Comparison of 18F-fluorodeoxyglucose Positron Emission Tomography and Coronary Computed Tomography in Assessing Vascular Inflammation

Sponsor

Korea University (Other)

Overall Status

Completed

CT.gov ID

NCT01100671

Collaborator

(none)

120

Enrollment

Location

Duration (Months)

7.5

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.cardiac multidetector-row CT can provide measurements of coronary artery calcium (CAC), the degree of stenosis, and the characteristics of plaque including its potential vulnerability. Therefore, the purpose of the investigators study is to compare the usefulness of 18 FDG-PET and MDCT in assessing the vascular inflammatory status and vulnerability.

Condition or Disease	Intervention/Treatment	Phase
Atherosclerosis	Other: Cross section study

Study Design

Study Type:

Observational

Actual Enrollment :

120 participants

Observational Model:

Cohort

Time Perspective:

Cross-Sectional

Official Title:

Comparison of 18F-fluorodeoxyglucose Positron Emission Tomography and Coronary Computed Tomography in Assessing Vascular Inflammation in Healthy Population

Study Start Date :

Apr 1, 2010

Actual Primary Completion Date :

Jul 1, 2011

Actual Study Completion Date :

Aug 1, 2011

Arms and Interventions

Arm	Intervention/Treatment
Healthy patients	Other: Cross section study This is not intervention study. The purpose of the study is to examine the relationship of vascular inflammation assessed by 18FDG-PET and MDCT at the cross section setting

Arm

Intervention/Treatment

Healthy patients

Other: Cross section study

This is not intervention study. The purpose of the study is to examine the relationship of vascular inflammation assessed by 18FDG-PET and MDCT at the cross section setting

Outcome Measures

Primary Outcome Measures

Correlation between vascular inflammatory status measured by 18FDG PET and MDCT [20weeks]

Secondary Outcome Measures

Comparison the correlation with inflammatory marker and vascular inflammatory status assessed by 18FDG PET and MDCT [20 weeks]

Eligibility Criteria

Criteria

Ages Eligible for Study:

20 Years to 80 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Healthy patients for visiting routine medical check in our clinic

Exclusion Criteria:

History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization)
Diabetes
Stage 2 hypertension (resting blood pressure, ≥ 160/100 mmHg)
Malignancy
Severe renal or hepatic disease
Subjects taking medications that might affect inflammation such as NSIAD and statin