States | 72205 |
| 7 | Highlands Oncology Group | Springdale | Arkansas | United States | 72764 |
| 8 | Comprehensive Blood and Cancer Center | Bakersfield | California | United States | 93309 |
| 9 | Providence St. Joseph Medical Center | Burbank | California | United States | 91505 |
| 10 | Compassionate Cancer Care Medical Group, Inc. | Fountain Valley | California | United States | 92708 |
| 11 | California Oncology of the Central Valley | Fresno | California | United States | 93710 |
| 12 | Virginia K. Crosson Cancer Center | Fullerton | California | United States | 92835 |
| 13 | Glendale Adventist Medical Center | Glendale | California | United States | 91206 |
| 14 | Scripps Green Hospital | La Jolla | California | United States | 92037 |
| 15 | Wilshire Oncology Medical Group | La Verne | California | United States | 91767 |
| 16 | Pacific Shores Medical Group | Long Beach | California | United States | 90813 |
| 17 | USC Norris Cancer Center | Los Angeles | California | United States | 90033 |
| 18 | Synergy Hematology-Oncology Medical Associates | Los Angeles | California | United States | 90036 |
| 19 | Novartis Investigative Site | Los Angeles | California | United States | 90095 |
| 20 | UCLA School of Medicine | Los Angeles | California | United States | 90095 |
| 21 | Eddie Hong-Lung Hu, M.D. | Monterey Park | California | United States | 91754 |
| 22 | North Valley Hematology/Oncology Medical Group | Northridge | California | United States | 91328 |
| 23 | Medical Oncology Care Associates | Orange | California | United States | 92868 |
| 24 | Ventura County Hematology-Oncology Specialists | Oxnard | California | United States | 93030 |
| 25 | Sierra View District Hospital | Porterville | California | United States | 93257 |
| 26 | Cancer Care Associates Medical Group, Inc. | Redondo Beach | California | United States | 90277 |
| 27 | Santa Clara Valley Medical Center | San Jose | California | United States | 95128 |
| 28 | Sansum Santa Barbara Foundation Medical Clinic | Santa Barbara | California | United States | 93105 |
| 29 | Santa Barbara Hematology Oncology Medical Group, Inc. | Santa Barbara | California | United States | 93105 |
| 30 | San Diego Cancer Center Medical Group | Vista | California | United States | 92083 |
| 31 | Mile High Oncology | Denver | Colorado | United States | 80210 |
| 32 | Rocky Mountain Cancer Center | Denver | Colorado | United States | 80220 |
| 33 | Manchester Hematology/Oncology Assoc. | Manchester | Connecticut | United States | 06040 |
| 34 | Washington Oncology/Hematology Center | Washington | District of Columbia | United States | 20037 |
| 35 | The Center for Hematology and Oncology | Boca Raton | Florida | United States | 33486 |
| 36 | Florida Cancer Specialists | Ft. Myers | Florida | United States | 33901 |
| 37 | Hematology Oncology Associates | Lake Worth | Florida | United States | 33461-4710 |
| 38 | University of Miami School of Medicine | Miami | Florida | United States | 33136 |
| 39 | Oncology/Hematology Group of South Florida | Miami | Florida | United States | 33176 |
| 40 | Hematology Oncology Associates of Treasure Coast | Port St. Lucie | Florida | United States | 34952 |
| 41 | Florida Medical Clinic | Zephyrhills | Florida | United States | 33542 |
| 42 | Atlanta Cancer Care | Marietta | Georgia | United States | 30060 |
| 43 | Office of Research | Savannah | Georgia | United States | 31405 |
| 44 | Coastal Hematology & Oncology | Savannah | Georgia | United States | 31406 |
| 45 | Lewis Hall Singletary Oncology Center | Thomasville | Georgia | United States | 31792 |
| 46 | North Idaho Cancer Center | Coeur d'Alene | Idaho | United States | 83814 |
| 47 | University of Chicago medical Center, Hematology/Oncology | Chicago | Illinois | United States | 60637 |
| 48 | Oncology Hematology Associates of Central Illinois, PC | Peoria | Illinois | United States | 61602 |
| 49 | Northshore Cancer Research Association | Skokie | Illinois | United States | 60076 |
| 50 | Midwest Cancer Research Group | Skokie | Illinois | United States | 60077 |
| 51 | Fort Wayne Medical Oncology & Hematology, Inc. | Fort Wayne | Indiana | United States | 46815 |
| 52 | Munster Community Hospital | Munster | Indiana | United States | 46321 |
| 53 | Cotton O'Neil Oncology Clinic | Topeka | Kansas | United States | 66606 |
| 54 | Vijay Raghaven, M.D. | Louisville | Kentucky | United States | 40215 |
| 55 | Owensboro Medical Health System | Owensboro | Kentucky | United States | 42303 |
| 56 | Cabrini Center for Cancer Care | Alexandria | Louisiana | United States | 71301 |
| 57 | LSU Medical Center | New Orleans | Louisiana | United States | 70112 |
| 58 | Tulane University Health Sciences Center | New Orleans | Louisiana | United States | 70112 |
| 59 | LSU Health Sciences Center | Shreveport | Louisiana | United States | 71130-3932 |
| 60 | Maine Center for Cancer Medicine & Blood Disorders | Scarborough | Maine | United States | 04074 |
| 61 | St. Agnes Healthcare | Baltimore | Maryland | United States | 21229-5299 |
| 62 | Franklin Square Hospital Center | Baltimore | Maryland | United States | 21237 |
| 63 | Kaiser Permanente | Rockville | Maryland | United States | 20850 |
| 64 | Fallon Clinic at Worcester Medical Center | Worcester | Massachusetts | United States | 01605 |
| 65 | University of Michigan | Ann Arbor | Michigan | United States | 48109-0934 |
| 66 | Spectrum Health -- Cook Research Dept. | Grand Rapids | Michigan | United States | 49503 |
| 67 | Providence Cancer Center | Southfield | Michigan | United States | 48075 |
| 68 | Oncology Care Associates, PLLC | St. Joseph | Michigan | United States | 49085 |
| 69 | Minnesota CGOP | Minneapolis | Minnesota | United States | 55407 |
| 70 | Heartland Hematology | Kansas City | Missouri | United States | 64118 |
| 71 | Missouri Cancer Care, PC | St. Charles | Missouri | United States | 63301 |
| 72 | Saint Louis University | St. Louis | Missouri | United States | 63110 |
| 73 | Washington University School of Medicine | St. Louis | Missouri | United States | 63110 |
| 74 | Missouri Baptist Cancer Center | St. Louis | Missouri | United States | 63131 |
| 75 | Arch Medical Services Incorporated | St. Louis | Missouri | United States | 63141 |
| 76 | North Central Montana Professional Building | Great Falls | Montana | United States | 59405 |
| 77 | Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | United States | 89109 |
| 78 | Nevada Cancer Center | Las Vegas | Nevada | United States | 89109 |
| 79 | NH Oncology-Hematology, PA | Hooksett | New Hampshire | United States | 03106 |
| 80 | Center for Cancer and Hematologic Disease | Cherry Hill | New Jersey | United States | 08003 |
| 81 | St. Barnabas Cancer Center | Livingston | New Jersey | United States | 07039 |
| 82 | Hematology Oncology Associates of Northern New Jersey | Morristown | New Jersey | United States | 07960 |
| 83 | Cooper Cancer Center | Voorhees | New Jersey | United States | 08043 |
| 84 | Hematology/Oncology Associates | Albuquerque | New Mexico | United States | 87102 |
| 85 | New Mexico Oncology/Hematology | Albuquerque | New Mexico | United States | 87109 |
| 86 | Roswell Park Cancer Institute | Buffalo | New York | United States | 14263 |
| 87 | Hematology/Oncology Associates of Central NY | East Syracuse | New York | United States | 13057 |
| 88 | Queens Medical Associates, PC | Fresh Meadows | New York | United States | 11365 |
| 89 | Charles R. Wood Cancer Center | Glens Falls | New York | United States | 12801 |
| 90 | North Shore University Hospital | Manhasset | New York | United States | 11030 |
| 91 | St. Vincent's Catholic Medical Centers of New York | New York | New York | United States | 10011 |
| 92 | Hematology-Oncology Associates of Rockland | Nyack | New York | United States | 10956 |
| 93 | Pluta Cancer Center | Rochester | New York | United States | 14623 |
| 94 | James P. Wilmot Cancer Center | Rochester | New York | United States | 14642 |
| 95 | Lineberger Comprehensive Cancer Center | Chapel Hill | North Carolina | United States | 27599-7305 |
| 96 | Carolinas Hematology/Oncology Associates | Charlotte | North Carolina | United States | 28203 |
| 97 | Nashat Gabrail, M.D. | Canton | Ohio | United States | 44718 |
| 98 | Case Western Reserve University | Cleveland | Ohio | United States | 44106-5056 |
| 99 | The Cleveland Clinic Foundation | Cleveland | Ohio | United States | 44195 |
| 100 | Columbus CCOP | Columbus | Ohio | United States | 43206 |
| 101 | The University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | United States | 73104 |
| 102 | Oklahoma Oncology, Inc. | Tulsa | Oklahoma | United States | 74104 |
| 103 | Consultants in Medical Oncology & Hematology | Drexel Hill | Pennsylvania | United States | 19026 |
| 104 | Hematology & Oncology Associates of NE PA | Dunmore | Pennsylvania | United States | 18512 |
| 105 | Penn State Hershey Medical Center | Hershey | Pennsylvania | United States | 17033-0850 |
| 106 | Monongahela Valley Hospital | Monongahela | Pennsylvania | United States | 15063 |
| 107 | Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | United States | 19107 |
| 108 | Allegheny General Hospital | Pittsburgh | Pennsylvania | United States | 15212-4772 |
| 109 | UPMC Cancer Pavillion | Pittsburgh | Pennsylvania | United States | 15232 |
| 110 | Charleston Cancer Center | Charleston | South Carolina | United States | 29406 |
| 111 | South Carolina Oncology Associates | Columbia | South Carolina | United States | 29201 |
| 112 | WJB Dom VAMC | Columbia | South Carolina | United States | 29209 |
| 113 | Cancer Center of the Carolinas | Greenville | South Carolina | United States | 29615 |
| 114 | Spartanburg Regional Medical Center | Spartanburg | South Carolina | United States | 29303 |
| 115 | Erlanger Health System | Chattanooga | Tennessee | United States | 37403 |
| 116 | Clarksville Regional Hematology/Oncology | Clarksville | Tennessee | United States | 37043 |
| 117 | The Jones Clinic | Germantown | Tennessee | United States | 38138 |
| 118 | Baptist Regional Cancer Center | Knoxville | Tennessee | United States | 37920 |
| 119 | University of Tennessee Cancer Institute | Memphis | Tennessee | United States | 38104 |
| 120 | Sarah Cannon Cancer Center | Nashville | Tennessee | United States | 37203 |
| 121 | Meharry Medical College | Nashville | Tennessee | United States | 37208 |
| 122 | Vanderbilt-Ingram Cancer Center | Nashville | Tennessee | United States | 37212 |
| 123 | Vanderbilt University School of Medicine | Nashville | Tennessee | United States | 37232-6307 |
| 124 | Harrington Cancer Center | Amarillo | Texas | United States | 79106 |
| 125 | Center for Oncology Research & Treatment | Dallas | Texas | United States | 75230 |
| 126 | Clinical Hematology & Oncology | Dallas | Texas | United States | 75235 |
| 127 | Oncology Consultants | Houston | Texas | United States | 77024 |
| 128 | H. Alejandro Preti, M.D., PA | Houston | Texas | United States | 77030 |
| 129 | M.D. Anderson Cancer Center | Houston | Texas | United States | 77030 |
| 130 | South Texas Oncology & Hematology | San Antonio | Texas | United States | 78207 |
| 131 | Scott & White Hospital | Temple | Texas | United States | 76508 |
| 132 | Northern Utah Cancer Associates | Ogden | Utah | United States | 84403 |
| 133 | Southwestern Vermont Health Care | Bennington | Vermont | United States | 05201 |
| 134 | Virginia Oncology Associates | Norfolk | Virginia | United States | 23502 |
| 135 | Cancer Treatment Centers of America in Hampton Roads | Portsmouth | Virginia | United States | 23704 |
| 136 | Western Washington Clinic | Everett | Washington | United States | 98201 |
| 137 | Cascade Cancer Center | Kirkland | Washington | United States | 98034 |
| 138 | Rainier Oncology | Puyallup | Washington | United States | 98372 |
| 139 | Virginia Mason Medical Center | Seattle | Washington | United States | 98101 |
| 140 | Swedish Cancer Institute | Seattle | Washington | United States | 98104 |
| 141 | West Virginia University Health Sciences Center | Morgantown | West Virginia | United States | 26506 |
| 142 | Waukesha Memorial Hospital | Waukesha | Wisconsin | United States | 53188 |
| 143 | Kettle Morain Oncology | West Bend | Wisconsin | United States | 53095 |
| 144 | Novartis Investigative Site | Frankston | Australia | VIC | |
| 145 | Novartis Investigative Site | Woodville South | Australia | SA | |
| 146 | Novartis Investigative Site | St. Veit an der Glan | Austria | 9300 | |
| 147 | Novartis Investigative Site | Antwerpen | Belgium | 2020 | |
| 148 | Novartis Investigative Site | Brasschaat | Belgium | 2930 | |
| 149 | Novartis Investigative Site | Bruxelles | Belgium | 1200 | |
| 150 | Novartis Investigative Site | Leuven | Belgium | ||
| 151 | Novartis Investigative Site | Liège | Belgium | 4000 | |
| 152 | Novartis Investigative Site | Wilrijk | Belgium | 2610 | |
| 153 | Novartis Investigative Site | Porto Alegre RS | Brazil | CEP 90 610-000 | |
| 154 | Novartis Investigative Site | Salvador - Ba | Brazil | 41825-010 | |
| 155 | Novartis Investigative Site | Salvador, Bahia | Brazil | CEP 40170-070 | |
| 156 | Novartis Investigative Site | Sao Paulo | Brazil | 01236-000 | |
| 157 | Novartis Investigative Site | Sao Paulo | Brazil | 01308-050 | |
| 158 | Novartis Investigative Site | Sao Paulo | Brazil | 01406-100 | |
| 159 | Novartis Investigative Site | Calgary | Alberta | Canada | T2N4N2 |
| 160 | Novartis Investigative Site | Penticton | British Columbia | Canada | V2A3G6 |
| 161 | Novartis Investigative Site | Winnepeg | Manitoba | Canada | R2H 2A6 |
| 162 | Novartis Investigative Site | Sydney | Nova Scotia | Canada | B1P 1P3 |
| 163 | Novartis Investigative Site | Barrie | Ontario | Canada | L4M6M2 |
| 164 | Novartis Investigative Site | Brampton | Ontario | Canada | L6W 2Z8 |
| 165 | Novartis Investigative Site | Hamilton | Ontario | Canada | L8V 5C2 |
| 166 | Novartis Investigative Site | Ottawa | Ontario | Canada | K1H 1C4 |
| 167 | Novartis Investigative Site | Sainte-Foy | Ontario | Canada | G1V 4G5 |
| 168 | Novartis Investigative Site | St. Catharines | Ontario | Canada | L2R5K3 |
| 169 | Novartis Investigative Site | Sudbury | Ontario | Canada | P3E 5J1 |
| 170 | Novartis Investigative Site | Thunder Bay | Ontario | Canada | P7A 7T1 |
| 171 | Toronto | Ontario | Canada | M4C 3E7 | |
| 172 | Novartis Investigative Site | Toronto | Ontario | Canada | M4N3M5 |
| 173 | Novartis Investigative Site | Toronto | Ontario | Canada | M5G1X5 |
| 174 | Novartis Investigative Site | Toronto | Ontario | Canada | |
| 175 | Novartis Investigative Site | Windsor | Ontario | Canada | N8W 2X3 |
| 176 | Novartis Investigative Site | Greenfield Park | Quebec | Canada | J4V2H1 |
| 177 | Novartis Investigative Site | Montreal | Quebec | Canada | H2L 4M1 |
| 178 | Novartis Investigative Site | Montreal | Quebec | Canada | H2W 1S6 |
| 179 | Novartis Investigative Site | Saskatoon | Saskatchewan | Canada | S7N4H4 |
| 180 | Novartis Investigative Site | Avignon | France | 84000 | |
| 181 | Novartis Investigative Site | Boulogne Cedex | France | 92104 | |
| 182 | Novartis Investigative Site | Lille cedex | France | 59020 | |
| 183 | Novartis Investigative Site | Marseille cedex 05 | France | 13385 | |
| 184 | Novartis Investigative Site | Montpellier cedex 5 | France | 34298 | |
| 185 | Novartis Investigative Site | Nice cedex 2 | France | 6189 | |
| 186 | Novartis Investigative Site | Rennes cedex | France | 35042 | |
| 187 | Novartis Investigative Site | Saint Herblain | France | 44805 | |
| 188 | Novartis Investigative Site | Strasbourg | France | 67000 | |
| 189 | Novartis Investigative Site | Toulouse cedex | France | 31052 | |
| 190 | Novartis Investigative Site | Augsburg | Germany | 86150 | |
| 191 | Novartis Investigative Site | Berlin | Germany | 13585 | |
| 192 | Novartis Investigative Site | Berlin | Germany | 14195 | |
| 193 | Novartis Investigative Site | Bielefeld | Germany | 33604 | |
| 194 | Novartis Investigative Site | Braunschweig | Germany | 38100 | |
| 195 | Novartis Investigative Site | Dessau | Germany | 6822 | |
| 196 | Novartis Investigative Site | Dresden | Germany | 1307 | |
| 197 | Novartis Investigative Site | Essen | Germany | 45122 | |
| 198 | Novartis Investigative Site | Essen | Germany | 45136 | |
| 199 | Novartis Investigative Site | Frankfurt | Germany | 60488 | |
| 200 | Novartis Investigative Site | Hamburg | Germany | 22087 | |
| 201 | Novartis Investigative Site | Hannover | Germany | 30625 | |
| 202 | Novartis Investigative Site | Köln | Germany | 50677 | |
| 203 | Novartis Investigative Site | Magdeburg | Germany | 39002 | |
| 204 | Novartis Investigative Site | München | Germany | 81675 | |
| 205 | Novartis Investigative Site | Neumünster | Germany | 24534 | |
| 206 | Novartis Investigative Site | Trier | Germany | 54290 | |
| 207 | Novartis Investigative Site | Ulm | Germany | 89081 | |
| 208 | Novartis Investigative Site | Wiesbaden | Germany | 65199 | |
| 209 | Novartis Investigative Site | ChaiWan | Hong Kong | ||
| 210 | Novartis Investigative Site | Ancona | Italy | 60020 | |
| 211 | Novartis Investigative Site | Bergamo | Italy | 24128 | |
| 212 | Novartis Investigative Site | Brescia | Italy | 25124 | |
| 213 | Novartis Investigative Site | Cremona | Italy | 26100 | |
| 214 | Novartis Investigative Site | Genova | Italy | 16132 | |
| 215 | Novartis Investigative Site | Livorno | Italy | 57100 | |
| 216 | Novartis Investigative Site | Milano | Italy | 20100 | |
| 217 | Novartis Investigative Site | Milano | Italy | 20141 | |
| 218 | Novartis Investigative Site | Reggio Emilia | Italy | 42100 | |
| 219 | Novartis Investigative Site | Roma | Italy | 135 | |
| 220 | Novartis Investigative Site | Roma | Italy | 149 | |
| 221 | Novartis Investigative Site | Rozzano | Italy | 20089 | |
| 222 | Novartis Investigative Site | Auckland | New Zealand | ||
| 223 | Novartis Investigative Site | Christchurch | New Zealand | ||
| 224 | Novartis Investigative Site | Wellington | New Zealand | ||
| 225 | Novartis Investigative Site | Coimbra | Portugal | 3000-076 | |
| 226 | Novartis Investigative Site | Lisboa | Portugal | 1649-035 | |
| 227 | Novartis Investigative Site | Bratislava | Slovakia | 81250 | |
| 228 | Novartis Investigative Site | Cordoba | Spain | 14004 | |
| 229 | Novartis Investigative Site | Elche | Spain | 3202 | |
| 230 | Novartis Investigative Site | Madrid | Spain | 28007 | |
| 231 | Novartis Investigative Site | Madrid | Spain | 28033 | |
| 232 | Novartis Investigative Site | Madrid | Spain | 28040 | |
| 233 | Novartis Investigative Site | Madrid | Spain | 8907 | |
| 234 | Novartis Investigative Site | Malaga | Spain | 29010 | |
| 235 | Novartis Investigative Site | Zaragoza | Spain | 5009 | |
| 236 | Novartis Investigative Site | Goteborg | Sweden | SE-416 85 | |
| 237 | Novartis Investigative Site | Stockholm | Sweden | SE-118 83 | |
| 238 | Novartis Investigative Site | Bern | Switzerland | 3010 | |
| 239 | Novartis Investigative Site | Thun | Switzerland | 3600 | |
| 240 | Novartis Investigative Site | Changhua | Taiwan | ||
| 241 | Novartis Investigative Site | Kaohsiung | Taiwan | ||
| 242 | Novartis Investigative Site | Keelung | Taiwan | ||
| 243 | Novartis Investigative Site | Taichung | Taiwan | ||
| 244 | Novartis Investigative Site | Tainan | Taiwan | ||
| 245 | Novartis Investigative Site | Taipei | Taiwan | ||
| 246 | Novartis Investigative Site | Tao-Yuan | Taiwan | ||
| 247 | Novartis Investigative Site | Belfast | United Kingdom | BT9 7AB | |
| 248 | Novartis Investigative Site | Birmingham | United Kingdom | B15 2TH | |
| 249 | Novartis Investigative Site | Cardiff | United Kingdom | CF147TB | |
| 250 | Novartis Investigative Site | London | United Kingdom | W1T 3AA | |
| 251 | Novartis Investigative Site | Manchester | United Kingdom | M20 4BX |
Sponsors and Collaborators
- Novartis Pharmaceuticals
- Bayer
Investigators
- Study Chair: Novartis/Schering AG, Germany, Novartis / Schering AG Germany
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
Novartis Pharmaceuticals
ClinicalTrials.gov Identifier:
NCT00056446
Other Study ID Numbers:
- CPTK787 0133/304946
- NCT00068679
First Posted:
Mar 14, 2003
Last Update Posted:
Mar 6, 2017
Last Verified:
Jan 1, 2016
Keywords provided by Novartis Pharmaceuticals
Additional relevant MeSH terms: