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Comparison of Anterior Chamber Paracentesis and Conventional Mannitol Infusion in Patients With Primary Acute Angle-closure Glaucoma

Sponsor
Taipei Medical University WanFang Hospital (Other)
Overall Status
Completed
CT.gov ID
NCT01266343
Collaborator
(none)
60
Enrollment
1
Location
35
Duration (Months)
1.7
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The investigators wanted to reported the results of immediate anterior chamber paracentesis (ACP), compared to Mannitol infusion, in patients with acute primary angle-closure glaucoma (PACG). In this study, the investigators first divided patients into three sub-groups according to their initial intraocular pressure (IOP) for analyzing the differences of IOP control, severity of corneal edema, waiting time for laser peripheral iridotomy (LPI), and visual outcome between ACP and Mannitol infusion.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    The investigators demonstrated that ACP could be first considered in patients with initial IOP between 45 to 60 mmHg because it provided better visual outcome than Mannitol infusion through the rapid stabilization of the anterior segment, which was achieved by rapid IOP control, better corneal edema regression, shortening waiting time for LPI. However, ACP should be considered in patients with the initial IOP of 60mmHg and higher only when Mannitol was contraindicated.

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    60 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Retrospective
    Official Title:
    Comparison of Anterior Chamber Paracentesis and Conventional Mannitol Infusion in Patients With Primary Acute Angle-closure Glaucoma
    Study Start Date :
    Jan 1, 2007
    Actual Study Completion Date :
    Dec 1, 2009

    Arms and Interventions

    Arm Intervention/Treatment
    Experimental Group
    Control Group

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      20 Years and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:

      • first attack of acute PACG;

      • initial presenting IOP was higher than 45 mmHg;

      • diagnosis confirmed by gonioscopic examination;

      • patients within 48 hours of symptom onset.

      Exclusion Criteria:

      • been incompletely followed up within 2 weeks;

      • been using anti-glaucomatous medication before ACP or Mannitol infusion;

      • previous intraocular surgeries on the same eye;

      • contraindication for Mannitol;

      • history of other vision-threatening ocular diseases.

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Taipei Medical University - WanFang Hospital Taipei Taiwan

      Sponsors and Collaborators

      • Taipei Medical University WanFang Hospital

      Investigators

      • Principal Investigator: Hui-Chun Ho, Taipei Medical University WanFang Hospital

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT01266343
      Other Study ID Numbers:
      • 99018
      First Posted:
      Dec 24, 2010
      Last Update Posted:
      Dec 24, 2010
      Last Verified:
      Dec 1, 2010
      Keywords provided by , ,
      Glaucoma
      anterior chamber paracentesis
      conventional Mannitol infusion
      Additional relevant MeSH terms:
      Glaucoma
      Glaucoma, Angle-Closure

      Study Results

      No Results Posted as of Dec 24, 2010