Effects of Dexamethasone on Common Bile Duct Cannulation Time
Study Details
Study Description
Brief Summary
The main aim of this clinical trial is to evaluate the effects of dexamethasone on common bile duct cannulation time during endoscopic retrograde cholangiopancreatography (ERCP) in patients with biliary pathologies. The study will also study the effects of dexamethasone on total procedure time and total fluoroscopy time during ERCP.
Participants will be divided into two groups, treatment group and placebo group. Patients in treatment group will receive dexamethasone and those in placebo group will be given normal saline before undergoing ERCP. The results in both groups will be compared to determine the effects of dexamethasone.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Dexa Arm Experimental arm patients will be receiving 2 ml (4mg) of dexamenthasone prior to undergoing ERCP. |
Drug: Dexamethasone 4mg
An injection of 4mg of dexamethasone will be given to patients approximately 2 to 4 hours prior to the procedure of ERCP.
Other Names:
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| Placebo Comparator: NS Arm Placebo arm patients will be receiving 2 ml of normal saline prior to undergoing ERCP. |
Drug: Dexamethasone 4mg
An injection of 4mg of dexamethasone will be given to patients approximately 2 to 4 hours prior to the procedure of ERCP.
Other Names:
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Outcome Measures
Primary Outcome Measures
- Shortening of CBD cannulation time [CBD cannulation time will be calculated from the start of the procedure (0 minutes) till complete CBD cannulation has been achieved through catheter and confirmed by fluoroscopy or procedure abandoned if unsuccessful cannulation by 30 minutes.]
To determine the effects of dexamethasone on shortening of CBD cannulation time
Eligibility Criteria
Criteria
Inclusion Criteria:
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Age: 18 years or above
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Both genders, male and female patients
Exclusion Criteria:
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Age younger than 18 years or below
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Pregnant females
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Pre existing stent in CBD or pancreatic duct
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Previous history of ERCP
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Patients with billroth II surgery
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Anatomical abnormalities
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Lack of competence in patients
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Roux en Y gastric bypass
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Patients with contra indications for steroids like DM
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Gujranwala medical college District Headquarters Hospital, Gujranwala
Investigators
- Study Chair: Najam us Sehar Saeed, FCPS-Gastro, GMC-DHQ Hospital, Gujwanala, Pakistan
Study Documents (Full-Text)
None provided.More Information
Publications
- Allescher HD, Neuhaus H, Hagenmuller F, Classen M. Effect of N-butylscopolamine on sphincter of Oddi motility in patients during routine ERCP--a manometric study. Endoscopy. 1990 Jul;22(4):160-3. doi: 10.1055/s-2007-1012829.
- Devereaux BM, Lehman GA, Fein S, Phillips S, Fogel EL, Sherman S. Facilitation of pancreatic duct cannulation using a new synthetic porcine secretin. Am J Gastroenterol. 2002 Sep;97(9):2279-81. doi: 10.1111/j.1572-0241.2002.05982.x.
- Sherman S, Lehman GA. Endoscopic retrograde cholangiopancreatography, endoscopic sphincterotomy and stone removal, and endoscopic biliary and pancreatic drainage. In: Yamada T, et al. (eds.) Text book of gastroenterology. 3rd edn. Philadelphia: Lippincott, Williams & Wilkins ; 1999: 2718 - 2746
- Sola-Bonada N, de Andres-Lazaro AM, Roca-Massa M, Bordas-Alsina JM, Codina-Jane C, Ribas-Sala J. [1.6% peppermint oil solution as intestinal spasmolytic in retrograde endoscopic cholangiopancreatography]. Farm Hosp. 2012 Jul-Aug;36(4):256-60. doi: 10.1016/j.farma.2011.08.003. Epub 2011 Dec 1. Spanish.
- Wehrmann T, Schmitt T, Stergiou N, Caspary WF, Seifert H. Topical application of nitrates onto the papilla of Vater: manometric and clinical results. Endoscopy. 2001 Apr;33(4):323-8. doi: 10.1055/s-2001-13687.
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