Comparison Between Different Doses of Steroids in COVID-19 Patients
Study Details
Study Description
Brief Summary
aim of this study is to compare between standard dose methyl prednisolone and mega dose methyl prednisolone as regards outcome reflected by mortality rate, percentage of mechanically ventilated patients and icu length of stay of covid 19 patients admitted in intensive care unit.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Detailed Description
Retrospective study for comparison between standard dose methyl prednisolone and mega dose methyl prednisolone as regards outcome reflected by mortality rate ,percentage of mechanically ventilated patients and icu length of stay of covid 19 patients admitted in intensive care unit.
Previous studies suggested that cytokine release syndrome could be involved in the pathophysiology of critical SARS.COV.2 resulting in death so early suppression of cytokine storm may be lifesaving in critical patients.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
group treated with standard dose methyl prednisolone patients with positive PCR and requiring oxygen therapy |
Other: observation for outcome of methylprednisolone dose
no intervention as it is retrospective study for outcome
|
group treated with mega dose methyl prednisolone patients with positive PCR and requiring oxygen therapy |
Other: observation for outcome of methylprednisolone dose
no intervention as it is retrospective study for outcome
|
Outcome Measures
Primary Outcome Measures
- 28 days mortality rate [1 month]
observation for mortality rate in both groups
Secondary Outcome Measures
- mechanical ventilation and icu length of stay [up to 3 months]
observation for percentage of mechanically ventilated patients and length of stay
Eligibility Criteria
Criteria
Inclusion Criteria:
- All icu admitted covid 19 patients with positive PCR, diagnosed by CT chest and needing oxygen therapy
Exclusion Criteria:
-
Not requiring oxygen therapy
-
Negative PCR
-
Uncontrolled blood sugar or DKA
-
Patients on long term steroids therapy
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Ain shams university hospitals | Cairo | Egypt | ||
2 | Faculty of medicine, Ain Shams University | Cairo | Egypt |
Sponsors and Collaborators
- Ain Shams University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- MS41/2022