Community Acquired Pneumonia in Older Adults
Study Details
Study Description
Brief Summary
This study will utilize diagnostic imaging to estimate the prevalence of aspiration in older adults with suspected community-acquired bacterial pneumonia (CABP). 150 participants over the age of 60 diagnosed with pneumonia in the University of Wisconsin (UW) Emergency Department will be recruited into this study.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Pneumonia is the most common infectious cause of mortality in older adults. Standard practice for older adults with pneumonia involves hospitalization and antibiotics. However, recent studies suggest that a significant portion of suspected community-acquired bacterial pneumonia (CABP) cases may actually be due to distinct, dysphagia-related aspiration syndromes (e.g. aspiration pneumonia, pneumonitis).
The proposed study will utilize diagnostic imaging to generate a prevalence estimate for aspiration in older adults diagnosed with pneumonia. The following aim will be completed:
Determine the prevalence of aspiration among older adults with pneumonia and rates of recurrent pneumonia in this population.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Pneumonia Participants will be over the age of 65 and diagnosed with pneumonia in the UW Emergency Department. |
Diagnostic Test: Videofluoroscopic Swallowing Study
Participants swallow different barium containing liquid and food boluses types that are captured on fluoroscopic imaging in real time.
Diagnostic Test: Nuclear medicine pulmonary aspiration study
Participants will be administered radiotracer (Tc-99m-Sulfur Colloid) orally and static images of the chest will then be obtained at specified intervals over the next 2 hours to determine location of the radiotracer.
Diagnostic Test: TOR-BSST and 3 oz Water Swallow
The research specialist will conduct ten 1 tsp water swallows, one cup sip of water and a 3 ounce water swallow test with the patient. After each swallow, the participant is asked to say "ah" so that their voice quality can be assessed.
Other Names:
Diagnostic Test: Sputum Culture
Patients will have sputum collected during stay
|
Outcome Measures
Primary Outcome Measures
- Number of Participants with Aspiration [Any point during follow up within 6 months of index visit]
As defined by imaging studies.
Secondary Outcome Measures
- Recurrent pneumonia [Any point during follow up within 6 months of index visit]
As assessed on medical chart review
Eligibility Criteria
Criteria
Inclusion Criteria:
-
60 years of age or older
-
Patient has pneumonia or is being treated for pneumonia as defined by abnormal chest imaging or receiving antibiotics for a chest infection or the provider thinks the patient has pneumonia or is planning to treat the patient for pneumonia.
-
Patient is clinically stable and able to safely drink water, per the emergency department provider
-
Ability to provide consent or the presence of a legally authorized representative (LAR) who can consent on behalf of the patient
Exclusion Criteria:
-
Prisoner
-
Non-English speaking
-
Allergy to barium
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of Wisconsin | Madison | Wisconsin | United States | 53705 |
Sponsors and Collaborators
- University of Wisconsin, Madison
Investigators
- Principal Investigator: Michael Pulia, MD, MS, University of Wisconsin, Madison
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2020-1121
- Protocol Version 0.11
- A534100
- SMPH/EMERG MED
- A534255