CAPACITY: Cognitive Auditory Evoked Potential After Cardiac Arrest: Interest of Mismatch negativiTY
Study Details
Study Description
Brief Summary
Determination of vital and functional outcome in comatose survivors after cardiac arrest is principally based on the identification of predictors of non-awakening, using by clinical, biological and electrophysiological tools. In patients without presence of non-awakening predictors, it would be of interest to identify predictive criteria of awakening. The presence of mismatch negativity during the cortical auditory-evoked potential could contribute to further progress in neurological prognostication of these patients. However, at this time, its prognostic value has been insufficiently studied and the optimal time of realization remains unknown.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
We hypothesized that the presence of the mismatch negativity during the cortical auditory-evoked potential would predict a favorable outcome in comatose survivors after cardiac arrest.The main objective is to determine the capacity of the presence of the mismatch negativity during the cortical auditory-evoked potential to predict a 1-year favorable outcome in comatose survivors after cardiac arrest
The secondary objectives are:
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To assess the capacity of the presence of the mismatch negativity during the cortical auditory-evoked potential to predict awakening during the hospitalisation stay.
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To determine the optimal time of realization of the cortical auditory-evoked potential
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To determine the capacity of the presence of the mismatch negativity during the cortical auditory-evoked potential to predict ICU discharge and/or hospital discharge favorable outcome in comatose survivors after cardiac arrest
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To determine the impact of the sedations drugs during the hypothermia phase, and during the ICU stay The main judgement criterion is the 1-year CPC score (CPC 1 to 2 as a favorable outcome)
Study design : Prospective, multicentre, interventional study. Decision making to withdrawal of life support will be strictly codified according current knowledge and standardized among the participating centres. In the absence of predictors of non-awakening, care will be continued without limitation. The design of the study will focus on the determination of the capacity of the presence of the mismatch negativity during the cortical auditory-evoked potential to predict awakening. Cortical auditory-evoked potential will be performed bedside in the ICU by qualified neurophysiologists. Results of cortical auditory-evoked potential will remain blinded of bedside clinicians providing care for the patients. Awakening will be assessed bedside daily. CPC score will be evaluated at discharge of the ICU, of the hospital, at 3 months and 1 year by an independent evaluator, blinded of the results of the cortical auditory-evoked potentials.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Other: 1:Mismatch negativity Presence of the mismatch negativity during the cortical auditory-evoked potential would predict a favorable outcome in comatose survivors after cardiac arrest. |
Procedure: Auditory-evoked potentials
cortical auditory-evoked potentials are performed to all included patients at inclusion, at day 5 to day 10, day without sedation (up to 1 year), day of awakening
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Outcome Measures
Primary Outcome Measures
- CPC score of 1 or 2 (favorable outcome) [1 year]
1-year CPC score of 1 or 2 (favorable outcome)
Secondary Outcome Measures
- Awakeness [up to 1 year]
Awakeness during the hospitalisation stay
- Time of realization of the cortical auditory-evoked potential [up to 1 year]
the optimal time of realization of the cortical auditory-evoked potential
- CPC score of 1 or 2 at ICU discharge [up to 1 year]
the CPC score of 1 or 2 at ICU and at hospital discharge
- Length of mechanical ventilation, ICU stay, hospital stay and vital status at discharge [up to 1 year]
impact of the sedations drugs during the ICU stay impact of therapeutic hypothermia
- CPC score of 1 or 2 at hospital discharge [up to 1 year]
the CPC score of 1 or 2 at hospital discharge
Eligibility Criteria
Criteria
Inclusion Criteria:
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Adults (age ≥ 18 years)
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hospitalized in the intensive care unit in the aftermath of a intra-or extra-hospital cardiac arrest
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alive but remaining comatose between the 2nd day and the 5th day after cardiopulmonary arrest
Exclusion Criteria:
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moribund patients (treatment limitations or the life expectancy of the inclusion estimated at less than 1 year)
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patient awake at day of potential inclusion
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brain death state
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failure to realize the cortical
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patient whose hearing loss is known
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Lariboisière Hospital - Medical and toxicology unit | Paris | France | 75010 | |
| 2 | Dr Stéphane LEGRIEL - Intensive Care Unit | Versailles | France | 78150 |
Sponsors and Collaborators
- Assistance Publique - Hôpitaux de Paris
Investigators
- Principal Investigator: Stephane LEGRIEL, MD, Versailles Hospital - 78150 Le Chesnay - France
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- P091118
- 2010-A01378-31